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Strain Name:
C57BL/6J-MtgxR2041Btlr/Mmmh
Stock Number:
040048-MU
Citation ID:
RRID:MMRRC_040048-MU
Other Names:
R2041 (G1), C57BL/6J-MtgxR2041Btlr
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Dlc1
Name: deleted in liver cancer 1
Synonyms: p122-RhoGAP, STARD12, Arhgap7, A730069N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Plcb4
Name: phospholipase C, beta 4
Synonyms: C230058B11Rik, A930039J07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Vps54
Name: VPS54 GARP complex subunit
Synonyms: Vps54l, 5330404P15Rik, mSLP8, wr
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245944
Homologene: 5605
Sh3gl3
Name: SH3-domain GRB2-like 3
Synonyms: SH3P13, EEN-B2, endophilin III, Sh3d2c, Sh3d2c2, endophilin A3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20408
Homologene: 37723
Anks1
Name: ankyrin repeat and SAM domain containing 1
Synonyms: Odin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224650
Homologene: 9068
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 127,937,990 bp
  • A to G, chromosome 1 at 144,002,222 bp
  • C to T, chromosome 2 at 25,568,170 bp
  • G to A, chromosome 2 at 30,108,274 bp
  • T to C, chromosome 2 at 87,902,797 bp
  • T to C, chromosome 2 at 88,402,224 bp
  • T to C, chromosome 2 at 128,831,589 bp
  • C to T, chromosome 2 at 135,938,271 bp
  • C to A, chromosome 3 at 123,672,215 bp
  • T to C, chromosome 4 at 57,084,070 bp
  • A to G, chromosome 4 at 106,653,617 bp
  • T to G, chromosome 4 at 116,599,592 bp
  • T to A, chromosome 4 at 135,705,837 bp
  • T to A, chromosome 4 at 138,105,306 bp
  • A to T, chromosome 4 at 147,755,339 bp
  • A to G, chromosome 4 at 152,283,353 bp
  • T to C, chromosome 4 at 155,090,942 bp
  • T to C, chromosome 5 at 25,760,130 bp
  • T to C, chromosome 5 at 110,848,664 bp
  • T to C, chromosome 5 at 114,387,233 bp
  • T to A, chromosome 5 at 145,045,401 bp
  • T to C, chromosome 6 at 73,073,439 bp
  • T to C, chromosome 7 at 5,083,875 bp
  • T to A, chromosome 7 at 18,614,778 bp
  • T to A, chromosome 7 at 26,450,186 bp
  • T to C, chromosome 7 at 34,202,802 bp
  • A to G, chromosome 7 at 41,625,979 bp
  • C to T, chromosome 7 at 47,464,160 bp
  • A to C, chromosome 7 at 82,270,778 bp
  • T to A, chromosome 7 at 102,948,963 bp
  • T to C, chromosome 7 at 120,991,916 bp
  • A to G, chromosome 8 at 36,582,768 bp
  • A to G, chromosome 8 at 89,032,801 bp
  • T to C, chromosome 8 at 104,488,477 bp
  • A to T, chromosome 9 at 19,496,835 bp
  • A to T, chromosome 9 at 121,982,288 bp
  • C to T, chromosome 10 at 3,259,972 bp
  • C to T, chromosome 10 at 4,356,489 bp
  • A to G, chromosome 10 at 10,746,603 bp
  • A to G, chromosome 10 at 12,658,681 bp
  • A to T, chromosome 10 at 39,069,991 bp
  • A to T, chromosome 10 at 62,766,048 bp
  • A to G, chromosome 10 at 117,359,128 bp
  • A to G, chromosome 11 at 21,271,690 bp
  • A to T, chromosome 11 at 26,547,914 bp
  • T to A, chromosome 11 at 69,197,691 bp
  • T to A, chromosome 11 at 71,025,306 bp
  • T to A, chromosome 11 at 72,031,506 bp
  • C to T, chromosome 11 at 98,701,657 bp
  • C to T, chromosome 12 at 29,984,419 bp
  • A to G, chromosome 12 at 108,113,392 bp
  • C to A, chromosome 13 at 48,897,767 bp
  • A to G, chromosome 13 at 49,341,776 bp
  • A to C, chromosome 15 at 6,644,787 bp
  • A to T, chromosome 15 at 11,215,735 bp
  • G to A, chromosome 15 at 58,558,306 bp
  • T to A, chromosome 15 at 75,919,295 bp
  • C to G, chromosome 17 at 12,675,235 bp
  • CAGGAA to CA, chromosome 17 at 18,022,334 bp
  • T to A, chromosome 17 at 28,008,414 bp
  • C to A, chromosome 17 at 46,986,047 bp
  • T to C, chromosome 17 at 58,104,770 bp
  • T to A, chromosome 17 at 58,198,989 bp
  • G to T, chromosome 18 at 22,523,451 bp
  • C to T, chromosome 18 at 36,530,793 bp
  • T to A, chromosome 18 at 37,967,676 bp
  • C to T, chromosome 18 at 71,370,772 bp
  • A to T, chromosome 19 at 13,146,677 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2041 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040048-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.