Strain Name:
C57BL/6J-MtgxR2048Btlr/Mmmh
Stock Number:
040055-MU
Citation ID:
RRID:MMRRC_040055-MU
Other Names:
R2048 (G1), C57BL/6J-MtgxR2048Btlr
Major Collection:

Gene Information

Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: NMHC II-A, Myhn1, Fltn, E030044M24Rik, Myhn-1, D0Jmb2, myosin IIA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Adk
Name: adenosine kinase
Synonyms: 5033405D03Rik, 2310026J05Rik, AK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 11534
VEGA: 14
HGNC: HGNC:257
Homologene: 4891
Oxsr1
Name: oxidative-stress responsive 1
Synonyms: 2810422B09Rik, Osr1, 2210022N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 108737
HGNC: HGNC:8508
Homologene: 31288
Slc4a2
Name: solute carrier family 4 (anion exchanger), member 2
Synonyms: Ae2, B3RP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20535
Homologene: 128699
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Phr1, C130061D10Rik, Pam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: 1110037D04Rik, Lrrc16, Carmil, Lrrc16a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68732
Homologene: 9757
Tab1
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
Synonyms: Tak1-binding protein 1, Map3k7ip1, b2b449Clo, 2310012M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66513
VEGA: 15
Homologene: 4461
Tbcd
Name: tubulin-specific chaperone d
Synonyms: 2310057L06Rik, A030005L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108903
Homologene: 4368
Ptpn21
Name: protein tyrosine phosphatase, non-receptor type 21
Synonyms: PTPRL10, PTPD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 24000
VEGA: 12
HGNC: HGNC:9651
Homologene: 5110
Rsf1
Name: remodeling and spacing factor 1
Synonyms: C030033M12Rik, Hbxap, XAP8, 4832420A03Rik, p325
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233532
Homologene: 41142
Fbxo21
Name: F-box protein 21
Synonyms: 2810425J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231670
Homologene: 14145
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRTe, SMRT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Aff4
Name: AF4/FMR2 family, member 4
Synonyms: Alf4, Laf4l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 93736
Homologene: 8683
Cit
Name: citron
Synonyms: CRIK-SK, citron kinase, Cit-k, C030025P15Rik, citron-N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Camsap1
Name: calmodulin regulated spectrin-associated protein 1
Synonyms: 9530003A05Rik, PRO2405
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227634
Homologene: 19202
Cyp51
Name: cytochrome P450, family 51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13121
HGNC: HGNC:2649
Homologene: 55488
Epg5
Name: ectopic P-granules autophagy protein 5 homolog (C. elegans)
Synonyms: 5430411K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Pi4k2b
Name: phosphatidylinositol 4-kinase type 2 beta
Synonyms: 2610042N09Rik, 4933409G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67073
Homologene: 32405
Rpl24
Name: ribosomal protein L24
Synonyms: Bst, 0610008L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 68193
Homologene: 763
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: 2210407G14Rik, Hapip, E530005C20Rik, LOC224126
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Thsd1
Name: thrombospondin, type I, domain 1
Synonyms: Tmtsp, 4833423O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56229
Homologene: 10264
Klf7
Name: Kruppel-like factor 7 (ubiquitous)
Synonyms: 9830124P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 93691
HGNC: HGNC:6350
Homologene: 2751
Epb41l4b
Name: erythrocyte membrane protein band 4.1 like 4b
Synonyms: D4Ertd346e, Ehm2, Epb4.1l4b, 6430543G08Rik, Lulu2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 54357
Homologene: 69270
Col24a1
Name: collagen, type XXIV, alpha 1
Synonyms: 5430404K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71355
Homologene: 65061
Tas2r124
Name: taste receptor, type 2, member 124
Synonyms: Tas2r24, mGR24, T2R24, mt2r50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387351
Homologene: 87293
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Il12rb2
Name: interleukin 12 receptor, beta 2
Synonyms: IL-12RB2, Ifnm, A930027I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16162
HGNC: HGNC:5972
Homologene: 1197
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Poteg
Name: POTE ankyrin domain family, member G
Synonyms: 4921537P18Rik, 4930456F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70952
Homologene: 134158
Fsip1
Name: fibrous sheath-interacting protein 1
Synonyms: 1700012M13Rik, 4933432K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71313
Homologene: 12390
Hal
Name: histidine ammonia lyase
Synonyms: Hsd, histidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15109
HGNC: HGNC:4806
Homologene: 68229
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: 2310047C17Rik, 1110004P15Rik, DY6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Cntn4
Name: contactin 4
Synonyms: BIG-2A, Axcam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 269784
HGNC: HGNC:2174
Homologene: 14257
Slc9a3
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3
Synonyms: 9030624O13Rik, NHE3, NHE-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105243
VEGA: 13
Homologene: 55804
Adhfe1
Name: alcohol dehydrogenase, iron containing, 1
Synonyms: 6330565B14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76187
Homologene: 5865
Zfp541
Name: zinc finger protein 541
Synonyms: EG666528
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 666528
Homologene: 12991
Adam10
Name: a disintegrin and metallopeptidase domain 10
Synonyms: kuz, 1700031C13Rik, kuzbanian
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11487
HGNC: HGNC:188
Homologene: 865
Cyp2d26
Name: cytochrome P450, family 2, subfamily d, polypeptide 26
Synonyms: 1300006E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76279
VEGA: 15
Homologene: 130660
Fpr-rs4
Name: formyl peptide receptor, related sequence 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14291
Homologene: 130629
Ptk2b
Name: PTK2 protein tyrosine kinase 2 beta
Synonyms: PYK2, CAKbeta, calcium-dependent tyrosine kinase, cellular adhesion kinase beta, Raftk, proline-rich tyrosine kinase 2, E430023O05Rik, related adhesion focal tyrosine kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19229
HGNC: HGNC:9612
Homologene: 23001
Ccdc63
Name: coiled-coil domain containing 63
Synonyms: 4921511C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330188
Homologene: 45136
Cyp3a13
Name: cytochrome P450, family 3, subfamily a, polypeptide 13
Synonyms: steroid inducible, IIIAm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13113
HGNC: HGNC:2640
Homologene: 133564
Pilrb1
Name: paired immunoglobin-like type 2 receptor beta 1
Synonyms: Fdact, Pilrb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 170741
Homologene: 114502
Pde3a
Name: phosphodiesterase 3A, cGMP inhibited
Synonyms: A930022O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54611
HGNC: HGNC:8778
Homologene: 708
Gtpbp6
Name: GTP binding protein 6 (putative)
Synonyms: Pgbpll, pgpl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 107999
Homologene: 8157
Ceacam1
Name: carcinoembryonic antigen-related cell adhesion molecule 1
Synonyms: Mhv-1, Hv-2, Cc1, Cea7, MHVR1, CD66a, Cea-7, mmCGM2, Cea-1, Bgp1, Hv2, C-CAM, mCEA1, Cea1, mmCGM1, Bgp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26365
HGNC: HGNC:1814
Homologene: 128630
Ift27
Name: intraflagellar transport 27
Synonyms: Rabl4, 2600013G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67042
VEGA: 15
Homologene: 4998
Olfr441
Name: olfactory receptor 441
Synonyms: MOR261-3, GA_x6K02T2P3E9-4442577-4441645
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258649
Homologene: 88438
Krt6b
Name: keratin 6B
Synonyms: mK6[b], Krt2-6b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16688
VEGA: 15
Homologene: 136794
Kng1
Name: kininogen 1
Synonyms: L-kininogen, H-kininigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16644
HGNC: HGNC:6383
Homologene: 88343
Magohb
Name: mago homolog B, exon junction complex core component
Synonyms: Magoh-rs1, 2010012C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66441
Homologene: 56794
Vegfc
Name: vascular endothelial growth factor C
Synonyms: VEGF-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22341
Homologene: 3962
Lpcat2
Name: lysophosphatidylcholine acyltransferase 2
Synonyms: lysoPAFAT/LPCAT2, Aytl1, LPCAT2, Aytl1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270084
Homologene: 41201
Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Synonyms: PPAR Gamma Coactivator-1, Pgc-1alpha, Gm11133, A830037N07Rik, Pgc-1alphaa, Pgc1, Pgco1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19017
HGNC: HGNC:9237
Homologene: 7485
Shisa3
Name: shisa family member 3
Synonyms: mShisa3, D830007B15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330096
Homologene: 47831
Dipk1a
Name: divergent protein kinase domain 1A
Synonyms: 2900024C23Rik, Fam69a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67266
Homologene: 12104
Gm10152
Name: predicted gene 10152
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Nradd
Name: neurotrophin receptor associated death domain
Synonyms: NRDD, 2610311B09Rik, PLAIDD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67169
Homologene: 12091
Olfr819
Name: olfactory receptor 819
Synonyms: GA_x6K02T2PULF-11644164-11643823, MOR265-2_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100043200
Homologene: 73929
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 9,563,553 bp
  • A to G, chromosome 1 at 64,078,754 bp
  • T to C, chromosome 2 at 25,929,743 bp
  • C to A, chromosome 2 at 118,241,716 bp
  • T to A, chromosome 3 at 145,524,116 bp
  • T to G, chromosome 4 at 57,142,866 bp
  • G to A, chromosome 5 at 4,086,636 bp
  • A to G, chromosome 5 at 24,431,559 bp
  • A to G, chromosome 5 at 51,548,516 bp
  • A to T, chromosome 5 at 52,748,431 bp
  • G to A, chromosome 5 at 67,611,308 bp
  • T to C, chromosome 5 at 107,910,020 bp
  • A to C, chromosome 5 at 110,107,065 bp
  • T to C, chromosome 5 at 115,886,813 bp
  • T to A, chromosome 5 at 118,008,104 bp
  • A to C, chromosome 5 at 122,130,287 bp
  • C to T, chromosome 5 at 125,084,932 bp
  • T to C, chromosome 5 at 137,854,891 bp
  • A to T, chromosome 5 at 137,909,975 bp
  • A to G, chromosome 6 at 40,656,429 bp
  • T to A, chromosome 6 at 43,116,378 bp
  • G to T, chromosome 6 at 67,360,545 bp
  • A to G, chromosome 6 at 106,437,864 bp
  • A to T, chromosome 6 at 131,289,422 bp
  • A to G, chromosome 6 at 132,754,895 bp
  • A to G, chromosome 6 at 141,489,006 bp
  • A to G, chromosome 7 at 16,078,327 bp
  • G to T, chromosome 7 at 25,476,688 bp
  • A to T, chromosome 7 at 46,287,639 bp
  • GCG to GCGACGGCGACG, chromosome 7 at 97,579,907 bp
  • T to C, chromosome 7 at 144,763,312 bp
  • A to G, chromosome 8 at 22,259,317 bp
  • A to T, chromosome 8 at 27,456,746 bp
  • T to C, chromosome 8 at 54,181,429 bp
  • T to G, chromosome 8 at 92,869,843 bp
  • A to G, chromosome 9 at 70,740,075 bp
  • T to C, chromosome 9 at 110,621,629 bp
  • A to G, chromosome 9 at 119,247,074 bp
  • A to G, chromosome 10 at 93,491,140 bp
  • G to A, chromosome 10 at 129,965,992 bp
  • A to G, chromosome 11 at 53,398,385 bp
  • G to T, chromosome 11 at 121,540,936 bp
  • A to G, chromosome 12 at 98,689,526 bp
  • A to G, chromosome 13 at 24,106,392 bp
  • A to G, chromosome 13 at 74,163,741 bp
  • A to G, chromosome 14 at 21,318,176 bp
  • T to G, chromosome 14 at 66,172,505 bp
  • A to G, chromosome 14 at 103,232,524 bp
  • G to A, chromosome 15 at 77,771,132 bp
  • A to G, chromosome 15 at 78,173,763 bp
  • T to C, chromosome 15 at 80,158,916 bp
  • A to G, chromosome 15 at 82,792,727 bp
  • T to A, chromosome 15 at 101,678,404 bp
  • A to G, chromosome 16 at 23,058,604 bp
  • A to G, chromosome 16 at 34,252,310 bp
  • A to G, chromosome 16 at 49,155,565 bp
  • T to A, chromosome 16 at 55,998,009 bp
  • CAGGAA to CA, chromosome 17 at 18,022,334 bp
  • A to G, chromosome 18 at 78,023,987 bp
  • T to A, chromosome 19 at 9,007,056 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2048 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040055-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.