Strain Name:
C57BL/6J-MtgxR2085Btlr/Mmmh
Stock Number:
040090-MU
Citation ID:
RRID:MMRRC_040090-MU
Other Names:
R2085 (G1), C57BL/6J-MtgxR2085Btlr
Major Collection:

Gene Information

Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: C030027L06Rik, Tkrb, trkB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Mbd5
Name: methyl-CpG binding domain protein 5
Synonyms: OTTMUSG00000012483, 9430004D19Rik, C030040A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 109241
Homologene: 81861
Bahcc1
Name: BAH domain and coiled-coil containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268515
Homologene: 129585
Mbd4
Name: methyl-CpG binding domain protein 4
Synonyms: Med1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17193
HGNC: HGNC:6919
Homologene: 2916
Cd9
Name: CD9 antigen
Synonyms: Tspan29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12527
HGNC: HGNC:1709
Homologene: 20420
F2r
Name: coagulation factor II (thrombin) receptor
Synonyms: Cf2r, Par1, ThrR, thrombin receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14062
VEGA: 13
HGNC: HGNC:3537
Homologene: 1510
Polr2j
Name: polymerase (RNA) II (DNA directed) polypeptide J
Synonyms: Rpo2-4, Rpb11a, RNA polymerase II subunit RPB14, 14.5kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20022
HGNC: HGNC:9197
Homologene: 4542
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, rjs, jdf2, D7H15F37S1, D15F32S1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Zfp318
Name: zinc finger protein 318
Synonyms: TZF, D530032D06Rik, 2610034E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57908
Homologene: 22808
Malt1
Name: MALT1 paracaspase
Synonyms: D430033E09Rik, paracaspase, Pcasp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240354
HGNC: HGNC:6819
Homologene: 4938
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, Zfp650, A130030D10Rik, 1110059H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68795
Homologene: 52092
Megf9
Name: multiple EGF-like-domains 9
Synonyms: Egfl5, 4933405H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230316
HGNC: HGNC:3234
Homologene: 18209
Rdh11
Name: retinol dehydrogenase 11
Synonyms: 2610319N22Rik, Psdr1, Arsdr1, M42C60, Mdt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 17252
Homologene: 100724
Nid2
Name: nidogen 2
Synonyms: entactin-2, entactin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18074
VEGA: 14
Homologene: 40575
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20743
VEGA: 19
Homologene: 48482
Bub1b
Name: BUB1B, mitotic checkpoint serine/threonine kinase
Synonyms: BUBR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12236
HGNC: HGNC:1149
Homologene: 933
Zfp874a
Name: zinc finger protein 874a
Synonyms: C330011K17Rik, Rslcan15, Zfp874
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238692
Homologene: 135597
Clec9a
Name: C-type lectin domain family 9, member a
Synonyms: DNGR-1, 9830005G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232414
Homologene: 52106
Hyal4
Name: hyaluronoglucosaminidase 4
Synonyms: 4632428M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 77042
HGNC: HGNC:5323
Homologene: 69117
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Acad10
Name: acyl-Coenzyme A dehydrogenase family, member 10
Synonyms: 2410021P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71985
Homologene: 49825
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: Dnhd3, 2900022L05Rik, Dnahc2, D330014H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Hsh2d
Name: hematopoietic SH2 domain containing
Synonyms: ALX, Hsh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 209488
Homologene: 13142
Olfr905
Name: olfactory receptor 905
Synonyms: MOR167-1, GA_x6K02T2PVTD-32165709-32166641
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258800
VEGA: 9
Homologene: 110524
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: MIBP1, Gm20114, Shn-2, Schnurri-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Hipk1
Name: homeodomain interacting protein kinase 1
Synonyms: Myak, 1110062K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15257
Homologene: 56483
Stab2
Name: stabilin 2
Synonyms: STAB-2, FEEL-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 192188
Homologene: 23022
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Gas2l2
Name: growth arrest-specific 2 like 2
Synonyms: OTTMUSG00000000934
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237891
Homologene: 16409
Olfr186
Name: olfactory receptor 186
Synonyms: GA_x54KRFPKG5P-55257214-55256285, MOR183-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258318
Homologene: 133671
Duox2
Name: dual oxidase 2
Synonyms: A430065P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214593
Homologene: 9689
Ppp1r16a
Name: protein phosphatase 1, regulatory subunit 16A
Synonyms: 2900084E10Rik, Mypt3, R75527
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 73062
Homologene: 13161
Cgnl1
Name: cingulin-like 1
Synonyms: 9930020M10Rik, Jacop, 4933421H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68178
Homologene: 41901
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: Cryabp1, alphaA-CRYBP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Tifab
Name: TRAF-interacting protein with forkhead-associated domain, family member B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 212937
VEGA: 13
Homologene: 27087
Inpp4b
Name: inositol polyphosphate-4-phosphatase, type II
Synonyms: E130107I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234515
HGNC: HGNC:6075
Homologene: 20832
Lingo4
Name: leucine rich repeat and Ig domain containing 4
Synonyms: LERN4, A530050P17Rik, Lrrn6d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 320747
Homologene: 18563
Smc1b
Name: structural maintenance of chromosomes 1B
Synonyms: Smc1l2, SMC1beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 140557
VEGA: 15
Homologene: 13786
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
Me1
Name: malic enzyme 1, NADP(+)-dependent, cytosolic
Synonyms: Mod1, Mdh-1, Mod-1, D9Ertd267e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17436
HGNC: HGNC:6983
Homologene: 134785
Prickle2
Name: prickle planar cell polarity protein 2
Synonyms: 6230400G14Rik, mpk2, 6720451F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243548
Homologene: 17889
Wdr46
Name: WD repeat domain 46
Synonyms: 2310007I04Rik, Bing4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57315
Homologene: 3981
Adprm
Name: ADP-ribose/CDP-alcohol diphosphatase, manganese dependent
Synonyms: 2310004I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66358
Homologene: 10632
Zscan29
Name: zinc finger SCAN domains 29
Synonyms: Zfp690
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99334
Homologene: 17586
Itih4
Name: inter alpha-trypsin inhibitor, heavy chain 4
Synonyms: Itih-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16427
HGNC: HGNC:6169
Homologene: 1670
Sgk2
Name: serum/glucocorticoid regulated kinase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27219
Homologene: 8446
Usp17lb
Name: ubiquitin specific peptidase 17-like B
Synonyms: Dub1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381944
Homologene: 131315
Plscr2
Name: phospholipid scramblase 2
Synonyms: PL scramblase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18828
Homologene: 134152
Map3k3
Name: mitogen-activated protein kinase kinase kinase 3
Synonyms: Mekk3, MAPKKK3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 26406
HGNC: HGNC:6855
Homologene: 69110
Dpep3
Name: dipeptidase 3
Synonyms: 1700018F16Rik, MBD-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71854
Homologene: 23357
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: E130207I19Rik, NEDL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 94253
VEGA: 13
Homologene: 9004
Olfr20
Name: olfactory receptor 20
Synonyms: Olfr21, GA_x6K02T2P1NL-3514066-3515010, MOR135-11, MTPCR55, MTPCR06
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258925
Homologene: 128054
Efhb
Name: EF hand domain family, member B
Synonyms: 4921525D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 211482
VEGA: 17
Homologene: 16982
Fcamr
Name: Fc receptor, IgA, IgM, high affinity
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 64435
Homologene: 12929
Olfr62
Name: olfactory receptor 62
Synonyms: IH12, GA_x6K02T2QD9B-18877756-18876809, MOR258-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18363
Olfr728
Name: olfactory receptor 728
Synonyms: GA_x6K02T2PMLR-5831021-5830086, MOR246-1P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258039
Homologene: 74224
Sdhaf3
Name: succinate dehydrogenase complex assembly factor 3
Synonyms: 4933430A16Rik, Acn9, 0610005M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71238
Homologene: 41349
Galt
Name: galactose-1-phosphate uridyl transferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14430
HGNC: HGNC:4135
Homologene: 126
2810408A11Rik
Name: RIKEN cDNA 2810408A11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70419
Homologene: 49883
Nkx1-1
Name: NK1 homeobox 1
Synonyms: Sax2, Nkx-1.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 672284
Homologene: 78303
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 130,811,598 bp
  • T to A, chromosome 2 at 49,279,311 bp
  • C to T, chromosome 2 at 69,953,764 bp
  • A to G, chromosome 2 at 118,622,195 bp
  • A to T, chromosome 2 at 121,169,946 bp
  • G to T, chromosome 2 at 122,280,967 bp
  • T to C, chromosome 2 at 163,012,970 bp
  • C to A, chromosome 3 at 94,402,245 bp
  • T to C, chromosome 3 at 103,750,354 bp
  • C to T, chromosome 3 at 114,158,142 bp
  • G to A, chromosome 4 at 41,758,162 bp
  • T to C, chromosome 4 at 70,448,767 bp
  • T to C, chromosome 4 at 118,666,104 bp
  • A to G, chromosome 5 at 33,433,617 bp
  • A to G, chromosome 5 at 121,649,460 bp
  • T to C, chromosome 5 at 136,116,771 bp
  • A to G, chromosome 6 at 6,956,048 bp
  • C to T, chromosome 6 at 24,755,750 bp
  • T to C, chromosome 6 at 92,376,364 bp
  • T to A, chromosome 6 at 115,848,957 bp
  • T to G, chromosome 6 at 121,676,959 bp
  • A to T, chromosome 6 at 125,463,771 bp
  • T to C, chromosome 6 at 129,410,311 bp
  • C to A, chromosome 7 at 56,212,965 bp
  • T to A, chromosome 7 at 104,840,415 bp
  • C to T, chromosome 8 at 72,196,787 bp
  • A to G, chromosome 8 at 81,952,274 bp
  • A to G, chromosome 8 at 105,974,714 bp
  • A to G, chromosome 9 at 38,472,927 bp
  • G to A, chromosome 9 at 71,630,878 bp
  • T to C, chromosome 9 at 86,613,554 bp
  • A to G, chromosome 9 at 92,282,197 bp
  • C to A, chromosome 10 at 14,128,969 bp
  • C to A, chromosome 10 at 14,139,529 bp
  • A to T, chromosome 10 at 27,204,841 bp
  • A to G, chromosome 10 at 86,954,159 bp
  • T to A, chromosome 11 at 67,041,852 bp
  • A to C, chromosome 11 at 69,500,862 bp
  • G to T, chromosome 11 at 69,900,372 bp
  • T to C, chromosome 11 at 73,354,421 bp
  • C to A, chromosome 11 at 83,427,383 bp
  • G to T, chromosome 11 at 106,151,147 bp
  • A to G, chromosome 11 at 120,288,082 bp
  • C to T, chromosome 12 at 8,012,240 bp
  • T to C, chromosome 12 at 79,182,782 bp
  • A to T, chromosome 13 at 14,264,087 bp
  • A to G, chromosome 13 at 42,183,750 bp
  • T to C, chromosome 13 at 56,176,297 bp
  • T to C, chromosome 13 at 58,842,871 bp
  • T to A, chromosome 13 at 67,442,848 bp
  • T to C, chromosome 13 at 95,604,910 bp
  • G to A, chromosome 14 at 19,778,043 bp
  • A to G, chromosome 14 at 30,892,323 bp
  • T to A, chromosome 14 at 50,140,123 bp
  • T to A, chromosome 15 at 76,693,596 bp
  • A to G, chromosome 15 at 85,121,851 bp
  • C to T, chromosome 16 at 59,027,869 bp
  • G to T, chromosome 17 at 33,941,451 bp
  • T to A, chromosome 17 at 46,409,664 bp
  • C to T, chromosome 17 at 53,426,909 bp
  • A to G, chromosome 18 at 65,473,147 bp
  • A to G, chromosome 19 at 4,738,559 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2085 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040090-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.