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Strain Name:
C57BL/6J-MtgxR2132Btlr/Mmmh
Stock Number:
040135-MU
Citation ID:
RRID:MMRRC_040135-MU
Other Names:
R2132 (G1), C57BL/6J-MtgxR2132Btlr
Major Collection:

Strain Information

Ntrk3
Name: neurotrophic tyrosine kinase, receptor, type 3
Synonyms: TrkC
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18213
HGNC: HGNC:8033
Homologene: 49183
Magi1
Name: membrane associated guanylate kinase, WW and PDZ domain containing 1
Synonyms: WWP3, Gukmi1, AIP3, BAP1, Baiap1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14924
HGNC: HGNC:946
Homologene: 31257
Kansl2
Name: KAT8 regulatory NSL complex subunit 2
Synonyms: 2310037I24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69612
VEGA: 15
Homologene: 32367
Mcm7
Name: minichromosome maintenance complex component 7
Synonyms: mCDC47, Mcmd7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17220
HGNC: HGNC:6950
Homologene: 4323
Ift70b
Name: intraflagellar transport 70B
Synonyms: 2510042P03Rik, Ttc30b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72421
Homologene: 71716
Ap2b1
Name: adaptor-related protein complex 2, beta 1 subunit
Synonyms: 1300012O03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71770
HGNC: HGNC:563
Homologene: 137384
Vps35l
Name: VPS35 endosomal protein sorting factor like
Synonyms: 9030624J02Rik, Vsp35l
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71517
Homologene: 10659
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 15,805,685 bp
  • T to G, chromosome 1 at 40,607,741 bp
  • C to T, chromosome 1 at 45,442,881 bp
  • A to G, chromosome 1 at 58,169,843 bp
  • A to C, chromosome 1 at 74,907,691 bp
  • G to A, chromosome 1 at 82,497,860 bp
  • T to A, chromosome 1 at 132,449,484 bp
  • T to C, chromosome 1 at 143,745,104 bp
  • A to C, chromosome 1 at 156,007,562 bp
  • A to G, chromosome 1 at 173,729,771 bp
  • C to A, chromosome 1 at 176,955,889 bp
  • T to C, chromosome 2 at 31,335,582 bp
  • A to G, chromosome 2 at 36,480,047 bp
  • A to G, chromosome 2 at 36,937,692 bp
  • T to A, chromosome 2 at 49,758,805 bp
  • C to T, chromosome 2 at 65,350,131 bp
  • A to T, chromosome 2 at 67,508,048 bp
  • G to T, chromosome 2 at 75,936,785 bp
  • T to A, chromosome 2 at 76,586,214 bp
  • A to G, chromosome 2 at 86,131,261 bp
  • G to T, chromosome 2 at 91,010,446 bp
  • T to C, chromosome 2 at 103,981,062 bp
  • C to T, chromosome 2 at 131,179,306 bp
  • T to A, chromosome 2 at 135,325,667 bp
  • G to A, chromosome 2 at 153,052,896 bp
  • A to C, chromosome 2 at 153,621,666 bp
  • T to C, chromosome 2 at 178,283,966 bp
  • G to T, chromosome 3 at 59,265,282 bp
  • T to C, chromosome 3 at 86,920,046 bp
  • A to T, chromosome 3 at 121,451,935 bp
  • C to A, chromosome 4 at 62,327,899 bp
  • A to T, chromosome 4 at 89,688,709 bp
  • A to G, chromosome 4 at 100,410,025 bp
  • A to G, chromosome 4 at 109,442,706 bp
  • A to G, chromosome 4 at 109,710,845 bp
  • A to T, chromosome 4 at 114,610,008 bp
  • A to T, chromosome 4 at 115,491,391 bp
  • T to C, chromosome 4 at 123,246,083 bp
  • A to T, chromosome 4 at 124,785,168 bp
  • A to T, chromosome 4 at 129,596,926 bp
  • T to A, chromosome 4 at 141,005,016 bp
  • T to A, chromosome 4 at 145,624,233 bp
  • T to A, chromosome 4 at 147,985,997 bp
  • A to G, chromosome 5 at 87,964,476 bp
  • A to T, chromosome 5 at 107,578,455 bp
  • T to C, chromosome 5 at 108,320,052 bp
  • TGGGG to TGGG, chromosome 5 at 114,209,767 bp
  • G to A, chromosome 5 at 134,136,153 bp
  • T to C, chromosome 5 at 138,169,102 bp
  • C to T, chromosome 5 at 144,174,988 bp
  • T to A, chromosome 5 at 144,208,645 bp
  • T to C, chromosome 5 at 151,045,168 bp
  • G to A, chromosome 6 at 29,443,676 bp
  • C to A, chromosome 6 at 42,744,135 bp
  • T to C, chromosome 6 at 93,697,274 bp
  • T to A, chromosome 6 at 129,641,538 bp
  • T to A, chromosome 7 at 4,523,801 bp
  • C to T, chromosome 7 at 28,155,474 bp
  • T to C, chromosome 7 at 34,205,914 bp
  • A to T, chromosome 7 at 62,377,738 bp
  • G to T, chromosome 7 at 75,611,434 bp
  • G to A, chromosome 7 at 78,477,935 bp
  • C to T, chromosome 7 at 86,321,479 bp
  • T to A, chromosome 7 at 92,901,280 bp
  • T to C, chromosome 7 at 118,794,575 bp
  • T to C, chromosome 7 at 127,386,935 bp
  • C to A, chromosome 7 at 143,592,474 bp
  • C to T, chromosome 7 at 143,617,840 bp
  • T to A, chromosome 8 at 25,851,900 bp
  • A to C, chromosome 8 at 28,875,529 bp
  • T to G, chromosome 8 at 54,672,506 bp
  • G to A, chromosome 8 at 71,693,327 bp
  • A to T, chromosome 8 at 72,386,868 bp
  • A to G, chromosome 8 at 79,185,721 bp
  • A to T, chromosome 8 at 111,297,402 bp
  • G to A, chromosome 8 at 116,934,797 bp
  • A to T, chromosome 8 at 128,498,516 bp
  • A to G, chromosome 9 at 16,246,719 bp
  • A to G, chromosome 9 at 21,846,518 bp
  • T to C, chromosome 9 at 30,433,443 bp
  • T to G, chromosome 9 at 35,789,743 bp
  • T to C, chromosome 9 at 72,308,005 bp
  • A to G, chromosome 9 at 107,744,169 bp
  • G to A, chromosome 10 at 5,346,808 bp
  • A to G, chromosome 10 at 11,343,682 bp
  • G to A, chromosome 10 at 31,248,933 bp
  • T to A, chromosome 10 at 81,278,054 bp
  • T to G, chromosome 10 at 127,011,892 bp
  • A to G, chromosome 11 at 3,679,787 bp
  • A to T, chromosome 11 at 4,150,004 bp
  • A to T, chromosome 11 at 23,464,556 bp
  • G to A, chromosome 11 at 28,434,151 bp
  • C to A, chromosome 11 at 48,807,592 bp
  • A to G, chromosome 11 at 54,063,737 bp
  • T to A, chromosome 11 at 62,859,857 bp
  • A to G, chromosome 11 at 67,292,876 bp
  • A to G, chromosome 11 at 68,807,289 bp
  • T to G, chromosome 11 at 69,651,738 bp
  • T to A, chromosome 11 at 83,324,761 bp
  • A to G, chromosome 11 at 87,797,361 bp
  • T to A, chromosome 11 at 94,367,600 bp
  • T to C, chromosome 11 at 96,464,733 bp
  • G to A, chromosome 11 at 118,033,747 bp
  • T to A, chromosome 11 at 118,393,287 bp
  • T to A, chromosome 12 at 79,268,434 bp
  • A to C, chromosome 12 at 108,311,690 bp
  • A to G, chromosome 13 at 13,509,486 bp
  • T to A, chromosome 13 at 15,725,549 bp
  • A to G, chromosome 13 at 54,991,083 bp
  • G to T, chromosome 13 at 59,701,043 bp
  • G to A, chromosome 13 at 93,069,383 bp
  • C to T, chromosome 13 at 93,674,235 bp
  • A to C, chromosome 14 at 7,873,376 bp
  • T to C, chromosome 14 at 56,678,704 bp
  • T to C, chromosome 15 at 48,457,503 bp
  • A to G, chromosome 15 at 82,618,501 bp
  • A to G, chromosome 15 at 83,505,235 bp
  • T to A, chromosome 15 at 86,031,967 bp
  • A to G, chromosome 15 at 93,244,970 bp
  • T to A, chromosome 15 at 98,075,967 bp
  • A to G, chromosome 15 at 98,529,397 bp
  • A to C, chromosome 16 at 4,835,971 bp
  • C to A, chromosome 16 at 56,767,918 bp
  • A to T, chromosome 17 at 12,722,208 bp
  • A to G, chromosome 17 at 22,375,970 bp
  • A to G, chromosome 17 at 35,909,439 bp
  • T to C, chromosome 17 at 43,624,833 bp
  • T to C, chromosome 17 at 46,161,202 bp
  • T to C, chromosome 17 at 52,893,933 bp
  • G to T, chromosome 17 at 66,343,623 bp
  • T to A, chromosome 18 at 20,340,797 bp
  • T to A, chromosome 18 at 76,288,084 bp
  • T to C, chromosome 18 at 80,117,308 bp
  • T to C, chromosome 18 at 82,621,304 bp
  • T to A, chromosome 19 at 12,999,038 bp
  • T to G, chromosome 19 at 53,926,326 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2132 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040135-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.