Strain Name:
C57BL/6J-MtgxR2150Btlr/Mmmh
Stock Number:
040153-MU
Citation ID:
RRID:MMRRC_040153-MU
Other Names:
R2150 (G1), C57BL/6J-MtgxR2150Btlr
Major Collection:

Strain Information

Abca12
Name: ATP-binding cassette, sub-family A (ABC1), member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74591
Homologene: 45441
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Cdca2
Name: cell division cycle associated 2
Synonyms: 2610311M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 108912
Homologene: 18444
Parvb
Name: parvin, beta
Synonyms: D15Gsk1, affixin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170736
Homologene: 8342
Arfgef1
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
Synonyms: D730028O18Rik, ARFGEP1, P200, BIG1, D130059B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 211673
Homologene: 4687
Anapc2
Name: anaphase promoting complex subunit 2
Synonyms: expressed during mesenchymal induction 4, Emi4, APC2, 9230107K09Rik, Imi4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99152
Homologene: 8359
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: PEPP2, 2810431N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109135
Homologene: 10377
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: p200RhoGAP, GC-GAP, PX-RICS, 3426406O18Rik, Grit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330914
Homologene: 8812
Nrf1
Name: nuclear respiratory factor 1
Synonyms: D6Ertd415e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18181
HGNC: HGNC:7996
Homologene: 3674
Senp1
Name: SUMO1/sentrin specific peptidase 1
Synonyms: 2310046A20Rik, E330036L07Rik, D15Ertd528e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223870
Homologene: 8731
Atg4c
Name: autophagy related 4C, cysteine peptidase
Synonyms: autophagin 3, Apg4-C, Autl1, Apg4c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242557
Homologene: 56296
Anxa2
Name: annexin A2
Synonyms: lipocortin II, 36-kDa calelectrin, Cal1h, annexin II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12306
Homologene: 20857
Tmem131
Name: transmembrane protein 131
Synonyms: CC28, 2610524E03Rik, YR-23, D1Bwg0491e, Neg, Rw1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56030
Homologene: 32428
Themis
Name: thymocyte selection associated
Synonyms: E430004N04Rik, Tsepa, Gasp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 210757
Homologene: 72287
Glb1
Name: galactosidase, beta 1
Synonyms: Bgs, Bge, Bgt, Bgl, Bgl-t, Bgl-s, Bgl-e, C130097A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12091
VEGA: 9
HGNC: HGNC:4298
Homologene: 47922
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269700
Homologene: 28297
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, CED-5, Hch
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, 2900022L05Rik, Dnhd3, Dnahc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Elmod1
Name: ELMO/CED-12 domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270162
VEGA: 9
Homologene: 10280
Gpld1
Name: glycosylphosphatidylinositol specific phospholipase D1
Synonyms: 6330541J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14756
HGNC: HGNC:4459
Homologene: 1152
Cyp2j11
Name: cytochrome P450, family 2, subfamily j, polypeptide 11
Synonyms: Cyp2j11-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100066
HGNC: HGNC:2634
Homologene: 133819
Myh1
Name: myosin, heavy polypeptide 1, skeletal muscle, adult
Synonyms: MyHC-IId/x, Myhs-f2, Myhs-f, Myhsf2, A530084A17Rik, MYHC-IIX, myosin heavy chain 2X, IId, IId/x
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17879
HGNC: HGNC:7567
Homologene: 133718
Nek9
Name: NIMA (never in mitosis gene a)-related expressed kinase 9
Synonyms: C130021H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217718
Homologene: 13222
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 252866
Homologene: 78104
Vmn1r195
Name: vomeronasal 1 receptor 195
Synonyms: V1ri6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171257
Homologene: 110880
Itgb7
Name: integrin beta 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16421
HGNC: HGNC:6162
Homologene: 20247
C330019G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Krt84
Name: keratin 84
Synonyms: HRb-1, Krt2-3, Krt2-16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16680
VEGA: 15
HGNC: HGNC:6461
Homologene: 22473
Man2a2
Name: mannosidase 2, alpha 2
Synonyms: alpha mannosidase IIx, MX, 4931438M07Rik, 1700052O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 140481
HGNC: HGNC:6825
Homologene: 55954
Dennd3
Name: DENN/MADD domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105841
Homologene: 28254
Igsf9b
Name: immunoglobulin superfamily, member 9B
Synonyms: LOC235086, AI414108
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235086
Homologene: 19472
Dab2
Name: disabled 2, mitogen-responsive phosphoprotein
Synonyms: D15Wsu122e, 5730435J12Rik, p96, D630005B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13132
HGNC: HGNC:2662
Homologene: 1026
Adprm
Name: ADP-ribose/CDP-alcohol diphosphatase, manganese dependent
Synonyms: 2310004I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66358
Homologene: 10632
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320405
Homologene: 23060
Dsel
Name: dermatan sulfate epimerase-like
Synonyms: 9330132E09Rik, DS-epi2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319901
Homologene: 12964
Mcam
Name: melanoma cell adhesion molecule
Synonyms: s-endo, CD146, s-gicerin, 1-gicerin, Muc18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 84004
HGNC: HGNC:6934
Homologene: 4742
Fah
Name: fumarylacetoacetate hydrolase
Synonyms: swst
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14085
HGNC: HGNC:3579
Homologene: 110
Poldip2
Name: polymerase (DNA-directed), delta interacting protein 2
Synonyms: 1300003F06Rik, mitogenin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67811
Homologene: 9201
Ccdc63
Name: coiled-coil domain containing 63
Synonyms: 4921511C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330188
Homologene: 45136
Zfp956
Name: zinc finger protein 956
Synonyms: AI894139
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101197
Homologene: 128449
Zfr2
Name: zinc finger RNA binding protein 2
Synonyms: 2010013I23Rik, 9130206N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103406
Homologene: 88124
Flt4
Name: FMS-like tyrosine kinase 4
Synonyms: VEGFR3, VEGFR-3, Flt-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14257
HGNC: HGNC:3767
Homologene: 7321
Mfrp
Name: membrane frizzled-related protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 259172
Homologene: 12866
Mgat5
Name: mannoside acetylglucosaminyltransferase 5
Synonyms: GlcNAc-TV, beta1,6N-acetylglucosaminyltransferase V, 5330407H02Rik, 4930471A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 107895
HGNC: HGNC:7049
Homologene: 1808
Or9g19
Name: olfactory receptor family 9 subfamily G member 19
Synonyms: GA_x6K02T2Q125-47248551-47249468, MOR213-2, Olfr1013
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258757
Homologene: 74096
Siae
Name: sialic acid acetylesterase
Synonyms: LSE, clone 165, Ysg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22619
Homologene: 8001
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: 9330155G14Rik, WI-18508, Nope, WI-16786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Rimkla
Name: ribosomal modification protein rimK-like family member A
Synonyms: Rimk, NAAGS-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 194237
Homologene: 18336
Thnsl1
Name: threonine synthase-like 1 (bacterial)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208967
Homologene: 32609
5430401F13Rik
Name: RIKEN cDNA 5430401F13 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71392
Homologene: 136510
Disp1
Name: dispatched RND transporter family member 1
Synonyms: DispA, 1190008H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68897
Homologene: 14133
C1qtnf12
Name: C1q and tumor necrosis factor related 12
Synonyms: 1110035L05Rik, C1qdc2, alipolin, Fam132a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67389
Homologene: 12123
Tada2a
Name: transcriptional adaptor 2A
Synonyms: D030022J10Rik, Tada2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217031
Homologene: 38834
Ghdc
Name: GH3 domain containing
Synonyms: D11Lgp1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 80860
Homologene: 32760
Pecr
Name: peroxisomal trans-2-enoyl-CoA reductase
Synonyms: 2400003B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 111175
Homologene: 69255
Stambpl1
Name: STAM binding protein like 1
Synonyms: 8230401J17Rik, 1700095N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76630
Homologene: 23253
4933402J07Rik
Name: RIKEN cDNA 4933402J07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330820
Homologene: 51633
Apoc4
Name: apolipoprotein C-IV
Synonyms: Acl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11425
HGNC: HGNC:611
Homologene: 1245
Tmem178b
Name: transmembrane protein 178B
Synonyms: Gm5567, A930009E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434008
Homologene: 86704
Vmn2r-ps36
Name: vomeronasal 2, receptor, pseudogene 36
Synonyms: EG665442
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 665442
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 10,199,878 bp
  • C to A, chromosome 1 at 36,812,609 bp
  • C to A, chromosome 1 at 71,263,488 bp
  • T to C, chromosome 1 at 72,277,358 bp
  • A to T, chromosome 1 at 111,860,257 bp
  • T to C, chromosome 1 at 127,469,250 bp
  • A to G, chromosome 1 at 183,088,372 bp
  • T to C, chromosome 2 at 21,212,533 bp
  • T to C, chromosome 2 at 25,272,670 bp
  • T to C, chromosome 2 at 85,769,998 bp
  • G to A, chromosome 4 at 96,316,358 bp
  • C to A, chromosome 4 at 99,221,226 bp
  • T to A, chromosome 4 at 119,474,582 bp
  • A to G, chromosome 4 at 155,966,465 bp
  • T to C, chromosome 5 at 32,830,702 bp
  • T to C, chromosome 5 at 121,253,858 bp
  • C to G, chromosome 5 at 122,127,565 bp
  • G to T, chromosome 6 at 23,838,999 bp
  • T to C, chromosome 6 at 30,118,939 bp
  • A to T, chromosome 6 at 40,207,501 bp
  • G to A, chromosome 6 at 47,963,871 bp
  • A to G, chromosome 6 at 131,489,058 bp
  • T to C, chromosome 6 at 140,570,403 bp
  • C to T, chromosome 7 at 7,428,540 bp
  • T to A, chromosome 7 at 19,678,635 bp
  • A to G, chromosome 7 at 80,367,784 bp
  • A to T, chromosome 7 at 84,594,834 bp
  • A to G, chromosome 8 at 43,652,501 bp
  • C to T, chromosome 8 at 87,586,063 bp
  • T to C, chromosome 9 at 27,334,337 bp
  • A to G, chromosome 9 at 32,116,140 bp
  • T to A, chromosome 9 at 37,642,629 bp
  • T to C, chromosome 9 at 44,103,718 bp
  • T to C, chromosome 9 at 44,136,635 bp
  • T to A, chromosome 9 at 53,934,227 bp
  • A to G, chromosome 9 at 65,125,335 bp
  • TCCC to TCC, chromosome 9 at 69,489,754 bp
  • T to C, chromosome 9 at 114,450,648 bp
  • T to A, chromosome 10 at 28,668,727 bp
  • T to G, chromosome 10 at 81,242,116 bp
  • A to G, chromosome 11 at 34,229,472 bp
  • T to C, chromosome 11 at 49,645,997 bp
  • A to G, chromosome 11 at 67,038,229 bp
  • A to C, chromosome 11 at 67,222,408 bp
  • T to C, chromosome 11 at 69,515,761 bp
  • T to A, chromosome 11 at 78,521,244 bp
  • T to C, chromosome 11 at 84,079,629 bp
  • T to C, chromosome 11 at 100,769,192 bp
  • A to G, chromosome 12 at 85,329,903 bp
  • C to G, chromosome 13 at 22,278,764 bp
  • T to C, chromosome 13 at 24,962,647 bp
  • T to C, chromosome 14 at 67,714,809 bp
  • G to A, chromosome 14 at 103,155,922 bp
  • T to C, chromosome 15 at 6,416,917 bp
  • T to G, chromosome 15 at 44,499,982 bp
  • A to T, chromosome 15 at 73,555,060 bp
  • A to G, chromosome 15 at 84,232,168 bp
  • C to T, chromosome 15 at 98,058,315 bp
  • T to C, chromosome 15 at 101,529,584 bp
  • C to T, chromosome 15 at 102,222,118 bp
  • T to A, chromosome 19 at 34,226,704 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2150 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040153-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.