Strain Name:
C57BL/6J-MtgxR2175Btlr/Mmmh
Stock Number:
040177-MU
Citation ID:
RRID:MMRRC_040177-MU
Other Names:
R2175 (G1), C57BL/6J-MtgxR2175Btlr
Major Collection:

Strain Information

Strap
Name: serine/threonine kinase receptor associated protein
Synonyms: Unrip, C78091
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20901
Homologene: 43881
Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Hdac1
Name: histone deacetylase 1
Synonyms: HD1, RPD3, MommeD5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433759
HGNC: HGNC:4852
Homologene: 68426
Mok
Name: MOK protein kinase
Synonyms: MAPK/MAK/MRK/ overlapping kinase, Stk30, MOK, Rage
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 26448
HGNC: HGNC:9833
Homologene: 8062
Adra2a
Name: adrenergic receptor, alpha 2a
Synonyms: alpha2A, Adra-2a, alpha2A-adrenergic receptor, alpha(2A)AR, alpha2A-AR, Adra-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11551
VEGA: 19
HGNC: HGNC:281
Homologene: 47944
Smarcc1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
Synonyms: SRG3, BAF155, msp3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20588
Homologene: 68296
Tex2
Name: testis expressed gene 2
Synonyms: Taz4, 4930568E07Rik, Def-5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21763
Homologene: 32414
Mphosph6
Name: M phase phosphoprotein 6
Synonyms: 1110001M01Rik, C86426
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68533
HGNC: HGNC:7214
Homologene: 38100
Rnf20
Name: ring finger protein 20
Synonyms: 4833430L21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109331
Homologene: 5571
Nfrkb
Name: nuclear factor related to kappa B binding protein
Synonyms: A530090G11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235134
HGNC: HGNC:7802
Homologene: 4492
C6
Name: complement component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12274
HGNC: HGNC:1339
Homologene: 47
Lepr
Name: leptin receptor
Synonyms: OB-RGRP, Leprb, leptin receptor gene-related protein, LEPROT, Obr, obl, Modb1, obese-like
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16847
HGNC: HGNC:6554
Homologene: 1731
Hnrnpl
Name: heterogeneous nuclear ribonucleoprotein L
Synonyms: Hnrpl, D830027H13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15388
HGNC: HGNC:5045
Homologene: 1174
Rbm33
Name: RNA binding motif protein 33
Synonyms: 3200001K10Rik, 6430512A10Rik, Prr8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381626
Homologene: 137386
Steap2
Name: six transmembrane epithelial antigen of prostate 2
Synonyms: 4921538B17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74051
Homologene: 17682
Htt
Name: huntingtin
Synonyms: HD, IT15, C430023I11Rik, htt, Hdh, huntingtin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Ncoa2
Name: nuclear receptor coactivator 2
Synonyms: SRC-2, Grip1, TIF2/GRIP-1, D1Ertd433e, KAT13C, glucocorticoid receptor-interacting protein 1, bHLHe75, TIF2, TIF-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17978
HGNC: HGNC:7669
Homologene: 4768
Zfp148
Name: zinc finger protein 148
Synonyms: ZBP-89, BFCOL1, BERF-1, 2210405J08Rik, beta enolase repressor factor 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22661
VEGA: 16
Homologene: 8003
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Zcchc2
Name: zinc finger, CCHC domain containing 2
Synonyms: 9930114B20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227449
Homologene: 9808
Asxl3
Name: ASXL transcriptional regulator 3
Synonyms: D430002O22Rik, LOC381127, D930044O18Rik, C230079D11Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 211961
Homologene: 19371
Ift172
Name: intraflagellar transport 172
Synonyms: 4930553F24Rik, wim, avc1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67661
Homologene: 15202
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, skrr, calcium release channel isoform 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Fam151b
Name: family with sequence similarity 151, member B
Synonyms: 4930405M20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73942
VEGA: 13
Homologene: 17853
Myef2
Name: myelin basic protein expression factor 2, repressor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17876
Homologene: 69079
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: mXin beta, myomaxin, 2310003D02Rik, Cmya3, 2310008C07Rik, A530024P18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384813
Homologene: 78104
Vmn2r63
Name: vomeronasal 2, receptor 63
Synonyms: EG435975
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 435975
Homologene: 104832
Inpp4b
Name: inositol polyphosphate-4-phosphatase, type II
Synonyms: E130107I17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234515
HGNC: HGNC:6075
Homologene: 20832
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330267
Homologene: 46582
Cttnbp2
Name: cortactin binding protein 2
Synonyms: ORF4, 4732477G22Rik, 3010022N24Rik, Cortbp2, 9130022E09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30785
Homologene: 14125
Ankfn1
Name: ankyrin-repeat and fibronectin type III domain containing 1
Synonyms: mWAKE, LOC382543, nmf9, 4932411E22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 382543
Homologene: 34996
Evi5l
Name: ecotropic viral integration site 5 like
Synonyms: 1700084G18Rik, 3110007G05Rik, B130050I23Rik, 2310039H16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 213027
Homologene: 134635
Or5an1b
Name: olfactory receptor family 5 subfamily AN member 1B
Synonyms: MOR214-6, Olfr1437, GA_x6K02T2RE5P-2658227-2657289
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258117
Homologene: 83129
Siae
Name: sialic acid acetylesterase
Synonyms: clone 165, Ysg2, LSE
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22619
Homologene: 8001
Cox10
Name: heme A:farnesyltransferase cytochrome c oxidase assembly factor 10
Synonyms: 2410004F01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70383
HGNC: HGNC:2260
Homologene: 80170
Alox8
Name: arachidonate 8-lipoxygenase
Synonyms: 8S-lipoxygenase, Alox15b, 8-LOX, 8S-LOX
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11688
HGNC: HGNC:434
Homologene: 886
Or10ag2
Name: olfactory receptor family 10 subfamily AG member 2
Synonyms: MOR264-17, GA_x6K02T2Q125-48917235-48918206, Olfr1123
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258347
Homologene: 105187
Ephx3
Name: epoxide hydrolase 3
Synonyms: Abhd9, 2310063B19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71932
Homologene: 69386
Nkx1-1
Name: NK1 homeobox 1
Synonyms: Nkx-1.1, Sax2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 672284
Homologene: 78303
Gm6316
Name: predicted pseudogene 6316
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 622339
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 13,224,613 bp
  • G to A, chromosome 1 at 66,677,355 bp
  • T to C, chromosome 1 at 106,027,423 bp
  • C to T, chromosome 2 at 67,509,914 bp
  • T to A, chromosome 2 at 87,418,156 bp
  • A to T, chromosome 2 at 125,098,455 bp
  • C to T, chromosome 4 at 49,642,188 bp
  • T to A, chromosome 4 at 101,765,379 bp
  • G to A, chromosome 4 at 129,534,670 bp
  • T to A, chromosome 5 at 5,673,501 bp
  • T to A, chromosome 5 at 28,389,830 bp
  • A to G, chromosome 5 at 31,266,685 bp
  • G to A, chromosome 5 at 33,431,254 bp
  • T to C, chromosome 5 at 34,905,439 bp
  • T to C, chromosome 6 at 12,331,944 bp
  • A to C, chromosome 6 at 18,434,829 bp
  • A to G, chromosome 6 at 137,750,592 bp
  • T to G, chromosome 7 at 28,821,203 bp
  • T to G, chromosome 7 at 29,068,442 bp
  • C to T, chromosome 7 at 42,933,580 bp
  • A to G, chromosome 8 at 4,187,269 bp
  • T to A, chromosome 8 at 43,625,438 bp
  • T to C, chromosome 8 at 81,856,699 bp
  • A to C, chromosome 8 at 117,792,788 bp
  • A to G, chromosome 9 at 31,389,014 bp
  • G to T, chromosome 9 at 37,627,796 bp
  • A to T, chromosome 9 at 110,164,809 bp
  • G to A, chromosome 11 at 64,071,649 bp
  • T to C, chromosome 11 at 69,187,766 bp
  • A to G, chromosome 11 at 89,526,537 bp
  • A to G, chromosome 11 at 106,503,687 bp
  • T to C, chromosome 12 at 69,921,343 bp
  • A to T, chromosome 12 at 98,876,223 bp
  • T to C, chromosome 12 at 110,815,200 bp
  • T to C, chromosome 13 at 92,477,918 bp
  • A to G, chromosome 15 at 4,759,787 bp
  • G to T, chromosome 15 at 53,068,728 bp
  • C to G, chromosome 16 at 33,496,746 bp
  • T to A, chromosome 17 at 32,188,459 bp
  • T to C, chromosome 18 at 22,516,595 bp
  • T to A, chromosome 19 at 12,322,521 bp
  • A to G, chromosome 19 at 54,046,362 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2175 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040177-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.