Strain Name:
C57BL/6J-MtgxR2175Btlr/Mmmh
Stock Number:
040177-MU
Citation ID:
RRID:MMRRC_040177-MU
Other Names:
R2175 (G1), C57BL/6J-MtgxR2175Btlr
Major Collection:

Gene Information

Strap
Name: serine/threonine kinase receptor associated protein
Synonyms: Unrip, C78091
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 20901
Homologene: 43881
Ext1
Name: exostoses (multiple) 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Hdac1
Name: histone deacetylase 1
Synonyms: MommeD5, HD1, RPD3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 433759
HGNC: HGNC:4852
Homologene: 68426
Mok
Name: MOK protein kinase
Synonyms: MAPK/MAK/MRK/ overlapping kinase, MOK, Stk30, Rage
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 26448
HGNC: HGNC:9833
Homologene: 8062
Adra2a
Name: adrenergic receptor, alpha 2a
Synonyms: alpha(2A)AR, Adra-2a, alpha2A, alpha2A-adrenergic receptor, alpha2A-AR, Adra-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 11551
VEGA: 19
HGNC: HGNC:281
Homologene: 47944
Smarcc1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
Synonyms: BAF155, msp3, SRG3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20588
Homologene: 68296
Tex2
Name: testis expressed gene 2
Synonyms: Taz4, Def-5, 4930568E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 21763
Homologene: 32414
Mphosph6
Name: M phase phosphoprotein 6
Synonyms: 1110001M01Rik, C86426
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 68533
HGNC: HGNC:7214
Homologene: 38100
Rnf20
Name: ring finger protein 20
Synonyms: 4833430L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 109331
Homologene: 5571
Nfrkb
Name: nuclear factor related to kappa B binding protein
Synonyms: A530090G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235134
HGNC: HGNC:7802
Homologene: 4492
C6
Name: complement component 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12274
HGNC: HGNC:1339
Homologene: 47
Lepr
Name: leptin receptor
Synonyms: Leprb, LEPROT, Modb1, OB-RGRP, leptin receptor gene-related protein, obl, obese-like, Obr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16847
HGNC: HGNC:6554
Homologene: 1731
Hnrnpl
Name: heterogeneous nuclear ribonucleoprotein L
Synonyms: D830027H13Rik, Hnrpl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 15388
HGNC: HGNC:5045
Homologene: 1174
Rbm33
Name: RNA binding motif protein 33
Synonyms: 3200001K10Rik, 6430512A10Rik, Prr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 381626
Homologene: 137386
Steap2
Name: six transmembrane epithelial antigen of prostate 2
Synonyms: 4921538B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 74051
Homologene: 17682
Htt
Name: huntingtin
Synonyms: huntingtin, IT15, HD, C430023I11Rik, htt, Hdh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Ncoa2
Name: nuclear receptor coactivator 2
Synonyms: SRC-2, TIF-2, D1Ertd433e, TIF2, Grip1, bHLHe75, glucocorticoid receptor-interacting protein 1, KAT13C, TIF2/GRIP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 17978
HGNC: HGNC:7669
Homologene: 4768
Zfp148
Name: zinc finger protein 148
Synonyms: 2210405J08Rik, BFCOL1, ZBP-89, beta enolase repressor factor 1, BERF-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 22661
VEGA: 16
Homologene: 8003
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 319670
VEGA: 12
Homologene: 26807
Zcchc2
Name: zinc finger, CCHC domain containing 2
Synonyms: 9930114B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227449
Homologene: 9808
Asxl3
Name: additional sex combs like 3, transcriptional regulator
Synonyms: LOC381127, D430002O22Rik, C230079D11Rik, D930044O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 211961
Homologene: 19371
Ift172
Name: intraflagellar transport 172
Synonyms: avc1, wim, 4930553F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 67661
Homologene: 15202
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: skrr, Ryr, calcium release channel isoform 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20190
Homologene: 68069
Fam151b
Name: family with sequence similarity 151, member B
Synonyms: 4930405M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 73942
VEGA: 13
Homologene: 17853
Myef2
Name: myelin basic protein expression factor 2, repressor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17876
Homologene: 69079
Unc80
Name: unc-80, NALCN activator
Synonyms: C030018G13Rik, C230061B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 329178
Homologene: 122243
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, myomaxin, Cmya3, 2310008C07Rik, mXin beta, 2310003D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241431
Homologene: 19388
Gm5346
Name: predicted gene 5346
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 384813
Homologene: 78104
Vmn2r63
Name: vomeronasal 2, receptor 63
Synonyms: EG435975
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 435975
Homologene: 104832
Inpp4b
Name: inositol polyphosphate-4-phosphatase, type II
Synonyms: E130107I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234515
HGNC: HGNC:6075
Homologene: 20832
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330267
Homologene: 46582
Cttnbp2
Name: cortactin binding protein 2
Synonyms: ORF4, 3010022N24Rik, Cortbp2, 9130022E09Rik, 4732477G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 30785
Homologene: 14125
Ankfn1
Name: ankyrin-repeat and fibronectin type III domain containing 1
Synonyms: LOC382543, 4932411E22Rik, nmf9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 382543
Homologene: 34996
Evi5l
Name: ecotropic viral integration site 5 like
Synonyms: 2310039H16Rik, 3110007G05Rik, B130050I23Rik, 1700084G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 213027
Homologene: 134635
Olfr1437
Name: olfactory receptor 1437
Synonyms: GA_x6K02T2RE5P-2658227-2657289, MOR214-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258117
Homologene: 83129
Siae
Name: sialic acid acetylesterase
Synonyms: Ysg2, clone 165, LSE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 22619
Homologene: 8001
Cox10
Name: heme A:farnesyltransferase cytochrome c oxidase assembly factor 10
Synonyms: 2410004F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 70383
HGNC: HGNC:2260
Homologene: 80170
Alox8
Name: arachidonate 8-lipoxygenase
Synonyms: 8S-lipoxygenase, 8-LOX, 8S-LOX, Alox15b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11688
HGNC: HGNC:434
Homologene: 886
Olfr1123
Name: olfactory receptor 1123
Synonyms: MOR264-17, GA_x6K02T2Q125-48917235-48918206
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258347
Homologene: 105187
Ephx3
Name: epoxide hydrolase 3
Synonyms: 2310063B19Rik, Abhd9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 71932
Homologene: 69386
Nkx1-1
Name: NK1 homeobox 1
Synonyms: Nkx-1.1, Sax2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 672284
Homologene: 78303
Gm6316
Name: predicted pseudogene 6316
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 622339
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 13,224,613 bp
  • G to A, chromosome 1 at 66,677,355 bp
  • T to C, chromosome 1 at 106,027,423 bp
  • C to T, chromosome 2 at 67,509,914 bp
  • T to A, chromosome 2 at 87,418,156 bp
  • A to T, chromosome 2 at 125,098,455 bp
  • C to T, chromosome 4 at 49,642,188 bp
  • T to A, chromosome 4 at 101,765,379 bp
  • G to A, chromosome 4 at 129,534,670 bp
  • T to A, chromosome 5 at 5,673,501 bp
  • T to A, chromosome 5 at 28,389,830 bp
  • A to G, chromosome 5 at 31,266,685 bp
  • G to A, chromosome 5 at 33,431,254 bp
  • T to C, chromosome 5 at 34,905,439 bp
  • T to C, chromosome 6 at 12,331,944 bp
  • A to C, chromosome 6 at 18,434,829 bp
  • A to G, chromosome 6 at 137,750,592 bp
  • T to G, chromosome 7 at 28,821,203 bp
  • T to G, chromosome 7 at 29,068,442 bp
  • C to T, chromosome 7 at 42,933,580 bp
  • A to G, chromosome 8 at 4,187,269 bp
  • T to A, chromosome 8 at 43,625,438 bp
  • T to C, chromosome 8 at 81,856,699 bp
  • A to C, chromosome 8 at 117,792,788 bp
  • A to G, chromosome 9 at 31,389,014 bp
  • G to T, chromosome 9 at 37,627,796 bp
  • A to T, chromosome 9 at 110,164,809 bp
  • G to A, chromosome 11 at 64,071,649 bp
  • T to C, chromosome 11 at 69,187,766 bp
  • A to G, chromosome 11 at 89,526,537 bp
  • A to G, chromosome 11 at 106,503,687 bp
  • T to C, chromosome 12 at 69,921,343 bp
  • A to T, chromosome 12 at 98,876,223 bp
  • T to C, chromosome 12 at 110,815,200 bp
  • T to C, chromosome 13 at 92,477,918 bp
  • A to G, chromosome 15 at 4,759,787 bp
  • G to T, chromosome 15 at 53,068,728 bp
  • C to G, chromosome 16 at 33,496,746 bp
  • T to A, chromosome 17 at 32,188,459 bp
  • T to C, chromosome 18 at 22,516,595 bp
  • T to A, chromosome 19 at 12,322,521 bp
  • A to G, chromosome 19 at 54,046,362 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2175 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040177-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.