Strain Name:
C57BL/6J-MtgxR2177Btlr/Mmmh
Stock Number:
040179-MU
Citation ID:
RRID:MMRRC_040179-MU
Other Names:
R2177 (G1), C57BL/6J-MtgxR2177Btlr
Major Collection:

Gene Information

Apoa1
Name: apolipoprotein A-I
Synonyms: Apoa-1, Alp-1, Sep-1, Brp-14, Lvtw-1, Sep-2, Sep2, Ltw-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11806
HGNC: HGNC:600
Homologene: 47900
Ulk2
Name: unc-51 like kinase 2
Synonyms: Unc51.2, A830085I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 29869
Homologene: 5891
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Pcm1
Name: pericentriolar material 1
Synonyms: 9430077F19Rik, 2600002H09Rik, C030044G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18536
HGNC: HGNC:8727
Homologene: 4518
Snx4
Name: sorting nexin 4
Synonyms: 1810036H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 69150
VEGA: 16
Homologene: 36143
Clcn6
Name: chloride channel, voltage-sensitive 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26372
HGNC: HGNC:2024
Homologene: 985
Acap2
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Synonyms: 9530039J15Rik, Centb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 78618
VEGA: 16
Homologene: 8182
Exo1
Name: exonuclease 1
Synonyms: Msa, 5730442G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26909
HGNC: HGNC:3511
Homologene: 31352
Sec24a
Name: Sec24 related gene family, member A (S. cerevisiae)
Synonyms: 9430090N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77371
Homologene: 70131
Ddx6
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
Synonyms: mRCK/P54, HLR2, E230023J21Rik, p54, rck, 1110001P04Rik, C430015D01Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13209
VEGA: 9
HGNC: HGNC:2747
Homologene: 3238
Gbf1
Name: golgi-specific brefeldin A-resistance factor 1
Synonyms: 1700083E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107338
HGNC: HGNC:4181
Homologene: 37897
Parp4
Name: poly (ADP-ribose) polymerase family, member 4
Synonyms: VPARP, VAULT3, p193, PH5P, E230037B21Rik, Adprtl1, C030027K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 328417
HGNC: HGNC:271
Homologene: 124423
Prom1
Name: prominin 1
Synonyms: AC133, CD133, Prom, 4932416E19Rik, Prom-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Usp53
Name: ubiquitin specific peptidase 53
Synonyms: Sp6, Phxr3, mbo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99526
Homologene: 34521
Marf1
Name: meiosis regulator and mRNA stability 1
Synonyms: 4921513D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 223989
VEGA: 16
Homologene: 40967
Rock1
Name: Rho-associated coiled-coil containing protein kinase 1
Synonyms: Rock-I, 1110055K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 19877
VEGA: 18
Homologene: 55899
Fcho1
Name: FCH domain only 1
Synonyms: 3322402E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74015
Homologene: 22869
Fxyd4
Name: FXYD domain-containing ion transport regulator 4
Synonyms: Chif, 0610008I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108017
HGNC: HGNC:4028
Homologene: 11183
Mme
Name: membrane metallo endopeptidase
Synonyms: CD10, neprilysin, 6030454K05Rik, NEP, neutral endopeptidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Maea
Name: macrophage erythroblast attacher
Synonyms: 1110030D19Rik, Gid9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 59003
Homologene: 4298
Rdh13
Name: retinol dehydrogenase 13 (all-trans and 9-cis)
Synonyms: 8430425D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108841
Homologene: 121782
Washc5
Name: WASH complex subunit 5
Synonyms: strumpellin, E430025E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223593
VEGA: 15
Homologene: 8898
Man1a2
Name: mannosidase, alpha, class 1A, member 2
Synonyms: Man1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17156
HGNC: HGNC:6822
Homologene: 55982
Kat2a
Name: K(lysine) acetyltransferase 2A
Synonyms: PCAF-B/GCN5, 1110051E14Rik, Gcn5, Gcn5l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14534
HGNC: HGNC:4201
Homologene: 41343
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Aplp1
Name: amyloid beta (A4) precursor-like protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11803
HGNC: HGNC:597
Homologene: 68447
Dscam
Name: DS cell adhesion molecule
Synonyms: 4932410A21Rik, Down syndrome cell adhesion molecule
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Me3
Name: malic enzyme 3, NADP(+)-dependent, mitochondrial
Synonyms: B230207H15Rik, 1700020C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 109264
HGNC: HGNC:6985
Homologene: 100773
Slc20a1
Name: solute carrier family 20, member 1
Synonyms: Glvr-1, Glvr1, PiT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20515
Homologene: 38049
Rabgap1l
Name: RAB GTPase activating protein 1-like
Synonyms: Hh1, 9630005B12Rik, 5830411O09Rik, 8430421H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 29809
Homologene: 8143
Cfap69
Name: cilia and flagella associated protein 69
Synonyms: A330021E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 207686
Homologene: 11718
Adamts2
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
Synonyms: ADAM-TS2, hPCPNI, a disintegrin and metalloproteinase with thrombospondin repeats, procollagen N-proteinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216725
HGNC: HGNC:218
Homologene: 8597
Adamts19
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
Synonyms: D230034E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240322
VEGA: 18
Homologene: 15860
Vmn2r79
Name: vomeronasal 2, receptor 79
Synonyms: EG621430
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 621430
Homologene: 115466
Cpb1
Name: carboxypeptidase B1 (tissue)
Synonyms: 2210008M23Rik, 0910001A18Rik, 1810063F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76703
HGNC: HGNC:2299
Homologene: 68127
Als2cl
Name: ALS2 C-terminal like
Synonyms: D930044G19Rik, mRn.49018
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235633
Homologene: 17152
Bok
Name: BCL2-related ovarian killer
Synonyms: matador, mtd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 51800
HGNC: HGNC:1087
Homologene: 9632
AW551984
Name: expressed sequence AW551984
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244810
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68625
Homologene: 51350
Mrgprb2
Name: MAS-related GPR, member B2
Synonyms: 4833406I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243979
Homologene: 86246
Krtap16-1
Name: keratin associated protein 16-1
Synonyms: AI450886
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100504183
Homologene: 99988
Iqce
Name: IQ motif containing E
Synonyms: 1700028P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74239
Homologene: 49912
Vmn2r68
Name: vomeronasal 2, receptor 68
Synonyms: EG620697, Vmn2r68-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620697
Homologene: 115466
Olfr297
Name: olfactory receptor 297
Synonyms: GA_x6K02T2NHDJ-9587747-9586815, MOR220-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258611
Homologene: 115526
Klk1b1
Name: kallikrein 1-related peptidase b1
Synonyms: mGK-1, TK, tissue kallikrein, mK1, Klk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16623
HGNC: HGNC:6364
Homologene: 68141
Tchh
Name: trichohyalin
Synonyms: AHF, Thh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99681
Homologene: 136273
Zfp119b
Name: zinc finger protein 119b
Synonyms: BC031441
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240120
Nlrp4e
Name: NLR family, pyrin domain containing 4E
Synonyms: Nalp-epsilon, Nalp4e, 4930406H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 446099
Homologene: 75315
Ch25h
Name: cholesterol 25-hydroxylase
Synonyms: m25OH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12642
VEGA: 19
HGNC: HGNC:1907
Homologene: 2942
Sesn1
Name: sestrin 1
Synonyms: 1110002G11Rik, SEST1, PA26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 140742
Homologene: 8697
Mmel1
Name: membrane metallo-endopeptidase-like 1
Synonyms: Nl1, NEPLP gamma, NEPLP beta, NEPLP alpha, SEP, Mell1, Nep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 27390
Homologene: 22778
Olfr32
Name: olfactory receptor 32
Synonyms: MTPCR05, MOR227-7P, GA_x6K02T2Q125-51573576-51572650, MOR227-9_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18331
HGNC: HGNC:8290
Homologene: 110550
Csf1r
Name: colony stimulating factor 1 receptor
Synonyms: CSF-1R, M-CSFR, CD115, Fim-2, Fms, Csfmr, Fim2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12978
HGNC: HGNC:2433
Homologene: 3817
2310003L06Rik
Name: RIKEN cDNA 2310003L06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Olfr922
Name: olfactory receptor 922
Synonyms: GA_x6K02T2PVTD-32518237-32519172, MOR161-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258777
VEGA: 9
Homologene: 27262
Sdhaf4
Name: succinate dehydrogenase complex assembly factor 4
Synonyms: 1110058L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68002
Homologene: 32661
Mrpl36
Name: mitochondrial ribosomal protein L36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 94066
VEGA: 13
Homologene: 41872
Gm5577
Name: predicted gene 5577
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434064
Gm10275
Name: predicted pseudogene 10275
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19897
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 23,996,289 bp
  • C to T, chromosome 1 at 93,695,065 bp
  • A to G, chromosome 1 at 160,724,062 bp
  • T to A, chromosome 1 at 175,882,890 bp
  • T to A, chromosome 2 at 90,138,464 bp
  • A to T, chromosome 2 at 129,204,169 bp
  • T to A, chromosome 3 at 20,266,447 bp
  • A to T, chromosome 3 at 63,301,005 bp
  • A to G, chromosome 3 at 93,444,132 bp
  • A to T, chromosome 3 at 100,632,531 bp
  • T to C, chromosome 3 at 122,936,057 bp
  • T to G, chromosome 4 at 118,606,688 bp
  • T to A, chromosome 4 at 148,014,600 bp
  • A to G, chromosome 4 at 154,894,103 bp
  • T to A, chromosome 5 at 5,625,803 bp
  • C to G, chromosome 5 at 33,371,690 bp
  • A to T, chromosome 5 at 44,026,739 bp
  • T to A, chromosome 5 at 87,972,453 bp
  • T to C, chromosome 5 at 140,691,593 bp
  • T to C, chromosome 6 at 88,005,081 bp
  • C to T, chromosome 6 at 117,934,432 bp
  • T to C, chromosome 7 at 4,427,667 bp
  • A to T, chromosome 7 at 23,355,261 bp
  • A to T, chromosome 7 at 30,442,521 bp
  • G to T, chromosome 7 at 43,969,271 bp
  • A to G, chromosome 7 at 48,552,380 bp
  • G to A, chromosome 7 at 85,221,915 bp
  • G to A, chromosome 7 at 86,527,662 bp
  • A to G, chromosome 7 at 86,996,631 bp
  • A to C, chromosome 7 at 89,633,070 bp
  • T to C, chromosome 8 at 41,275,965 bp
  • A to G, chromosome 8 at 71,712,261 bp
  • A to T, chromosome 9 at 38,816,186 bp
  • G to A, chromosome 9 at 39,599,815 bp
  • A to G, chromosome 9 at 44,627,731 bp
  • A to T, chromosome 9 at 46,230,073 bp
  • T to C, chromosome 9 at 110,894,281 bp
  • T to C, chromosome 10 at 29,699,005 bp
  • A to G, chromosome 10 at 41,903,782 bp
  • T to A, chromosome 11 at 50,777,228 bp
  • T to C, chromosome 11 at 51,704,401 bp
  • T to A, chromosome 11 at 61,791,509 bp
  • A to G, chromosome 11 at 99,986,449 bp
  • A to G, chromosome 11 at 100,710,822 bp
  • T to A, chromosome 13 at 73,331,469 bp
  • A to T, chromosome 14 at 56,659,289 bp
  • A to G, chromosome 15 at 44,459,395 bp
  • A to T, chromosome 15 at 59,363,269 bp
  • G to T, chromosome 16 at 14,152,607 bp
  • C to T, chromosome 16 at 31,133,528 bp
  • T to A, chromosome 16 at 33,286,058 bp
  • T to A, chromosome 16 at 96,610,324 bp
  • A to G, chromosome 17 at 30,653,393 bp
  • A to T, chromosome 17 at 55,938,639 bp
  • C to G, chromosome 18 at 10,070,263 bp
  • T to C, chromosome 18 at 58,954,554 bp
  • T to A, chromosome 18 at 61,114,943 bp
  • T to C, chromosome 19 at 21,811,785 bp
  • G to T, chromosome 19 at 34,474,697 bp
  • T to C, chromosome 19 at 46,265,670 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2177 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040179-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.