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Strain Name:
C57BL/6J-MtgxR2179Btlr/Mmmh
Stock Number:
040181-MU
Citation ID:
RRID:MMRRC_040181-MU
Other Names:
R2179 (G1), C57BL/6J-MtgxR2179Btlr
Major Collection:

Strain Information

Gaa
Name: glucosidase, alpha, acid
Synonyms: E430018M07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14387
HGNC: HGNC:4065
Homologene: 37268
Mga
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Paics
Name: phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
Synonyms: ADE2H1, PAIS, AIRC, 2610511I09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67054
HGNC: HGNC:8587
Homologene: 4710
Stam2
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms: Hbp, 1200004O12Rik, 5730456G07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56324
Homologene: 68490
Chuk
Name: conserved helix-loop-helix ubiquitous kinase
Synonyms: Chuk1, IKK1, IKK[a], IKK-alpha, IkappaB kinase alpha, IKK 1, IKK alpha, IKKalpha, IKK-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12675
HGNC: HGNC:1974
Homologene: 979
Igf1r
Name: insulin-like growth factor I receptor
Synonyms: CD221, IGF-1R, line 186, hyft, A330103N21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16001
HGNC: HGNC:5465
Homologene: 30997
Shmt1
Name: serine hydroxymethyltransferase 1 (soluble)
Synonyms: mshmt2, mshmt1, mshmt, Shmt
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20425
Homologene: 3074
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 82,290,219 bp
  • G to T, chromosome 1 at 139,731,541 bp
  • T to A, chromosome 2 at 13,318,242 bp
  • T to C, chromosome 2 at 18,210,793 bp
  • T to C, chromosome 2 at 52,694,924 bp
  • A to G, chromosome 2 at 71,453,371 bp
  • T to A, chromosome 2 at 119,960,442 bp
  • C to T, chromosome 3 at 19,200,144 bp
  • A to T, chromosome 3 at 19,987,987 bp
  • T to G, chromosome 3 at 86,354,281 bp
  • A to G, chromosome 3 at 106,492,460 bp
  • T to C, chromosome 4 at 43,566,306 bp
  • T to C, chromosome 4 at 55,009,524 bp
  • A to T, chromosome 5 at 76,961,444 bp
  • A to T, chromosome 5 at 92,209,979 bp
  • T to C, chromosome 5 at 136,991,008 bp
  • G to A, chromosome 6 at 116,314,781 bp
  • A to T, chromosome 6 at 132,700,868 bp
  • A to G, chromosome 6 at 146,375,966 bp
  • A to G, chromosome 7 at 27,517,985 bp
  • T to C, chromosome 7 at 30,728,647 bp
  • A to G, chromosome 7 at 35,198,830 bp
  • A to G, chromosome 7 at 68,003,950 bp
  • A to T, chromosome 7 at 83,688,079 bp
  • GGCGGCGGC to GGCGGCGGCCGCGGCGGC, chromosome 7 at 97,579,909 bp
  • C to T, chromosome 8 at 22,681,753 bp
  • A to T, chromosome 8 at 104,452,715 bp
  • T to C, chromosome 8 at 104,472,737 bp
  • T to A, chromosome 8 at 106,160,287 bp
  • T to C, chromosome 9 at 40,000,924 bp
  • T to A, chromosome 9 at 110,594,688 bp
  • T to C, chromosome 10 at 10,395,274 bp
  • T to A, chromosome 10 at 24,805,895 bp
  • T to C, chromosome 10 at 87,567,335 bp
  • T to C, chromosome 10 at 109,880,722 bp
  • T to A, chromosome 10 at 117,683,361 bp
  • A to G, chromosome 11 at 59,787,358 bp
  • A to G, chromosome 11 at 60,806,999 bp
  • A to T, chromosome 11 at 69,228,578 bp
  • A to C, chromosome 11 at 82,898,754 bp
  • A to G, chromosome 11 at 109,429,832 bp
  • A to G, chromosome 11 at 119,275,058 bp
  • A to G, chromosome 12 at 53,501,293 bp
  • A to G, chromosome 12 at 57,673,118 bp
  • C to A, chromosome 12 at 69,198,297 bp
  • T to A, chromosome 12 at 89,254,678 bp
  • A to T, chromosome 13 at 11,705,793 bp
  • A to T, chromosome 13 at 53,351,639 bp
  • A to G, chromosome 14 at 32,335,345 bp
  • A to G, chromosome 14 at 51,070,781 bp
  • A to G, chromosome 14 at 56,042,116 bp
  • A to G, chromosome 14 at 70,648,309 bp
  • G to A, chromosome 15 at 4,921,446 bp
  • A to G, chromosome 15 at 81,337,950 bp
  • T to C, chromosome 15 at 95,956,030 bp
  • T to C, chromosome 16 at 5,008,191 bp
  • G to T, chromosome 16 at 18,310,898 bp
  • T to C, chromosome 17 at 71,752,526 bp
  • T to A, chromosome 17 at 84,994,434 bp
  • C to A, chromosome 19 at 7,014,414 bp
  • T to C, chromosome 19 at 12,036,088 bp
  • T to C, chromosome 19 at 13,705,394 bp
  • T to C, chromosome 19 at 21,590,566 bp
  • C to A, chromosome 19 at 44,103,721 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2179 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040181-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.