Strain Name:
C57BL/6J-MtgxR2183Btlr/Mmmh
Stock Number:
040185-MU
Citation ID:
RRID:MMRRC_040185-MU
Other Names:
R2183 (G1), C57BL/6J-MtgxR2183Btlr
Major Collection:

Gene Information

Ptprz1
Name: protein tyrosine phosphatase, receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Yes1
Name: YES proto-oncogene 1, Src family tyrosine kinase
Synonyms: Yes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22612
Homologene: 55900
Cdc6
Name: cell division cycle 6
Synonyms: cell division cycle 18 homolog (S.pombe)-like, CDC18L, CDC18(S.pombe)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23834
HGNC: HGNC:1744
Homologene: 68172
Ipo11
Name: importin 11
Synonyms: E330021B14Rik, 1700081H05Rik, 2510001A17Rik, Ranbp11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76582
Homologene: 7089
Larp4
Name: La ribonucleoprotein domain family, member 4
Synonyms: D330037H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 207214
VEGA: 15
Homologene: 19173
Phc1
Name: polyhomeotic 1
Synonyms: Rae-28, Mph1, rae28, Edr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13619
HGNC: HGNC:3182
Homologene: 107079
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195018
Homologene: 9027
Wwc2
Name: WW, C2 and coiled-coil domain containing 2
Synonyms: D8Ertd594e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 52357
Homologene: 32618
Angel2
Name: angel homolog 2
Synonyms: 5730410O10Rik, 2610307I21Rik, D1Ertd654e, D1Ertd396e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 52477
Homologene: 16932
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 627872
Homologene: 41287
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, heb, QBRICK, eyes2, crf11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329872
Homologene: 27049
Atf7
Name: activating transcription factor 7
Synonyms: C130020M04Rik, 1110012F10Rik, 9430065F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223922
HGNC: HGNC:792
Homologene: 4994
Recql5
Name: RecQ protein-like 5
Synonyms: Recql5b, Recq5b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170472
HGNC: HGNC:9950
Homologene: 31232
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Hs1bp3
Name: HCLS1 binding protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 58240
VEGA: 12
Homologene: 10980
Prpf4
Name: pre-mRNA processing factor 4
Synonyms: 1600015H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70052
Homologene: 3446
Tubgcp2
Name: tubulin, gamma complex associated protein 2
Synonyms: 1700022B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74237
Homologene: 55980
Cenpk
Name: centromere protein K
Synonyms: C530004N04Rik, B130045K24Rik, Solt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 60411
VEGA: 13
Homologene: 11035
Tmem130
Name: transmembrane protein 130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243339
Homologene: 17680
Tnip2
Name: TNFAIP3 interacting protein 2
Synonyms: ABIN-2, 1810020H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231130
Homologene: 11515
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Irbp, Rbp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
Dhx57
Name: DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106794
VEGA: 17
Homologene: 56267
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Atg9b
Name: autophagy related 9B
Synonyms: LOC213948, eONE, Apg9l2, Nos3as
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 213948
Homologene: 72638
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: 4921507O14Rik, D3Ertd789e, b2b1735Clo, b2b1304Clo, b2b2025.1Clo, prh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 51938
Homologene: 12149
Nebl
Name: nebulette
Synonyms: Lnebl, 1200007O21Rik, A630080F05Rik, D830029A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74103
Homologene: 128431
Fam38b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Paox
Name: polyamine oxidase (exo-N4-amino)
Synonyms: Pao, 2410012F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 212503
Homologene: 72096
Olfr342
Name: olfactory receptor 342
Synonyms: GA_x6K02T2NLDC-33222024-33222962, MOR136-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258950
Homologene: 74223
Tbx18
Name: T-box18
Synonyms: 2810012F10Rik, 2810404D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76365
Homologene: 11384
Spg20
Name: spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)
Synonyms: TAHCCP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229285
Rbsn
Name: rabenosyn, RAB effector
Synonyms: 5330426D11Rik, Rabenosyn-5, Zfyve20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78287
Homologene: 41477
Nrg2
Name: neuregulin 2
Synonyms: NTAK, Don1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100042150
HGNC: HGNC:7998
Homologene: 75024
Trp53rkb
Name: transformation related protein 53 regulating kinase B
Synonyms: PRPK, mNori-2p, 4933401B08Rik, Nori-2, 5630401H01Rik, Trp53rk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76367
Homologene: 6042
Spata7
Name: spermatogenesis associated 7
Synonyms: HSD3, B230306G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104871
Homologene: 10189
Scai
Name: suppressor of cancer cell invasion
Synonyms: A930041I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320271
Homologene: 15523
Pla2g6
Name: phospholipase A2, group VI
Synonyms: iPLA2, iPLA2beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 53357
HGNC: HGNC:9039
Homologene: 2635
Cc2d1a
Name: coiled-coil and C2 domain containing 1A
Synonyms: Freud-1, Tape
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212139
Homologene: 23040
Irag1
Name: inositol 1,4,5-triphosphate receptor associated 1
Synonyms: Ris1, Mrvi1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17540
HGNC: HGNC:7237
Homologene: 4425
Proca1
Name: protein interacting with cyclin A1
Synonyms: 4933404M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216974
Homologene: 51856
Wdr86
Name: WD repeat domain 86
Synonyms: 2810046M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269633
Homologene: 90112
Lrp8
Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Synonyms: apoER2, 4932703M08Rik, Lr8b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16975
HGNC: HGNC:6700
Homologene: 31250
Olfr1086
Name: olfactory receptor 1086
Synonyms: GA_x6K02T2Q125-48168771-48167839, MOR179-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258585
Homologene: 73975
Sgms2
Name: sphingomyelin synthase 2
Synonyms: 4933405A16Rik, 5133401H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74442
Homologene: 32705
Gdpd1
Name: glycerophosphodiester phosphodiesterase domain containing 1
Synonyms: 2610020H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66569
Homologene: 7069
Sftpa1
Name: surfactant associated protein A1
Synonyms: SP-A, surfactant pulmonary associated protein A1, SFTPA1, Sftp-1, Sftp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 20387
Homologene: 3946
Zfp971
Name: zinc finger protein 971
Synonyms: Etohi1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 626848
Homologene: 134324
Olfr299
Name: olfactory receptor 299
Synonyms: GA_x6K02T2NHDJ-9643949-9642957, MOR221-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257929
Homologene: 115489
Gcsh
Name: glycine cleavage system protein H (aminomethyl carrier)
Synonyms: 1100001L02Rik, 5730591C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 68133
HGNC: HGNC:4208
Homologene: 90880
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 53,702,084 bp
  • T to C, chromosome 1 at 190,939,165 bp
  • T to C, chromosome 2 at 17,404,216 bp
  • C to T, chromosome 2 at 36,527,711 bp
  • G to A, chromosome 2 at 39,080,126 bp
  • A to T, chromosome 2 at 86,677,036 bp
  • G to T, chromosome 2 at 166,793,957 bp
  • T to A, chromosome 2 at 178,033,740 bp
  • T to C, chromosome 3 at 33,821,432 bp
  • A to G, chromosome 3 at 55,117,133 bp
  • A to C, chromosome 3 at 131,336,285 bp
  • G to A, chromosome 4 at 62,411,809 bp
  • G to A, chromosome 4 at 82,991,495 bp
  • T to C, chromosome 4 at 107,803,265 bp
  • C to T, chromosome 5 at 24,390,493 bp
  • T to G, chromosome 5 at 24,713,901 bp
  • T to A, chromosome 5 at 32,645,026 bp
  • TCTCCT to TCT, chromosome 5 at 34,499,613 bp
  • T to C, chromosome 5 at 144,755,432 bp
  • G to A, chromosome 6 at 23,002,285 bp
  • C to A, chromosome 6 at 92,189,637 bp
  • C to A, chromosome 6 at 122,323,325 bp
  • T to A, chromosome 7 at 86,466,386 bp
  • A to T, chromosome 7 at 110,898,982 bp
  • G to T, chromosome 7 at 139,998,915 bp
  • A to G, chromosome 7 at 140,131,635 bp
  • A to T, chromosome 8 at 47,842,926 bp
  • A to T, chromosome 8 at 84,140,399 bp
  • A to T, chromosome 8 at 116,989,146 bp
  • T to A, chromosome 9 at 87,705,736 bp
  • C to T, chromosome 11 at 72,886,718 bp
  • A to T, chromosome 11 at 78,204,149 bp
  • T to C, chromosome 11 at 87,035,276 bp
  • A to T, chromosome 11 at 98,908,698 bp
  • T to C, chromosome 11 at 115,896,787 bp
  • T to C, chromosome 12 at 8,321,610 bp
  • A to T, chromosome 12 at 98,637,612 bp
  • T to C, chromosome 13 at 104,234,163 bp
  • T to C, chromosome 13 at 106,925,087 bp
  • C to T, chromosome 14 at 33,956,018 bp
  • G to T, chromosome 14 at 41,132,866 bp
  • T to A, chromosome 15 at 4,918,225 bp
  • C to T, chromosome 15 at 79,313,167 bp
  • T to C, chromosome 15 at 100,011,897 bp
  • T to C, chromosome 15 at 102,546,473 bp
  • A to G, chromosome 17 at 67,791,009 bp
  • T to A, chromosome 17 at 80,275,331 bp
  • T to C, chromosome 18 at 36,196,751 bp
  • A to G, chromosome 18 at 63,106,274 bp
  • G to A, chromosome 19 at 21,823,793 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2183 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040185-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.