Strain Name:
C57BL/6J-MtgxR2214Btlr/Mmmh
Stock Number:
040216-MU
Citation ID:
RRID:MMRRC_040216-MU
Other Names:
R2214 (G1), C57BL/6J-MtgxR2214Btlr
Major Collection:

Strain Information

Dnm2
Name: dynamin 2
Synonyms: Dyn2, b2b2159Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13430
HGNC: HGNC:2974
Homologene: 90883
Ntrk3
Name: neurotrophic tyrosine kinase, receptor, type 3
Synonyms: TrkC
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18213
HGNC: HGNC:8033
Homologene: 49183
Lgals8
Name: lectin, galactose binding, soluble 8
Synonyms: D13Ertd524e, Lgals-8, 1200015E08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56048
HGNC: HGNC:6569
Homologene: 31386
Dst
Name: dystonin
Synonyms: A830042E19Rik, nmf339, bullous pemphigoid antigen 1, Bpag1, 2310001O04Rik, Bpag, Macf2, BPAG1, BPAG1-n, athetoid, bullous pemphigoid antigen 1, ah, nmf203
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Upp1
Name: uridine phosphorylase 1
Synonyms: UPase, Up, UdRPase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22271
Homologene: 2524
Map2k6
Name: mitogen-activated protein kinase kinase 6
Synonyms: SAPKK3, MAP kinase kinase 6, Prkmk6, MKK6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26399
HGNC: HGNC:6846
Homologene: 55686
Ubap2
Name: ubiquitin-associated protein 2
Synonyms: 1190005K07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68926
Homologene: 73649
Rps6kb1
Name: ribosomal protein S6 kinase, polypeptide 1
Synonyms: 2610318I15Rik, p70s6k, p70/85s6k, p70S6K1, S6K1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72508
Homologene: 81703
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: mechanistic target of rapamycin (serine/threonine kinase), Frap1, RAFT1, 2610315D21Rik, FKBP-rapamycin-associated protein FRAP, flat, RAPT1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Acap2
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Synonyms: Centb2, 9530039J15Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78618
VEGA: 16
Homologene: 8182
Myh10
Name: myosin, heavy polypeptide 10, non-muscle
Synonyms: Myhn2, Fltn, Fltn, NMHC II-B, 5730504C04Rik, nonmuscle myosin heavy chain IIB, 9330167F11Rik, myosin IIB, nonmuscle myosin heavy chain II-B, Myhn-2, SMemb, Myosin IIB, NMHC-B
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77579
HGNC: HGNC:7568
Homologene: 55941
Kat7
Name: K(lysine) acetyltransferase 7
Synonyms: Hboa, Hbo1, Myst2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217127
Homologene: 5134
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: 9530001P15Rik, Sh3d5, Ponsin, c-Cbl-associated protein, CAP, 2310065E01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
Srrm2
Name: serine/arginine repetitive matrix 2
Synonyms: SRm300, 5033413A03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75956
Rnf20
Name: ring finger protein 20
Synonyms: 4833430L21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109331
Homologene: 5571
Rasgrp1
Name: RAS guanyl releasing protein 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19419
HGNC: HGNC:9878
Homologene: 4195
Akap8l
Name: A kinase anchor protein 8-like
Synonyms: Nakap95
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54194
VEGA: 17
Homologene: 8658
Casr
Name: calcium-sensing receptor
Synonyms: CaR, cation sensing receptor, Gprc2a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12374
HGNC: HGNC:1514
Homologene: 332
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: E130018M02Rik, mGluR7, Gpr1g, mGlu7a receptor, 6330570A01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Map2
Name: microtubule-associated protein 2
Synonyms: G1-397-34, Mtap2, repro4, MAP-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Timm23
Name: translocase of inner mitochondrial membrane 23
Synonyms: Tim23
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 53600
Homologene: 9651
Paxip1
Name: PAX interacting (with transcription-activation domain) protein 1
Synonyms: PTIP, D5Ertd149e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 55982
HGNC: HGNC:8624
Zkscan8
Name: zinc finger with KRAB and SCAN domains 8
Synonyms: 2510038J07Rik, Zfp192, LD5-1, D430019P06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 93681
Homologene: 21268
Tsc22d2
Name: TSC22 domain family, member 2
Synonyms: 1810043J12Rik, 5530402M19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72033
Homologene: 8860
Usp37
Name: ubiquitin specific peptidase 37
Synonyms: 4932415L06Rik, C330008N13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319651
Homologene: 10858
Nhlrc3
Name: NHL repeat containing 3
Synonyms: 8030451K01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 212114
Homologene: 35239
Pdgfd
Name: platelet-derived growth factor, D polypeptide
Synonyms: 1110003I09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71785
VEGA: 9
Homologene: 11875
Stag3
Name: STAG3 cohesin complex component
Synonyms: stromalin 3, SA-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50878
Homologene: 40844
Adamtsl3
Name: ADAMTS-like 3
Synonyms: punctin-2, 9230119C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269959
Homologene: 18912
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Myo16
Name: myosin XVI
Synonyms: Nyap3, C230040D10Rik, BM140241
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244281
Homologene: 34710
Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
Synonyms: 7420452D20Rik, ASK, Mekk5, ASK1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 26408
HGNC: HGNC:6857
Homologene: 38114
Tapbp
Name: TAP binding protein
Synonyms: tapasin, TPN, D17Wsu91e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21356
Homologene: 2401
Ptprh
Name: protein tyrosine phosphatase receptor type H
Synonyms: SAP-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545902
HGNC: HGNC:9672
Homologene: 37693
Uqcc4
Name: ubiquinol-cytochrome c reductase complex assembly factor 4
Synonyms: BC003965
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 214489
VEGA: 17
Homologene: 52829
Tmem63a
Name: transmembrane protein 63a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208795
Homologene: 101673
Nckap5
Name: NCK-associated protein 5
Synonyms: D130011D22Rik, E030049G20Rik, LOC380609
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210356
Homologene: 35542
Or14a259
Name: olfactory receptor family 14 subfamily A member 259
Synonyms: MOR219-2, GA_x6K02T2NHDJ-9744055-9745014, Olfr305
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258609
Homologene: 128128
Ccdc110
Name: coiled-coil domain containing 110
Synonyms: LOC212392
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212392
Homologene: 17668
Col9a1
Name: collagen, type IX, alpha 1
Synonyms: Col9a-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12839
HGNC: HGNC:2217
Homologene: 1393
Or1e29
Name: olfactory receptor family 1 subfamily E member 29
Synonyms: Olfr389, GA_x6K02T2P1NL-3932085-3931147, MOR135-6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259011
Homologene: 85925
Pfkfb4
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270198
HGNC: HGNC:8875
Homologene: 48288
Serpinb9f
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9f
Synonyms: Spi13, NK21, ovalbumin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20709
HGNC: HGNC:8955
Homologene: 69093
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546980
Homologene: 115466
Ccdc178
Name: coiled coil domain containing 178
Synonyms: 4921528I01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70950
VEGA: 18
Homologene: 12373
Adam22
Name: a disintegrin and metallopeptidase domain 22
Synonyms: 2900022I03Rik, MDC2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11496
HGNC: HGNC:201
Homologene: 37898
Kbtbd11
Name: kelch repeat and BTB (POZ) domain containing 11
Synonyms: 4930465M17Rik, 2900016B01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74901
Homologene: 28701
Gm1110
Name: predicted gene 1110
Synonyms: LOC382064
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382064
VEGA: 9
Homologene: 78608
Ercc4
Name: excision repair cross-complementing rodent repair deficiency, complementation group 4
Synonyms: Xpf
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50505
HGNC: HGNC:3436
Homologene: 3836
Cyp26a1
Name: cytochrome P450, family 26, subfamily a, polypeptide 1
Synonyms: P450RA, retinoic acid hydrolase, P450RAI, RAH, Cyp26
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13082
VEGA: 19
HGNC: HGNC:2603
Homologene: 37349
Tmem174
Name: transmembrane protein 174
Synonyms: 0610009B10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68344
VEGA: 13
Homologene: 17711
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: cytoplasmic linker protein 50, restin, Clip 170, Clip50, Rsn, 4631429H07Rik, 1110007I12Rik, CLIP-170
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56430
Homologene: 74455
AC091683.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Habp2
Name: hyaluronic acid binding protein 2
Synonyms: FSAP
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226243
HGNC: HGNC:4798
Homologene: 3050
Lmtk3
Name: lemur tyrosine kinase 3
Synonyms: AATYK3, Aatyk3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381983
Homologene: 79449
Pp2d1
Name: protein phosphatase 2C-like domain containing 1
Synonyms: 4921523A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110332
VEGA: 17
Homologene: 16981
Wdr20rt
Name: WD repeat domain 20, retrogene
Synonyms: Wdr20b, 4921538B03Rik, 4930427E19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70948
VEGA: 12
Tmcc1
Name: transmembrane and coiled coil domains 1
Synonyms: 3632431M01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330401
Homologene: 8995
Syt15
Name: synaptotagmin XV
Synonyms: sytXV, CHR10SYT, E230025K04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319508
Homologene: 12901
Klrc1
Name: killer cell lectin-like receptor subfamily C, member 1
Synonyms: NKG2A, CD159a, NKG2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16641
Homologene: 86848
Or4p20
Name: olfactory receptor family 4 subfamily P member 20
Synonyms: MOR225-9P, GA_x6K02T2Q125-49911636-49910701, Olfr1181
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258060
Homologene: 86666
Prr7
Name: proline rich 7 (synaptic)
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 432763
VEGA: 13
Homologene: 57114
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 24,208,202 bp
  • C to T, chromosome 1 at 34,271,401 bp
  • A to T, chromosome 1 at 66,420,186 bp
  • A to G, chromosome 1 at 74,479,752 bp
  • A to T, chromosome 1 at 126,025,750 bp
  • A to G, chromosome 1 at 180,961,114 bp
  • A to G, chromosome 2 at 76,817,081 bp
  • C to T, chromosome 2 at 88,423,117 bp
  • A to T, chromosome 2 at 117,285,165 bp
  • T to C, chromosome 3 at 53,456,454 bp
  • A to G, chromosome 3 at 58,416,206 bp
  • A to G, chromosome 4 at 41,199,714 bp
  • T to A, chromosome 4 at 49,648,344 bp
  • A to G, chromosome 4 at 148,538,870 bp
  • C to T, chromosome 5 at 8,136,805 bp
  • T to C, chromosome 5 at 27,742,501 bp
  • A to G, chromosome 5 at 123,623,275 bp
  • C to T, chromosome 5 at 138,301,266 bp
  • A to T, chromosome 6 at 111,358,997 bp
  • C to CAT, chromosome 6 at 116,042,870 bp
  • A to T, chromosome 6 at 129,677,750 bp
  • T to A, chromosome 7 at 4,552,922 bp
  • A to G, chromosome 7 at 45,794,853 bp
  • T to A, chromosome 7 at 78,516,772 bp
  • T to C, chromosome 7 at 82,603,706 bp
  • A to G, chromosome 7 at 85,955,546 bp
  • T to A, chromosome 7 at 86,364,206 bp
  • A to T, chromosome 7 at 104,841,432 bp
  • T to A, chromosome 8 at 10,438,803 bp
  • T to A, chromosome 8 at 15,029,178 bp
  • T to C, chromosome 8 at 45,935,011 bp
  • A to G, chromosome 9 at 6,288,464 bp
  • T to C, chromosome 9 at 21,485,723 bp
  • C to A, chromosome 9 at 26,902,490 bp
  • T to A, chromosome 9 at 109,005,609 bp
  • T to A, chromosome 10 at 20,026,289 bp
  • T to A, chromosome 11 at 9,136,033 bp
  • A to G, chromosome 11 at 68,783,127 bp
  • A to T, chromosome 11 at 73,776,829 bp
  • A to T, chromosome 11 at 86,534,070 bp
  • G to A, chromosome 11 at 95,275,805 bp
  • G to A, chromosome 11 at 110,496,341 bp
  • A to G, chromosome 12 at 65,227,413 bp
  • T to A, chromosome 13 at 12,454,832 bp
  • A to T, chromosome 13 at 21,520,912 bp
  • C to A, chromosome 13 at 33,334,609 bp
  • T to A, chromosome 13 at 49,901,360 bp
  • C to A, chromosome 13 at 55,472,800 bp
  • A to C, chromosome 13 at 98,637,249 bp
  • A to T, chromosome 14 at 32,198,987 bp
  • A to T, chromosome 14 at 34,223,032 bp
  • C to A, chromosome 16 at 13,110,024 bp
  • T to C, chromosome 16 at 31,108,128 bp
  • T to C, chromosome 16 at 36,515,758 bp
  • T to C, chromosome 17 at 23,816,745 bp
  • T to C, chromosome 17 at 25,184,725 bp
  • T to C, chromosome 17 at 32,338,825 bp
  • T to C, chromosome 17 at 33,920,326 bp
  • T to C, chromosome 17 at 53,515,396 bp
  • T to C, chromosome 18 at 21,914,990 bp
  • T to C, chromosome 19 at 37,698,287 bp
  • C to T, chromosome 19 at 40,296,631 bp
  • A to G, chromosome 19 at 56,317,817 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2214 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040216-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.