Strain Name:
C57BL/6J-MtgxR2238Btlr/Mmmh
Stock Number:
040238-MU
Citation ID:
RRID:MMRRC_040238-MU
Other Names:
R2238 (G1), C57BL/6J-MtgxR2238Btlr
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: Ptprz, Ptpz, Rptpbeta, RPTPz, DSD-1-PG, PTPbeta, phosphacan, PTPzeta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Ly6k
Name: lymphocyte antigen 6 family member K
Synonyms: mLy-6K, 3110035B01Rik, 2410015A16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76486
Homologene: 130772
Sgcd
Name: sarcoglycan, delta (dystrophin-associated glycoprotein)
Synonyms: delta-SG
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 24052
Homologene: 285
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Eomes
Name: eomesodermin
Synonyms: Tbr2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13813
HGNC: HGNC:3372
Homologene: 3971
Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Synonyms: 1110001J02Rik, p110beta
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74769
HGNC: HGNC:8976
Homologene: 21250
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: D630035I23Rik, TRIP8, 5430433L24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Tmem59l
Name: transmembrane protein 59-like
Synonyms: 5330410G16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67937
Homologene: 8104
Dnmbp
Name: dynamin binding protein
Synonyms: 2410003M15Rik, Tuba, 2410003L07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71972
Homologene: 9061
Sec24d
Name: SEC24 homolog D, COPII coat complex component
Synonyms: 2310020L09Rik, LOC383951
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69608
Homologene: 40986
Ints1
Name: integrator complex subunit 1
Synonyms: 1110015K06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68510
Homologene: 53111
Kdm6a
Name: lysine (K)-specific demethylase 6A
Synonyms: Utx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 22289
Homologene: 7586
Fndc3a
Name: fibronectin type III domain containing 3A
Synonyms: 1700094E19Rik, D14Ertd453e, sys, Fndc3, F730017H24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319448
Homologene: 8952
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Gbf1
Name: golgi-specific brefeldin A-resistance factor 1
Synonyms: 1700083E03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107338
HGNC: HGNC:4181
Homologene: 37897
Phka2
Name: phosphorylase kinase alpha 2
Synonyms: k, Phk, 6330505C01Rik
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 110094
HGNC: HGNC:8926
Homologene: 246
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 2810487N22Rik, B130055D15Rik, 4632407J06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Hipk2
Name: homeodomain interacting protein kinase 2
Synonyms: B230339E18Rik, Stank, 1110014O20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15258
Homologene: 68766
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: Acc1, acetyl-CoA carboxylase, Acac, LOC327983, A530025K05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Sp2
Name: Sp2 transcription factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78912
Homologene: 2340
Adgrl4
Name: adhesion G protein-coupled receptor L4
Synonyms: Eltd1, 1110033N21Rik, Etl, EGF-TM7 receptor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170757
Homologene: 11170
Adam18
Name: a disintegrin and metallopeptidase domain 18
Synonyms: Dtgn3, Adam27
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13524
HGNC: HGNC:196
Homologene: 74941
Dctn2
Name: dynactin 2
Synonyms: RBP50, 2310042E05Rik, DCTN-50, C130077D06Rik, p50
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69654
VEGA: 10
HGNC: HGNC:2712
Homologene: 4667
Cdc37
Name: cell division cycle 37
Synonyms: p50Cdc37
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12539
VEGA: 9
HGNC: HGNC:1735
Homologene: 38268
Dact2
Name: dishevelled-binding antagonist of beta-catenin 2
Synonyms: dapper2, Frd2, Dpr2, 2900084M21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240025
VEGA: 17
Homologene: 18237
Emilin2
Name: elastin microfibril interfacer 2
Synonyms: basilin, FOAP-10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 246707
VEGA: 17
Homologene: 36483
Aadacl4fm1
Name: AADACL4 family member 1
Synonyms: 9430007A20Rik, LOC381572
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381572
Homologene: 28662
Vmn1r204
Name: vomeronasal 1 receptor 204
Synonyms: Gm11301
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 632793
Homologene: 110880
Deup1
Name: deuterosome assembly protein 1
Synonyms: Ccdc67, 4933401K09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234964
Homologene: 18760
Gcc1
Name: golgi coiled coil 1
Synonyms: 4932417P04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74375
Homologene: 11567
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 671232
VEGA: 9
Homologene: 19835
Tcaf3
Name: TRPM8 channel-associated factor 3
Synonyms: Eapa2, Fam115e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 403088
Homologene: 74374
Vmn2r98
Name: vomeronasal 2, receptor 98
Synonyms: EG224552
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224552
Homologene: 115024
Kdr
Name: kinase insert domain protein receptor
Synonyms: Flk1, VEGFR2, Flk-1, VEGFR-2, vascular endothelial growth factor receptor- 2, orv, VEGF receptor-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16542
HGNC: HGNC:6307
Homologene: 55639
Clnk
Name: cytokine-dependent hematopoietic cell linker
Synonyms: MIST
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27278
Homologene: 8450
Bmi1
Name: Bmi1 polycomb ring finger oncogene
Synonyms: Bmi1, Pcgf4, Bmi-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12151
Homologene: 3797
Herc6
Name: hect domain and RLD 6
Synonyms: 1700121D12Rik, 4930427L17Rik, CEB1, Herc5, 2510038N07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67138
Homologene: 70768
Sncaip
Name: synuclein, alpha interacting protein (synphilin)
Synonyms: synphilin-1, SYPH1, 4933427B05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67847
Homologene: 3987
Rassf8
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
Synonyms: mHoj-1, 5133400D11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71323
Homologene: 5219
Stac
Name: src homology three (SH3) and cysteine rich domain
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20840
Homologene: 2371
Clca3a1
Name: chloride channel accessory 3A1
Synonyms: Clca1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12722
HGNC: HGNC:2017
Homologene: 77224
Gopc
Name: golgi associated PDZ and coiled-coil motif containing
Synonyms: GOPC1, 2210402P09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 94221
VEGA: 10
Homologene: 10695
Pcgf5
Name: polycomb group ring finger 5
Synonyms: 1110054A01Rik, 9530023M17Rik, 5830406C17Rik, 5830443C21Rik, 0610009F02Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76073
VEGA: 19
Homologene: 12632
Tnfsf11
Name: tumor necrosis factor (ligand) superfamily, member 11
Synonyms: Ly109l, OPGL, osteoclast differentiation factor, Trance, RANKL, OPGL, ODF
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21943
VEGA: 14
Homologene: 2744
Carf
Name: calcium response factor
Synonyms: Als2cr8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241066
Homologene: 11689
Mindy4
Name: MINDY lysine 48 deubiquitinase 4
Synonyms: C330043M08Rik, LOC384387, Fam188b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330323
Homologene: 49991
Tmem40
Name: transmembrane protein 40
Synonyms: 9030407H20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 94346
Homologene: 10124
Neil3
Name: nei like 3 (E. coli)
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234258
Homologene: 10094
Rnf148
Name: ring finger protein 148
Synonyms: 4933432M07Rik, Greul3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71300
Homologene: 82404
Men1
Name: multiple endocrine neoplasia 1
Synonyms: menin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17283
HGNC: HGNC:7010
Homologene: 7418
Msl2
Name: MSL complex subunit 2
Synonyms: Rnf184, Msl2l1, E130103E02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77853
Homologene: 10021
Or10v5
Name: olfactory receptor family 10 subfamily V member 5
Synonyms: GA_x6K02T2RE5P-2172809-2171862, Olfr1417, MOR266-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258938
Homologene: 27304
Sesn3
Name: sestrin 3
Synonyms: SEST3, 5630400E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75747
Homologene: 14386
Pabpc4l
Name: poly(A) binding protein, cytoplasmic 4-like
Synonyms: C330050A14Rik, EG241989
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241989
Homologene: 66336
Spata4
Name: spermatogenesis associated 4
Synonyms: 1700001N01Rik, SRG2, TSARG2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69281
Homologene: 15868
Nt5c1b
Name: 5'-nucleotidase, cytosolic IB
Synonyms: CN-IB, 4921514H13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70881
Homologene: 12370
Epn1
Name: epsin 1
Synonyms: Ibp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13854
Homologene: 32172
Srcin1
Name: SRC kinase signaling inhibitor 1
Synonyms: p140Cap, P140
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56013
Homologene: 10324
Arhgap36
Name: Rho GTPase activating protein 36
Synonyms: 1100001E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 75404
Homologene: 17012
Htatsf1
Name: HIV TAT specific factor 1
Synonyms: 1600023H17Rik, 2700077B20Rik, TAT-SF1, 2600017A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 72459
HGNC: HGNC:5276
Homologene: 40950
Spin2c
Name: spindlin family, member 2C
Synonyms: Spin2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 278240
Homologene: 10370
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 60,148,034 bp
  • T to C, chromosome 2 at 18,683,414 bp
  • A to C, chromosome 3 at 46,446,702 bp
  • T to A, chromosome 3 at 123,349,894 bp
  • T to A, chromosome 3 at 144,752,005 bp
  • A to T, chromosome 3 at 151,500,142 bp
  • T to A, chromosome 4 at 144,519,899 bp
  • A to G, chromosome 5 at 38,764,351 bp
  • T to A, chromosome 5 at 75,949,519 bp
  • G to A, chromosome 5 at 139,765,200 bp
  • A to T, chromosome 6 at 22,987,377 bp
  • T to C, chromosome 6 at 23,654,346 bp
  • A to G, chromosome 6 at 28,420,463 bp
  • A to G, chromosome 6 at 38,729,915 bp
  • A to G, chromosome 6 at 42,593,328 bp
  • T to C, chromosome 6 at 55,301,070 bp
  • A to G, chromosome 6 at 57,654,401 bp
  • C to T, chromosome 6 at 115,731,077 bp
  • T to C, chromosome 6 at 145,817,184 bp
  • A to G, chromosome 7 at 5,097,602 bp
  • T to C, chromosome 8 at 24,646,287 bp
  • T to C, chromosome 8 at 53,599,276 bp
  • A to C, chromosome 8 at 54,602,629 bp
  • T to C, chromosome 8 at 70,485,122 bp
  • T to C, chromosome 8 at 95,769,521 bp
  • T to C, chromosome 9 at 14,308,465 bp
  • A to C, chromosome 9 at 15,575,301 bp
  • G to A, chromosome 9 at 21,142,533 bp
  • A to G, chromosome 9 at 27,067,024 bp
  • A to G, chromosome 9 at 99,041,028 bp
  • T to A, chromosome 9 at 101,101,370 bp
  • G to A, chromosome 9 at 111,690,122 bp
  • A to G, chromosome 9 at 118,482,291 bp
  • C to T, chromosome 9 at 122,771,147 bp
  • T to C, chromosome 10 at 52,353,403 bp
  • T to C, chromosome 10 at 67,218,266 bp
  • C to T, chromosome 10 at 127,276,388 bp
  • T to C, chromosome 11 at 47,132,682 bp
  • T to C, chromosome 11 at 84,391,505 bp
  • C to T, chromosome 11 at 96,955,936 bp
  • T to C, chromosome 11 at 97,534,819 bp
  • C to A, chromosome 12 at 10,375,558 bp
  • A to G, chromosome 12 at 10,390,108 bp
  • A to G, chromosome 13 at 13,743,263 bp
  • A to G, chromosome 13 at 22,556,823 bp
  • A to T, chromosome 14 at 72,574,339 bp
  • A to T, chromosome 14 at 78,299,981 bp
  • T to C, chromosome 15 at 74,797,169 bp
  • A to T, chromosome 17 at 14,197,050 bp
  • T to A, chromosome 17 at 19,065,951 bp
  • T to C, chromosome 17 at 71,274,739 bp
  • T to C, chromosome 18 at 52,868,547 bp
  • T to A, chromosome 19 at 6,337,590 bp
  • T to C, chromosome 19 at 11,828,450 bp
  • A to T, chromosome 19 at 36,437,354 bp
  • A to G, chromosome 19 at 43,868,864 bp
  • T to C, chromosome 19 at 46,163,618 bp
  • T to C, chromosome X at 18,199,237 bp
  • G to T, chromosome X at 49,493,405 bp
  • G to T, chromosome X at 57,066,504 bp
  • A to G, chromosome X at 153,833,676 bp
  • A to G, chromosome X at 160,541,412 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2238 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040238-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.