Strain Name:
C57BL/6J-MtgxR2251Btlr/Mmmh
Stock Number:
040251-MU
Citation ID:
RRID:MMRRC_040251-MU
Other Names:
R2251 (G1), C57BL/6J-MtgxR2251Btlr
Major Collection:

Gene Information

Fgb
Name: fibrinogen beta chain
Synonyms: 2510049G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 110135
HGNC: HGNC:3662
Homologene: 3772
Etv5
Name: ets variant 5
Synonyms: 8430401F14Rik, erm, 1110005E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 104156
HGNC: HGNC:3494
Homologene: 3276
Actn4
Name: actinin alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 60595
HGNC: HGNC:166
Homologene: 55857
Gch1
Name: GTP cyclohydrolase 1
Synonyms: GTPCH, GTP-CH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14528
VEGA: 14
HGNC: HGNC:4193
Homologene: 132
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: med, seal, motor end-plate disease, nmf2, ataxia 3, mnd2, mnd-2, C630029C19Rik, nmf58, NaCh6, Nav1.6, nmf335, NMF335, nur14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20273
Homologene: 7927
Slc6a4
Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Synonyms: 5-HTT, Htt, Sert
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15567
Homologene: 817
Tm9sf2
Name: transmembrane 9 superfamily member 2
Synonyms: P76, 1500001N15Rik, D14Ertd64e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 68059
Homologene: 21004
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, RA-GEF-2, Pdzgef2, C030018K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192786
Homologene: 22968
Kif13b
Name: kinesin family member 13B
Synonyms: GAKIN, N-3 kinesin, C130021D12Rik, 5330429L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16554
VEGA: 14
Homologene: 9073
Akap13
Name: A kinase (PRKA) anchor protein 13
Synonyms: AKAP-Lbc, PROTO-LBC, PROTO-LB, Ht31, 5730522G15Rik, 1700026G02Rik, 5830460E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Armc8
Name: armadillo repeat containing 8
Synonyms: HSPC056, 1200015K23Rik, Gid5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74125
Homologene: 9121
Tut4
Name: terminal uridylyl transferase 4
Synonyms: 6030404K05Rik, 9230115F04Rik, Tent3a, Zcchc11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230594
Homologene: 35279
Kpna1
Name: karyopherin (importin) alpha 1
Synonyms: mSRP1, m-importin-alpha-S1, Rch2, NPI1, importin alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16646
HGNC: HGNC:6394
Homologene: 55642
Nav2
Name: neuron navigator 2
Synonyms: POMFIL2, Unc53H2, HELAD1, RAINB2, 5330421F07Rik, Rainb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78286
Homologene: 52330
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: c-Abl, E430008G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
Casp3
Name: caspase 3
Synonyms: CPP32, Apopain, Yama, Caspase-3, A830040C14Rik, CC3, mldy, AC-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12367
HGNC: HGNC:1504
Homologene: 37912
Ngdn
Name: neuroguidin, EIF4E binding protein
Synonyms: neuroguidin, 1500001L15Rik, Ngd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 68966
VEGA: 14
Homologene: 44286
N4bp2
Name: NEDD4 binding protein 2
Synonyms: LOC333789, LOC386488, B3bp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 333789
Homologene: 32396
Smim11
Name: small integral membrane protein 11
Synonyms: 1190017O12Rik, Fam165b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 68936
HGNC: HGNC:1293
Homologene: 129924
Cntn2
Name: contactin 2
Synonyms: Tax, TAG-1, axonin, D130012K04Rik, TAG1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21367
HGNC: HGNC:2172
Homologene: 3720
Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Synonyms: GR, Grl-1, Grl1, glucocorticoid receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14815
HGNC: HGNC:7978
Homologene: 30960
B3gnt3
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Synonyms: 2210008L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72297
Homologene: 113516
Nfix
Name: nuclear factor I/X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18032
HGNC: HGNC:7788
Homologene: 1872
Tap2
Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms: MTP2, PSF2, Ham2, Ham-2, Tap-2, HAM2, Abcb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21355
HGNC: HGNC:44
Homologene: 37323
Treml1
Name: triggering receptor expressed on myeloid cells-like 1
Synonyms: TLT-1, 5430401J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71326
VEGA: 17
Homologene: 52257
Khdrbs1
Name: KH domain containing, RNA binding, signal transduction associated 1
Synonyms: p62, Sam68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20218
Homologene: 4781
Pwp2
Name: PWP2 periodic tryptophan protein homolog (yeast)
Synonyms: Pwp2, 6530411D08Rik, Pwp2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110816
VEGA: 10
HGNC: HGNC:9711
Homologene: 3702
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Ten-m3, 2610100B16Rik, Odz3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23965
Homologene: 22673
Gzf1
Name: GDNF-inducible zinc finger protein 1
Synonyms: 8430437G08Rik, Zfp336
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74533
Homologene: 11200
Ccdc171
Name: coiled-coil domain containing 171
Synonyms: 4930418J05Rik, A330015D16Rik, 4930473A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320226
Homologene: 27942
Slc7a2
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Synonyms: Tea, Atrc2, Cat2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11988
Homologene: 20659
Enpep
Name: glutamyl aminopeptidase
Synonyms: Bp-1/6C3, APA, Ly-51, Ly51, 6030431M22Rik, aminopeptidase-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: Mlsn1, 4732499L03Rik, melastatin, LTRPC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Dgkg
Name: diacylglycerol kinase, gamma
Synonyms: Dagk3, E430001K23Rik, 2900055E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 110197
HGNC: HGNC:2853
Homologene: 1029
Plcb2
Name: phospholipase C, beta 2
Synonyms: B230205M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18796
HGNC: HGNC:9055
Homologene: 20957
Tcp11l2
Name: t-complex 11 (mouse) like 2
Synonyms: E430026E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216198
Homologene: 17129
Zfp867
Name: zinc finger protein 867
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237775
Homologene: 64827
Zfp575
Name: zinc finger protein 575
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101544
Homologene: 45485
Spn
Name: sialophorin
Synonyms: leukosialin, 3E8 antigen, Cd43, Ly-48, A630014B01Rik, Ly48, Galgp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20737
Homologene: 36108
Ubxn8
Name: UBX domain protein 8
Synonyms: Rep8h, Rep-8, D0H8S2298E, Ubxd6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 108159
Homologene: 4149
Tlr11
Name: toll-like receptor 11
Synonyms: LOC239081
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239081
Homologene: 77905
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76645
Homologene: 124481
Spata17
Name: spermatogenesis associated 17
Synonyms: 4930504I07Rik, 1700065F16Rik, 4930513F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74717
Homologene: 12551
Usp3
Name: ubiquitin specific peptidase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235441
Homologene: 4766
Vstm2a
Name: V-set and transmembrane domain containing 2A
Synonyms: 9330184N17Rik, Vstm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 211739
Homologene: 17123
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72277
1700129C05Rik
Name: RIKEN cDNA 1700129C05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67932
Homologene: 130749
Olfr1279
Name: olfactory receptor 1279
Synonyms: GA_x6K02T2Q125-72357646-72358581, MOR245-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258388
Homologene: 121520
Pbld2
Name: phenazine biosynthesis-like protein domain containing 2
Synonyms: 3110049J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67307
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68655
Olfr138
Name: olfactory receptor 138
Synonyms: Olfr89, GA_x6K02T2PSCP-2718585-2719523, MOR256-40P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 170648
Homologene: 119758
Olfr672
Name: olfactory receptor 672
Synonyms: GA_x6K02T2PBJ9-7625746-7624808, MOR32-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258755
Homologene: 138317
Vmn1r189
Name: vomeronasal 1 receptor 189
Synonyms: V1rh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 252906
Homologene: 110880
Olfr988
Name: olfactory receptor 988
Synonyms: GA_x6K02T2Q125-46830591-46829662, MOR203-5P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258166
Homologene: 103791
Mrpl40
Name: mitochondrial ribosomal protein L40
Synonyms: Nlvcf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 18100
Homologene: 2800
Rnf133
Name: ring finger protein 133
Synonyms: Greul2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 386611
Homologene: 44549
Vps45
Name: vacuolar protein sorting 45
Synonyms: mVps45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22365
Homologene: 5250
Zfp768
Name: zinc finger protein 768
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233890
Homologene: 11650
H2-M10.1
Name: histocompatibility 2, M region locus 10.1
Synonyms: 9.5H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14985
Homologene: 117973
Ly6d
Name: lymphocyte antigen 6 complex, locus D
Synonyms: Ly-61, Thb, Ly61
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17068
Homologene: 2742
Faap20
Name: Fanconi anemia core complex associated protein 20
Synonyms: 2610002J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67513
Homologene: 18793
Mbtps2
Name: membrane-bound transcription factor peptidase, site 2
Synonyms: 9630032G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 270669
Homologene: 9287
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 132,525,321 bp
  • A to T, chromosome 1 at 187,048,473 bp
  • T to A, chromosome 2 at 31,779,119 bp
  • A to G, chromosome 2 at 85,353,858 bp
  • A to G, chromosome 2 at 111,306,310 bp
  • T to C, chromosome 2 at 118,723,765 bp
  • T to C, chromosome 2 at 148,683,936 bp
  • T to G, chromosome 3 at 83,043,284 bp
  • A to T, chromosome 3 at 96,057,040 bp
  • A to T, chromosome 3 at 129,284,196 bp
  • T to A, chromosome 4 at 83,635,626 bp
  • T to A, chromosome 4 at 108,520,208 bp
  • A to G, chromosome 4 at 129,725,730 bp
  • A to C, chromosome 4 at 155,250,553 bp
  • G to A, chromosome 5 at 65,806,728 bp
  • T to C, chromosome 6 at 23,649,175 bp
  • A to T, chromosome 7 at 24,585,590 bp
  • G to A, chromosome 7 at 28,898,266 bp
  • A to G, chromosome 7 at 49,453,277 bp
  • G to A, chromosome 7 at 64,209,976 bp
  • C to T, chromosome 7 at 75,739,477 bp
  • A to T, chromosome 7 at 104,996,595 bp
  • T to C, chromosome 7 at 127,137,159 bp
  • T to C, chromosome 7 at 127,344,378 bp
  • A to G, chromosome 8 at 33,635,364 bp
  • T to C, chromosome 8 at 40,905,621 bp
  • G to T, chromosome 8 at 46,637,955 bp
  • A to G, chromosome 8 at 48,292,277 bp
  • A to T, chromosome 8 at 71,692,818 bp
  • T to C, chromosome 8 at 84,716,170 bp
  • A to G, chromosome 8 at 95,763,186 bp
  • T to C, chromosome 8 at 117,057,438 bp
  • T to C, chromosome 9 at 66,562,578 bp
  • T to A, chromosome 9 at 99,502,600 bp
  • T to A, chromosome 9 at 108,971,961 bp
  • G to T, chromosome 10 at 63,024,605 bp
  • T to A, chromosome 10 at 78,181,088 bp
  • T to C, chromosome 10 at 84,605,069 bp
  • C to A, chromosome 11 at 16,368,273 bp
  • A to G, chromosome 11 at 54,561,406 bp
  • T to A, chromosome 11 at 59,465,493 bp
  • T to C, chromosome 11 at 77,016,616 bp
  • T to C, chromosome 13 at 22,102,548 bp
  • T to C, chromosome 14 at 47,189,341 bp
  • T to A, chromosome 14 at 50,360,792 bp
  • T to C, chromosome 14 at 55,023,395 bp
  • G to A, chromosome 14 at 59,142,612 bp
  • C to T, chromosome 14 at 64,742,298 bp
  • T to A, chromosome 14 at 122,139,731 bp
  • A to G, chromosome 15 at 74,762,593 bp
  • T to C, chromosome 15 at 99,945,097 bp
  • A to G, chromosome 15 at 101,017,106 bp
  • T to C, chromosome 16 at 18,875,375 bp
  • T to C, chromosome 16 at 22,421,878 bp
  • A to T, chromosome 16 at 22,622,260 bp
  • T to C, chromosome 16 at 36,021,569 bp
  • T to C, chromosome 16 at 92,310,828 bp
  • G to A, chromosome 17 at 7,753,607 bp
  • A to G, chromosome 17 at 34,211,954 bp
  • A to C, chromosome 17 at 36,325,606 bp
  • C to T, chromosome 17 at 38,274,903 bp
  • C to T, chromosome 17 at 48,366,057 bp
  • G to T, chromosome 18 at 39,486,751 bp
  • A to T, chromosome X at 157,559,033 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2251 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040251-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.