Strain Name:
C57BL/6J-MtgxR2310Btlr/Mmmh
Stock Number:
040309-MU
Citation ID:
RRID:MMRRC_040309-MU
Other Names:
R2310 (G1), C57BL/6J-MtgxR2310Btlr
Major Collection:

Gene Information

Aatf
Name: apoptosis antagonizing transcription factor
Synonyms: 5830465M17Rik, Che-1, Trb, 4933415H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56321
Homologene: 40811
Ulk1
Name: unc-51 like kinase 1
Synonyms: Unc51.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22241
Homologene: 2640
Map3k8
Name: mitogen-activated protein kinase kinase kinase 8
Synonyms: Tpl-2, Tpl2, Cot, Cot/Tpl2, c-COT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 26410
HGNC: HGNC:6860
Homologene: 3812
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: B630009I04Rik, ASC1p200, Helic1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Golga5
Name: golgi autoantigen, golgin subfamily a, 5
Synonyms: Ret-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 27277
VEGA: 12
HGNC: HGNC:4428
Homologene: 38009
Pip5k1c
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
Synonyms: PIP5KIgamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18717
HGNC: HGNC:8996
Homologene: 69032
Ubap1
Name: ubiquitin-associated protein 1
Synonyms: NAG20, 2700092A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67123
Homologene: 9554
Slc45a4
Name: solute carrier family 45, member 4
Synonyms: 9330175B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 106068
Homologene: 69908
Nek1
Name: NIMA (never in mitosis gene a)-related expressed kinase 1
Synonyms: kat, kidney, anemia and testis, D8Ertd790e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18004
HGNC: HGNC:7744
Homologene: 14376
Kif23
Name: kinesin family member 23
Synonyms: Knsl5, MKLP1, MKLP-1, 3110001D19Rik, CHO1, C87313
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71819
VEGA: 9
HGNC: HGNC:6392
Homologene: 11491
Trmt6
Name: tRNA methyltransferase 6
Synonyms: 3300001M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66926
Homologene: 6816
Tjp1
Name: tight junction protein 1
Synonyms: ZO1, ZO-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21872
Homologene: 2445
Kansl3
Name: KAT8 regulatory NSL complex subunit 3
Synonyms: 4632411B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226976
Homologene: 9949
Flrt2
Name: fibronectin leucine rich transmembrane protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 399558
HGNC: HGNC:3761
Homologene: 8291
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20743
VEGA: 19
Homologene: 48482
Shq1
Name: SHQ1 homolog (S. cerevisiae)
Synonyms: 2810403P18Rik, Grim-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72171
Homologene: 31683
Ddx41
Name: DEAD box helicase 41
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 41, 2900024F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72935
VEGA: 13
Homologene: 9431
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola-2, Cola2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Pramel13
Name: PRAME like 13
Synonyms: 4930569K13Rik, Pramef12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77632
Homologene: 135701
Zfyve9
Name: zinc finger, FYVE domain containing 9
Synonyms: Madhip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230597
HGNC: HGNC:6775
Homologene: 3527
Olfr720
Name: olfactory receptor 720
Synonyms: MOR274-2, GA_x6K02T2PLTE-6544896-6543946
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258387
Homologene: 74036
Mcc
Name: mutated in colorectal cancers
Synonyms: D18Ertd451e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 328949
HGNC: HGNC:6935
Homologene: 20539
Intu
Name: inturned planar cell polarity protein
Synonyms: 9230116I04Rik, Pdzd6, Pdzk6, 9430087H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 380614
Homologene: 41059
Gsap
Name: gamma-secretase activating protein
Synonyms: A530088I07Rik, Pion
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 212167
Homologene: 45504
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: 2310003D02Rik, A530024P18Rik, 2310008C07Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241431
Homologene: 19388
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: E130120L08Rik, Liprin-alpha2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Wnk2
Name: WNK lysine deficient protein kinase 2
Synonyms: 1810073P09Rik, X83337, ESTM15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75607
Homologene: 19155
Gas2l2
Name: growth arrest-specific 2 like 2
Synonyms: OTTMUSG00000000934
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237891
Homologene: 16409
Arhgef10l
Name: Rho guanine nucleotide exchange factor (GEF) 10-like
Synonyms: 2810441C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72754
Homologene: 10017
Frmd4a
Name: FERM domain containing 4A
Synonyms: Gm13190, C230040M21Rik, 2700017I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209630
Homologene: 9971
Cpa3
Name: carboxypeptidase A3, mast cell
Synonyms: MC-CPA, mast cell carboxypeptidase A, mMC-CPA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12873
HGNC: HGNC:2298
Homologene: 122138
Tcaf3
Name: TRPM8 channel-associated factor 3
Synonyms: Eapa2, Fam115e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 403088
Homologene: 74374
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: EG381742, Zfp469
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231861
Homologene: 45603
Cyp2c65
Name: cytochrome P450, family 2, subfamily c, polypeptide 65
Synonyms: 2210009K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72303
HGNC: HGNC:2623
Homologene: 133566
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 628185
Homologene: 86604
Mcmdc2
Name: minichromosome maintenance domain containing 2
Synonyms: 6030422M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240697
Homologene: 18309
Msl3l2
Name: MSL3 like 2
Synonyms: 1700060H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 73390
VEGA: 10
Homologene: 128448
Krt31
Name: keratin 31
Synonyms: Kha1, Ha1, Krt1-1, MKHA-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16660
HGNC: HGNC:6448
Homologene: 74433
Zfp119a
Name: zinc finger protein 119a
Synonyms: Zfp119, Mzf13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 104349
Olfr1246
Name: olfactory receptor 1246
Synonyms: GA_x6K02T2Q125-51034790-51033846, MOR231-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258788
Homologene: 74246
Rassf5
Name: Ras association (RalGDS/AF-6) domain family member 5
Synonyms: Nore1B, Nore1A, 1300019G20Rik, Rapl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54354
Homologene: 10296
Poglut2
Name: protein O-glucosyltransferase 2
Synonyms: 5730416C13Rik, 1810049A15Rik, Kdel1, EP58, Kdelc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72050
Homologene: 11367
Mrpl19
Name: mitochondrial ribosomal protein L19
Synonyms: Rpml15, RLX1, MRP-L15, D6Ertd157e, 9030416F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56284
Homologene: 8851
Efhd1
Name: EF hand domain containing 1
Synonyms: mitocalcin, 4931430I01Rik, PP3051
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98363
Homologene: 41618
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 9,930,766 bp
  • T to A, chromosome 1 at 36,343,364 bp
  • T to C, chromosome 1 at 44,110,953 bp
  • T to C, chromosome 1 at 87,264,628 bp
  • A to T, chromosome 1 at 131,244,740 bp
  • GAA to G, chromosome 2 at 4,572,399 bp
  • A to G, chromosome 2 at 67,526,247 bp
  • A to G, chromosome 2 at 89,590,450 bp
  • G to T, chromosome 2 at 132,808,912 bp
  • C to T, chromosome 3 at 20,227,223 bp
  • C to T, chromosome 3 at 40,653,813 bp
  • T to A, chromosome 4 at 41,379,341 bp
  • A to G, chromosome 4 at 108,650,355 bp
  • A to C, chromosome 4 at 140,593,118 bp
  • A to T, chromosome 4 at 144,392,905 bp
  • A to T, chromosome 5 at 21,196,090 bp
  • C to T, chromosome 5 at 110,789,357 bp
  • C to G, chromosome 5 at 142,788,553 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • T to C, chromosome 6 at 42,590,024 bp
  • A to T, chromosome 6 at 81,964,073 bp
  • C to T, chromosome 6 at 100,631,002 bp
  • C to T, chromosome 7 at 65,329,742 bp
  • T to A, chromosome 7 at 141,637,531 bp
  • A to T, chromosome 8 at 61,072,846 bp
  • A to G, chromosome 9 at 61,924,144 bp
  • T to A, chromosome 10 at 50,748,892 bp
  • C to A, chromosome 10 at 56,115,325 bp
  • T to G, chromosome 10 at 81,306,308 bp
  • T to C, chromosome 10 at 106,854,980 bp
  • A to G, chromosome 11 at 83,427,439 bp
  • A to G, chromosome 11 at 84,467,451 bp
  • A to C, chromosome 11 at 100,047,065 bp
  • A to G, chromosome 12 at 95,780,090 bp
  • A to G, chromosome 12 at 102,492,161 bp
  • T to C, chromosome 13 at 49,050,577 bp
  • G to A, chromosome 13 at 55,534,480 bp
  • A to G, chromosome 14 at 14,175,836 bp
  • A to G, chromosome 15 at 73,589,560 bp
  • T to A, chromosome 17 at 22,603,115 bp
  • A to T, chromosome 17 at 55,865,440 bp
  • A to T, chromosome 18 at 4,349,001 bp
  • T to C, chromosome 18 at 44,431,366 bp
  • A to G, chromosome 19 at 4,718,935 bp
  • A to G, chromosome 19 at 39,093,382 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2310 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040309-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.