Strain Name:
C57BL/6J-MtgxR2323Btlr/Mmmh
Stock Number:
040314-MU
Citation ID:
RRID:MMRRC_040314-MU
Other Names:
R2323 (G1), C57BL/6J-MtgxR2323Btlr
Major Collection:

Strain Information

Pygb
Name: brain glycogen phosphorylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110078
HGNC: HGNC:9723
Homologene: 100930
Dst
Name: dystonin
Synonyms: BPAG1-n, BPAG1, 2310001O04Rik, bullous pemphigoid antigen 1, athetoid, nmf203, Macf2, ah, A830042E19Rik, Bpag1, nmf339, Bpag, bullous pemphigoid antigen 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Myo1e
Name: myosin IE
Synonyms: 9130023P14Rik, 2310020N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71602
VEGA: 9
HGNC: HGNC:7599
Homologene: 55864
Ep400
Name: E1A binding protein p400
Synonyms: mDomino, 1700020J09Rik, p400
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75560
Homologene: 38779
Anks3
Name: ankyrin repeat and sterile alpha motif domain containing 3
Synonyms: 2700067D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 72615
VEGA: 16
Homologene: 12475
Prdm5
Name: PR domain containing 5
Synonyms: 6530401I24Rik, PFM2, E130112L17Rik, 4432417F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70779
HGNC: HGNC:9349
Homologene: 10274
Chek2
Name: checkpoint kinase 2
Synonyms: Rad53, CHK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 50883
Homologene: 38289
Ints12
Name: integrator complex subunit 12
Synonyms: A230056J18Rik, 4930529N21Rik, 2810027J24Rik, Phf22, 1110020M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71793
Homologene: 32474
Tnfrsf21
Name: tumor necrosis factor receptor superfamily, member 21
Synonyms: TR7, DR6, Death receptor 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 94185
VEGA: 17
Homologene: 8696
Myt1
Name: myelin transcription factor 1
Synonyms: Nztf2, NZF-2b, NZF-2a, Nzf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17932
HGNC: HGNC:7622
Homologene: 3332
Crebrf
Name: CREB3 regulatory factor
Synonyms: A930001N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 77128
Homologene: 12672
Rundc1
Name: RUN domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217201
Homologene: 15095
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Slc4a3
Name: solute carrier family 4 (anion exchanger), member 3
Synonyms: Ae3, A930038D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20536
Homologene: 129474
Liph
Name: lipase, member H
Synonyms: LPDLR, Lpdlr, D16Wsu119e, PLA1B, mPA-PLA1, C130037N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239759
VEGA: 16
Homologene: 71802
Mcoln2
Name: mucolipin 2
Synonyms: TRPML2, mucolipidin 2, 3300002C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68279
Homologene: 12258
Ints10
Name: integrator complex subunit 10
Synonyms: 4921521J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70885
Homologene: 10029
Zscan18
Name: zinc finger and SCAN domain containing 18
Synonyms: EG232875
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232875
Homologene: 122136
Hmox2
Name: heme oxygenase 2
Synonyms: HO2, HO-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15369
HGNC: HGNC:5014
Homologene: 1611
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Gpr98, Mgr1, VLGR1, Mass1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Myo7b
Name: myosin VIIB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17922
HGNC: HGNC:7607
Homologene: 81947
Npas3
Name: neuronal PAS domain protein 3
Synonyms: 4930423H22Rik, bHLHe12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 27386
VEGA: 12
Homologene: 8461
Npsr1
Name: neuropeptide S receptor 1
Synonyms: Gpr154, PGR14, VRR1, 9330128H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319239
Homologene: 45515
Wnk4
Name: WNK lysine deficient protein kinase 4
Synonyms: 2010002J11Rik, Prkwnk4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69847
Homologene: 13020
Albfm1
Name: albumin superfamily member 1
Synonyms: 5830473C10Rik, Gm17754, ARG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 622307
Homologene: 129803
Vmn2r98
Name: vomeronasal 2, receptor 98
Synonyms: EG224552
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224552
Homologene: 115024
Abca2
Name: ATP-binding cassette, sub-family A member 2
Synonyms: D2H0S1474E, Abc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Or52h7
Name: olfactory receptor family 52 subfamily H member 7
Synonyms: MOR31-8, GA_x6K02T2PBJ9-7191524-7192471, Olfr652
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259050
Homologene: 17477
Asap2
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Synonyms: Ddef2, 6530401G17Rik, LOC385250
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 211914
HGNC: HGNC:2721
Homologene: 2888
Catip
Name: ciliogenesis associated TTC17 interacting protein
Synonyms: Gm216, LOC241112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241112
Asb15
Name: ankyrin repeat and SOCS box-containing 15
Synonyms: 4930400E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78910
Homologene: 43797
Zfp558
Name: zinc finger protein 558
Synonyms: 1700007A21Rik, Zfp558-ps, 4932704I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72230
Homologene: 44903
Cela2a
Name: chymotrypsin-like elastase family, member 2A
Synonyms: Ela2a, Ela-2, Ela2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13706
Homologene: 40598
Esrp2
Name: epithelial splicing regulatory protein 2
Synonyms: Rbm35b, 9530027K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 77411
Homologene: 32617
Tgfbr2
Name: transforming growth factor, beta receptor II
Synonyms: TbetaRII, TBR-II, 1110020H15Rik, TbetaR-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21813
VEGA: 9
Homologene: 2435
Vmn1r234
Name: vomeronasal 1 receptor 234
Synonyms: V1rf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171232
Tulp1
Name: TUB like protein 1
Synonyms: Tulp1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22157
Homologene: 2491
Vmn1r26
Name: vomeronasal 1 receptor 26
Synonyms: V1rc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171190
Rtkn2
Name: rhotekin 2
Synonyms: Mbf, RTKN2, B130039D23Rik, Plekhk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 170799
Homologene: 17065
Tmem181a
Name: transmembrane protein 181A
Synonyms: C76977, 5930418K15Rik, Gpr178, Tmem181
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 77106
Homologene: 44787
Snrpc
Name: U1 small nuclear ribonucleoprotein C
Synonyms: U1-C, Snrp1c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20630
Homologene: 134217
Gm20636
Name: predicted gene 20636
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 105246968
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,228,437 bp
  • A to T, chromosome 1 at 74,363,278 bp
  • T to C, chromosome 1 at 75,552,818 bp
  • G to T, chromosome 2 at 25,445,175 bp
  • T to C, chromosome 2 at 150,816,745 bp
  • G to T, chromosome 2 at 181,806,557 bp
  • G to A, chromosome 3 at 133,109,365 bp
  • A to G, chromosome 3 at 146,163,707 bp
  • G to C, chromosome 4 at 141,826,079 bp
  • T to A, chromosome 5 at 90,584,852 bp
  • A to G, chromosome 5 at 110,693,347 bp
  • T to A, chromosome 5 at 110,867,061 bp
  • A to G, chromosome 5 at 112,374,732 bp
  • T to C, chromosome 5 at 124,742,000 bp
  • T to A, chromosome 6 at 24,556,601 bp
  • T to C, chromosome 6 at 58,008,857 bp
  • T to A, chromosome 6 at 65,883,519 bp
  • T to C, chromosome 7 at 12,775,459 bp
  • T to C, chromosome 7 at 104,564,619 bp
  • A to G, chromosome 8 at 68,819,345 bp
  • T to A, chromosome 8 at 106,134,302 bp
  • A to T, chromosome 9 at 18,469,277 bp
  • A to G, chromosome 9 at 24,300,436 bp
  • T to A, chromosome 9 at 70,378,758 bp
  • T to C, chromosome 9 at 116,110,144 bp
  • A to G, chromosome 10 at 68,001,934 bp
  • T to A, chromosome 11 at 101,268,481 bp
  • T to C, chromosome 11 at 101,425,275 bp
  • T to C, chromosome 12 at 21,203,968 bp
  • T to A, chromosome 12 at 54,068,346 bp
  • A to G, chromosome 13 at 81,595,179 bp
  • A to T, chromosome 16 at 4,765,856 bp
  • T to C, chromosome 16 at 4,950,770 bp
  • A to G, chromosome 16 at 21,984,004 bp
  • T to A, chromosome 17 at 6,295,786 bp
  • T to A, chromosome 17 at 19,065,819 bp
  • T to C, chromosome 17 at 21,229,703 bp
  • T to C, chromosome 17 at 26,763,607 bp
  • T to G, chromosome 17 at 27,847,974 bp
  • C to T, chromosome 17 at 28,362,482 bp
  • C to A, chromosome 17 at 43,085,529 bp
  • T to C, chromosome 18 at 31,971,345 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2323 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040314-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.