Strain Name:
C57BL/6J-MtgxR2326Btlr/Mmmh
Stock Number:
040317-MU
Citation ID:
RRID:MMRRC_040317-MU
Other Names:
R2326 (G1), C57BL/6J-MtgxR2326Btlr
Major Collection:

Gene Information

Prph
Name: peripherin
Synonyms: Prph1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19132
VEGA: 15
HGNC: HGNC:9461
Homologene: 4559
Cdh3
Name: cadherin 3
Synonyms: P-cadherin, Cadp, Pcad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12560
HGNC: HGNC:1762
Homologene: 20425
Sort1
Name: sortilin 1
Synonyms: sortilin, neurotensin receptor 3, Ntsr3, Ntr3, 2900053A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20661
Homologene: 136097
Dnmt1
Name: DNA methyltransferase (cytosine-5) 1
Synonyms: MTase, Dnmt1o, Cxxc9, MommeD2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13433
VEGA: 9
HGNC: HGNC:2976
Homologene: 124071
Ewsr1
Name: Ewing sarcoma breakpoint region 1
Synonyms: Ews
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14030
HGNC: HGNC:3508
Homologene: 134632
Plcb4
Name: phospholipase C, beta 4
Synonyms: A930039J07Rik, C230058B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Cdyl2
Name: chromodomain protein, Y chromosome-like 2
Synonyms: 1700029M19Rik, 4930453I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75796
Homologene: 41779
Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Synonyms: cholesterol 7 alpha hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13122
HGNC: HGNC:2651
Homologene: 30987
Flrt3
Name: fibronectin leucine rich transmembrane protein 3
Synonyms: 5530600M07Rik, C430047I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71436
HGNC: HGNC:3762
Homologene: 8322
Dazap1
Name: DAZ associated protein 1
Synonyms: 2410042M16Rik, mPrrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70248
HGNC: HGNC:2683
Homologene: 134440
Saal1
Name: serum amyloid A-like 1
Synonyms: 5031425D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78935
Homologene: 34706
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930516E05Rik, D330038K10Rik, 4930543C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Dnajc13
Name: DnaJ heat shock protein family (Hsp40) member C13
Synonyms: Rme8, LOC382100, D030002L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235567
Homologene: 13574
Foxp2
Name: forkhead box P2
Synonyms: 2810043D05Rik, D0Kist7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 114142
Homologene: 134404
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Gm5600
Name: predicted gene 5600
Synonyms: ENSMUSG00000073862
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108167501
Dusp8
Name: dual specificity phosphatase 8
Synonyms: Nttp1, 5530400B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18218
HGNC: HGNC:3074
Homologene: 31239
Stab2
Name: stabilin 2
Synonyms: STAB-2, FEEL-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 192188
Homologene: 23022
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242274
Homologene: 10817
Vmn2r61
Name: vomeronasal 2, receptor 61
Synonyms: Casr-rs2, EG637873, Gprc2a-rs2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637873
Homologene: 129683
Vmn1r58
Name: vomeronasal 1 receptor 58
Synonyms: V3R4, V1rd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 81014
Homologene: 41799
Haspin
Name: histone H3 associated protein kinase
Synonyms: Gsg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14841
Homologene: 49236
Fem1b
Name: fem 1 homolog b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 14155
VEGA: 9
HGNC: HGNC:3649
Homologene: 7714
Mrc2
Name: mannose receptor, C type 2
Synonyms: novel lectin, Endo180, uPARAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17534
Homologene: 4408
Slc23a2
Name: solute carrier family 23 (nucleobase transporters), member 2
Synonyms: YSPL3, SVCT2, Slc23a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 54338
Homologene: 68440
Slc40a1
Name: solute carrier family 40 (iron-regulated transporter), member 1
Synonyms: Ol5, ferroportin1, IREG1, FPN1, metal transporting protein 1, MTP1, Slc11a3, Dusg, Pcm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53945
Homologene: 40959
Plekhd1
Name: pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
Synonyms: 3830431G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217682
Homologene: 15090
Syne3
Name: spectrin repeat containing, nuclear envelope family member 3
Synonyms: nesprin-3beta, nesprin-3alpha, nesprin-3, 4831426I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 212073
VEGA: 12
Homologene: 17625
Bglap3
Name: bone gamma-carboxyglutamate protein 3
Synonyms: mOC-X, ORG, Bglap-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12095
HGNC: HGNC:1043
Homologene: 104130
Rassf2
Name: Ras association (RalGDS/AF-6) domain family member 2
Synonyms: 3830431H01Rik, 9030412M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 215653
HGNC: HGNC:9883
Homologene: 22840
Serpina3a
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3A
Synonyms: 4933406L18Rik, antitrypsin, alpha-1 antiproteinase,
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74069
HGNC: HGNC:16
Crygs
Name: crystallin, gamma S
Synonyms: Opj
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12970
VEGA: 16
HGNC: HGNC:2417
Homologene: 40695
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 45,911,544 bp
  • C to T, chromosome 2 at 132,000,432 bp
  • C to T, chromosome 2 at 132,094,195 bp
  • C to T, chromosome 2 at 135,939,973 bp
  • C to A, chromosome 2 at 140,661,391 bp
  • G to C, chromosome 3 at 88,369,512 bp
  • C to T, chromosome 3 at 108,337,779 bp
  • A to T, chromosome 3 at 158,170,661 bp
  • A to T, chromosome 4 at 6,268,396 bp
  • T to A, chromosome 6 at 15,409,939 bp
  • G to T, chromosome 7 at 5,410,940 bp
  • T to G, chromosome 7 at 42,266,863 bp
  • A to G, chromosome 7 at 46,692,811 bp
  • G to T, chromosome 7 at 113,707,804 bp
  • A to G, chromosome 7 at 142,090,063 bp
  • A to G, chromosome 8 at 106,511,308 bp
  • A to G, chromosome 8 at 116,623,798 bp
  • A to T, chromosome 9 at 20,924,146 bp
  • T to C, chromosome 9 at 62,797,003 bp
  • A to G, chromosome 9 at 104,233,525 bp
  • T to A, chromosome 10 at 39,042,567 bp
  • T to A, chromosome 10 at 80,284,233 bp
  • T to A, chromosome 10 at 86,954,474 bp
  • A to G, chromosome 11 at 5,091,857 bp
  • A to G, chromosome 11 at 73,136,085 bp
  • G to A, chromosome 11 at 105,348,431 bp
  • A to G, chromosome 12 at 80,722,099 bp
  • C to T, chromosome 12 at 104,116,499 bp
  • T to A, chromosome 12 at 104,969,234 bp
  • C to G, chromosome 15 at 99,055,282 bp
  • C to T, chromosome 16 at 22,805,551 bp
  • T to C, chromosome 19 at 16,743,057 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2326 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040317-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.