Strain Name:
C57BL/6J-MtgxR2329Btlr/Mmmh
Stock Number:
040320-MU
Citation ID:
RRID:MMRRC_040320-MU
Other Names:
R2329 (G1), C57BL/6J-MtgxR2329Btlr
Major Collection:

Gene Information

Adora2a
Name: adenosine A2a receptor
Synonyms: ARA2A, AA2AR, A2a, Rs, A2AAR, A2aR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11540
VEGA: 10
HGNC: HGNC:263
Homologene: 20166
Gad2
Name: glutamic acid decarboxylase 2
Synonyms: GAD65, GAD(65), Gad-2, 6330404F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14417
HGNC: HGNC:4093
Homologene: 20223
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Naa25
Name: N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Synonyms: C330023M02Rik, 4833422K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231713
Homologene: 6891
Mars1
Name: methionine-tRNA synthetase 1
Synonyms: MetRS, methionine tRNA ligase, methionyl-tRNA synthetase, Mars
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216443
HGNC: HGNC:6898
Homologene: 90878
Vps8
Name: VPS8 CORVET complex subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 209018
Homologene: 44592
Hus1
Name: HUS1 checkpoint clamp component
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15574
HGNC: HGNC:5309
Homologene: 37932
Fosb
Name: FBJ osteosarcoma oncogene B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14282
HGNC: HGNC:3797
Homologene: 31403
Uhrf1
Name: ubiquitin-like, containing PHD and RING finger domains, 1
Synonyms: ICBP90, Np95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18140
Homologene: 7866
Tsg101
Name: tumor susceptibility gene 101
Synonyms: CC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22088
Homologene: 4584
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l7Rn3, Doc4, Odz4, Ten-m4, ELM2, l(7)-3Rn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 23966
Homologene: 8034
Susd1
Name: sushi domain containing 1
Synonyms: Gm12528
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 634731
Homologene: 11204
Amph
Name: amphiphysin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218038
HGNC: HGNC:471
Homologene: 121585
Fnip1
Name: folliculin interacting protein 1
Synonyms: A730024A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216742
Homologene: 28173
Cdh23
Name: cadherin 23 (otocadherin)
Synonyms: sals, 4930542A03Rik, mdfw, bob, nmf112, nmf181, nmf252, ahl, USH1D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22295
Homologene: 11142
Ern2
Name: endoplasmic reticulum (ER) to nucleus signalling 2
Synonyms: Ire1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26918
Homologene: 22687
Scd2
Name: stearoyl-Coenzyme A desaturase 2
Synonyms: Scd-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20250
VEGA: 19
Homologene: 136612
Ttn
Name: titin
Synonyms: 2310036G12Rik, mdm, 1100001C23Rik, shru, D830007G01Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, L56, connectin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Efcab6
Name: EF-hand calcium binding domain 6
Synonyms: 4932408N08Rik, 4931407K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 77627
Homologene: 11259
Prl8a6
Name: prolactin family 8, subfamily a, member 6
Synonyms: Prlpc, PLP-Ca, PLP-calpha, Prlpc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19112
Taf5
Name: TATA-box binding protein associated factor 5
Synonyms: 6330528C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226182
VEGA: 19
Homologene: 5064
Ulk4
Name: unc-51-like kinase 4
Synonyms: 4932415A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209012
Homologene: 41205
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Gstk1
Name: glutathione S-transferase kappa 1
Synonyms: DsbA-L, 0610025I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 76263
Homologene: 41075
Ros1
Name: Ros1 proto-oncogene
Synonyms: c-ros, Ros-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19886
Homologene: 2207
Ccdc146
Name: coiled-coil domain containing 146
Synonyms: 4930528G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75172
Homologene: 67159
Dpp6
Name: dipeptidylpeptidase 6
Synonyms: Rw, Peplb, Dpp-6, In(5)6H-p, LOC384168, B930011P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13483
HGNC: HGNC:3010
Homologene: 22560
Cspg4
Name: chondroitin sulfate proteoglycan 4
Synonyms: NG2, Cspg4a, AN2, 4732461B14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 121021
VEGA: 9
HGNC: HGNC:2466
Homologene: 20445
Adamts15
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235130
VEGA: 9
Homologene: 8610
Gm19684
Name: predicted gene, 19684
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Zfp932
Name: zinc finger protein 932
Synonyms: 2310001H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69504
Homologene: 137770
Dab2
Name: disabled 2, mitogen-responsive phosphoprotein
Synonyms: D630005B22Rik, p96, 5730435J12Rik, D15Wsu122e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13132
HGNC: HGNC:2662
Homologene: 1026
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72371
Homologene: 89234
Nostrin
Name: nitric oxide synthase trafficker
Synonyms: mDaIP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329416
Homologene: 43142
Vmn1r184
Name: vomeronasal 1 receptor, 184
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100312477
Homologene: 74353
Slc35c1
Name: solute carrier family 35, member C1
Synonyms: FUCT1, E430007K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228368
Homologene: 41258
Slc34a3
Name: solute carrier family 34 (sodium phosphate), member 3
Synonyms: NPTIIc, Npt2c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 142681
Homologene: 15444
Mrpl38
Name: mitochondrial ribosomal protein L38
Synonyms: Rpml3, 1110036N21Rik, MRP-L3, 4733401F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 60441
Homologene: 11476
Csn3
Name: casein kappa
Synonyms: Csnk, CSN10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12994
HGNC: HGNC:2446
Homologene: 3818
Batf3
Name: basic leucine zipper transcription factor, ATF-like 3
Synonyms: 9130211I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381319
Homologene: 41280
Kbtbd8
Name: kelch repeat and BTB (POZ) domain containing 8
Synonyms: SSEC 51, SSEC-51, SSEC51, Takrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243574
Homologene: 13043
Crygs
Name: crystallin, gamma S
Synonyms: Opj
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12970
VEGA: 16
HGNC: HGNC:2417
Homologene: 40695
Rapgefl1
Name: Rap guanine nucleotide exchange factor (GEF)-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268480
Homologene: 41126
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • CTCTCTCTCTCTCTCTCTCTCTCTCTC to CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC, chromosome 1 at 88,247,714 bp
  • A to T, chromosome 1 at 191,108,449 bp
  • G to A, chromosome 2 at 22,668,289 bp
  • T to C, chromosome 2 at 25,229,410 bp
  • GTGGCT to GT, chromosome 2 at 29,154,061 bp
  • A to T, chromosome 2 at 69,161,094 bp
  • G to A, chromosome 2 at 76,769,442 bp
  • A to G, chromosome 2 at 76,778,068 bp
  • A to T, chromosome 2 at 92,458,695 bp
  • T to C, chromosome 4 at 59,379,715 bp
  • C to T, chromosome 5 at 21,308,612 bp
  • T to C, chromosome 5 at 27,451,288 bp
  • A to G, chromosome 5 at 87,930,003 bp
  • A to T, chromosome 5 at 110,009,540 bp
  • T to A, chromosome 5 at 121,434,814 bp
  • T to A, chromosome 6 at 42,246,914 bp
  • T to C, chromosome 6 at 95,126,780 bp
  • T to C, chromosome 7 at 19,307,185 bp
  • A to T, chromosome 7 at 26,266,962 bp
  • A to T, chromosome 7 at 46,891,120 bp
  • A to G, chromosome 7 at 96,895,862 bp
  • C to T, chromosome 7 at 122,173,487 bp
  • G to T, chromosome 9 at 30,902,485 bp
  • A to G, chromosome 9 at 56,888,550 bp
  • C to T, chromosome 9 at 121,272,887 bp
  • A to G, chromosome 10 at 52,162,887 bp
  • T to A, chromosome 10 at 60,306,233 bp
  • T to A, chromosome 10 at 75,326,183 bp
  • T to A, chromosome 10 at 127,305,637 bp
  • A to G, chromosome 11 at 9,007,492 bp
  • A to G, chromosome 11 at 54,466,107 bp
  • G to A, chromosome 11 at 98,849,994 bp
  • T to A, chromosome 11 at 116,132,019 bp
  • T to A, chromosome 13 at 19,139,350 bp
  • T to C, chromosome 13 at 27,437,067 bp
  • A to C, chromosome 13 at 77,303,325 bp
  • C to A, chromosome 15 at 6,429,563 bp
  • C to T, chromosome 15 at 83,950,048 bp
  • C to G, chromosome 16 at 21,518,098 bp
  • C to T, chromosome 16 at 22,805,551 bp
  • T to A, chromosome 17 at 36,128,453 bp
  • C to A, chromosome 17 at 56,310,671 bp
  • T to A, chromosome 19 at 44,298,053 bp
  • C to T, chromosome 19 at 47,075,124 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2329 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040320-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.