Strain Name:
C57BL/6J-MtgxR2366Btlr/Mmmh
Stock Number:
040347-MU
Citation ID:
RRID:MMRRC_040347-MU
Other Names:
R2366 (G1), C57BL/6J-MtgxR2366Btlr
Major Collection:

Strain Information

Rest
Name: RE1-silencing transcription factor
Synonyms: 2610008J04Rik, NRSF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19712
HGNC: HGNC:9966
Homologene: 4099
Matr3
Name: matrin 3
Synonyms: D030046F20Rik, 2810017I02Rik, 1110061A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17184
HGNC: HGNC:6912
Homologene: 7830
Med1
Name: mediator complex subunit 1
Synonyms: TRAP 220, TRAP220, CRSP210, DRIP205, Pparbp, l11Jus15, PBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Slc9a3r1
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
Synonyms: sodium-hydrogen exchanger regulatory factor, NHE-RF, NHERF1, EBP-50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 26941
Homologene: 3137
Zfp101
Name: zinc finger protein 101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22643
Homologene: 137226
Apbb2
Name: amyloid beta (A4) precursor protein-binding, family B, member 2
Synonyms: TR2L, Rirl1, 2310007D03Rik, Zfra, FE65L1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11787
HGNC: HGNC:582
Homologene: 32079
Erbin
Name: Erbb2 interacting protein
Synonyms: 1700028E05Rik, Erbin, Erbb2ip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 59079
Homologene: 41282
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208628
Homologene: 32227
Ncapg2
Name: non-SMC condensin II complex, subunit G2
Synonyms: Mtb, 5830426I05Rik, Luzp5, mCAP-G2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76044
VEGA: 12
Homologene: 9820
Tcf4
Name: transcription factor 4
Synonyms: SEF-2, ITF-2, MITF-2B, MITF-2A, ME2, E2.2, TFE, E2-2, SEF2-1, ASP-I2, ITF-2b, 5730422P05Rik, bHLHb19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 21413
Homologene: 2407
Gps1
Name: G protein pathway suppressor 1
Synonyms: COPS1, Csn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 209318
HGNC: HGNC:4549
Homologene: 3046
Prox1
Name: prospero homeobox 1
Synonyms: A230003G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19130
HGNC: HGNC:9459
Homologene: 2069
Lsm5
Name: LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
Synonyms: 2310034K10Rik, 2010208O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66373
Homologene: 40833
Lzts1
Name: leucine zipper, putative tumor suppressor 1
Synonyms: F37, FEZ1, PSD-Zip70
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 211134
Homologene: 10873
Knop1
Name: lysine rich nucleolar protein 1
Synonyms: Tsg118, 2310008H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66356
Homologene: 49729
Zfp398
Name: zinc finger protein 398
Synonyms: 5730513I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 272347
Homologene: 12358
Arl6ip6
Name: ADP-ribosylation factor-like 6 interacting protein 6
Synonyms: Aip-6, 2610529A11Rik, 2310057C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65103
Homologene: 11302
Usp6nl
Name: USP6 N-terminal like
Synonyms: TRE2NL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98910
Homologene: 6879
Dennd6a
Name: DENN/MADD domain containing 6A
Synonyms: A630054L15Rik, Fam116a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 211922
Homologene: 13503
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, ALS2CR17, A530083I02Rik, 2310076G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269198
Homologene: 16453
Rundc3a
Name: RUN domain containing 3A
Synonyms: Rpip8, Rap2ip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 51799
Homologene: 4871
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: B930001P07Rik, 6330504P12Rik, MLSN2, melastatin 2, LTRPC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
F3
Name: coagulation factor III
Synonyms: tissue factor, TF, Cf-3, CD142, Cf3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14066
HGNC: HGNC:3541
Homologene: 1511
9930021J03Rik
Name: RIKEN cDNA 9930021J03 gene
Synonyms: Gm9832
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240613
Homologene: 19046
Hc
Name: hemolytic complement
Synonyms: C5a, C5, He, Hfib2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Vipr1
Name: vasoactive intestinal peptide receptor 1
Synonyms: VIP-R1, VPAC1, VIP receptor subtype 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22354
Homologene: 3399
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245026
Homologene: 18260
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: PG10.2, IPM200, Spacrcan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224224
Homologene: 9439
A630091E08Rik
Name: RIKEN cDNA A630091E08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Synonyms: p110alpha, caPI3K, 6330412C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18706
HGNC: HGNC:8975
Homologene: 21249
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76645
Homologene: 124481
Drc1
Name: dynein regulatory complex subunit 1
Synonyms: LOC381738, Gm1060, Ccdc164, b2b1654Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381738
Homologene: 35977
Stx6
Name: syntaxin 6
Synonyms: 2410005I16Rik, 2310039E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 58244
Homologene: 115622
Cep250
Name: centrosomal protein 250
Synonyms: Inmp, B230210E21Rik, Cep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Adamts5
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
Synonyms: ADAM-TS5, 9530092O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 23794
VEGA: 16
HGNC: HGNC:221
Homologene: 5109
Napsa
Name: napsin A aspartic peptidase
Synonyms: napsin, pronapsin, NAP1, Kdap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16541
Homologene: 68418
Cyp2d12
Name: cytochrome P450, family 2, subfamily d, polypeptide 12
Synonyms: 9030605E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 380997
VEGA: 15
HGNC: HGNC:2625
Homologene: 86099
Or5af1
Name: olfactory receptor family 5 subfamily AF member 1
Synonyms: GA_x6K02T2NKPP-575829-574903, MOR222-4P, Olfr312
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258065
Homologene: 77375
Cd38
Name: CD38 antigen
Synonyms: Cd38-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12494
HGNC: HGNC:1667
Homologene: 1345
Cyp2c69
Name: cytochrome P450, family 2, subfamily c, polypeptide 69
Synonyms: AI098658
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 100043108
VEGA: 19
Homologene: 74936
Fads3
Name: fatty acid desaturase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 60527
VEGA: 19
HGNC: HGNC:3576
Homologene: 11025
Ubqln3
Name: ubiquilin 3
Synonyms: 4933400K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244178
Homologene: 9700
Dnajc28
Name: DnaJ heat shock protein family (Hsp40) member C28
Synonyms: ORF28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 246738
HGNC: HGNC:1297
Homologene: 9869
Gm10311
Name: predicted gene 10311
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Pramel39
Name: PRAME like 39
Synonyms: Gm16522, A430089I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 331195
Homologene: 77633
Gm8893
Name: predicted gene 8893
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 667951
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 60,251,352 bp
  • A to T, chromosome 1 at 155,201,960 bp
  • T to A, chromosome 1 at 190,161,882 bp
  • T to A, chromosome 2 at 6,440,959 bp
  • T to C, chromosome 2 at 35,013,636 bp
  • T to C, chromosome 2 at 53,192,367 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • G to A, chromosome 2 at 155,992,632 bp
  • G to A, chromosome 3 at 32,462,794 bp
  • G to A, chromosome 3 at 121,732,545 bp
  • A to G, chromosome 5 at 30,366,550 bp
  • T to G, chromosome 5 at 43,903,590 bp
  • T to C, chromosome 5 at 66,307,727 bp
  • C to A, chromosome 5 at 77,268,187 bp
  • T to C, chromosome 5 at 94,303,113 bp
  • C to T, chromosome 5 at 123,781,192 bp
  • C to T, chromosome 6 at 47,863,209 bp
  • T to C, chromosome 6 at 56,703,018 bp
  • T to A, chromosome 7 at 44,582,485 bp
  • G to A, chromosome 7 at 98,543,742 bp
  • C to A, chromosome 7 at 104,141,049 bp
  • C to A, chromosome 7 at 118,852,528 bp
  • T to C, chromosome 8 at 69,140,605 bp
  • A to T, chromosome 8 at 69,373,580 bp
  • A to T, chromosome 8 at 117,043,317 bp
  • C to A, chromosome 9 at 105,755,694 bp
  • T to G, chromosome 9 at 121,665,184 bp
  • C to A, chromosome 11 at 58,831,213 bp
  • A to G, chromosome 11 at 98,161,182 bp
  • A to G, chromosome 11 at 102,397,665 bp
  • G to A, chromosome 11 at 115,163,628 bp
  • A to C, chromosome 11 at 120,788,119 bp
  • G to A, chromosome 12 at 103,819,011 bp
  • G to A, chromosome 12 at 116,420,729 bp
  • G to A, chromosome 13 at 103,844,909 bp
  • A to T, chromosome 14 at 26,616,973 bp
  • T to A, chromosome 15 at 82,555,154 bp
  • T to C, chromosome 16 at 56,259,873 bp
  • C to T, chromosome 16 at 85,862,758 bp
  • G to A, chromosome 16 at 91,616,867 bp
  • A to T, chromosome 17 at 33,380,998 bp
  • A to T, chromosome 18 at 35,588,395 bp
  • T to A, chromosome 18 at 69,349,154 bp
  • A to G, chromosome 19 at 10,041,969 bp
  • T to C, chromosome 19 at 22,897,820 bp
  • A to T, chromosome 19 at 29,753,635 bp
  • T to C, chromosome 19 at 39,877,594 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2366 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040347-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.