Strain Name:
C57BL/6J-MtgxR2377Btlr/Mmmh
Stock Number:
040354-MU
Citation ID:
RRID:MMRRC_040354-MU
Other Names:
R2377 (G1), C57BL/6J-MtgxR2377Btlr
Major Collection:

Strain Information

Ntrk1
Name: neurotrophic tyrosine kinase, receptor, type 1
Synonyms: TrkA, Tkr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18211
HGNC: HGNC:8031
Homologene: 1898
Gli2
Name: GLI-Kruppel family member GLI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14633
HGNC: HGNC:4318
Homologene: 12725
Tnpo3
Name: transportin 3
Synonyms: 5730544L10Rik, C430013M08Rik, D6Ertd313e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320938
Homologene: 40848
Polr1a
Name: polymerase (RNA) I polypeptide A
Synonyms: mRPA1, RPA194, 194kDa, 3010014K16Rik, Rpo1-4, 2900087K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20019
Homologene: 7033
Apaf1
Name: apoptotic peptidase activating factor 1
Synonyms: Apaf1l, 6230400I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11783
HGNC: HGNC:576
Homologene: 7626
Aqr
Name: aquarius
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11834
Homologene: 7629
Hr
Name: lysine demethylase and nuclear receptor corepressor
Synonyms: N, ba, rh, rh-bmh, bldy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 15460
HGNC: HGNC:5172
Homologene: 3774
Uba6
Name: ubiquitin-like modifier activating enzyme 6
Synonyms: 5730469D23Rik, Ube1l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231380
Homologene: 10080
Dhx32
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 32
Synonyms: Ddx32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101437
Homologene: 56798
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218333
VEGA: 13
Homologene: 18902
Chst4
Name: carbohydrate sulfotransferase 4
Synonyms: high endothelial cell GlcNAC-6-sulphotransferase, HEC-GlcNAc6ST, GST-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26887
HGNC: HGNC:1972
Homologene: 4216
Ccdc38
Name: coiled-coil domain containing 38
Synonyms: 4933417K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237465
Homologene: 52182
Mcc
Name: mutated in colorectal cancers
Synonyms: D18Ertd451e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 328949
HGNC: HGNC:6935
Homologene: 20539
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
9930021J03Rik
Name: RIKEN cDNA 9930021J03 gene
Synonyms: Gm9832
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240613
Homologene: 19046
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: PBP, Moca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5c, Nav1.5, mH1, SkM2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20271
Homologene: 22738
Kcnt1
Name: potassium channel, subfamily T, member 1
Synonyms: Slack, slo2, C030030G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227632
Homologene: 11055
Sla2
Name: Src-like-adaptor 2
Synonyms: SLAP-2, SLAP2, A930009E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77799
Homologene: 49989
Rad21
Name: RAD21 cohesin complex component
Synonyms: SCC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19357
VEGA: 15
HGNC: HGNC:9811
Homologene: 38161
Adamts10
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10
Synonyms: ZnMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224697
Homologene: 81940
Atp8b5
Name: ATPase, class I, type 8B, member 5
Synonyms: FetA, 4930417M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320571
Homologene: 99882
Col5a1
Name: collagen, type V, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12831
HGNC: HGNC:2209
Homologene: 55434
Ptk2b
Name: PTK2 protein tyrosine kinase 2 beta
Synonyms: CAKbeta, Raftk, calcium-dependent tyrosine kinase, related adhesion focal tyrosine kinase, cellular adhesion kinase beta, proline-rich tyrosine kinase 2, PYK2, E430023O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19229
HGNC: HGNC:9612
Homologene: 23001
Vmn1r226
Name: vomeronasal 1 receptor 226
Synonyms: V1re2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171225
Homologene: 74362
Abcc1
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Synonyms: MRP, Mdrap, Mrp1, Abcc1b, Abcc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Or5b97
Name: olfactory receptor family 5 subfamily B member 97
Synonyms: GA_x6K02T2RE5P-3231251-3230331, MOR202-3, Olfr1447
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258698
HGNC: HGNC:8324
Homologene: 74233
Msl3l2
Name: MSL3 like 2
Synonyms: 1700060H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 73390
VEGA: 10
Homologene: 128448
Or14j5
Name: olfactory receptor family 14 subfamily J member 5
Synonyms: MOR218-1, GA_x6K02T2PSCP-2307164-2308123, Olfr126
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258892
Homologene: 134080
Or4b13
Name: olfactory receptor family 4 subfamily B member 13
Synonyms: K20, MOR227-2, GA_x6K02T2Q125-51607674-51606757, Olfr142
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 406186
HGNC: HGNC:8290
Homologene: 45081
Miga2
Name: mitoguardin 2
Synonyms: R74766, 5730472N09Rik, Fam73b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 108958
Homologene: 13125
Or4f14b
Name: olfactory receptor family 4 subfamily F member 14B
Synonyms: GA_x6K02T2Q125-72988111-72987173, MOR245-19P, Olfr1307
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257956
Homologene: 128383
Blvrb
Name: biliverdin reductase B (flavin reductase (NADPH))
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233016
HGNC: HGNC:1063
Homologene: 573
Fbxo10
Name: F-box protein 10
Synonyms: FBX10, LOC269529
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269529
Homologene: 19544
Msl1
Name: male specific lethal 1
Synonyms: 4930463F05Rik, 2810017F12Rik, 4121402D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74026
Homologene: 129785
Gm44503
Name: predicted readthrough transcript (NMD candidate), 44503
Synonyms: Gm20510, Dyx1c1Ccpg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Pcmtd2
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
Synonyms: 5330414D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 245867
Homologene: 10099
Zfp729b
Name: zinc finger protein 729b
Synonyms: AA987161
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100416706
Homologene: 133713
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 118,837,125 bp
  • T to C, chromosome 2 at 25,912,648 bp
  • T to C, chromosome 2 at 27,928,177 bp
  • T to A, chromosome 2 at 30,383,990 bp
  • A to G, chromosome 2 at 82,976,249 bp
  • A to G, chromosome 2 at 90,252,911 bp
  • A to T, chromosome 2 at 111,944,643 bp
  • A to T, chromosome 2 at 114,140,940 bp
  • G to A, chromosome 2 at 156,875,942 bp
  • A to G, chromosome 2 at 181,855,279 bp
  • T to A, chromosome 3 at 87,791,407 bp
  • A to G, chromosome 4 at 43,366,096 bp
  • A to C, chromosome 4 at 45,044,719 bp
  • T to C, chromosome 5 at 86,124,370 bp
  • A to C, chromosome 6 at 29,579,619 bp
  • T to C, chromosome 6 at 71,972,826 bp
  • T to A, chromosome 7 at 27,459,599 bp
  • G to T, chromosome 7 at 133,724,478 bp
  • T to A, chromosome 8 at 110,030,172 bp
  • T to C, chromosome 9 at 73,001,665 bp
  • G to A, chromosome 9 at 106,895,891 bp
  • A to T, chromosome 9 at 119,539,727 bp
  • T to C, chromosome 10 at 56,115,563 bp
  • T to A, chromosome 10 at 91,079,893 bp
  • C to T, chromosome 10 at 93,574,035 bp
  • A to G, chromosome 11 at 98,803,963 bp
  • A to C, chromosome 13 at 67,591,701 bp
  • G to A, chromosome 13 at 70,602,780 bp
  • T to A, chromosome 14 at 66,172,548 bp
  • C to T, chromosome 14 at 70,557,878 bp
  • A to G, chromosome 15 at 51,968,438 bp
  • A to G, chromosome 16 at 14,467,923 bp
  • T to G, chromosome 17 at 20,687,730 bp
  • C to A, chromosome 17 at 33,528,892 bp
  • A to G, chromosome 17 at 37,850,607 bp
  • C to G, chromosome 18 at 44,519,549 bp
  • T to A, chromosome 19 at 12,900,853 bp
  • A to G, chromosome 19 at 29,735,218 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2377 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040354-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.