Strain Name:
C57BL/6J-MtgxR2380Btlr/Mmmh
Stock Number:
040356-MU
Citation ID:
RRID:MMRRC_040356-MU
Other Names:
R2380 (G1), C57BL/6J-MtgxR2380Btlr
Major Collection:

Gene Information

Ppp5c
Name: protein phosphatase 5, catalytic subunit
Synonyms: ANP receptor, PP5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19060
HGNC: HGNC:9322
Homologene: 4550
Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Kcmf1
Name: potassium channel modulatory factor 1
Synonyms: clone DEBT-91, 1700094M07Rik, Pmcf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74287
Homologene: 99845
Pmepa1
Name: prostate transmembrane protein, androgen induced 1
Synonyms: N4wbp4, 2210418I02Rik, PMEPA1, STAG1, Tmepai
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65112
Homologene: 10608
Rgs3
Name: regulator of G-protein signaling 3
Synonyms: 4930506N09Rik, C2pa, PDZ-RGS3, RGS3S, C2PA-RGS3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50780
HGNC: HGNC:9999
Homologene: 32440
Cilk1
Name: ciliogenesis associated kinase 1
Synonyms: 2210420N10Rik, Ick
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56542
Homologene: 69218
Fam169a
Name: family with sequence similarity 169, member A
Synonyms: B230112C05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 320557
VEGA: 13
Homologene: 52656
Ago3
Name: argonaute RISC catalytic subunit 3
Synonyms: argonaute 3, eIF2C3, C130014L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214150
Homologene: 49799
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, Aspm, D330028K02Rik, MCPH5, Calmbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12316
Homologene: 7650
Utp6
Name: UTP6 small subunit processome component
Synonyms: HCA66, 4732497O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216987
Homologene: 41265
Lgr4
Name: leucine-rich repeat-containing G protein-coupled receptor 4
Synonyms: A930009A08Rik, Gpr48, A330106J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 107515
Homologene: 10226
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: PEPP2, 2810431N21Rik, Ayu21-9, Gt(Ayu21)9Imeg, AMH-Cre, Tg(AMH-cre)1Flor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109135
Homologene: 10377
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRTe, SMRT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: A530081C03Rik, Murr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17847
Homologene: 40978
Pold1
Name: polymerase (DNA directed), delta 1, catalytic subunit
Synonyms: 125kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18971
HGNC: HGNC:9175
Homologene: 2014
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: TFIIIB150, TFIIIB90, TAF3B1, TFC5, Tfnr, G630013P12Rik, B130055N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 544971
Homologene: 34582
Cog8
Name: component of oligomeric golgi complex 8
Synonyms: C87832
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 97484
Homologene: 13018
Arl10
Name: ADP-ribosylation factor-like 10
Synonyms: ARL10, Arm1, Arl10a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56795
Homologene: 10550
Enpp3
Name: ectonucleotide pyrophosphatase/phosphodiesterase 3
Synonyms: CD203c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 209558
VEGA: 10
HGNC: HGNC:3358
Homologene: 3683
Gca
Name: grancalcin
Synonyms: 5133401E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227960
Homologene: 22702
Ttc7b
Name: tetratricopeptide repeat domain 7B
Synonyms: Ttc7l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104718
VEGA: 12
Homologene: 14675
Zfp988
Name: zinc finger protein 988
Synonyms: Gm13151
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Itgae
Name: integrin alpha E, epithelial-associated
Synonyms: CD103, alpha-E1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16407
HGNC: HGNC:6147
Homologene: 113560
Col24a1
Name: collagen, type XXIV, alpha 1
Synonyms: 5430404K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71355
Homologene: 65061
Lig1
Name: ligase I, DNA, ATP-dependent
Synonyms: mLigI, LigI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16881
HGNC: HGNC:6598
Homologene: 197
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545370
Homologene: 23741
Zbtb41
Name: zinc finger and BTB domain containing 41
Synonyms: 8430415N23Rik, 9830132G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226470
Homologene: 27795
Slc35f4
Name: solute carrier family 35, member F4
Synonyms: 4930550L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75288
Homologene: 45939
Olfr594
Name: olfactory receptor 594
Synonyms: GA_x6K02T2PBJ9-5935234-5936169, MOR32-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258246
Homologene: 17480
Emilin2
Name: elastin microfibril interfacer 2
Synonyms: basilin, FOAP-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 246707
VEGA: 17
Homologene: 36483
Cdh5
Name: cadherin 5
Synonyms: VE-cadherin, 7B4/cadherin-5, VEC, CD144, VE-Cad, VECD, VEcad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12562
HGNC: HGNC:1764
Homologene: 1359
Ampd3
Name: adenosine monophosphate deaminase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11717
HGNC: HGNC:470
Homologene: 408
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, fmd, mdg, sj, muscle dysgenesis, Cav1.1, DHPR alpha1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Pwwp2b
Name: PWWP domain containing 2B
Synonyms: D930023J19Rik, D7Ertd517e, Pwwp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101631
Homologene: 19056
Camk2g
Name: calcium/calmodulin-dependent protein kinase II gamma
Synonyms: CaMK II, Ca2+/calmodulin-dependent protein kinase II, Camkg, 5930429P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12325
VEGA: 14
HGNC: HGNC:1463
Homologene: 15596
Kdm1b
Name: lysine (K)-specific demethylase 1B
Synonyms: 4632428N09Rik, Aof1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218214
Homologene: 14695
4930407I10Rik
Name: RIKEN cDNA 4930407I10 gene
Synonyms: LOC328573
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 328573
VEGA: 15
Homologene: 130065
Axdnd1
Name: axonemal dynein light chain domain containing 1
Synonyms: LOC381304, 9430070O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77352
Homologene: 52328
Smr2l
Name: submaxillary gland androgen regulated protein 2 like
Synonyms: Gm7714
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665615
Olfr1156
Name: olfactory receptor 1156
Synonyms: GA_x6K02T2Q125-49433499-49432537, MOR174-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258814
HGNC: HGNC:8351
Homologene: 72031
Olfr1463
Name: olfactory receptor 1463
Synonyms: GA_x6K02T2RE5P-3560863-3561795, MOR202-29P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258120
HGNC: HGNC:8324
Homologene: 133886
Ac165356.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Dhrs7c
Name: dehydrogenase/reductase (SDR family) member 7C
Synonyms: 1110001P11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68460
Homologene: 19108
Trmt5
Name: TRM5 tRNA methyltransferase 5
Synonyms: 2610027O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76357
VEGA: 12
Homologene: 6096
Hsd17b1
Name: hydroxysteroid (17-beta) dehydrogenase 1
Synonyms: 17beta-HSD, Hsd17ba
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15485
HGNC: HGNC:5210
Homologene: 37303
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 136,095,848 bp
  • T to C, chromosome 1 at 139,423,814 bp
  • C to T, chromosome 1 at 139,479,348 bp
  • T to A, chromosome 1 at 150,565,384 bp
  • A to T, chromosome 1 at 156,365,651 bp
  • T to A, chromosome 2 at 62,690,377 bp
  • T to C, chromosome 2 at 87,949,397 bp
  • T to C, chromosome 2 at 110,012,393 bp
  • G to A, chromosome 2 at 173,228,133 bp
  • T to A, chromosome 3 at 145,358,508 bp
  • A to T, chromosome 4 at 62,625,887 bp
  • G to A, chromosome 4 at 113,546,536 bp
  • G to A, chromosome 4 at 126,368,522 bp
  • A to C, chromosome 4 at 147,332,785 bp
  • T to G, chromosome 5 at 88,282,554 bp
  • A to G, chromosome 5 at 125,036,080 bp
  • A to G, chromosome 6 at 72,858,772 bp
  • G to A, chromosome 6 at 140,552,798 bp
  • T to C, chromosome 7 at 13,303,796 bp
  • A to G, chromosome 7 at 17,006,115 bp
  • C to T, chromosome 7 at 44,532,898 bp
  • A to T, chromosome 7 at 103,220,608 bp
  • T to C, chromosome 7 at 106,082,167 bp
  • C to T, chromosome 7 at 110,800,710 bp
  • A to G, chromosome 7 at 139,255,450 bp
  • A to G, chromosome 8 at 16,190,087 bp
  • C to A, chromosome 8 at 104,125,672 bp
  • C to A, chromosome 8 at 107,056,361 bp
  • T to C, chromosome 9 at 78,155,336 bp
  • T to C, chromosome 10 at 24,776,872 bp
  • T to C, chromosome 11 at 23,370,363 bp
  • G to A, chromosome 11 at 67,815,864 bp
  • A to G, chromosome 11 at 73,145,569 bp
  • A to G, chromosome 11 at 79,936,005 bp
  • A to T, chromosome 11 at 101,078,463 bp
  • A to G, chromosome 12 at 73,285,114 bp
  • A to G, chromosome 12 at 100,355,001 bp
  • T to A, chromosome 13 at 47,073,755 bp
  • G to T, chromosome 13 at 54,575,149 bp
  • T to A, chromosome 13 at 97,118,535 bp
  • T to C, chromosome 13 at 100,060,370 bp
  • A to G, chromosome 14 at 20,739,387 bp
  • A to G, chromosome 14 at 49,306,203 bp
  • T to C, chromosome 15 at 82,064,835 bp
  • T to A, chromosome 17 at 71,310,224 bp
  • C to A, chromosome 19 at 5,751,523 bp
  • T to C, chromosome 19 at 13,234,721 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2380 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040356-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.