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Strain Name:
C57BL/6J-MtgxR2402Btlr/Mmmh
Stock Number:
040368-MU
Citation ID:
RRID:MMRRC_040368-MU
Other Names:
R2402 (G1), C57BL/6J-MtgxR2402Btlr
Major Collection:

Strain Information

Htr3a
Name: 5-hydroxytryptamine (serotonin) receptor 3A
Synonyms: 5-HT3 receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15561
VEGA: 9
HGNC: HGNC:5297
Homologene: 671
Atic
Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Synonyms: 2610509C24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108147
HGNC: HGNC:794
Homologene: 2983
Cr1l
Name: complement C3b/C4b receptor 1 like
Synonyms: mCRY, Crry
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12946
Homologene: 128275
Akap10
Name: A kinase anchor protein 10
Synonyms: D-AKAP2, 1500031L16Rik, B130049N18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56697
HGNC: HGNC:368
Homologene: 32452
Gon4l
Name: gon-4 like
Synonyms: 1500041I23Rik, 2610100B20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76022
Homologene: 13002
Nr4a1
Name: nuclear receptor subfamily 4, group A, member 1
Synonyms: Nur77, TIS1, TR3, N10, NP10, GFRP1, NGFI-B, Hbr-1, Gfrp, Hbr1, Hmr
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15370
VEGA: 15
HGNC: HGNC:7980
Homologene: 1612
Nisch
Name: nischarin
Synonyms: 1200007D05Rik, 3202002H23Rik, edsn
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 64652
Homologene: 136161
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 58,213,017 bp
  • T to C, chromosome 1 at 60,006,292 bp
  • T to A, chromosome 1 at 71,569,057 bp
  • A to C, chromosome 1 at 139,423,185 bp
  • G to T, chromosome 1 at 139,423,187 bp
  • A to G, chromosome 1 at 151,689,614 bp
  • A to T, chromosome 1 at 155,863,136 bp
  • T to A, chromosome 1 at 195,106,902 bp
  • G to A, chromosome 2 at 34,678,643 bp
  • T to C, chromosome 2 at 42,323,730 bp
  • A to G, chromosome 2 at 60,257,068 bp
  • A to G, chromosome 2 at 119,153,370 bp
  • A to T, chromosome 2 at 146,353,192 bp
  • A to T, chromosome 2 at 164,834,893 bp
  • G to T, chromosome 3 at 88,859,043 bp
  • A to G, chromosome 4 at 43,095,843 bp
  • A to T, chromosome 4 at 46,117,093 bp
  • A to G, chromosome 4 at 94,627,082 bp
  • T to C, chromosome 4 at 124,705,688 bp
  • C to T, chromosome 5 at 87,851,029 bp
  • T to C, chromosome 5 at 128,784,888 bp
  • T to A, chromosome 5 at 138,230,520 bp
  • T to A, chromosome 6 at 67,316,180 bp
  • A to T, chromosome 6 at 78,467,492 bp
  • A to G, chromosome 6 at 131,243,901 bp
  • A to G, chromosome 7 at 7,133,185 bp
  • A to G, chromosome 7 at 42,300,105 bp
  • A to T, chromosome 7 at 46,015,575 bp
  • A to G, chromosome 7 at 122,221,172 bp
  • C to A, chromosome 7 at 126,848,747 bp
  • C to T, chromosome 7 at 127,108,360 bp
  • T to C, chromosome 7 at 143,017,296 bp
  • T to C, chromosome 8 at 85,690,912 bp
  • T to A, chromosome 8 at 86,509,141 bp
  • T to C, chromosome 8 at 88,144,572 bp
  • T to A, chromosome 8 at 95,343,131 bp
  • C to T, chromosome 8 at 109,721,240 bp
  • T to A, chromosome 9 at 18,945,200 bp
  • T to A, chromosome 9 at 21,583,540 bp
  • T to C, chromosome 9 at 21,835,816 bp
  • C to T, chromosome 9 at 22,646,063 bp
  • T to C, chromosome 9 at 24,581,248 bp
  • T to C, chromosome 9 at 38,607,101 bp
  • C to T, chromosome 9 at 48,901,495 bp
  • C to A, chromosome 9 at 53,374,925 bp
  • A to G, chromosome 9 at 71,725,179 bp
  • A to T, chromosome 9 at 71,856,510 bp
  • C to T, chromosome 9 at 82,875,305 bp
  • A to T, chromosome 9 at 88,731,496 bp
  • A to G, chromosome 9 at 89,199,742 bp
  • G to A, chromosome 10 at 69,270,424 bp
  • T to A, chromosome 10 at 81,564,878 bp
  • T to C, chromosome 11 at 49,059,130 bp
  • A to G, chromosome 11 at 49,637,819 bp
  • T to C, chromosome 11 at 59,131,646 bp
  • T to C, chromosome 11 at 61,915,222 bp
  • T to C, chromosome 11 at 118,125,974 bp
  • A to G, chromosome 12 at 51,745,534 bp
  • T to C, chromosome 12 at 69,596,799 bp
  • A to G, chromosome 12 at 85,783,003 bp
  • A to G, chromosome 12 at 111,422,256 bp
  • T to C, chromosome 13 at 34,128,226 bp
  • T to C, chromosome 13 at 49,724,800 bp
  • C to T, chromosome 13 at 61,000,574 bp
  • T to A, chromosome 14 at 31,185,014 bp
  • A to G, chromosome 15 at 101,137,399 bp
  • G to T, chromosome 15 at 101,271,737 bp
  • T to A, chromosome 17 at 24,503,808 bp
  • A to T, chromosome 17 at 36,117,739 bp
  • T to A, chromosome 18 at 23,595,478 bp
  • T to C, chromosome 18 at 60,916,467 bp
  • T to A, chromosome 18 at 77,854,864 bp
  • A to T, chromosome 19 at 17,474,834 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2402 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040368-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.