Strain Name:
C57BL/6J-MtgxR2411Btlr/Mmmh
Stock Number:
040376-MU
Citation ID:
RRID:MMRRC_040376-MU
Other Names:
R2411 (G1), C57BL/6J-MtgxR2411Btlr
Major Collection:

Gene Information

Uso1
Name: USO1 vesicle docking factor
Synonyms: TAP, Vdp, transcytosis associated protein p115
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 56041
Homologene: 2754
Ppp2r3c
Name: protein phosphatase 2, regulatory subunit B'', gamma
Synonyms: 5730412A08Rik, G5pr, G4-1, 4930511A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 59032
VEGA: 12
Homologene: 9915
Col6a1
Name: collagen, type VI, alpha 1
Synonyms: Col6a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 12833
HGNC: HGNC:2211
Homologene: 1391
Dlg4
Name: discs large MAGUK scaffold protein 4
Synonyms: PSD-95, SAP90, Dlgh4, PSD95, SAP90A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 13385
HGNC: HGNC:2903
Homologene: 1047
Vps35l
Name: VPS35 endosomal protein sorting factor like
Synonyms: Vsp35l, 9030624J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71517
Homologene: 10659
Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Synonyms: Nik, 9430080K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 26921
HGNC: HGNC:6866
Homologene: 7442
Setd2
Name: SET domain containing 2
Synonyms: KMT3A, 4921524K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235626
Homologene: 56493
Nsf
Name: N-ethylmaleimide sensitive fusion protein
Synonyms: SKD2, N-ethylmaleimide sensitive factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18195
HGNC: HGNC:8016
Homologene: 4502
Rttn
Name: rotatin
Synonyms: C530033I08Rik, 4921538A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 246102
VEGA: 18
Homologene: 65275
Rffl
Name: ring finger and FYVE like domain containing protein
Synonyms: Carp-2, 4930516L10Rik, 1700051E09Rik, rififylin, fring, Carp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67338
Homologene: 12116
Fam204a
Name: family with sequence similarity 204, member A
Synonyms: 2310065H12Rik, 2610015K05Rik, D19Ertd737e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 76539
VEGA: 19
Homologene: 41463
Zfp160
Name: zinc finger protein 160
Synonyms: 6720480D16Rik, 6720480D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224585
VEGA: 17
Homologene: 137372
Clock
Name: circadian locomotor output cycles kaput
Synonyms: KAT13D, bHLHe8, 5330400M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12753
HGNC: HGNC:2082
Homologene: 3603
Tor1b
Name: torsin family 1, member B
Synonyms: DQ1, torsinB, 2610016F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 30934
Homologene: 56677
Zfp869
Name: zinc finger protein 869
Synonyms: 1200003I07Rik, U 2-7-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 66869
VEGA: 8
Homologene: 134644
Ifitm1
Name: interferon induced transmembrane protein 1
Synonyms: 1110036C17Rik, fragilis2, Mil2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 68713
HGNC: HGNC:5412
Homologene: 135938
Creld1
Name: cysteine-rich with EGF-like domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 171508
Homologene: 32265
St14
Name: suppression of tumorigenicity 14 (colon carcinoma)
Synonyms: Tmprss14, Prss14, Epithin, matriptase, MT-SP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 19143
Homologene: 7906
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: 2210407G14Rik, Hapip, E530005C20Rik, LOC224126
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Stag3
Name: stromal antigen 3
Synonyms: stromalin 3, SA-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 50878
Homologene: 40844
Ackr4
Name: atypical chemokine receptor 4
Synonyms: PPR1, Ccrl1, A630091E18Rik, VSHK1, CCX-CKR, CCR11, CCBP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 252837
HGNC: HGNC:1611
Homologene: 49474
Btbd16
Name: BTB (POZ) domain containing 16
Synonyms: E330040A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 330660
Homologene: 77327
Hormad1
Name: HORMA domain containing 1
Synonyms: Nohma, 4921522K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 67981
Homologene: 69415
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Nckap1l
Name: NCK associated protein 1 like
Synonyms: Hem1, 4930568P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105855
VEGA: 15
HGNC: HGNC:4862
Homologene: 3901
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: PG10.2, IPM200, Spacrcan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224224
Homologene: 9439
Lipe
Name: lipase, hormone sensitive
Synonyms: HSL, 4933403G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16890
HGNC: HGNC:6621
Homologene: 3912
Ror2
Name: receptor tyrosine kinase-like orphan receptor 2
Synonyms: Ntrkr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 26564
Homologene: 55831
Mybpc2
Name: myosin binding protein C, fast-type
Synonyms: Fast-type C-protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233199
HGNC: HGNC:7550
Homologene: 3331
Igbp1b
Name: immunoglobulin (CD79A) binding protein 1b
Synonyms: alpha4-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 50540
Homologene: 75049
Filip1
Name: filamin A interacting protein 1
Synonyms: FILIP, 5730485H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 70598
Homologene: 6700
Acap1
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Synonyms: Centb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216859
Homologene: 22835
Lilra6
Name: leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
Synonyms: 7M1, Pira3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18726
HGNC: HGNC:6607
Homologene: 134028
Fam129a
Name: family with sequence similarity 129, member A
Synonyms: Niban
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 63913
Homologene: 62170
Hes6
Name: hairy and enhancer of split 6
Synonyms: bHLHb41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 55927
Homologene: 23111
Ptpru
Name: protein tyrosine phosphatase, receptor type, U
Synonyms: Ptprl, RPTPlambda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Mtmr10
Name: myotubularin related protein 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233315
Homologene: 9822
Vmn1r10
Name: vomeronasal 1 receptor 10
Synonyms: V1rc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 113858
Homologene: 76459
Olfr1197
Name: olfactory receptor 1197
Synonyms: MOR225-10P, MOR225-14, GA_x6K02T2Q125-50202854-50201910
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 433449
Homologene: 123770
Aadacl2
Name: arylacetamide deacetylase like 2
Synonyms: EG639634
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 639634
Homologene: 28634
1700012B07Rik
Name: RIKEN cDNA 1700012B07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69324
Homologene: 78000
Zfp957
Name: zinc finger protein 957
Synonyms: AU017455
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105590
9030612E09Rik
Name: RIKEN cDNA 9030612E09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 74530
VEGA: 10
Hddc3
Name: HD domain containing 3
Synonyms: 1110033O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 68695
Homologene: 12279
Adck5
Name: aarF domain containing kinase 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 268822
Homologene: 34378
Olfr301
Name: olfactory receptor 301
Synonyms: MOR221-4, MOR221-1P, GA_x6K02T2NHDJ-9693313-9692378, Olfr1531-ps1, MOR221-1P, MOR211-8P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 257958
Homologene: 128067
Olfr1377
Name: olfactory receptor 1377
Synonyms: GA_x6K02T2QP88-4453480-4452557, MOR129-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258913
Homologene: 64929
Sytl3
Name: synaptotagmin-like 3
Synonyms: Slp3, Slp3-a, Slp3-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 83672
Homologene: 12855
Gm14295
Name: predicted gene 14295
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 100039123
Homologene: 133105
4933402D24Rik
Name: RIKEN cDNA 4933402D24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 74426
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 40,007,496 bp
  • A to G, chromosome 1 at 63,756,214 bp
  • A to C, chromosome 1 at 91,413,264 bp
  • G to A, chromosome 1 at 151,700,095 bp
  • G to T, chromosome 2 at 30,955,812 bp
  • T to A, chromosome 2 at 76,738,015 bp
  • C to T, chromosome 2 at 88,729,397 bp
  • G to T, chromosome 2 at 176,807,413 bp
  • A to G, chromosome 3 at 60,017,423 bp
  • A to G, chromosome 3 at 95,580,015 bp
  • A to T, chromosome 4 at 131,771,469 bp
  • A to C, chromosome 5 at 76,231,513 bp
  • T to A, chromosome 5 at 92,158,399 bp
  • A to G, chromosome 5 at 138,283,028 bp
  • G to T, chromosome 6 at 57,114,139 bp
  • A to G, chromosome 6 at 113,489,776 bp
  • A to C, chromosome 6 at 138,657,873 bp
  • T to C, chromosome 7 at 3,911,454 bp
  • T to G, chromosome 7 at 25,380,517 bp
  • G to A, chromosome 7 at 44,506,238 bp
  • A to T, chromosome 7 at 64,297,497 bp
  • A to T, chromosome 7 at 80,343,593 bp
  • T to C, chromosome 7 at 86,413,082 bp
  • G to C, chromosome 7 at 118,792,595 bp
  • T to C, chromosome 7 at 130,790,224 bp
  • A to G, chromosome 7 at 140,969,798 bp
  • A to G, chromosome 8 at 69,706,529 bp
  • G to A, chromosome 9 at 31,108,234 bp
  • T to A, chromosome 9 at 79,898,433 bp
  • T to G, chromosome 9 at 104,086,023 bp
  • A to G, chromosome 9 at 110,550,429 bp
  • G to T, chromosome 10 at 43,174,800 bp
  • G to T, chromosome 10 at 76,711,088 bp
  • A to G, chromosome 11 at 50,984,931 bp
  • A to T, chromosome 11 at 69,885,485 bp
  • G to A, chromosome 11 at 70,041,929 bp
  • G to A, chromosome 11 at 82,811,013 bp
  • C to T, chromosome 11 at 103,930,752 bp
  • G to T, chromosome 11 at 109,794,154 bp
  • T to C, chromosome 12 at 55,298,484 bp
  • G to A, chromosome 13 at 53,130,944 bp
  • T to C, chromosome 14 at 79,214,342 bp
  • G to A, chromosome 15 at 76,594,459 bp
  • C to A, chromosome 15 at 103,483,568 bp
  • C to T, chromosome 16 at 33,989,810 bp
  • T to A, chromosome 16 at 56,252,154 bp
  • T to C, chromosome 17 at 6,736,493 bp
  • C to T, chromosome 17 at 21,025,745 bp
  • T to C, chromosome 18 at 88,975,676 bp
  • A to T, chromosome 19 at 60,199,438 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2411 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040376-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.