Strain Name:
C57BL/6J-MtgxR2419Btlr/Mmmh
Stock Number:
040381-MU
Citation ID:
RRID:MMRRC_040381-MU
Other Names:
R2419 (G1), C57BL/6J-MtgxR2419Btlr
Major Collection:

Gene Information

Elp2
Name: elongator acetyltransferase complex subunit 2
Synonyms: Stat3-interacting protein, StIP1, Statip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 58523
VEGA: 18
Homologene: 6019
Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Cnmd
Name: chondromodulin
Synonyms: Chondromodulin 1, ChM-I, Bricd3, Chmd, Lect1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16840
Homologene: 5095
Itk
Name: IL2 inducible T cell kinase
Synonyms: Emt, Tsk, Tcsk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16428
HGNC: HGNC:6171
Homologene: 4051
Get4
Name: golgi to ER traffic protein 4
Synonyms: 1110007L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67604
Homologene: 41080
Ski
Name: ski sarcoma viral oncogene homolog (avian)
Synonyms: 2610001A11Rik, 2310012I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20481
Homologene: 31124
Cnot8
Name: CCR4-NOT transcription complex, subunit 8
Synonyms: 1810022F04Rik, 1500015I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69125
HGNC: HGNC:9207
Homologene: 48304
Setd2
Name: SET domain containing 2
Synonyms: 4921524K10Rik, KMT3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235626
Homologene: 56493
Rbbp5
Name: retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit
Synonyms: 4933411J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213464
HGNC: HGNC:9888
Homologene: 3709
Sdad1
Name: SDA1 domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231452
Homologene: 6036
Mical3
Name: microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms: MICAL-3, C130040D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 194401
Homologene: 85288
Actr2
Name: ARP2 actin-related protein 2
Synonyms: 4921510D23Rik, D6Ertd746e, Arp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66713
HGNC: HGNC:169
Homologene: 4181
Zfp619
Name: zinc finger protein 619
Synonyms: 3000002G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70227
Homologene: 133818
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233532
Homologene: 41142
Tbc1d8
Name: TBC1 domain family, member 8
Synonyms: BUB2-like protein 1, HBLP1, AD3, GRAM domain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54610
Homologene: 31421
Tacc1
Name: transforming, acidic coiled-coil containing protein 1
Synonyms: 4833447E04Rik, B230378H13Rik, Tacc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320165
Homologene: 4575
Hey1
Name: hairy/enhancer-of-split related with YRPW motif 1
Synonyms: hesr-1, HRT1, Herp2, Hesr1, bHLHb31, CHF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15213
HGNC: HGNC:4880
Homologene: 7756
Lmbr1l
Name: limb region 1 like
Synonyms: 1110013E13Rik, D15Ertd735e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74775
Homologene: 10011
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, LOC381026, 9330188B09Rik, D630001M17Rik, 4921513O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66725
Homologene: 18982
Plxnb2
Name: plexin B2
Synonyms: Debt, 1110007H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 140570
HGNC: HGNC:9104
Homologene: 66630
Kif7
Name: kinesin family member 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16576
Homologene: 72555
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329252
Homologene: 49680
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Ten-m3, 2610100B16Rik, Odz3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23965
Homologene: 22673
Trap1
Name: TNF receptor-associated protein 1
Synonyms: HSP75, 2410002K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 68015
Homologene: 9457
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72205
Homologene: 8125
Arap3
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Synonyms: DRAG1, E030006K04Rik, Centd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 106952
VEGA: 18
Homologene: 11199
Zcchc14
Name: zinc finger, CCHC domain containing 14
Synonyms: Bdg29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 142682
Homologene: 9037
Ccdc38
Name: coiled-coil domain containing 38
Synonyms: 4933417K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237465
Homologene: 52182
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Plcb1
Name: phospholipase C, beta 1
Synonyms: 3110043I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18795
Homologene: 22876
Vmn1r204
Name: vomeronasal 1 receptor 204
Synonyms: Gm11301
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 632793
Homologene: 110880
Tmem62
Name: transmembrane protein 62
Synonyms: B830009D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 96957
Homologene: 11801
1700022I11Rik
Name: RIKEN cDNA 1700022I11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67317
Homologene: 52406
Klkb1
Name: kallikrein B, plasma 1
Synonyms: Kal-3, Kal3, Klk3, PSA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16621
HGNC: HGNC:6371
Homologene: 68097
Zpr1
Name: ZPR1 zinc finger
Synonyms: ZPR1, Zfp259
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22687
Homologene: 2900
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71947
Homologene: 8831
Olfr340
Name: olfactory receptor 340
Synonyms: GA_x6K02T2NLDC-33147742-33148680, MOR136-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258953
Homologene: 74159
Ugt2b38
Name: UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms: 9430041C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100559
Homologene: 137225
Nup210
Name: nucleoporin 210
Synonyms: gp210, gp190, Pom210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54563
Homologene: 41286
Kcna2
Name: potassium voltage-gated channel, shaker-related subfamily, member 2
Synonyms: Kv1.2, Kca1-2, Mk-2, Akr6a4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16490
HGNC: HGNC:6220
Homologene: 21034
Abca2
Name: ATP-binding cassette, sub-family A (ABC1), member 2
Synonyms: Abc2, D2H0S1474E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Dusp18
Name: dual specificity phosphatase 18
Synonyms: LMWDSP20, DUSP20, 4930527G07Rik, DSP18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75219
Homologene: 34984
Cdh20
Name: cadherin 20
Synonyms: Cdh7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23836
HGNC: HGNC:1760
Homologene: 8015
Slc27a1
Name: solute carrier family 27 (fatty acid transporter), member 1
Synonyms: FATP1, Fatp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26457
Homologene: 8063
Mcur1
Name: mitochondrial calcium uniporter regulator 1
Synonyms: 6230416A05Rik, Ccdc90a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76137
VEGA: 13
Homologene: 134447
Olfr1357
Name: olfactory receptor 1357
Synonyms: GA_x6K02T2QGN0-3196801-3197742, MOR128-4, MOR128-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 257883
HGNC: HGNC:8207
Homologene: 72920
Olfr1212
Name: olfactory receptor 1212
Synonyms: GA_x6K02T2Q125-50437014-50437949, MOR233-20, MOR233-17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258241
Homologene: 66154
Vmn1r168
Name: vomeronasal 1 receptor 168
Synonyms: Gm10659
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100043101
Homologene: 122945
Foxb2
Name: forkhead box B2
Synonyms: Fkh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14240
VEGA: 19
Homologene: 136311
Vmn1r203
Name: vomeronasal 1 receptor 203
Synonyms: V1rh11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171270
Homologene: 110880
Plcxd3
Name: phosphatidylinositol-specific phospholipase C, X domain containing 3
Synonyms: B130016O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239318
Homologene: 45574
Bcorl1
Name: BCL6 co-repressor-like 1
Synonyms: 6720425J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 320376
Homologene: 41458
Rfpl4b
Name: ret finger protein-like 4B
Synonyms: LOC215919, Gm62, Gm3037
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215919
Homologene: 130122
Phc3
Name: polyhomeotic 3
Synonyms: EDR3, HPH3, E030046K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 241915
Homologene: 69390
Lrat
Name: lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
Synonyms: 1300010A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 79235
HGNC: HGNC:6685
Homologene: 3483
Acyp2
Name: acylphosphatase 2, muscle type
Synonyms: 2310004B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75572
HGNC: HGNC:180
Homologene: 41776
Leng9
Name: leukocyte receptor cluster (LRC) member 9
Synonyms: 9530024C23Rik, F630035L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243813
Homologene: 18466
Arl4d
Name: ADP-ribosylation factor-like 4D
Synonyms: Arl5, 1110036H21Rik, Arf4l, Arfl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 80981
HGNC: HGNC:656
Homologene: 1255
Cd6
Name: CD6 antigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12511
HGNC: HGNC:1691
Homologene: 4893
Matn4
Name: matrilin 4
Synonyms: matrilin-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17183
HGNC: HGNC:6910
Homologene: 2844
Cyp2ab1
Name: cytochrome P450, family 2, subfamily ab, polypeptide 1
Synonyms: EG224044
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224044
Homologene: 120487
Samt2
Name: spermatogenesis associated multipass transmembrane protein 2
Synonyms: Gm5647
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 434881
Homologene: 86844
B430319F04Rik
Name: RIKEN cDNA B430319F04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 619306
Snx18
Name: sorting nexin 18
Synonyms: Snag1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 170625
VEGA: 13
Homologene: 14164
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 39,376,902 bp
  • G to A, chromosome 1 at 104,975,015 bp
  • T to C, chromosome 1 at 132,493,826 bp
  • A to G, chromosome 1 at 135,063,704 bp
  • G to A, chromosome 2 at 25,437,989 bp
  • T to A, chromosome 2 at 36,453,326 bp
  • A to G, chromosome 2 at 88,959,036 bp
  • G to A, chromosome 2 at 121,007,105 bp
  • A to G, chromosome 2 at 135,262,100 bp
  • A to G, chromosome 2 at 164,401,106 bp
  • A to G, chromosome 3 at 8,665,943 bp
  • T to C, chromosome 3 at 30,950,878 bp
  • A to G, chromosome 3 at 82,903,685 bp
  • G to A, chromosome 3 at 107,104,153 bp
  • A to G, chromosome 4 at 42,974,146 bp
  • A to G, chromosome 4 at 155,160,893 bp
  • T to C, chromosome 5 at 87,423,732 bp
  • T to C, chromosome 5 at 92,305,818 bp
  • T to A, chromosome 5 at 139,267,154 bp
  • T to C, chromosome 6 at 17,535,830 bp
  • G to A, chromosome 6 at 91,017,556 bp
  • A to G, chromosome 6 at 120,959,923 bp
  • A to G, chromosome 7 at 4,148,627 bp
  • A to G, chromosome 7 at 19,176,695 bp
  • A to T, chromosome 7 at 23,541,399 bp
  • A to G, chromosome 7 at 39,535,883 bp
  • C to A, chromosome 7 at 79,698,693 bp
  • CG to CGACGGCGGGG, chromosome 7 at 97,579,908 bp
  • A to G, chromosome 7 at 110,768,369 bp
  • A to G, chromosome 8 at 25,182,813 bp
  • A to T, chromosome 8 at 45,289,112 bp
  • C to T, chromosome 8 at 48,276,658 bp
  • A to G, chromosome 8 at 71,579,916 bp
  • T to A, chromosome 8 at 121,603,936 bp
  • T to C, chromosome 9 at 46,276,192 bp
  • T to A, chromosome 9 at 110,548,997 bp
  • T to C, chromosome 10 at 38,821,372 bp
  • T to A, chromosome 10 at 78,612,387 bp
  • T to A, chromosome 10 at 93,548,975 bp
  • T to C, chromosome 11 at 3,897,018 bp
  • A to G, chromosome 11 at 20,064,866 bp
  • T to C, chromosome 11 at 30,632,316 bp
  • A to G, chromosome 11 at 46,338,217 bp
  • G to A, chromosome 11 at 58,115,310 bp
  • A to T, chromosome 11 at 66,095,415 bp
  • A to T, chromosome 11 at 101,666,888 bp
  • A to G, chromosome 11 at 115,796,815 bp
  • T to A, chromosome 13 at 22,524,834 bp
  • T to G, chromosome 13 at 22,556,250 bp
  • C to T, chromosome 13 at 43,549,537 bp
  • T to C, chromosome 13 at 113,617,219 bp
  • G to A, chromosome 14 at 79,638,048 bp
  • G to T, chromosome 15 at 4,574,763 bp
  • A to G, chromosome 15 at 89,161,069 bp
  • C to A, chromosome 15 at 91,797,526 bp
  • A to C, chromosome 15 at 98,907,537 bp
  • A to G, chromosome 16 at 4,068,330 bp
  • G to A, chromosome 16 at 20,314,995 bp
  • A to G, chromosome 18 at 24,615,237 bp
  • T to C, chromosome 18 at 37,989,944 bp
  • G to A, chromosome 19 at 10,792,852 bp
  • G to C, chromosome 19 at 16,872,961 bp
  • A to G, chromosome X at 48,370,541 bp
  • A to T, chromosome X at 154,575,227 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2419 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040381-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.