Strain Name:
C57BL/6J-MtgxR2425Btlr/Mmmh
Stock Number:
040387-MU
Citation ID:
RRID:MMRRC_040387-MU
Other Names:
R2425 (G1), C57BL/6J-MtgxR2425Btlr
Major Collection:

Gene Information

Gldc
Name: glycine decarboxylase
Synonyms: D030049L12Rik, b2b2679Clo, D19Wsu57e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 104174
VEGA: 19
HGNC: HGNC:4313
Homologene: 141
Upf1
Name: UPF1 regulator of nonsense transcripts homolog (yeast)
Synonyms: PNORF-1, Rent1, B430202H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 19704
HGNC: HGNC:9962
Homologene: 2185
Draxin
Name: dorsal inhibitory axon guidance protein
Synonyms: 2610109H07Rik, Neucrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 70433
Homologene: 19233
Wdr70
Name: WD repeat domain 70
Synonyms: 4833422F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 545085
VEGA: 15
Homologene: 9972
Rad23b
Name: RAD23 homolog B, nucleotide excision repair protein
Synonyms: mHR23B, 0610007D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 19359
HGNC: HGNC:9813
Homologene: 37704
Pdxdc1
Name: pyridoxal-dependent decarboxylase domain containing 1
Synonyms: 2210010A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 94184
Homologene: 22858
Ints3
Name: integrator complex subunit 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229543
Homologene: 11309
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 3010027A04Rik, Yod, 9530048I21Rik, 2410104C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 77087
Homologene: 69134
Fkbp15
Name: FK506 binding protein 15
Synonyms: C430014M02Rik, FKBP133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 338355
Homologene: 28743
Il3
Name: interleukin 3
Synonyms: BPA, HCGF, MCGF, PSF, Csfmu, Il-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16187
HGNC: HGNC:6011
Homologene: 49243
Kcne1
Name: potassium voltage-gated channel, Isk-related subfamily, member 1
Synonyms: nmf190, Isk, MinK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 16509
VEGA: 16
Homologene: 185
Rasgrp1
Name: RAS guanyl releasing protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 19419
HGNC: HGNC:9878
Homologene: 4195
Ddx39
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
Synonyms: BAT1, 2610307C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 68278
Homologene: 68487
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Shld2
Name: shieldin complex subunit 2
Synonyms: Fam35a, 3110001K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 75698
VEGA: 14
Homologene: 56840
Rb1
Name: RB transcriptional corepressor 1
Synonyms: retinoblastoma 1, Rb-1, pRb, Rb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 19645
HGNC: HGNC:9884
Homologene: 272
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4933421G18Rik, 4921518A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 71175
VEGA: 15
Homologene: 15850
Usp42
Name: ubiquitin specific peptidase 42
Synonyms: 2410140K03Rik, D5Ertd591e, 3110031A07Rik, A630018G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 76800
Homologene: 35425
Slc12a9
Name: solute carrier family 12 (potassium/chloride transporters), member 9
Synonyms: CIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 83704
Homologene: 5429
Plxna2
Name: plexin A2
Synonyms: 2810428A13Rik, PlexA2, Plxn2, OCT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 94109
Homologene: 69536
Elane
Name: elastase, neutrophil expressed
Synonyms: F430011M15Rik, NE, Ela2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 50701
VEGA: 10
HGNC: HGNC:3309
Homologene: 20455
Pramel1
Name: preferentially expressed antigen in melanoma-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 83491
Homologene: 87078
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Ush2a
Name: usherin
Synonyms: Ush2a, Ushrn, MUSH2A, A930037M10Rik, A930011D15Rik, LOC269160, LOC381317
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22283
Homologene: 66151
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: AS250, RGC2, A230067G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241694
Homologene: 28131
Astn1
Name: astrotactin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 11899
HGNC: HGNC:773
Homologene: 7233
Abca15
Name: ATP-binding cassette, sub-family A (ABC1), member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 320631
Homologene: 87255
Gas7
Name: growth arrest specific 7
Synonyms: B230343A10Rik, Gas7-cb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14457
HGNC: HGNC:4169
Homologene: 69015
Atp2c2
Name: ATPase, Ca++ transporting, type 2C, member 2
Synonyms: 1810010G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 69047
Homologene: 73463
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: Marlin-1, C330021K24Rik, 5830437M04Rik, Gababrbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 76071
Homologene: 90789
Gjd4
Name: gap junction protein, delta 4
Synonyms: Cx39, 9430022F06Rik, connexin 39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225152
VEGA: 18
Homologene: 17692
Galntl5
Name: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
Synonyms: 1700021B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 67909
Homologene: 12210
Bnc1
Name: basonuclin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12173
HGNC: HGNC:1081
Homologene: 31048
Olfr975
Name: olfactory receptor 975
Synonyms: MOR224-2, GA_x6K02T2PVTD-33651220-33650288
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258825
VEGA: 9
Homologene: 27275
Fam171a2
Name: family with sequence similarity 171, member A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217219
Homologene: 19144
Cyp2c50
Name: cytochrome P450, family 2, subfamily c, polypeptide 50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 107141
Homologene: 137231
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226438
Homologene: 130054
Tmc8
Name: transmembrane channel-like gene family 8
Synonyms: EVIN2, Ever2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217356
Homologene: 45126
Ano3
Name: anoctamin 3
Synonyms: Tmem16c, B230324K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228432
Homologene: 57147
Abcc10
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Synonyms: Mrp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224814
HGNC: HGNC:52
Homologene: 58616
Gpr161
Name: G protein-coupled receptor 161
Synonyms: vl, LOC240888
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240888
Homologene: 17824
Klhl18
Name: kelch-like 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 270201
Homologene: 14805
Rbm12b1
Name: RNA binding motif protein 12 B1
Synonyms: Rbm12b, 3000004N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 72397
Homologene: 28658
CN725425
Name: cDNA sequence CN725425
Synonyms: Gm5807
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 545126
Amacr
Name: alpha-methylacyl-CoA racemase
Synonyms: 2-arylpropionyl-CoA epimerase, Macr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 17117
VEGA: 15
HGNC: HGNC:451
Homologene: 7410
Cd44
Name: CD44 antigen
Synonyms: Pgp-1, Ly-24, HERMES
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12505
HGNC: HGNC:1681
Homologene: 508
Olfr1053
Name: olfactory receptor 1053
Synonyms: GA_x6K02T2Q125-47793414-47792471, Olfr1053-ps1, MOR187-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 257974
Homologene: 74197
Fbxo10
Name: F-box protein 10
Synonyms: LOC269529, FBX10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 269529
Homologene: 19544
Dnajb14
Name: DnaJ heat shock protein family (Hsp40) member B14
Synonyms: 5730496F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 70604
Homologene: 57015
Zfp935
Name: zinc finger protein 935
Synonyms: 8430426H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 71508
VEGA: 13
Tbc1d24
Name: TBC1 domain family, member 24
Synonyms: C530046L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224617
Homologene: 27469
Olfr330
Name: olfactory receptor 330
Synonyms: MOR275-1, GA_x6K02T2NKPP-895420-896349
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258879
Homologene: 133015
Abhd6
Name: abhydrolase domain containing 6
Synonyms: 0610041D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 66082
VEGA: 14
Homologene: 23246
Dhrs9
Name: dehydrogenase/reductase (SDR family) member 9
Synonyms: Rdh15, C730025I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241452
Homologene: 26079
Gm11295
Name: predicted gene 11295
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 665726
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 135,963,102 bp
  • T to G, chromosome 1 at 158,579,666 bp
  • T to A, chromosome 1 at 165,310,623 bp
  • T to A, chromosome 1 at 188,537,804 bp
  • C to T, chromosome 1 at 194,749,317 bp
  • A to G, chromosome 2 at 69,392,964 bp
  • A to G, chromosome 2 at 86,314,395 bp
  • T to A, chromosome 2 at 102,861,586 bp
  • C to A, chromosome 2 at 110,862,843 bp
  • C to G, chromosome 2 at 117,289,450 bp
  • A to G, chromosome 2 at 146,315,064 bp
  • T to C, chromosome 3 at 90,394,110 bp
  • T to G, chromosome 3 at 137,892,905 bp
  • T to A, chromosome 4 at 12,146,443 bp
  • C to T, chromosome 4 at 45,051,642 bp
  • T to A, chromosome 4 at 55,385,438 bp
  • T to C, chromosome 4 at 62,312,365 bp
  • T to G, chromosome 4 at 143,398,466 bp
  • T to A, chromosome 4 at 148,112,756 bp
  • A to G, chromosome 5 at 25,220,081 bp
  • C to T, chromosome 5 at 37,141,805 bp
  • G to T, chromosome 5 at 137,315,597 bp
  • T to C, chromosome 5 at 143,715,839 bp
  • C to A, chromosome 7 at 81,969,031 bp
  • T to C, chromosome 7 at 120,359,810 bp
  • C to T, chromosome 8 at 16,199,843 bp
  • C to T, chromosome 8 at 70,338,460 bp
  • A to G, chromosome 8 at 83,719,606 bp
  • C to T, chromosome 8 at 119,734,281 bp
  • T to A, chromosome 8 at 122,893,163 bp
  • T to C, chromosome 9 at 39,949,841 bp
  • T to C, chromosome 9 at 79,678,366 bp
  • T to C, chromosome 9 at 110,455,491 bp
  • C to T, chromosome 10 at 79,887,776 bp
  • A to T, chromosome 11 at 54,265,549 bp
  • A to G, chromosome 11 at 58,529,311 bp
  • G to A, chromosome 11 at 67,643,295 bp
  • A to C, chromosome 11 at 102,438,361 bp
  • A to G, chromosome 11 at 117,792,569 bp
  • A to G, chromosome 13 at 22,283,060 bp
  • G to T, chromosome 13 at 62,455,108 bp
  • T to A, chromosome 14 at 8,049,857 bp
  • A to G, chromosome 14 at 34,268,689 bp
  • T to C, chromosome 14 at 55,778,017 bp
  • A to G, chromosome 14 at 73,298,172 bp
  • C to A, chromosome 15 at 7,887,359 bp
  • A to G, chromosome 15 at 8,351,482 bp
  • A to G, chromosome 15 at 10,983,368 bp
  • A to C, chromosome 15 at 91,245,855 bp
  • A to T, chromosome 16 at 13,879,508 bp
  • A to G, chromosome 16 at 92,348,758 bp
  • A to T, chromosome 17 at 24,186,008 bp
  • A to G, chromosome 17 at 46,310,157 bp
  • G to T, chromosome 18 at 9,280,811 bp
  • T to A, chromosome 19 at 30,131,790 bp
  • T to C, chromosome 19 at 40,089,848 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2425 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040387-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.