Strain Name:
C57BL/6J-MtgxR2432Btlr/Mmmh
Stock Number:
040393-MU
Citation ID:
RRID:MMRRC_040393-MU
Other Names:
R2432 (G1), C57BL/6J-MtgxR2432Btlr
Major Collection:

Gene Information

Myo5a
Name: myosin VA
Synonyms: 9630007J19Rik, MyoVA, flail, MVa, Myo5, Dbv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Notch3
Name: notch 3
Synonyms: N3, hpbk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18131
HGNC: HGNC:7883
Homologene: 376
Ptprk
Name: protein tyrosine phosphatase, receptor type, K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Tfdp2
Name: transcription factor Dp 2
Synonyms: DP3, A330080J22Rik, DP-3, DP3, 1110029I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 211586
Homologene: 4578
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, Acf7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 11426
Homologene: 136191
Slc44a2
Name: solute carrier family 44, member 2
Synonyms: CTL2, 1110028E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 68682
VEGA: 9
Homologene: 10711
Slc25a13
Name: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
Synonyms: citrin, Ctrn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 50799
Homologene: 22800
Helb
Name: helicase (DNA) B
Synonyms: D10Ertd664e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 117599
Homologene: 50463
Rrm1
Name: ribonucleotide reductase M1
Synonyms: RnrM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20133
Homologene: 806
Prpf4b
Name: pre-mRNA processing factor 4B
Synonyms: Prp4, Prp4k, Prpk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 19134
VEGA: 13
Homologene: 134085
Hspa5
Name: heat shock protein 5
Synonyms: Sez7, Bip, D2Wsu17e, D2Wsu141e, Hsce70, XAP-1 antigen, 78kDa, baffled, Grp78, mBiP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14828
HGNC: HGNC:5238
Homologene: 3908
Rps6ka5
Name: ribosomal protein S6 kinase, polypeptide 5
Synonyms: MSK1, 3110005L17Rik, 6330404E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 73086
VEGA: 12
Homologene: 48302
Tmprss6
Name: transmembrane serine protease 6
Synonyms: matriptase-2, 1300008A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 71753
VEGA: 15
Homologene: 12408
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: D3Bwg1534e, 2610040L17Rik, Ten-m2, Odz2, 9330187F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 23964
Homologene: 22672
Rxfp3
Name: relaxin family peptide receptor 3
Synonyms: Salpr, Rln3r1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239336
Homologene: 9568
Npat
Name: nuclear protein in the AT region
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244879
HGNC: HGNC:7896
Homologene: 1888
Rap1gds1
Name: RAP1, GTP-GDP dissociation stimulator 1
Synonyms: GDS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229877
HGNC: HGNC:9859
Homologene: 41422
Eif5b
Name: eukaryotic translation initiation factor 5B
Synonyms: A030003E17Rik, IF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226982
Homologene: 134613
Plekhm3
Name: pleckstrin homology domain containing, family M, member 3
Synonyms: Plekhm1l, A230102O09Rik, 9430067K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241075
Homologene: 18459
Pcdhb16
Name: protocadherin beta 16
Synonyms: Pcdhb8, PcdhbP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93887
HGNC: HGNC:8693
Homologene: 99843
Nr1h2
Name: nuclear receptor subfamily 1, group H, member 2
Synonyms: LXRbeta, RIP15, Unr2, LXRB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22260
HGNC: HGNC:7965
Homologene: 21397
Prdm14
Name: PR domain containing 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 383491
Homologene: 11556
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 268379
Homologene: 27991
Adamts6
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
Synonyms: A930019D11Rik, ADAM-TS6, b2b2228Clo, b2b1879.1Clo, b2b2029Clo, b2b2182Clo, b2b2187.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 108154
VEGA: 13
HGNC: HGNC:222
Homologene: 82573
Plekhg4
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 4
Synonyms: 4931414L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 102075
Homologene: 18516
Def6
Name: differentially expressed in FDCP 6
Synonyms: 6430538D02Rik, 2410003F05Rik, SLAT, IRF-4-binding protein, IBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 23853
HGNC: HGNC:2760
Homologene: 11103
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mgr1, Mass1, Gpr98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 110789
Homologene: 19815
Usp40
Name: ubiquitin specific peptidase 40
Synonyms: B230215L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227334
Homologene: 32400
Ppargc1b
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Synonyms: PGC-1beta/ERRL1, 4631412G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 170826
Homologene: 15776
Dnase1l2
Name: deoxyribonuclease 1-like 2
Synonyms: 4733401H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 66705
HGNC: HGNC:2958
Homologene: 74391
Cpt2
Name: carnitine palmitoyltransferase 2
Synonyms: CPT II, CPTII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12896
HGNC: HGNC:2330
Homologene: 77
Adamts9
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9
Synonyms: 1810011L16Rik, UND3, Mhdaund4, UND4, 8430403M15Rik, E030027K14Rik, Gsfund3, Mhdaund3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 101401
Homologene: 18821
Myo1f
Name: myosin IF
Synonyms: C330006B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 17916
HGNC: HGNC:7600
Homologene: 56276
Pdzrn3
Name: PDZ domain containing RING finger 3
Synonyms: 1110020C07Rik, LNX3, Semcap3, semaphorin cytoplasmic domain-associated protein 3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 55983
Homologene: 10328
Olfr804
Name: olfactory receptor 804
Synonyms: GA_x6K02T2PULF-11383575-11384519, MOR110-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258068
Homologene: 133581
Mug2
Name: murinoglobulin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 17837
Homologene: 136663
Calr3
Name: calreticulin 3
Synonyms: calsperin, Crt2, 1700031L01Rik, 6330586I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 73316
Homologene: 57091
Olfr1302
Name: olfactory receptor 1302
Synonyms: MOR248-3, GA_x6K02T2Q125-72831562-72832500
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258891
Homologene: 27290
Vmn2r28
Name: vomeronasal 2, receptor 28
Synonyms: EG665255
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 665255
Homologene: 129605
Krt83
Name: keratin 83
Synonyms: 5430421N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 100126226
HGNC: HGNC:6460
Homologene: 68248
Usp16
Name: ubiquitin specific peptidase 16
Synonyms: 6330514E22Rik, 2810483I07Rik, UBP-M, 1200004E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 74112
Homologene: 38183
Slc30a3
Name: solute carrier family 30 (zinc transporter), member 3
Synonyms: Znt3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22784
Homologene: 74470
Prdm12
Name: PR domain containing 12
Synonyms: LOC381359
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 381359
Homologene: 10999
Cyp2d34
Name: cytochrome P450, family 2, subfamily d, polypeptide 34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223706
VEGA: 15
Homologene: 86099
4921506M07Rik
Name: RIKEN cDNA 4921506M07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
Jhy
Name: junctional cadherin complex regulator
Synonyms: 4931429I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 70989
Homologene: 11726
Trim3
Name: tripartite motif-containing 3
Synonyms: HAC1, BERP1, Rnf22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 55992
Homologene: 21290
Zfp382
Name: zinc finger protein 382
Synonyms: 5930415A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233060
Homologene: 32798
Golim4
Name: golgi integral membrane protein 4
Synonyms: Golph4, 3110027H23Rik, P138, GPP130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 73124
Homologene: 8716
Ifna12
Name: interferon alpha 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242519
HGNC: HGNC:5425
Homologene: 68536
Slc11a1
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Synonyms: Nramp, Lsh, Ity1, Ity, Bcg, ity, Nramp1, host resistance locus Bcg/Ity/Lsh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18173
Homologene: 73884
Prp2
Name: proline rich protein 2
Synonyms: MP14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 83380
Tas2r119
Name: taste receptor, type 2, member 119
Synonyms: mGR19, Tas2r19, T2R19, mt2r19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 57254
Homologene: 10480
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 13,125,633 bp
  • A to G, chromosome 1 at 38,019,342 bp
  • A to G, chromosome 1 at 64,937,856 bp
  • A to G, chromosome 1 at 74,383,751 bp
  • T to C, chromosome 1 at 87,982,082 bp
  • T to G, chromosome 2 at 31,651,852 bp
  • C to T, chromosome 2 at 34,773,316 bp
  • T to C, chromosome 2 at 111,780,671 bp
  • T to C, chromosome 3 at 75,891,942 bp
  • A to G, chromosome 3 at 138,956,250 bp
  • T to A, chromosome 4 at 88,603,353 bp
  • A to T, chromosome 4 at 107,904,526 bp
  • G to T, chromosome 4 at 123,683,996 bp
  • T to C, chromosome 5 at 31,088,694 bp
  • A to T, chromosome 6 at 6,114,017 bp
  • C to A, chromosome 6 at 92,857,900 bp
  • G to T, chromosome 6 at 101,150,791 bp
  • C to A, chromosome 6 at 122,084,376 bp
  • C to T, chromosome 6 at 132,599,911 bp
  • T to C, chromosome 7 at 5,488,702 bp
  • A to G, chromosome 7 at 30,133,749 bp
  • T to C, chromosome 7 at 44,551,367 bp
  • T to A, chromosome 7 at 102,443,072 bp
  • A to G, chromosome 7 at 105,619,239 bp
  • A to G, chromosome 8 at 72,438,426 bp
  • T to A, chromosome 8 at 105,381,836 bp
  • A to T, chromosome 9 at 21,344,834 bp
  • T to A, chromosome 9 at 40,960,886 bp
  • A to T, chromosome 9 at 53,558,135 bp
  • T to A, chromosome 9 at 75,212,873 bp
  • T to C, chromosome 9 at 96,310,590 bp
  • T to A, chromosome 10 at 28,592,844 bp
  • A to T, chromosome 10 at 120,105,537 bp
  • A to G, chromosome 10 at 129,704,925 bp
  • T to C, chromosome 11 at 9,451,333 bp
  • C to A, chromosome 11 at 36,027,191 bp
  • C to T, chromosome 12 at 57,622,035 bp
  • A to G, chromosome 12 at 100,554,405 bp
  • A to G, chromosome 13 at 34,883,341 bp
  • GA to GAA, chromosome 13 at 81,540,132 bp
  • A to T, chromosome 13 at 104,426,977 bp
  • T to C, chromosome 15 at 11,036,140 bp
  • A to G, chromosome 15 at 32,178,019 bp
  • A to G, chromosome 15 at 78,465,104 bp
  • A to G, chromosome 15 at 82,619,011 bp
  • A to T, chromosome 15 at 101,488,156 bp
  • T to A, chromosome 16 at 87,466,358 bp
  • G to A, chromosome 17 at 24,442,725 bp
  • A to T, chromosome 17 at 28,228,069 bp
  • A to T, chromosome 17 at 32,153,804 bp
  • A to G, chromosome 17 at 33,575,849 bp
  • A to T, chromosome 18 at 37,479,930 bp
  • G to A, chromosome 18 at 61,307,799 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2432 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040393-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.