Strain Name:
C57BL/6J-MtgxR2495Btlr/Mmmh
Stock Number:
040409-MU
Citation ID:
RRID:MMRRC_040409-MU
Other Names:
R2495 (G1), C57BL/6J-MtgxR2495Btlr
Major Collection:

Gene Information

Aven
Name: apoptosis, caspase activation inhibitor
Synonyms: 1700013A01Rik, mAven-S, mAven-L, 1700056A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74268
Homologene: 10683
Gsn
Name: gelsolin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227753
HGNC: HGNC:4620
Homologene: 147
Ptprk
Name: protein tyrosine phosphatase, receptor type, K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Trnt1
Name: tRNA nucleotidyl transferase, CCA-adding, 1
Synonyms: 2610044E04Rik, CGI-47, 2410043H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70047
Homologene: 9333
Pcm1
Name: pericentriolar material 1
Synonyms: 9430077F19Rik, 2600002H09Rik, C030044G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18536
HGNC: HGNC:8727
Homologene: 4518
Abhd17c
Name: abhydrolase domain containing 17C
Synonyms: 2210412D01Rik, Fam108c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70178
Homologene: 26429
Cltc
Name: clathrin, heavy polypeptide (Hc)
Synonyms: CHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Dido1
Name: death inducer-obliterator 1
Synonyms: DIO-1, 6720461J16Rik, D130048F08Rik, Datf1, dido, C130092D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23856
HGNC: HGNC:2680
Homologene: 34139
Taf3
Name: TATA-box binding protein associated factor 3
Synonyms: mTAFII140, 4933439M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209361
Homologene: 35415
Nol6
Name: nucleolar protein family 6 (RNA-associated)
Synonyms: Nrap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230082
Homologene: 41505
Cntrob
Name: centrobin, centrosomal BRCA2 interacting protein
Synonyms: Lip8, 9830165K03Rik, Nip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216846
Homologene: 14205
Rbm26
Name: RNA binding motif protein 26
Synonyms: Pro1777, C230097K14Rik, 1700009P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74213
Homologene: 41468
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71722
Homologene: 87637
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 627872
Homologene: 41287
Ambn
Name: ameloblastin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11698
HGNC: HGNC:452
Homologene: 7625
Dsp
Name: desmoplakin
Synonyms: DP, 2300002E22Rik, 5730453H04Rik, rul
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Golga3
Name: golgi autoantigen, golgin subfamily a, 3
Synonyms: Mea-2, Mea2, 5430416E01Rik, G1-499-14, repro27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269682
HGNC: HGNC:4426
Homologene: 4308
Wdfy1
Name: WD repeat and FYVE domain containing 1
Synonyms: 1700013B03Rik, Jr1, 1700120F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69368
Homologene: 10825
Got2
Name: glutamatic-oxaloacetic transaminase 2, mitochondrial
Synonyms: mAspAT, mitochondrial aspartate aminotransferase, FABP-pm, plasma membrane fatty acid binding protein, Kyat4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14719
HGNC: HGNC:4433
Homologene: 1572
Acsl5
Name: acyl-CoA synthetase long-chain family member 5
Synonyms: 1700030F05Rik, Facl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 433256
VEGA: 19
Homologene: 69208
Rras
Name: related RAS viral (r-ras) oncogene
Synonyms: Rras1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20130
Homologene: 4565
Crmp1
Name: collapsin response mediator protein 1
Synonyms: Ulip3, DRP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12933
HGNC: HGNC:2365
Homologene: 20347
Lap3
Name: leucine aminopeptidase 3
Synonyms: Pep-S, Pep-7, LAP, peptidase S, Pep7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66988
Homologene: 41072
Cep95
Name: centrosomal protein 95
Synonyms: F630025I20Rik, 4732496G21Rik, Ccdc45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320162
Homologene: 16297
Gpatch8
Name: G patch domain containing 8
Synonyms: 5430405G24Rik, Gpatc8, ENSMUSG00000075516, Fbm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237943
Homologene: 46117
Cnbd1
Name: cyclic nucleotide binding domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 435772
Homologene: 27843
Ank1
Name: ankyrin 1, erythroid
Synonyms: Ank-1, pale
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11733
HGNC: HGNC:492
Homologene: 55427
Arhgef28
Name: Rho guanine nucleotide exchange factor (GEF) 28
Synonyms: RIP2, RhoGEF, Rho specific exchange factor, D13Bwg1089e, 9230110L08Rik, p190RhoGEF, Rgnef
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110596
VEGA: 13
Homologene: 8078
Zfp287
Name: zinc finger protein 287
Synonyms: SKAT-2, B230333C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170740
Homologene: 23244
Capn11
Name: calpain 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268958
HGNC: HGNC:1478
Homologene: 21392
Mipol1
Name: mirror-image polydactyly 1
Synonyms: 1700081O04Rik, D12Ertd19e, 6030439O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73490
Homologene: 16340
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: smMHC, SM2, SM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: A230067G21Rik, RGC2, AS250
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241694
Homologene: 28131
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229003
Homologene: 14118
Vmn2r10
Name: vomeronasal 2, receptor 10
Synonyms: VR16, V2r16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22307
Homologene: 129606
Agbl3
Name: ATP/GTP binding protein-like 3
Synonyms: 2900053G10Rik, 6530406M24Rik, 4930431N21Rik, Ccp3, Ccp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 76223
Homologene: 35330
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: LOC380658, 4930503E15Rik, Gm1557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74978
Homologene: 46007
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: NMDAR2B, NR2B, Nmdar2b, GluRepsilon2, GluN2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
Bcl11b
Name: B cell leukemia/lymphoma 11B
Synonyms: COUP-TF interacting protein 2, CTIP2, B630002E05Rik, Rit1, 9130430L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 58208
Homologene: 10974
Rfx6
Name: regulatory factor X, 6
Synonyms: 4930572O07Rik, Rfxdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320995
Homologene: 18318
Aox3
Name: aldehyde oxidase 3
Synonyms: AOH1, 1200011D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71724
Homologene: 90899
Slc9a3
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3
Synonyms: NHE3, 9030624O13Rik, NHE-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105243
VEGA: 13
Homologene: 55804
Tectb
Name: tectorin beta
Synonyms: [b]-tectorin, Tctnb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21684
Homologene: 7568
Mmp19
Name: matrix metallopeptidase 19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 58223
VEGA: 10
HGNC: HGNC:7165
Homologene: 1820
Phgdh
Name: 3-phosphoglycerate dehydrogenase
Synonyms: SERA, PGDH, PGD, PGAD, A10, 3-PGDH, 3PGDH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 236539
HGNC: HGNC:8923
Homologene: 39318
Gpx5
Name: glutathione peroxidase 5
Synonyms: Arep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14780
HGNC: HGNC:4557
Homologene: 1155
Fam75d3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Spsb4
Name: splA/ryanodine receptor domain and SOCS box containing 4
Synonyms: D030068E18Rik, Ssb4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 211949
Homologene: 25315
Zyg11b
Name: zyg-ll family member B, cell cycle regulator
Synonyms: LOC242610, 1110046I03Rik, D4Mgi23, 2810482G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 414872
Homologene: 14600
Shisa6
Name: shisa family member 6
Synonyms: LOC380702, Gm879, CKAMP52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380702
Homologene: 66164
Rbbp8nl
Name: RBBP8 N-terminal like
Synonyms: BC066135
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 271887
Homologene: 76811
Krt6b
Name: keratin 6B
Synonyms: mK6[b], Krt2-6b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16688
VEGA: 15
Homologene: 136794
Adamts14
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14
Synonyms: TS14, Adamts-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237360
Homologene: 16383
Gm5724
Name: predicted gene 5724
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 435927
Ubox5
Name: U box domain containing 5
Synonyms: UIP5, 1500010O06Rik, C330018L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 140629
Homologene: 8972
Cnksr1
Name: connector enhancer of kinase suppressor of Ras 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 194231
Homologene: 4604
Fbxo10
Name: F-box protein 10
Synonyms: FBX10, LOC269529
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269529
Homologene: 19544
Gm4559
Name: predicted gene 4559
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100043627
VEGA: 7
Agrp
Name: agouti related neuropeptide
Synonyms: Agrt, agouti related protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11604
HGNC: HGNC:330
Homologene: 7184
Ucn2
Name: urocortin 2
Synonyms: Urocortin II, Ucn-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 171530
Homologene: 50048
1810062G17Rik
Name: RIKEN cDNA 1810062G17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72282
Msc
Name: musculin
Synonyms: MyoR, bHLHa22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17681
HGNC: HGNC:7321
Homologene: 3738
Zfp88
Name: withdrawn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: UN
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 14,755,249 bp
  • T to C, chromosome 1 at 34,199,373 bp
  • T to A, chromosome 1 at 53,605,881 bp
  • T to C, chromosome 1 at 58,188,408 bp
  • A to T, chromosome 1 at 79,707,505 bp
  • G to T, chromosome 2 at 9,952,833 bp
  • A to C, chromosome 2 at 35,303,193 bp
  • T to G, chromosome 2 at 112,630,771 bp
  • A to T, chromosome 2 at 130,599,521 bp
  • G to T, chromosome 2 at 146,361,400 bp
  • C to A, chromosome 2 at 180,279,102 bp
  • A to G, chromosome 2 at 180,689,388 bp
  • A to G, chromosome 2 at 181,232,912 bp
  • T to C, chromosome 3 at 36,481,960 bp
  • A to G, chromosome 3 at 98,339,789 bp
  • A to T, chromosome 4 at 18,860,579 bp
  • A to T, chromosome 4 at 41,118,427 bp
  • A to G, chromosome 4 at 45,040,545 bp
  • A to G, chromosome 4 at 108,244,724 bp
  • A to T, chromosome 4 at 134,232,162 bp
  • G to A, chromosome 5 at 37,246,097 bp
  • A to G, chromosome 5 at 45,495,291 bp
  • T to C, chromosome 5 at 88,467,804 bp
  • G to A, chromosome 5 at 108,996,095 bp
  • T to A, chromosome 5 at 110,207,596 bp
  • A to G, chromosome 6 at 34,846,764 bp
  • T to A, chromosome 6 at 106,773,369 bp
  • T to C, chromosome 6 at 135,733,182 bp
  • C to A, chromosome 6 at 141,765,777 bp
  • A to G, chromosome 7 at 25,291,776 bp
  • G to A, chromosome 7 at 45,018,064 bp
  • C to T, chromosome 7 at 84,110,676 bp
  • A to T, chromosome 7 at 142,273,820 bp
  • T to C, chromosome 8 at 23,132,264 bp
  • A to G, chromosome 8 at 41,293,579 bp
  • A to G, chromosome 8 at 95,888,290 bp
  • T to C, chromosome 8 at 105,566,776 bp
  • T to C, chromosome 9 at 96,995,787 bp
  • C to T, chromosome 9 at 108,986,409 bp
  • A to T, chromosome 10 at 28,475,078 bp
  • A to C, chromosome 10 at 51,726,675 bp
  • A to T, chromosome 10 at 61,198,970 bp
  • G to A, chromosome 10 at 103,202,381 bp
  • A to G, chromosome 10 at 128,790,950 bp
  • A to T, chromosome 11 at 62,714,633 bp
  • G to A, chromosome 11 at 66,217,633 bp
  • G to T, chromosome 11 at 69,322,923 bp
  • A to G, chromosome 11 at 86,702,198 bp
  • A to T, chromosome 11 at 102,478,481 bp
  • A to G, chromosome 11 at 106,809,282 bp
  • A to T, chromosome 12 at 57,460,990 bp
  • G to A, chromosome 12 at 107,915,447 bp
  • T to A, chromosome 13 at 21,291,440 bp
  • T to A, chromosome 13 at 38,193,477 bp
  • A to G, chromosome 13 at 59,701,993 bp
  • A to G, chromosome 13 at 74,158,703 bp
  • A to T, chromosome 13 at 98,029,373 bp
  • T to G, chromosome 14 at 103,200,118 bp
  • T to C, chromosome 14 at 105,151,312 bp
  • T to A, chromosome 15 at 65,014,873 bp
  • A to T, chromosome 15 at 101,678,322 bp
  • C to A, chromosome 16 at 14,205,557 bp
  • T to A, chromosome 17 at 45,638,763 bp
  • C to G, chromosome 19 at 55,180,999 bp
  • A to T, chromosome 19 at 55,293,599 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2495 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040409-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.