Strain Name:
C57BL/6J-MtgxR2497Btlr/Mmmh
Stock Number:
040411-MU
Citation ID:
RRID:MMRRC_040411-MU
Other Names:
R2497 (G1), C57BL/6J-MtgxR2497Btlr
Major Collection:

Gene Information

Camkk2
Name: calcium/calmodulin-dependent protein kinase kinase 2, beta
Synonyms: 6330570N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 207565
HGNC: HGNC:1470
Homologene: 32756
Prrx1
Name: paired related homeobox 1
Synonyms: K-2, Prx1, mHox, Pmx1, mHox, A230024N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18933
HGNC: HGNC:9142
Homologene: 7896
Arhgap39
Name: Rho GTPase activating protein 39
Synonyms: D15Wsu169e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223666
Homologene: 27825
Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, Zap3, A930013E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56531
Homologene: 87707
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Nf-1, Dsk9, Mhdadsk9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Snd1
Name: staphylococcal nuclease and tudor domain containing 1
Synonyms: p100 co-activator, Tudor-SN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56463
Homologene: 8665
Agrn
Name: agrin
Synonyms: NMF380, Agrin, nmf380
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Sdad1
Name: SDA1 domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231452
Homologene: 6036
Rnf20
Name: ring finger protein 20
Synonyms: 4833430L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109331
Homologene: 5571
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 5730590C14Rik, 3526402J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77097
Homologene: 64680
Rab27a
Name: RAB27A, member RAS oncogene family
Synonyms: 2410003M20Rik, 4933437C11Rik, 2210402C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11891
HGNC: HGNC:9766
Homologene: 3069
Ccdc77
Name: coiled-coil domain containing 77
Synonyms: 2400002C23Rik, 2700091N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67200
Homologene: 12096
Myo1d
Name: myosin ID
Synonyms: 9930104H07Rik, D11Ertd9e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 338367
HGNC: HGNC:7598
Homologene: 45576
Cand1
Name: cullin associated and neddylation disassociated 1
Synonyms: 6330512O03Rik, 2310038O07Rik, D10Ertd516e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71902
Homologene: 10202
Pum2
Name: pumilio RNA-binding family member 2
Synonyms: Pumm2, 5730503J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 80913
Homologene: 69183
Pdgfrb
Name: platelet derived growth factor receptor, beta polypeptide
Synonyms: CD140b, Pdgfr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 18596
HGNC: HGNC:8804
Homologene: 1960
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268878
Homologene: 77451
Htt
Name: huntingtin
Synonyms: huntingtin, HD, htt, IT15, C430023I11Rik, Hdh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Zfp148
Name: zinc finger protein 148
Synonyms: beta enolase repressor factor 1, BERF-1, BFCOL1, 2210405J08Rik, ZBP-89
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22661
VEGA: 16
Homologene: 8003
Stimate
Name: STIM activating enhancer
Synonyms: 1810038N08Rik, 2310014H19Rik, Tmem110
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 69179
Homologene: 7082
Mtmr4
Name: myotubularin related protein 4
Synonyms: ESTM44, FYVE-DSP2, FYVE zinc finger phosphatase, ZFYVE11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170749
HGNC: HGNC:7452
Homologene: 3440
Tpcn1
Name: two pore channel 1
Synonyms: 5730403B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 252972
Homologene: 9905
Ssh1
Name: slingshot protein phosphatase 1
Synonyms: mSSH-1L, LOC384311
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231637
Homologene: 41299
Blnk
Name: B cell linker
Synonyms: SLP-65, BCA, BASH, BLNK, Ly-57, Bca, Ly57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 17060
Homologene: 32038
Mgat4c
Name: MGAT4 family, member C
Synonyms: 9130411I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67569
Homologene: 8297
Enam
Name: enamelin
Synonyms: abte
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13801
HGNC: HGNC:3344
Homologene: 9698
Cdkl2
Name: cyclin-dependent kinase-like 2 (CDC2-related kinase)
Synonyms: Kkm, KKIAMRE, 5330436L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 53886
HGNC: HGNC:1782
Homologene: 55793
Flywch1
Name: FLYWCH-type zinc finger 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224613
VEGA: 17
Homologene: 72130
Nacc2
Name: nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
Synonyms: 0610020I02Rik, C030048H19Rik, Btbd14a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67991
Homologene: 75239
Hgsnat
Name: heparan-alpha-glucosaminide N-acetyltransferase
Synonyms: 9430010M12Rik, D8Ertd354e, Tmem76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 52120
Homologene: 15586
Cmya5
Name: cardiomyopathy associated 5
Synonyms: Myospryn, 2310076E16Rik, 2310076E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Zhx2
Name: zinc fingers and homeoboxes 2
Synonyms: Raf, Afr-1, Afr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 387609
Homologene: 8968
Clspn
Name: claspin
Synonyms: E130314M08Rik, C85083
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269582
Homologene: 11138
Uspl1
Name: ubiquitin specific peptidase like 1
Synonyms: E430026A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231915
Homologene: 4235
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Atp11b
Name: ATPase, class VI, type 11B
Synonyms: 1110019I14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76295
Homologene: 32919
Mmp3
Name: matrix metallopeptidase 3
Synonyms: progelatinase, stromelysin 1, Str1, SLN1, SLN-1, stromelysin-1, Stmy1, STR-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17392
VEGA: 9
HGNC: HGNC:7173
Homologene: 20545
Wdr66
Name: WD repeat domain 66
Synonyms: 4930415N18Rik, 4933428F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269701
Homologene: 16964
Elfn2
Name: leucine rich repeat and fibronectin type III, extracellular 2
Synonyms: Lrrc62
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 207393
VEGA: 15
Homologene: 18835
Slc1a4
Name: solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
Synonyms: ASCT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 55963
Homologene: 20655
Pde6c
Name: phosphodiesterase 6C, cGMP specific, cone, alpha prime
Synonyms: cpfl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 110855
VEGA: 19
HGNC: HGNC:8787
Homologene: 4521
Tectb
Name: tectorin beta
Synonyms: [b]-tectorin, Tctnb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21684
Homologene: 7568
Olfml3
Name: olfactomedin-like 3
Synonyms: HNOEL-iso, 2810002E22Rik, mONT3, ONT3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99543
Homologene: 10613
Zdhhc23
Name: zinc finger, DHHC domain containing 23
Synonyms: LOC332175, LOC385651
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 332175
VEGA: 16
Homologene: 17840
Unc45b
Name: unc-45 myosin chaperone B
Synonyms: UNC45, D230041A13Rik, Cmya4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217012
Homologene: 14666
Serpinb9d
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9d
Synonyms: ovalbumin, Spi9, AT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20726
HGNC: HGNC:8955
Homologene: 69093
Nox4
Name: NADPH oxidase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 50490
HGNC: HGNC:7891
Homologene: 41065
Ptges
Name: prostaglandin E synthase
Synonyms: 2410099E23Rik, mPGES, D2Ertd369e, mPGES-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 64292
HGNC: HGNC:9599
Homologene: 3587
Acox2
Name: acyl-Coenzyme A oxidase 2, branched chain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 93732
HGNC: HGNC:120
Homologene: 74473
Cers6
Name: ceramide synthase 6
Synonyms: T1L, similar to TRH1, 4732462C07Rik, CerS6, Lass6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241447
Homologene: 72228
Smyd2
Name: SET and MYND domain containing 2
Synonyms: Zmynd14, 1110020E07Rik, KMT3C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226830
Homologene: 32466
Atg4d
Name: autophagy related 4D, cysteine peptidase
Synonyms: APG4-D, 9830134P12Rik, Autl4, Apg4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235040
VEGA: 9
Homologene: 13156
Aqp5
Name: aquaporin 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11830
VEGA: 15
HGNC: HGNC:638
Homologene: 20398
Mtres1
Name: mitochondrial transcription rescue factor 1
Synonyms: 1700021F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67851
Homologene: 41137
Csn1s2b
Name: casein alpha s2-like B
Synonyms: Csne, Csnd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12992
Homologene: 49221
Cdc34b
Name: cell division cycle 34B
Synonyms: Cdc34-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 111266
Atp6v1g2
Name: ATPase, H+ transporting, lysosomal V1 subunit G2
Synonyms: 1500002D01Rik, NG38, VAG2, Atp6g2, lysosomal 13kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66237
HGNC: HGNC:862
Homologene: 41518
Gm8089
Name: predicted gene 8089
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 666414
Gm5612
Name: predicted gene 5612
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 434375
VEGA: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 30,830,014 bp
  • T to C, chromosome 1 at 107,301,619 bp
  • A to G, chromosome 1 at 163,248,265 bp
  • T to A, chromosome 1 at 189,885,337 bp
  • A to T, chromosome 2 at 26,089,568 bp
  • C to T, chromosome 2 at 30,892,710 bp
  • T to C, chromosome 2 at 69,071,446 bp
  • A to G, chromosome 3 at 35,855,145 bp
  • T to A, chromosome 3 at 103,736,939 bp
  • G to A, chromosome 4 at 49,652,676 bp
  • A to G, chromosome 4 at 126,572,347 bp
  • T to C, chromosome 4 at 156,173,811 bp
  • T to C, chromosome 5 at 34,820,313 bp
  • T to A, chromosome 5 at 87,815,137 bp
  • T to A, chromosome 5 at 88,502,694 bp
  • T to A, chromosome 5 at 92,008,998 bp
  • T to C, chromosome 5 at 92,300,099 bp
  • T to C, chromosome 5 at 113,958,858 bp
  • C to T, chromosome 5 at 120,538,998 bp
  • C to A, chromosome 5 at 122,747,939 bp
  • T to C, chromosome 5 at 123,283,369 bp
  • C to T, chromosome 5 at 149,187,854 bp
  • A to G, chromosome 6 at 28,888,079 bp
  • C to T, chromosome 6 at 120,325,472 bp
  • T to A, chromosome 7 at 87,295,876 bp
  • C to T, chromosome 8 at 25,945,252 bp
  • A to G, chromosome 9 at 7,450,131 bp
  • T to C, chromosome 9 at 18,427,679 bp
  • C to T, chromosome 9 at 21,273,386 bp
  • T to C, chromosome 9 at 45,745,078 bp
  • T to C, chromosome 9 at 73,084,981 bp
  • T to C, chromosome 10 at 43,525,267 bp
  • T to A, chromosome 10 at 102,388,210 bp
  • T to C, chromosome 10 at 119,213,852 bp
  • T to C, chromosome 11 at 20,332,620 bp
  • G to T, chromosome 11 at 79,443,884 bp
  • T to A, chromosome 11 at 80,674,821 bp
  • A to T, chromosome 11 at 82,936,443 bp
  • T to A, chromosome 11 at 87,600,823 bp
  • A to G, chromosome 11 at 94,742,381 bp
  • T to C, chromosome 11 at 105,673,493 bp
  • T to C, chromosome 12 at 8,713,834 bp
  • C to G, chromosome 12 at 84,996,761 bp
  • T to C, chromosome 13 at 33,196,517 bp
  • T to C, chromosome 13 at 93,098,005 bp
  • A to G, chromosome 14 at 8,251,612 bp
  • C to T, chromosome 14 at 30,872,580 bp
  • CCTTTGCGCTT to CCTT, chromosome 15 at 47,741,236 bp
  • T to C, chromosome 15 at 57,823,155 bp
  • C to A, chromosome 15 at 76,725,385 bp
  • C to G, chromosome 15 at 78,674,264 bp
  • T to C, chromosome 15 at 99,591,299 bp
  • G to T, chromosome 16 at 29,339,071 bp
  • T to C, chromosome 16 at 33,496,385 bp
  • G to A, chromosome 16 at 43,973,915 bp
  • G to A, chromosome 17 at 23,755,711 bp
  • C to T, chromosome 17 at 30,741,365 bp
  • T to A, chromosome 17 at 35,236,786 bp
  • A to T, chromosome 18 at 61,078,628 bp
  • A to G, chromosome 19 at 38,153,694 bp
  • A to T, chromosome 19 at 40,934,412 bp
  • C to G, chromosome 19 at 55,180,999 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2497 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040411-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.