Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR2518Btlr/Mmmh
Stock Number:
040422-MU
Citation ID:
RRID:MMRRC_040422-MU
Other Names:
R2518 (G1), C57BL/6J-MtgxR2518Btlr
Major Collection:

Strain Information

Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk-2, Tsk2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9030421L11Rik, 9130004I02Rik, 9430095K15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15184
Homologene: 3995
Vps54
Name: VPS54 GARP complex subunit
Synonyms: Vps54l, 5330404P15Rik, mSLP8, wr
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245944
Homologene: 5605
Tmem63b
Name: transmembrane protein 63b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224807
Homologene: 101682
Cyfip1
Name: cytoplasmic FMR1 interacting protein 1
Synonyms: P140SRA-1, Shyc, pl-1, l(7)1Rl, Sra-1, E030028J09Rik, l7Rl1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20430
Homologene: 22628
Golga4
Name: golgin A4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Fam91a1
Name: family with sequence similarity 91, member A1
Synonyms: D15Ertd621e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210998
VEGA: 15
Homologene: 13388
Cpne1
Name: copine I
Synonyms: 1810028N16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 266692
HGNC: HGNC:2314
Homologene: 36501
Tjap1
Name: tight junction associated protein 1
Synonyms: 0610041D19Rik, Pilt, Tjp4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74094
VEGA: 17
Homologene: 12534
Copa
Name: coatomer protein complex subunit alpha
Synonyms: xenin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12847
HGNC: HGNC:2230
Homologene: 3218
Cit
Name: citron
Synonyms: CRIK-SK, citron-N, citron kinase, Cit-k, C030025P15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Zfp953
Name: zinc finger protein 953
Synonyms: E130120F12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 629016
Adam18
Name: a disintegrin and metallopeptidase domain 18
Synonyms: Adam27, Dtgn3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13524
HGNC: HGNC:196
Homologene: 74941
Lyar
Name: Ly1 antibody reactive clone
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17089
Homologene: 41200
Khdrbs1
Name: KH domain containing, RNA binding, signal transduction associated 1
Synonyms: p62, Sam68
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20218
Homologene: 4781
Xrcc4
Name: X-ray repair complementing defective repair in Chinese hamster cells 4
Synonyms: 2310057B22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 108138
Homologene: 2555
Nup58
Name: nucleoporin 58
Synonyms: 1700017F11Rik, Nupl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71844
VEGA: 14
Homologene: 40924
Shld1
Name: shieldin complex subunit 1
Synonyms: 1110034G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73747
Homologene: 51865
Slc25a36
Name: solute carrier family 25, member 36
Synonyms: C330005L02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 192287
Homologene: 10039
Cmtr1
Name: cap methyltransferase 1
Synonyms: 1300018I05Rik, Ftsjd2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74157
Homologene: 9003
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: 2810027M23Rik, auxilin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72685
Homologene: 8865
Itga2
Name: integrin alpha 2
Synonyms: VLA-2 receptor, alpha 2 subunit, CD49B, DX5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16398
VEGA: 13
HGNC: HGNC:6137
Homologene: 1662
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80892
Homologene: 23477
Tab2
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2
Synonyms: Tak1 binding protein 2, 1110030N06Rik, A530078N03Rik, Map3k7ip2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68652
Homologene: 9019
Adamts6
Name: ADAM metallopeptidase with thrombospondin type 1 motif 6
Synonyms: ADAM-TS6, A930019D11Rik, b2b2228Clo, b2b2187.1Clo, b2b2182Clo, b2b2029Clo, b2b1879.1Clo
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 108154
VEGA: 13
HGNC: HGNC:222
Homologene: 82573
Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
Synonyms: GM, RGL
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 140491
HGNC: HGNC:9291
Homologene: 48124
Fam135b
Name: family with sequence similarity 135, member B
Synonyms: A830008O07Rik, 1700010C24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70363
VEGA: 15
Homologene: 66605
Klk1
Name: kallikrein 1
Synonyms: mGk-6, 0610007D04Rik, Klk6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16612
Homologene: 68141
Or9i1
Name: olfactory receptor family 9 subfamily I member 1
Synonyms: GA_x6K02T2RE5P-4193992-4194942, MOR211-1, Olfr1502
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258793
Homologene: 17394
Slc66a1
Name: solute carrier family 66 member 1
Synonyms: Pqlc2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212555
Homologene: 56784
Ccdc146
Name: coiled-coil domain containing 146
Synonyms: 4930528G09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75172
Homologene: 67159
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: 2610014H22Rik, Mll2, Wbp7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75410
Homologene: 22838
Irs2
Name: insulin receptor substrate 2
Synonyms: Irs-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384783
HGNC: HGNC:6126
Homologene: 2778
Pde8a
Name: phosphodiesterase 8A
Synonyms: Pde8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18584
HGNC: HGNC:8793
Homologene: 1957
Gpat2
Name: glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms: Gpat2, A530057A03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215456
Homologene: 19037
Mat1a
Name: methionine adenosyltransferase 1A
Synonyms: AdoMet, SAMS, MAT, SAMS1, MATA1, Ams
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11720
VEGA: 14
HGNC: HGNC:6903
Homologene: 68057
Cd226
Name: CD226 antigen
Synonyms: TLiSA1, DNAM-1, DNAM1, Pta1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225825
Homologene: 4787
Rad51ap2
Name: RAD51 associated protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209550
VEGA: 12
Homologene: 85245
Slc24a4
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
Synonyms: NCKX4, A930002M03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238384
Homologene: 17798
Hdgfl1
Name: HDGF like 1
Synonyms: HRP-1, Hdgfrp1, Pwwp1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15192
Homologene: 56406
Ube4a
Name: ubiquitination factor E4A
Synonyms: UFD2b, 9930123J21Rik, 4732444G18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 140630
Homologene: 3517
Mrc2
Name: mannose receptor, C type 2
Synonyms: novel lectin, Endo180, uPARAP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17534
Homologene: 4408
Ren1
Name: renin 1 structural
Synonyms: Ren1d, Ren-A, Rn-1, Ren, Rnr, Ren-1, Ren1c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19701
HGNC: HGNC:9958
Homologene: 20151
Shox2
Name: SHOX homeobox 2
Synonyms: Prx3, Og12x, 6330543G17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20429
Homologene: 68535
Slco6d1
Name: solute carrier organic anion transporter family, member 6d1
Synonyms: 4921511I05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70866
Homologene: 86643
Skint1
Name: selection and upkeep of intraepithelial T cells 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 639781
Homologene: 87538
Bivm
Name: basic, immunoglobulin-like variable motif containing
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 246229
Homologene: 9783
Tst
Name: thiosulfate sulfurtransferase, mitochondrial
Synonyms: Rhodanese
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22117
VEGA: 15
Homologene: 37759
C2cd2
Name: C2 calcium-dependent domain containing 2
Synonyms: ORF25, 5830404H04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207781
VEGA: 16
HGNC: HGNC:1266
Homologene: 18368
Timm44
Name: translocase of inner mitochondrial membrane 44
Synonyms: Tim44, Mimt44, D8Ertd118e, 0710005E20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21856
Homologene: 4631
Trabd2b
Name: TraB domain containing 2B
Synonyms: Gm12824, Hkat
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666048
Homologene: 85034
Pramel12
Name: PRAME like 12
Synonyms: 4732496O08Rik, Pramef8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242736
Homologene: 128393
Septin14
Name: septin 14
Synonyms: 1700016K13Rik, Sept14
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74222
Homologene: 87501
Or14a256
Name: olfactory receptor family 14 subfamily A member 256
Synonyms: GA_x6K02T2NHDJ-9504525-9505532, MOR219-5, Olfr294
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257904
Slc35f1
Name: solute carrier family 35, member F1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215085
Homologene: 33552
Gm9945
Name: predicted gene 9945
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Tas2r130
Name: taste receptor, type 2, member 130
Synonyms: Tas2r30, STC 7-4, mt2r42, T2R30
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387355
Homologene: 41536
Ifi27l2b
Name: interferon, alpha-inducible protein 27 like 2B
Synonyms: 1810023F06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217845
Homologene: 137395
Nectin4
Name: nectin cell adhesion molecule 4
Synonyms: nectin 4, Prr4, 1200017F15Rik, Pvrl4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71740
Homologene: 32744
Tarbp2
Name: TARBP2, RISC loading complex RNA binding subunit
Synonyms: Prbp, TRBP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21357
Homologene: 7562
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 44,129,615 bp
  • T to A, chromosome 1 at 45,337,512 bp
  • G to A, chromosome 1 at 98,446,828 bp
  • G to A, chromosome 1 at 133,360,124 bp
  • A to G, chromosome 1 at 171,380,208 bp
  • A to G, chromosome 1 at 172,119,901 bp
  • T to A, chromosome 2 at 52,249,511 bp
  • G to A, chromosome 2 at 127,428,291 bp
  • T to A, chromosome 2 at 132,750,527 bp
  • G to T, chromosome 2 at 156,073,971 bp
  • C to T, chromosome 3 at 5,403,358 bp
  • T to C, chromosome 3 at 66,978,359 bp
  • T to A, chromosome 4 at 101,612,930 bp
  • T to C, chromosome 4 at 112,025,481 bp
  • A to T, chromosome 4 at 114,599,903 bp
  • T to C, chromosome 4 at 129,720,747 bp
  • A to G, chromosome 4 at 139,302,499 bp
  • A to G, chromosome 4 at 143,417,903 bp
  • T to C, chromosome 5 at 21,305,528 bp
  • T to A, chromosome 5 at 38,227,932 bp
  • A to G, chromosome 5 at 115,987,046 bp
  • A to T, chromosome 5 at 129,699,035 bp
  • A to T, chromosome 6 at 14,719,378 bp
  • C to A, chromosome 6 at 85,667,963 bp
  • A to T, chromosome 6 at 131,630,073 bp
  • T to C, chromosome 7 at 30,576,068 bp
  • T to C, chromosome 7 at 44,220,737 bp
  • C to T, chromosome 7 at 55,928,284 bp
  • C to A, chromosome 7 at 81,317,422 bp
  • A to T, chromosome 7 at 86,616,187 bp
  • A to C, chromosome 8 at 4,266,588 bp
  • C to A, chromosome 8 at 11,005,352 bp
  • A to G, chromosome 8 at 24,637,141 bp
  • A to T, chromosome 9 at 44,948,137 bp
  • A to T, chromosome 9 at 97,079,071 bp
  • A to G, chromosome 9 at 118,556,612 bp
  • G to A, chromosome 10 at 7,907,481 bp
  • A to G, chromosome 10 at 53,073,534 bp
  • T to C, chromosome 10 at 125,994,441 bp
  • G to T, chromosome 11 at 20,725,797 bp
  • C to T, chromosome 11 at 21,306,394 bp
  • C to T, chromosome 11 at 53,480,336 bp
  • A to G, chromosome 11 at 102,197,136 bp
  • G to A, chromosome 11 at 105,348,431 bp
  • A to G, chromosome 12 at 11,457,067 bp
  • T to A, chromosome 12 at 102,222,051 bp
  • T to A, chromosome 12 at 103,455,824 bp
  • G to T, chromosome 13 at 26,769,749 bp
  • A to G, chromosome 13 at 67,347,939 bp
  • T to C, chromosome 13 at 90,062,188 bp
  • T to A, chromosome 13 at 104,413,819 bp
  • A to T, chromosome 13 at 114,881,042 bp
  • T to A, chromosome 14 at 41,122,512 bp
  • A to T, chromosome 14 at 60,232,660 bp
  • T to A, chromosome 15 at 58,450,600 bp
  • C to T, chromosome 15 at 71,463,911 bp
  • T to C, chromosome 15 at 78,405,833 bp
  • A to G, chromosome 15 at 102,518,557 bp
  • G to A, chromosome 16 at 97,922,086 bp
  • T to A, chromosome 17 at 29,681,980 bp
  • A to G, chromosome 17 at 45,666,154 bp
  • A to T, chromosome 17 at 46,260,095 bp
  • A to G, chromosome 18 at 89,207,327 bp
  • A to G, chromosome 19 at 13,862,309 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2518 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040422-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.