Strain Name:
C57BL/6J-MtgxR2518Btlr/Mmmh
Stock Number:
040422-MU
Citation ID:
RRID:MMRRC_040422-MU
Other Names:
R2518 (G1), C57BL/6J-MtgxR2518Btlr
Major Collection:

Gene Information

Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk2, Tsk-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9030421L11Rik, 9430095K15Rik, 9130004I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15184
Homologene: 3995
Vps54
Name: VPS54 GARP complex subunit
Synonyms: wr, 5330404P15Rik, mSLP8, Vps54l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245944
Homologene: 5605
Tmem63b
Name: transmembrane protein 63b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224807
Homologene: 101682
Cyfip1
Name: cytoplasmic FMR1 interacting protein 1
Synonyms: l7Rl1, P140SRA-1, Shyc, l(7)1Rl, Sra-1, pl-1, E030028J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20430
Homologene: 22628
Golga4
Name: golgi autoantigen, golgin subfamily a, 4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Fam91a1
Name: family with sequence similarity 91, member A1
Synonyms: D15Ertd621e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 210998
VEGA: 15
Homologene: 13388
Cpne1
Name: copine I
Synonyms: 1810028N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 266692
HGNC: HGNC:2314
Homologene: 36501
Tjap1
Name: tight junction associated protein 1
Synonyms: 0610041D19Rik, Pilt, Tjp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74094
VEGA: 17
Homologene: 12534
Copa
Name: coatomer protein complex subunit alpha
Synonyms: xenin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12847
HGNC: HGNC:2230
Homologene: 3218
Cit
Name: citron
Synonyms: CRIK-SK, Cit-k, citron kinase, C030025P15Rik, citron-N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Aftph
Name: aftiphilin
Synonyms: 9130023F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216549
Homologene: 9764
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Zfp953
Name: zinc finger protein 953
Synonyms: E130120F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 629016
Adam18
Name: a disintegrin and metallopeptidase domain 18
Synonyms: Adam27, Dtgn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13524
HGNC: HGNC:196
Homologene: 74941
Lyar
Name: Ly1 antibody reactive clone
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17089
Homologene: 41200
Khdrbs1
Name: KH domain containing, RNA binding, signal transduction associated 1
Synonyms: p62, Sam68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20218
Homologene: 4781
Xrcc4
Name: X-ray repair complementing defective repair in Chinese hamster cells 4
Synonyms: 2310057B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 108138
Homologene: 2555
Nupl1
Name: nucleoporin like 1
Synonyms: 1700017F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71844
VEGA: 14
Homologene: 40924
Shld1
Name: shieldin complex subunit 1
Synonyms: 1110034G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 73747
Homologene: 51865
Slc25a36
Name: solute carrier family 25, member 36
Synonyms: C330005L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 192287
Homologene: 10039
Cmtr1
Name: cap methyltransferase 1
Synonyms: 1300018I05Rik, Ftsjd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74157
Homologene: 9003
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: auxilin, 2810027M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72685
Homologene: 8865
Itga2
Name: integrin alpha 2
Synonyms: CD49B, VLA-2 receptor, alpha 2 subunit, DX5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16398
VEGA: 13
HGNC: HGNC:6137
Homologene: 1662
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh4, Zfh-4, C130041O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80892
Homologene: 23477
Tab2
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2
Synonyms: 1110030N06Rik, Map3k7ip2, A530078N03Rik, Tak1 binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68652
Homologene: 9019
Adamts6
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
Synonyms: A930019D11Rik, b2b1879.1Clo, ADAM-TS6, b2b2029Clo, b2b2182Clo, b2b2187.1Clo, b2b2228Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 108154
VEGA: 13
HGNC: HGNC:222
Homologene: 82573
Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
Synonyms: RGL, GM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 140491
HGNC: HGNC:9291
Homologene: 48124
Fam135b
Name: family with sequence similarity 135, member B
Synonyms: 1700010C24Rik, A830008O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70363
VEGA: 15
Homologene: 66605
Klk1
Name: kallikrein 1
Synonyms: 0610007D04Rik, Klk6, mGk-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16612
Homologene: 68141
Olfr1502
Name: olfactory receptor 1502
Synonyms: MOR211-1, GA_x6K02T2RE5P-4193992-4194942
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258793
Homologene: 17394
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Slc66a1
Name: solute carrier family 66 member 1
Synonyms: Pqlc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 212555
Homologene: 56784
Ccdc146
Name: coiled-coil domain containing 146
Synonyms: 4930528G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75172
Homologene: 67159
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: 2610014H22Rik, Wbp7, Mll2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75410
Homologene: 22838
Irs2
Name: insulin receptor substrate 2
Synonyms: Irs-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 384783
HGNC: HGNC:6126
Homologene: 2778
Pde8a
Name: phosphodiesterase 8A
Synonyms: Pde8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18584
HGNC: HGNC:8793
Homologene: 1957
Gpat2
Name: glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms: A530057A03Rik, Gpat2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 215456
Homologene: 19037
Mat1a
Name: methionine adenosyltransferase I, alpha
Synonyms: MATA1, SAMS1, AdoMet, SAMS, Ams, MAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 11720
VEGA: 14
HGNC: HGNC:6903
Homologene: 68057
Cd226
Name: CD226 antigen
Synonyms: DNAM-1, Pta1, DNAM1, TLiSA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225825
Homologene: 4787
Rad51ap2
Name: RAD51 associated protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 209550
VEGA: 12
Homologene: 85245
Slc24a4
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
Synonyms: A930002M03Rik, NCKX4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238384
Homologene: 17798
Hdgfl1
Name: HDGF like 1
Synonyms: HRP-1, Pwwp1, Hdgfrp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15192
Homologene: 56406
Ube4a
Name: ubiquitination factor E4A
Synonyms: 4732444G18Rik, UFD2b, 9930123J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 140630
Homologene: 3517
Mrc2
Name: mannose receptor, C type 2
Synonyms: Endo180, novel lectin, uPARAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17534
Homologene: 4408
Ren1
Name: renin 1 structural
Synonyms: Ren-A, Rn-1, Ren, Ren1c, Rnr, Ren-1, Ren1d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19701
HGNC: HGNC:9958
Homologene: 20151
Shox2
Name: short stature homeobox 2
Synonyms: Og12x, 6330543G17Rik, Prx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20429
Homologene: 68535
Slco6d1
Name: solute carrier organic anion transporter family, member 6d1
Synonyms: 4921511I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70866
Homologene: 86643
Skint1
Name: selection and upkeep of intraepithelial T cells 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 639781
Homologene: 87538
Bivm
Name: basic, immunoglobulin-like variable motif containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 246229
Homologene: 9783
Tst
Name: thiosulfate sulfurtransferase, mitochondrial
Synonyms: Rhodanese
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22117
VEGA: 15
Homologene: 37759
C2cd2
Name: C2 calcium-dependent domain containing 2
Synonyms: ORF25, 5830404H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207781
VEGA: 16
HGNC: HGNC:1266
Homologene: 18368
Timm44
Name: translocase of inner mitochondrial membrane 44
Synonyms: Mimt44, D8Ertd118e, 0710005E20Rik, Tim44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21856
Homologene: 4631
Trabd2b
Name: TraB domain containing 2B
Synonyms: Hkat, Gm12824
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 666048
Homologene: 85034
Pramel12
Name: PRAME like 12
Synonyms: 4732496O08Rik, Pramef8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242736
Homologene: 128393
Septin14
Name: septin 14
Synonyms: Sept14, 1700016K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74222
Homologene: 87501
Olfr294
Name: olfactory receptor 294
Synonyms: GA_x6K02T2NHDJ-9504525-9505532, MOR219-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257904
Slc35f1
Name: solute carrier family 35, member F1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215085
Homologene: 33552
Gm9945
Name: predicted gene 9945
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Tas2r130
Name: taste receptor, type 2, member 130
Synonyms: T2R30, mt2r42, Tas2r30, STC 7-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387355
Homologene: 41536
Ifi27l2b
Name: interferon, alpha-inducible protein 27 like 2B
Synonyms: 1810023F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217845
Homologene: 137395
Nectin4
Name: nectin cell adhesion molecule 4
Synonyms: Prr4, nectin 4, 1200017F15Rik, Pvrl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71740
Homologene: 32744
Tarbp2
Name: TARBP2, RISC loading complex RNA binding subunit
Synonyms: Prbp, TRBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 21357
Homologene: 7562
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 44,129,615 bp
  • T to A, chromosome 1 at 45,337,512 bp
  • G to A, chromosome 1 at 98,446,828 bp
  • G to A, chromosome 1 at 133,360,124 bp
  • A to G, chromosome 1 at 171,380,208 bp
  • A to G, chromosome 1 at 172,119,901 bp
  • T to A, chromosome 2 at 52,249,511 bp
  • G to A, chromosome 2 at 127,428,291 bp
  • T to A, chromosome 2 at 132,750,527 bp
  • G to T, chromosome 2 at 156,073,971 bp
  • C to T, chromosome 3 at 5,403,358 bp
  • T to C, chromosome 3 at 66,978,359 bp
  • T to A, chromosome 4 at 101,612,930 bp
  • T to C, chromosome 4 at 112,025,481 bp
  • A to T, chromosome 4 at 114,599,903 bp
  • T to C, chromosome 4 at 129,720,747 bp
  • A to G, chromosome 4 at 139,302,499 bp
  • A to G, chromosome 4 at 143,417,903 bp
  • T to C, chromosome 5 at 21,305,528 bp
  • T to A, chromosome 5 at 38,227,932 bp
  • A to G, chromosome 5 at 115,987,046 bp
  • A to T, chromosome 5 at 129,699,035 bp
  • A to T, chromosome 6 at 14,719,378 bp
  • C to A, chromosome 6 at 85,667,963 bp
  • A to T, chromosome 6 at 131,630,073 bp
  • T to C, chromosome 7 at 30,576,068 bp
  • T to C, chromosome 7 at 44,220,737 bp
  • C to T, chromosome 7 at 55,928,284 bp
  • C to A, chromosome 7 at 81,317,422 bp
  • A to T, chromosome 7 at 86,616,187 bp
  • A to C, chromosome 8 at 4,266,588 bp
  • C to A, chromosome 8 at 11,005,352 bp
  • A to G, chromosome 8 at 24,637,141 bp
  • A to T, chromosome 9 at 44,948,137 bp
  • A to T, chromosome 9 at 97,079,071 bp
  • A to G, chromosome 9 at 118,556,612 bp
  • G to A, chromosome 10 at 7,907,481 bp
  • A to G, chromosome 10 at 53,073,534 bp
  • T to C, chromosome 10 at 125,994,441 bp
  • G to T, chromosome 11 at 20,725,797 bp
  • C to T, chromosome 11 at 21,306,394 bp
  • C to T, chromosome 11 at 53,480,336 bp
  • A to G, chromosome 11 at 102,197,136 bp
  • G to A, chromosome 11 at 105,348,431 bp
  • A to G, chromosome 12 at 11,457,067 bp
  • T to A, chromosome 12 at 102,222,051 bp
  • T to A, chromosome 12 at 103,455,824 bp
  • G to T, chromosome 13 at 26,769,749 bp
  • A to G, chromosome 13 at 67,347,939 bp
  • T to C, chromosome 13 at 90,062,188 bp
  • T to A, chromosome 13 at 104,413,819 bp
  • A to T, chromosome 13 at 114,881,042 bp
  • T to A, chromosome 14 at 41,122,512 bp
  • A to T, chromosome 14 at 60,232,660 bp
  • T to A, chromosome 15 at 58,450,600 bp
  • C to T, chromosome 15 at 71,463,911 bp
  • T to C, chromosome 15 at 78,405,833 bp
  • A to G, chromosome 15 at 102,518,557 bp
  • G to A, chromosome 16 at 97,922,086 bp
  • T to A, chromosome 17 at 29,681,980 bp
  • A to G, chromosome 17 at 45,666,154 bp
  • A to T, chromosome 17 at 46,260,095 bp
  • A to G, chromosome 18 at 89,207,327 bp
  • A to G, chromosome 19 at 13,862,309 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2518 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040422-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.