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Strain Name:
C57BL/6J-MtgxR2849Btlr/Mmmh
Stock Number:
040442-MU
Citation ID:
RRID:MMRRC_040442-MU
Other Names:
R2849 (G1), C57BL/6J-MtgxR2849Btlr
Major Collection:

Strain Information

Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18193
VEGA: 13
Homologene: 32543
Fis1
Name: fission, mitochondrial 1
Synonyms: 2010003O14Rik, Ttc11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66437
Homologene: 41099
Cers2
Name: ceramide synthase 2
Synonyms: Trh3, 0610013I17Rik, CerS2, Lass2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76893
Homologene: 39581
Ptpra
Name: protein tyrosine phosphatase receptor type A
Synonyms: RPTRalpha, PTPalpha, PTP[a], Ptpa, RPTPalpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19262
HGNC: HGNC:9664
Homologene: 20621
Syt3
Name: synaptotagmin III
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20981
Homologene: 9617
Osbpl8
Name: oxysterol binding protein-like 8
Synonyms: ORP-8, D330025H14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237542
VEGA: 10
Homologene: 68813
Fbxo42
Name: F-box protein 42
Synonyms: 6720460I06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 213499
Homologene: 16234
Smpd4
Name: sphingomyelin phosphodiesterase 4
Synonyms: neutral membrane (neutral sphingomyelinase-3), 4122402O22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77626
Homologene: 9813
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, D430004I05Rik, A130082H20Rik, TIF1alpha
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21848
Homologene: 20830
Gtf2ird1
Name: general transcription factor II I repeat domain-containing 1
Synonyms: WBSCR11, Cream1, GTF3, MusTRD1, binding factor for early enhancer, BEN, ESTM9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57080
HGNC: HGNC:4661
Homologene: 4158
Als2
Name: alsin Rho guanine nucleotide exchange factor
Synonyms: 3222402C23Rik, Als2cr6, 9430073A21Rik, Alsin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74018
HGNC: HGNC:443
Homologene: 23264
Lfng
Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms: lunatic fringe
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16848
HGNC: HGNC:6560
Homologene: 22475
Dclk2
Name: doublecortin-like kinase 2
Synonyms: 6330415M09Rik, Click-II, Dcamkl2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70762
Homologene: 69431
Ap3d1
Name: adaptor-related protein complex 3, delta 1 subunit
Synonyms: mBLVR1, Bolvr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11776
VEGA: 10
HGNC: HGNC:568
Homologene: 2926
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 30054
VEGA: 14
Homologene: 23727
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: mGluR7, Gpr1g, E130018M02Rik, 6330570A01Rik, mGlu7a receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Fbxo32
Name: F-box protein 32
Synonyms: 4833442G10Rik, ATROGIN1, MAFbx, atrogin-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67731
VEGA: 15
Homologene: 12182
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665775
Homologene: 45109
Fbf1
Name: Fas binding factor 1
Synonyms: 1110033G01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217335
Homologene: 16531
Abca17
Name: ATP-binding cassette, sub-family A member 17
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381072
Homologene: 86807
Crispld2
Name: cysteine-rich secretory protein LCCL domain containing 2
Synonyms: 1810049K24Rik, coffeecrisp, Lgl1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78892
Homologene: 41792
Lrrtm3
Name: leucine rich repeat transmembrane neuronal 3
Synonyms: 9630044H04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216028
Homologene: 37110
Lypd6
Name: LY6/PLAUR domain containing 6
Synonyms: E130115E03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320343
Homologene: 18555
Celf2
Name: CUGBP, Elav-like family member 2
Synonyms: Napor-2, ETR-3, B230345P09Rik, Cugbp2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14007
HGNC: HGNC:2550
Homologene: 4783
Deaf1
Name: DEAF1, transcription factor
Synonyms: C230009B13Rik, NUDR, suppressin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54006
Homologene: 9647
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Fyco1
Name: FYVE and coiled-coil domain containing 1
Synonyms: Mem2, 2810409M01Rik, ZFYVE7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17281
Homologene: 11561
Aldh9a1
Name: aldehyde dehydrogenase 9, subfamily A1
Synonyms: TMABA-DH, ESTM40
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56752
HGNC: HGNC:412
Homologene: 55483
Poteg
Name: POTE ankyrin domain family, member G
Synonyms: 4930456F22Rik, 4921537P18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70952
Homologene: 134158
Cimap1a
Name: ciliary microtubule associated protein 1A
Synonyms: SHIPPO1, 1700011O04Rik, Odf3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69287
Homologene: 12306
Abca8a
Name: ATP-binding cassette, sub-family A member 8a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Cfap251
Name: cilia and flagella associated protein 251
Synonyms: 4930415N18Rik, 4933428F06Rik, Wdr66
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269701
Homologene: 16964
Trnau1ap
Name: tRNA selenocysteine 1 associated protein 1
Synonyms: 1110007F05Rik, SECp43, Trspap1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71787
Homologene: 49509
Ksr1
Name: kinase suppressor of ras 1
Synonyms: D11Bhm183e, B-KSR1, D11Bhm184e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16706
HGNC: HGNC:6465
Homologene: 8410
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Ppp4r4
Name: protein phosphatase 4, regulatory subunit 4
Synonyms: 8430415E04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74521
Homologene: 12571
Atxn1
Name: ataxin 1
Synonyms: Atx1, Sca1, 2900016G23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20238
VEGA: 13
Homologene: 281
Slc6a15
Name: solute carrier family 6 (neurotransmitter transporter), member 15
Synonyms: v7-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103098
VEGA: 10
Homologene: 18163
Rnf43
Name: ring finger protein 43
Synonyms: 4732452J19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207742
Homologene: 37742
Vmn1r181
Name: vomeronasal 1 receptor 181
Synonyms: V1rd20
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404289
Homologene: 104166
Adcy7
Name: adenylate cyclase 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11513
HGNC: HGNC:238
Homologene: 866
Slc2a4
Name: solute carrier family 2 (facilitated glucose transporter), member 4
Synonyms: Glut-4, Glut4, twgy
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20528
Homologene: 74381
Slco6d1
Name: solute carrier organic anion transporter family, member 6d1
Synonyms: 4921511I05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70866
Homologene: 86643
Begain
Name: brain-enriched guanylate kinase-associated
Synonyms: LOC380785
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380785
Homologene: 10829
Vmn1r82
Name: vomeronasal 1 receptor 82
Synonyms: V1rg12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171268
Msl3l2
Name: MSL3 like 2
Synonyms: 1700060H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 73390
VEGA: 10
Homologene: 128448
Zw10
Name: zw10 kinetochore protein
Synonyms: MmZw10, 6330566F14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26951
VEGA: 9
Homologene: 37959
Tle6
Name: transducin-like enhancer of split 6
Synonyms: Grg6, 1810057E06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 114606
Homologene: 11701
Or52r1c
Name: olfactory receptor family 52 subfamily R member 1C
Synonyms: GA_x6K02T2PBJ9-5796876-5797820, MOR30-2, Olfr584
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259056
Zfp964
Name: zinc finger protein 964
Synonyms: Gm7187
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 636741
Homologene: 130114
Or1e1
Name: olfactory receptor family 1 subfamily E member 1
Synonyms: MTPCR55, MTPCR06, Olfr21, GA_x6K02T2P1NL-3514066-3515010, MOR135-11, Olfr20
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258925
Homologene: 128054
Nudt22
Name: nudix hydrolase 22
Synonyms: 0610006K04Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 22
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68323
Homologene: 12261
Zfp607b
Name: zinc finger protein 607B
Synonyms: C030039L03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 112415
Homologene: 134321
Tox3
Name: TOX high mobility group box family member 3
Synonyms: CAGF9, Tnrc9, 500-9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244579
Homologene: 18257
Josd2
Name: Josephin domain containing 2
Synonyms: 1110007C05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66124
Homologene: 26696
Cstdc5
Name: cystatin domain containing 5
Synonyms: BC100530
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 100034684
HGNC: HGNC:2481
Homologene: 104045
Otop3
Name: otopetrin 3
Synonyms: 2310011E08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69602
Homologene: 26091
Or4g7
Name: olfactory receptor family 4 subfamily G member 7
Synonyms: GA_x6K02T2Q125-72530279-72531217, MOR245-9, Olfr1288
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258395
Homologene: 88360
Boll
Name: boule homolog, RNA binding protein
Synonyms: 4930597B14Rik, 4930554P13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75388
Homologene: 33650
Chst13
Name: carbohydrate sulfotransferase 13
Synonyms: Chst13, 1110067M19Rik, C4ST-3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71797
Homologene: 44360
Agpat2
Name: 1-acylglycerol-3-phosphate O-acyltransferase 2
Synonyms: LPAAT-beta, BSCL1, 2510002J07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67512
HGNC: HGNC:325
Homologene: 4678
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 55,346,373 bp
  • G to A, chromosome 1 at 59,206,538 bp
  • C to T, chromosome 1 at 98,466,716 bp
  • G to T, chromosome 1 at 150,563,599 bp
  • G to A, chromosome 1 at 167,352,628 bp
  • T to C, chromosome 2 at 6,604,125 bp
  • A to G, chromosome 2 at 26,597,239 bp
  • C to T, chromosome 2 at 50,165,652 bp
  • T to C, chromosome 2 at 111,479,354 bp
  • C to A, chromosome 2 at 130,544,999 bp
  • A to G, chromosome 3 at 86,793,223 bp
  • T to C, chromosome 3 at 95,322,459 bp
  • C to A, chromosome 4 at 132,321,734 bp
  • T to A, chromosome 4 at 141,200,510 bp
  • T to C, chromosome 5 at 41,838,076 bp
  • T to C, chromosome 5 at 115,249,112 bp
  • T to C, chromosome 5 at 123,288,823 bp
  • G to A, chromosome 5 at 134,359,007 bp
  • T to C, chromosome 5 at 136,963,117 bp
  • T to A, chromosome 5 at 140,611,867 bp
  • T to C, chromosome 6 at 32,185,532 bp
  • T to A, chromosome 6 at 37,956,453 bp
  • T to C, chromosome 6 at 90,309,158 bp
  • G to T, chromosome 6 at 110,646,348 bp
  • T to C, chromosome 7 at 12,305,406 bp
  • G to T, chromosome 7 at 23,984,518 bp
  • G to A, chromosome 7 at 27,702,394 bp
  • G to A, chromosome 7 at 42,820,407 bp
  • G to A, chromosome 7 at 44,393,442 bp
  • A to G, chromosome 7 at 44,468,973 bp
  • A to T, chromosome 7 at 103,086,112 bp
  • A to G, chromosome 7 at 140,849,269 bp
  • T to C, chromosome 7 at 141,314,454 bp
  • A to T, chromosome 8 at 27,481,676 bp
  • G to C, chromosome 8 at 69,663,854 bp
  • A to G, chromosome 8 at 88,327,393 bp
  • G to A, chromosome 8 at 90,248,390 bp
  • C to A, chromosome 8 at 120,015,259 bp
  • A to G, chromosome 8 at 125,760,927 bp
  • A to G, chromosome 9 at 49,057,641 bp
  • A to T, chromosome 9 at 123,834,826 bp
  • T to C, chromosome 10 at 56,115,442 bp
  • T to C, chromosome 10 at 64,089,031 bp
  • G to C, chromosome 10 at 80,741,908 bp
  • T to A, chromosome 10 at 81,594,401 bp
  • C to A, chromosome 10 at 103,404,691 bp
  • T to A, chromosome 10 at 111,269,436 bp
  • C to T, chromosome 10 at 127,542,296 bp
  • T to A, chromosome 11 at 69,946,171 bp
  • G to A, chromosome 11 at 73,353,745 bp
  • C to T, chromosome 11 at 79,020,822 bp
  • T to A, chromosome 11 at 87,732,267 bp
  • T to C, chromosome 11 at 110,042,105 bp
  • T to C, chromosome 11 at 115,344,558 bp
  • C to T, chromosome 11 at 116,157,688 bp
  • T to C, chromosome 12 at 103,606,933 bp
  • T to A, chromosome 12 at 109,033,118 bp
  • A to T, chromosome 13 at 45,566,699 bp
  • A to G, chromosome 13 at 55,213,692 bp
  • G to T, chromosome 14 at 56,504,049 bp
  • C to T, chromosome 15 at 58,207,972 bp
  • A to G, chromosome 16 at 17,642,212 bp
  • T to A, chromosome 16 at 36,367,452 bp
  • G to C, chromosome 17 at 24,289,507 bp
  • A to T, chromosome 19 at 6,993,484 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2849 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040442-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.