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Strain Name:
C57BL/6J-MtgxR2860Btlr/Mmmh
Stock Number:
040450-MU
Citation ID:
RRID:MMRRC_040450-MU
Other Names:
R2860 (G1), C57BL/6J-MtgxR2860Btlr
Major Collection:

Strain Information

Ano1
Name: anoctamin 1, calcium activated chloride channel
Synonyms: Tmem16a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101772
Homologene: 75079
Ctage5
Name: CTAGE family, member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Gab1
Name: growth factor receptor bound protein 2-associated protein 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14388
HGNC: HGNC:4066
Homologene: 1542
Cap1
Name: cyclase associated actin cytoskeleton regulatory protein 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12331
Homologene: 74572
Dennd10
Name: DENN domain containing 10
Synonyms: 1810055E12Rik, Fam45a
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67894
Homologene: 10217
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: chromatin remodeling factor, 8030453L17Rik, E430018P19Rik, KMT2H
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192195
Homologene: 10225
Pyroxd1
Name: pyridine nucleotide-disulphide oxidoreductase domain 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232491
Homologene: 11758
Apoe
Name: apolipoprotein E
Synonyms: Apoe
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11816
HGNC: HGNC:613
Homologene: 30951
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Nmnat2
Name: nicotinamide nucleotide adenylyltransferase 2
Synonyms: PNAT1, D030041I09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226518
Homologene: 75037
Itgb3bp
Name: integrin beta 3 binding protein (beta3-endonexin)
Synonyms: 4930471O16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67733
HGNC: HGNC:6157
Homologene: 8617
Gbx2
Name: gastrulation brain homeobox 2
Synonyms: MMoxA, Gbx-2, Stra7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14472
HGNC: HGNC:4186
Homologene: 1138
Pum3
Name: pumilio RNA-binding family member 3
Synonyms: 1110069H02Rik, D19Bwg1357e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 52874
VEGA: 19
Homologene: 5762
Itsn2
Name: intersectin 2
Synonyms: Sh3p18, Ese2, Eh domain, SH3 domain regulator of endocytosis 2, Sh3d1B
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Asph
Name: aspartate-beta-hydroxylase
Synonyms: cI-37, 2310005F16Rik, aspartyl beta-hydroxylase, calsequestrin-binding protein, Junctin, jumbug, BAH, 3110001L23Rik, junctate
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 65973
HGNC: HGNC:757
Homologene: 20910
Rnf41
Name: ring finger protein 41
Synonyms: 4930511A05Rik, FLRF, 4933415P08Rik, 2210404G21Rik, D10Ertd722e, Nrdp1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67588
VEGA: 10
Homologene: 4226
Btg3
Name: BTG anti-proliferation factor 3
Synonyms: tob5, ANA
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12228
HGNC: HGNC:1132
Homologene: 4953
Snx13
Name: sorting nexin 13
Synonyms: RGS-PX1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217463
VEGA: 12
Homologene: 41011
Gpn1
Name: GPN-loop GTPase 1
Synonyms: 2410004J02Rik, Xab1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74254
Homologene: 5257
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Mrgbp
Name: MRG/MORF4L binding protein
Synonyms: 1600027N09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73247
Homologene: 10104
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Vmn2r6
Name: vomeronasal 2, receptor 6
Synonyms: EG620718, EG667069
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 667069
Homologene: 129754
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: RIM1, RIM1a, C030033M19Rik, RIM1alpha
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116837
Homologene: 128399
Tshz1
Name: teashirt zinc finger family member 1
Synonyms: NY-CO-33, D18Bwg1409e, 5730407I04Rik, Mtsh1, Sdccag33, teashirt1, Tsh1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 110796
Homologene: 4227
Pitpnm2
Name: phosphatidylinositol transfer protein, membrane-associated 2
Synonyms: RDGBA2, NIR3, Rdgb2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19679
Homologene: 7915
Capn2
Name: calpain 2
Synonyms: m-calpain, Capa-2, Capa2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12334
HGNC: HGNC:1479
Homologene: 1326
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268527
Homologene: 8780
Col22a1
Name: collagen, type XXII, alpha 1
Synonyms: C80743, 2310067L16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69700
Homologene: 43567
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: CPS, CPSase I, 4732433M03Rik, D1Ucla3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Tex14
Name: testis expressed gene 14 intercellular bridge forming factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83560
Homologene: 12838
C2
Name: complement C2
Synonyms: classical-complement pathway C3/C5 convertase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12263
HGNC: HGNC:1248
Homologene: 45
Or6k6
Name: olfactory receptor family 6 subfamily K member 6
Synonyms: GA_x6K02T2P20D-21053942-21054499, GA_x6K02T2LER7-6-623, GA_x6K02T02K39-452-3, MOR105-4, Olfr425, Olfr244, Olfr231
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 404222
Homologene: 17363
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Med14
Name: mediator complex subunit 14
Synonyms: ORF1, LOC270579, 9930001L01Rik, Trap170, Crsp2, ENSMUSG00000073278
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 26896
HGNC: HGNC:2370
Homologene: 22082
Xirp1
Name: xin actin-binding repeat containing 1
Synonyms: Xin, mXin alpha, Cmya1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22437
VEGA: 9
Homologene: 7998
Cyp2c38
Name: cytochrome P450, family 2, subfamily c, polypeptide 38
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13097
Homologene: 117948
Cd38
Name: CD38 antigen
Synonyms: Cd38-rs1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12494
HGNC: HGNC:1667
Homologene: 1345
Gnpda2
Name: glucosamine-6-phosphate deaminase 2
Synonyms: 4921523I18Rik, Gnp2, 4933412A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67980
Homologene: 12381
Actg1
Name: actin, gamma, cytoplasmic 1
Synonyms: E51, Actl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11465
HGNC: HGNC:144
Homologene: 74402
Cd8b1
Name: CD8 subunit beta 1
Synonyms: Ly-C, Ly-3, Lyt-3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12526
Homologene: 3621
Krtap2-22
Name: keratin associated protein 2-22
Synonyms: Gm11938
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100041412
Homologene: 41961
Or4f56
Name: olfactory receptor family 4 subfamily F member 56
Synonyms: GA_x6K02T2Q125-72930843-72929905, MOR245-8, Olfr1305
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258396
Homologene: 74056
Kdf1
Name: keratinocyte differentiation factor 1
Synonyms: 1810019J16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69073
Homologene: 17563
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 22,432,976 bp
  • A to T, chromosome 1 at 67,166,375 bp
  • C to T, chromosome 1 at 89,929,131 bp
  • G to A, chromosome 1 at 153,112,425 bp
  • A to T, chromosome 1 at 164,184,964 bp
  • A to G, chromosome 1 at 174,117,732 bp
  • A to T, chromosome 1 at 182,472,920 bp
  • G to T, chromosome 2 at 111,873,473 bp
  • T to C, chromosome 2 at 180,187,247 bp
  • G to A, chromosome 2 at 180,583,410 bp
  • G to A, chromosome 3 at 36,965,849 bp
  • G to T, chromosome 3 at 64,547,339 bp
  • T to C, chromosome 3 at 89,054,478 bp
  • T to C, chromosome 4 at 9,598,277 bp
  • T to C, chromosome 4 at 99,802,088 bp
  • A to T, chromosome 4 at 122,864,725 bp
  • G to A, chromosome 4 at 133,528,541 bp
  • A to G, chromosome 5 at 31,497,320 bp
  • A to G, chromosome 5 at 43,901,433 bp
  • A to G, chromosome 5 at 69,578,164 bp
  • G to C, chromosome 5 at 124,121,437 bp
  • A to G, chromosome 6 at 71,334,101 bp
  • G to A, chromosome 6 at 142,359,173 bp
  • T to C, chromosome 7 at 19,697,554 bp
  • A to G, chromosome 7 at 28,094,214 bp
  • C to T, chromosome 7 at 144,590,012 bp
  • T to C, chromosome 8 at 80,784,753 bp
  • A to G, chromosome 9 at 120,018,378 bp
  • T to C, chromosome 10 at 128,438,154 bp
  • T to G, chromosome 11 at 87,474,417 bp
  • C to A, chromosome 11 at 99,603,146 bp
  • T to C, chromosome 11 at 120,346,801 bp
  • C to A, chromosome 12 at 4,700,315 bp
  • A to G, chromosome 12 at 16,711,745 bp
  • T to A, chromosome 12 at 35,138,117 bp
  • A to G, chromosome 12 at 59,154,410 bp
  • A to C, chromosome 15 at 44,540,871 bp
  • A to G, chromosome 15 at 71,815,943 bp
  • A to G, chromosome 16 at 78,364,980 bp
  • T to C, chromosome 17 at 34,863,878 bp
  • G to T, chromosome 18 at 84,014,980 bp
  • A to T, chromosome 19 at 27,420,125 bp
  • G to A, chromosome 19 at 39,460,694 bp
  • T to C, chromosome 19 at 60,814,794 bp
  • A to G, chromosome X at 12,719,697 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2860 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040450-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.