Strain Name:
C57BL/6J-MtgxR2861Btlr/Mmmh
Stock Number:
040451-MU
Citation ID:
RRID:MMRRC_040451-MU
Other Names:
R2861 (G1), C57BL/6J-MtgxR2861Btlr
Major Collection:

Gene Information

Pkd1
Name: polycystin 1, transient receptor poteintial channel interacting
Synonyms: PC1, PC-1, polycystin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Ctage5
Name: CTAGE family, member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
Ppp6r3
Name: protein phosphatase 6, regulatory subunit 3
Synonyms: Saps3, 9130026N02Rik, D19Bwg1430e, 4930528G08Rik, Pp6r3, Pptcs3, D19Ertd703e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 52036
VEGA: 19
HGNC: HGNC:1173
Homologene: 115911
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Cap1
Name: CAP, adenylate cyclase-associated protein 1 (yeast)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12331
Homologene: 74572
Fam45a
Name: family with sequence similarity 45, member A
Synonyms: 1810055E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 67894
Homologene: 10217
Gabpb1
Name: GA repeat binding protein, beta 1
Synonyms: GABPB1-2, E4Tf1B, NRF2B1, GABPB1-1, E4TF1-53, E4TF1-47, NRF2B2, E4TF1, BABPB2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14391
HGNC: HGNC:4074
Homologene: 7723
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 20191
VEGA: 13
Homologene: 37423
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: E430018P19Rik, 8030453L17Rik, KMT2H, chromatin remodeling factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 192195
Homologene: 10225
Nmnat2
Name: nicotinamide nucleotide adenylyltransferase 2
Synonyms: PNAT1, D030041I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226518
Homologene: 75037
Gbx2
Name: gastrulation brain homeobox 2
Synonyms: Stra7, Gbx-2, MMoxA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14472
HGNC: HGNC:4186
Homologene: 1138
Itsn2
Name: intersectin 2
Synonyms: Ese2, Eh domain, SH3 domain regulator of endocytosis 2, Sh3d1B, Sh3p18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Rnf41
Name: ring finger protein 41
Synonyms: 4930511A05Rik, 4933415P08Rik, Nrdp1, D10Ertd722e, FLRF, 2210404G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 67588
VEGA: 10
Homologene: 4226
Opn4
Name: opsin 4 (melanopsin)
Synonyms: 1110007J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 30044
VEGA: 14
Homologene: 69152
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 268379
Homologene: 27991
Snx13
Name: sorting nexin 13
Synonyms: RGS-PX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217463
VEGA: 12
Homologene: 41011
F5
Name: coagulation factor V
Synonyms: Cf5, Cf-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Vmn2r6
Name: vomeronasal 2, receptor 6
Synonyms: EG620718, EG667069
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 667069
Homologene: 129754
Abcc9
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Synonyms: SUR2A, SUR2B, Sur2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230622
Homologene: 135888
C4b
Name: complement component 4B (Chido blood group)
Synonyms: C4, Ss
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12268
Homologene: 36030
Vmn2r59
Name: vomeronasal 2, receptor 59
Synonyms: EG628444
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 628444
Homologene: 129683
Capn2
Name: calpain 2
Synonyms: m-calpain, Capa-2, Capa2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12334
HGNC: HGNC:1479
Homologene: 1326
Vmn2r72
Name: vomeronasal 2, receptor 72
Synonyms: Vmn2r72-ps, EG244114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 244114
Homologene: 115466
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 268527
Homologene: 8780
Wiz
Name: widely-interspaced zinc finger motifs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 22404
Homologene: 7997
Olfr231
Name: olfactory receptor 231
Synonyms: GA_x6K02T2LER7-6-623, GA_x6K02T02K39-452-3, GA_x6K02T2P20D-21053942-21054499, MOR105-4, Olfr244, Olfr425
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 404222
Homologene: 17363
Plin4
Name: perilipin 4
Synonyms: S3-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 57435
Homologene: 69311
Ovgp1
Name: oviductal glycoprotein 1
Synonyms: OGP, Chit5, MOGP, muc9, mucin 9, oviductin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12659
HGNC: HGNC:8524
Homologene: 74442
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 628185
Homologene: 86604
Med14
Name: mediator complex subunit 14
Synonyms: LOC270579, ORF1, 9930001L01Rik, Trap170, ENSMUSG00000073278, Crsp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 26896
HGNC: HGNC:2370
Homologene: 22082
Xirp1
Name: xin actin-binding repeat containing 1
Synonyms: mXin alpha, Cmya1, Xin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 22437
VEGA: 9
Homologene: 7998
Cyp3a16
Name: cytochrome P450, family 3, subfamily a, polypeptide 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 13114
HGNC: HGNC:2638
Homologene: 133568
Mlip
Name: muscular LMNA-interacting protein
Synonyms: cardiac ISL1-interacting protein, CIP, 2310046A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 69642
Homologene: 90445
Olfr490
Name: olfactory receptor 490
Synonyms: MOR204-17, GA_x6K02T2PBJ9-10617173-10616229
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258491
Homologene: 73955
Cyp2c38
Name: cytochrome P450, family 2, subfamily c, polypeptide 38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 13097
HGNC: HGNC:2622
Homologene: 117948
Hsd3b7
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101502
Homologene: 41617
Il18r1
Name: interleukin 18 receptor 1
Synonyms: Il1rrp, Il18ralpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16182
HGNC: HGNC:5988
Homologene: 2861
Parp16
Name: poly (ADP-ribose) polymerase family, member 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 214424
VEGA: 9
Homologene: 9878
Abcd1
Name: ATP-binding cassette, sub-family D (ALD), member 1
Synonyms: ALDP, Aldgh, Ald
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 11666
HGNC: HGNC:61
Homologene: 55426
Sri
Name: sorcin
Synonyms: 2900070H08Rik, 2210417O06Rik, Sor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 109552
Homologene: 37736
Pwwp3b
Name: PWWP domain containing 3B
Synonyms: Mum1l1, 9430086K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 245631
Homologene: 51851
Kcnn1
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
Synonyms: SK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 84036
HGNC: HGNC:6290
Homologene: 37595
Rnf113a1
Name: ring finger protein 113A1
Synonyms: 2810428C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 69942
Homologene: 133822
Ang
Name: angiogenin, ribonuclease, RNase A family, 5
Synonyms: Rnase5a, Ang1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 11727
VEGA: 14
HGNC: HGNC:483
Homologene: 74385
Olfr715b
Name: olfactory receptor 715B
Synonyms: EG384732, Gm10081
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 384732
HGNC: HGNC:8244
Homologene: 81541
Inka1
Name: inka box actin regulator 1
Synonyms: Inka1, 6230427J02Rik, Fam212a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 68176
Homologene: 19818
Maged1
Name: melanoma antigen, family D, 1
Synonyms: MAGE-D1, Dlxin-1, Nrage, 5430405L04Rik, DXBwg1492e, 2810433C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 94275
HGNC: HGNC:6813
Homologene: 5077
Slc25a10
Name: solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
Synonyms: Dic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 27376
Homologene: 6519
Kdf1
Name: keratinocyte differentiation factor 1
Synonyms: 1810019J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 69073
Homologene: 17563
Vegfd
Name: vascular endothelial growth factor D
Synonyms: Figf, VEGF-D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 14205
HGNC: HGNC:3708
Homologene: 3288
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 40,498,557 bp
  • C to T, chromosome 1 at 89,929,131 bp
  • G to A, chromosome 1 at 153,112,425 bp
  • A to T, chromosome 1 at 164,184,964 bp
  • A to G, chromosome 1 at 174,117,732 bp
  • A to T, chromosome 1 at 182,472,920 bp
  • A to G, chromosome 2 at 126,653,574 bp
  • G to T, chromosome 3 at 64,547,339 bp
  • T to C, chromosome 3 at 89,054,478 bp
  • T to C, chromosome 3 at 105,986,567 bp
  • A to G, chromosome 4 at 112,883,715 bp
  • A to T, chromosome 4 at 122,864,725 bp
  • G to A, chromosome 4 at 133,528,541 bp
  • A to T, chromosome 5 at 8,067,540 bp
  • A to T, chromosome 5 at 145,455,499 bp
  • C to T, chromosome 6 at 142,626,010 bp
  • A to G, chromosome 7 at 42,047,003 bp
  • A to T, chromosome 7 at 85,750,836 bp
  • T to A, chromosome 7 at 107,106,468 bp
  • A to G, chromosome 7 at 108,286,962 bp
  • T to G, chromosome 7 at 127,802,270 bp
  • T to C, chromosome 8 at 70,846,535 bp
  • G to T, chromosome 9 at 65,233,804 bp
  • A to G, chromosome 9 at 77,190,662 bp
  • A to G, chromosome 9 at 95,874,243 bp
  • T to C, chromosome 9 at 107,984,404 bp
  • T to C, chromosome 9 at 120,019,815 bp
  • T to C, chromosome 10 at 128,438,154 bp
  • A to G, chromosome 11 at 9,309,057 bp
  • G to A, chromosome 11 at 120,495,177 bp
  • C to A, chromosome 12 at 4,700,315 bp
  • A to G, chromosome 12 at 16,711,745 bp
  • T to A, chromosome 12 at 35,138,117 bp
  • A to G, chromosome 12 at 59,154,410 bp
  • T to C, chromosome 13 at 11,593,093 bp
  • A to G, chromosome 14 at 34,593,828 bp
  • G to T, chromosome 14 at 51,101,818 bp
  • T to A, chromosome 17 at 22,603,115 bp
  • C to T, chromosome 17 at 24,565,446 bp
  • G to T, chromosome 17 at 32,361,706 bp
  • T to A, chromosome 17 at 34,734,758 bp
  • T to C, chromosome 17 at 56,106,668 bp
  • G to T, chromosome 18 at 12,453,750 bp
  • A to C, chromosome 19 at 3,521,782 bp
  • G to A, chromosome 19 at 39,460,694 bp
  • T to C, chromosome 19 at 60,814,794 bp
  • A to G, chromosome X at 12,719,697 bp
  • A to G, chromosome X at 37,192,083 bp
  • T to A, chromosome X at 73,737,458 bp
  • G to A, chromosome X at 94,538,924 bp
  • G to A, chromosome X at 139,236,680 bp
  • A to G, chromosome X at 164,385,883 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2861 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040451-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.