Strain Name:
C57BL/6J-MtgxR2865Btlr/Mmmh
Stock Number:
040454-MU
Citation ID:
RRID:MMRRC_040454-MU
Other Names:
R2865 (G1), C57BL/6J-MtgxR2865Btlr
Major Collection:

Gene Information

Slc12a6
Name: solute carrier family 12, member 6
Synonyms: gaxp, KCC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 107723
Homologene: 21069
March4
Name: membrane-associated ring finger (C3HC4) 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 381270
Homologene: 66199
Gria2
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: Glur2, Glur-2, GluR2, GluA2, GluR-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 14800
HGNC: HGNC:4572
Homologene: 20225
Scarb1
Name: scavenger receptor class B, member 1
Synonyms: D5Ertd460e, Hdlq1, Chohd1, Hlb398, SR-BI, SRBI, Chohd1, Cla-1, Cd36l1, Srb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20778
HGNC: HGNC:1664
Homologene: 21132
Ppp4c
Name: protein phosphatase 4, catalytic subunit
Synonyms: 1110002D08Rik, PPX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 56420
HGNC: HGNC:9319
Homologene: 2038
Rtel1
Name: regulator of telomere elongation helicase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 269400
Homologene: 13168
Tead4
Name: TEA domain family member 4
Synonyms: Rtef1, TEAD-4, Tcf13r1, Tefr1a, ETFR-2a, Tef3, TEF-3, Tefr, Etfr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 21679
Homologene: 74463
Ipo11
Name: importin 11
Synonyms: 1700081H05Rik, Ranbp11, E330021B14Rik, 2510001A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 76582
Homologene: 7089
Fxr2
Name: fragile X mental retardation, autosomal homolog 2
Synonyms: Fxr2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 23879
HGNC: HGNC:4024
Homologene: 21014
Ppp1r10
Name: protein phosphatase 1, regulatory subunit 10
Synonyms: 2610025H06Rik, D17Ertd808e, PNUTS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 52040
HGNC: HGNC:9284
Homologene: 2033
Ddx6
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
Synonyms: p54, E230023J21Rik, HLR2, mRCK/P54, 1110001P04Rik, C430015D01Rik, rck
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 13209
VEGA: 9
HGNC: HGNC:2747
Homologene: 3238
Parp4
Name: poly (ADP-ribose) polymerase family, member 4
Synonyms: Adprtl1, VPARP, C030027K23Rik, E230037B21Rik, VAULT3, PH5P, p193
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 328417
HGNC: HGNC:271
Homologene: 124423
Kars
Name: lysyl-tRNA synthetase
Synonyms: D8Ertd698e, D8Wsu108e, LysRS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 85305
HGNC: HGNC:6215
Homologene: 4053
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71722
Homologene: 87637
Rph3a
Name: rabphilin 3A
Synonyms: Doc2 family, 2900002P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19894
Homologene: 7921
Dzip3
Name: DAZ interacting protein 3, zinc finger
Synonyms: 6430549P11Rik, 2A-HUB, 2310047C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224170
Homologene: 8771
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: CI-MPR, M6P/IGF2R, Mpr300, mannose-6-phosphate receptor, cation independent, CD222, IGF-II/CI-MPR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Luc7l
Name: Luc7-like
Synonyms: 1810045C04Rik, 2410018D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 66978
HGNC: HGNC:6723
Homologene: 100558
Fnip1
Name: folliculin interacting protein 1
Synonyms: A730024A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216742
Homologene: 28173
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Ip3r3, tf, Itpr-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Ldb3
Name: LIM domain binding 3
Synonyms: cypher, ZASP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 24131
VEGA: 14
Homologene: 134626
Bmper
Name: BMP-binding endothelial regulator
Synonyms: CV-2, Crim3, Cv2, 3110056H04Rik, crossveinless-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 73230
VEGA: 9
Homologene: 12494
Flt1
Name: FMS-like tyrosine kinase 1
Synonyms: vascular endothelial growth factor receptor-1, VEGFR-1, Flt-1, VEGFR1, sFlt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 14254
HGNC: HGNC:3763
Homologene: 134179
Fhod1
Name: formin homology 2 domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234686
Homologene: 136406
Usp40
Name: ubiquitin specific peptidase 40
Synonyms: B230215L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227334
Homologene: 32400
Myt1l
Name: myelin transcription factor 1-like
Synonyms: 2900093J19Rik, Pmng1, Nztf1, Png-1, 2900046C06Rik, C630034G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 17933
VEGA: 12
HGNC: HGNC:7623
Homologene: 7435
Gm7168
Name: predicted gene 7168
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 635895
Homologene: 133217
Olfr1100
Name: olfactory receptor 1100
Synonyms: GA_x6K02T2Q125-48465387-48464422, MOR206-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258587
Homologene: 34954
A230072I06Rik
Name: RIKEN cDNA A230072I06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 619290
VEGA: 8
Slc2a4
Name: solute carrier family 2 (facilitated glucose transporter), member 4
Synonyms: Glut4, twgy, Glut-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20528
Homologene: 74381
Ifna6
Name: interferon alpha 6
Synonyms: Ifna8, Ifa6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 15969
HGNC: HGNC:5425
Homologene: 68536
Olfr1094
Name: olfactory receptor 1094
Synonyms: GA_x6K02T2Q125-48321457-48322449, MOR179-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258362
Homologene: 133609
Gm5065
Name: predicted gene 5065
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 272350
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 72,452,575 bp
  • G to A, chromosome 1 at 87,949,979 bp
  • A to T, chromosome 2 at 86,828,854 bp
  • A to T, chromosome 2 at 86,978,461 bp
  • G to A, chromosome 2 at 112,347,317 bp
  • T to A, chromosome 2 at 181,349,972 bp
  • C to T, chromosome 3 at 80,732,085 bp
  • G to C, chromosome 4 at 88,827,862 bp
  • C to T, chromosome 5 at 120,947,927 bp
  • C to T, chromosome 5 at 125,289,627 bp
  • T to C, chromosome 5 at 147,594,621 bp
  • A to T, chromosome 6 at 128,248,099 bp
  • G to T, chromosome 7 at 5,359,669 bp
  • T to A, chromosome 7 at 25,273,221 bp
  • A to T, chromosome 7 at 126,792,100 bp
  • A to G, chromosome 8 at 12,279,635 bp
  • T to C, chromosome 8 at 105,332,911 bp
  • A to G, chromosome 8 at 111,998,704 bp
  • A to G, chromosome 9 at 23,483,941 bp
  • G to T, chromosome 9 at 44,614,256 bp
  • T to C, chromosome 11 at 54,502,424 bp
  • T to A, chromosome 11 at 69,639,427 bp
  • G to A, chromosome 11 at 69,946,116 bp
  • A to G, chromosome 12 at 29,910,789 bp
  • A to G, chromosome 13 at 106,891,779 bp
  • T to G, chromosome 14 at 34,529,503 bp
  • C to T, chromosome 14 at 56,613,724 bp
  • T to C, chromosome 16 at 48,927,719 bp
  • T to C, chromosome 17 at 12,686,724 bp
  • A to G, chromosome 17 at 13,949,855 bp
  • C to A, chromosome 17 at 26,266,361 bp
  • T to C, chromosome 17 at 27,091,551 bp
  • A to G, chromosome 17 at 35,928,492 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2865 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040454-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.