Strain Name:
C57BL/6J-MtgxR2867Btlr/Mmmh
Stock Number:
040456-MU
Citation ID:
RRID:MMRRC_040456-MU
Other Names:
R2867 (G1), C57BL/6J-MtgxR2867Btlr
Major Collection:

Gene Information

Birc2
Name: baculoviral IAP repeat-containing 2
Synonyms: MIAP1, cIAP1, HIAP1, mcIAP1, Api1, MIHB, IAP1, cIAP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 11797
HGNC: HGNC:590
Homologene: 900
Kif20b
Name: kinesin family member 20B
Synonyms: Kif20b, Mphosph1, magoo, C330014J10Rik, N-6 kinesin, 33cex
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 240641
VEGA: 19
HGNC: HGNC:7212
Homologene: 9418
Cstf1
Name: cleavage stimulation factor, 3' pre-RNA, subunit 1
Synonyms: 1700057K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 67337
HGNC: HGNC:2483
Homologene: 1012
Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Synonyms: cholesterol 7 alpha hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 13122
HGNC: HGNC:2651
Homologene: 30987
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 20191
VEGA: 13
Homologene: 37423
Adss
Name: adenylosuccinate synthetase, non muscle
Synonyms: AS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 11566
HGNC: HGNC:292
Homologene: 875
Epha6
Name: Eph receptor A6
Synonyms: Hek12, m-ehk2, Ehk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13840
Homologene: 56396
Lctl
Name: lactase-like
Synonyms: E130104I05Rik, KLPH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235435
Homologene: 70710
Mfsd7a
Name: major facilitator superfamily domain containing 7A
Synonyms: 4732482E20Rik, Mfsd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 243197
VEGA: 5
Homologene: 49990
Usp42
Name: ubiquitin specific peptidase 42
Synonyms: 2410140K03Rik, D5Ertd591e, 3110031A07Rik, A630018G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 76800
Homologene: 35425
N4bp1
Name: NEDD4 binding protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 80750
Homologene: 23703
Usp37
Name: ubiquitin specific peptidase 37
Synonyms: 4932415L06Rik, C330008N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 319651
Homologene: 10858
Cep295
Name: centrosomal protein 295
Synonyms: LOC382128, 5830418K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 319675
Homologene: 27936
Zfpm2
Name: zinc finger protein, multitype 2
Synonyms: FOG-2, B330005D23Rik, FOG2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22762
VEGA: 15
Homologene: 8008
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 328783
VEGA: 17
HGNC: null
Homologene: 18633
Pcdh7
Name: protocadherin 7
Synonyms: BH-protocadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 54216
HGNC: HGNC:8659
Homologene: 36101
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: Nmdar2b, GluN2B, NR2B, NMDAR2B, GluRepsilon2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: 5730414M22Rik, BKCa, Slo, BK channel alpha subunit, MaxiK, Slo1, mSlo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Tigd4
Name: tigger transposable element derived 4
Synonyms: C130063O11Rik, Tigd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 403175
Homologene: 131124
Slc35d3
Name: solute carrier family 35, member D3
Synonyms: 6230421J19Rik, Frcl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 76157
VEGA: 10
Homologene: 19123
Lrrc6
Name: leucine rich repeat containing 6 (testis)
Synonyms: LRTP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 54562
Homologene: 34534
Togaram2
Name: TOG array regulator of axonemal microtubules 2
Synonyms: Fam179a, 4632412N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 320159
Homologene: 65315
Tradd
Name: TNFRSF1A-associated via death domain
Synonyms: 9130005N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 71609
Homologene: 2807
Cpz
Name: carboxypeptidase Z
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 242939
HGNC: HGNC:2333
Homologene: 2709
Thnsl2
Name: threonine synthase-like 2 (bacterial)
Synonyms: TSH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232078
Homologene: 5489
Ctnna2
Name: catenin (cadherin associated protein), alpha 2
Synonyms: Catna, Catna2, alpha(N)-catenin, alpha N-catenin, chp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12386
HGNC: HGNC:2510
Homologene: 68394
Tspoap1
Name: TSPO associated protein 1
Synonyms: Bzrap1, peripheral
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 207777
Homologene: 37961
Proca1
Name: protein interacting with cyclin A1
Synonyms: 4933404M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216974
Homologene: 51856
Arid3c
Name: AT rich interactive domain 3C (BRIGHT-like)
Synonyms: OTTMUSG00000006683
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 550619
Homologene: 72499
Erp27
Name: endoplasmic reticulum protein 27
Synonyms: 1810047B09Rik, 1810033M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 69187
Homologene: 12303
Pramef25
Name: PRAME family member 25
Synonyms: Gm13109
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329984
HGNC: null
Homologene: 83161
Vmn2r23
Name: vomeronasal 2, receptor 23
Synonyms: EG435916
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 435916
HGNC: null
Homologene: 135826
Mapk10
Name: mitogen-activated protein kinase 10
Synonyms: JNK3, C230008H04Rik, p493F12, Serk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 26414
HGNC: HGNC:6872
Homologene: 56439
Prl7b1
Name: prolactin family 7, subfamily b, member 1
Synonyms: 1600014J19Rik, PLP-N, Prlpn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 75596
HGNC: null
Homologene: 17809
Alg5
Name: asparagine-linked glycosylation 5 (dolichyl-phosphate beta-glucosyltransferase)
Synonyms: 2600005J22Rik, 1500026A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 66248
Homologene: 7060
Igkv13-87
Name: immunoglobulin kappa variable 13-87
Synonyms: Gm11145
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 692153
HGNC: null
Homologene: null
Efhc2
Name: EF-hand domain (C-terminal) containing 2
Synonyms: 4933407D04Rik, mRib72-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 74405
Homologene: 11863
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 74,450,532 bp
  • T to C, chromosome 1 at 177,767,812 bp
  • A to T, chromosome 2 at 172,376,262 bp
  • A to G, chromosome 3 at 54,744,584 bp
  • A to G, chromosome 3 at 84,593,952 bp
  • T to C, chromosome 4 at 6,272,493 bp
  • T to C, chromosome 4 at 41,725,958 bp
  • T to A, chromosome 4 at 143,948,886 bp
  • T to C, chromosome 5 at 35,502,361 bp
  • A to T, chromosome 5 at 57,721,894 bp
  • C to T, chromosome 5 at 103,038,682 bp
  • G to A, chromosome 5 at 108,444,016 bp
  • G to A, chromosome 5 at 143,715,464 bp
  • T to C, chromosome 6 at 68,895,650 bp
  • C to A, chromosome 6 at 71,131,961 bp
  • T to C, chromosome 6 at 77,114,922 bp
  • A to G, chromosome 6 at 123,713,164 bp
  • A to G, chromosome 6 at 135,733,639 bp
  • A to G, chromosome 6 at 136,908,010 bp
  • T to C, chromosome 8 at 86,861,405 bp
  • G to T, chromosome 8 at 105,259,513 bp
  • A to C, chromosome 9 at 7,834,477 bp
  • TGGGG to TGGGGG, chromosome 9 at 15,327,957 bp
  • T to C, chromosome 9 at 64,137,868 bp
  • T to C, chromosome 10 at 19,849,463 bp
  • A to T, chromosome 11 at 78,204,980 bp
  • A to G, chromosome 11 at 87,769,665 bp
  • A to T, chromosome 13 at 11,761,349 bp
  • A to T, chromosome 13 at 27,602,153 bp
  • A to T, chromosome 14 at 23,373,207 bp
  • C to T, chromosome 15 at 41,099,389 bp
  • A to T, chromosome 15 at 66,438,408 bp
  • T to C, chromosome 16 at 59,960,296 bp
  • G to A, chromosome 17 at 25,742,934 bp
  • T to C, chromosome 17 at 71,709,597 bp
  • A to G, chromosome 19 at 34,940,128 bp
  • A to T, chromosome X at 17,161,245 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2867 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040456-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.