Strain Name:
C57BL/6J-MtgxR2875Btlr/Mmmh
Stock Number:
040463-MU
Citation ID:
RRID:MMRRC_040463-MU
Other Names:
R2875 (G1), C57BL/6J-MtgxR2875Btlr
Major Collection:

Gene Information

Uchl3
Name: ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 50933
VEGA: 14
Homologene: 4377
Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: b2b692Clo, SW1/SNF, b2b508.1Clo, Brg1, SNF2beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20586
Homologene: 135927
St3gal5
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Synonyms: mST3Gal V, 3S-T, ST3Gal V, [a]2, Siat9, GM3 synthase, GM3-specific sialytransferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 20454
Homologene: 2893
Phf12
Name: PHD finger protein 12
Synonyms: 2410142K10Rik, PF1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 268448
Homologene: 10841
Rad54l
Name: RAD54 like (S. cerevisiae)
Synonyms: RAD54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 19366
HGNC: HGNC:9826
Homologene: 48227
Zeb1
Name: zinc finger E-box binding homeobox 1
Synonyms: 3110032K11Rik, ZEB, Zfhx1a, Tcf18, Zfhep, Tcf8, [delta]EF1, Nil2, Zfx1a, Tw, AREB6, MEB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 21417
Homologene: 31779
Mgrn1
Name: mahogunin, ring finger 1
Synonyms: nc, 2610042J20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 17237
VEGA: 16
Homologene: 41020
Cenpf
Name: centromere protein F
Synonyms: 6530404A22Rik, mitosin, Lek1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Adrm1
Name: adhesion regulating molecule 1
Synonyms: Gp110, 1110063P18Rik, 2510006J17Rik, Rpn13, ARM-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56436
Homologene: 10513
Ttll4
Name: tubulin tyrosine ligase-like family, member 4
Synonyms: 4632407P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 67534
Homologene: 8764
Rad1
Name: RAD1 checkpoint DNA exonuclease
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 19355
HGNC: HGNC:9806
Homologene: 37695
Baz1a
Name: bromodomain adjacent to zinc finger domain 1A
Synonyms: Gtl5, Wcrf180, Acf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217578
HGNC: HGNC:960
Homologene: 45654
Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Synonyms: PERK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 13666
HGNC: HGNC:3255
Homologene: 3557
Grk6
Name: G protein-coupled receptor kinase 6
Synonyms: Gprk6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 26385
VEGA: 13
HGNC: HGNC:4545
Homologene: 37570
Sdc4
Name: syndecan 4
Synonyms: S4, syndecan-4, ryudocan, Synd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20971
Homologene: 31121
Timm21
Name: translocase of inner mitochondrial membrane 21
Synonyms: 2700002I20Rik, 1700034H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 67105
VEGA: 18
Homologene: 32211
Irf8
Name: interferon regulatory factor 8
Synonyms: IRF-8, Myls, ICSBP, Icsbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 15900
HGNC: HGNC:5358
Homologene: 1629
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, Hch, CED-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: (alpha)1 subunit, L-type Cav1.2, Cav1.2, Cchl1a1, D930026N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
4930432E11Rik
Name: RIKEN cDNA 4930432E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243900
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Dnahc12, HL-19, DLP12, HL19, DHC3, 4921531P07Rik, Hdhc3, Dnahc7l, LOC380889
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Eno1b
Name: enolase 1B, retrotransposed
Synonyms: Gm5506
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 433182
VEGA: 18
HGNC: HGNC:3350
Homologene: 134343
Olfr742
Name: olfactory receptor 742
Synonyms: MOR106-6, GA_x6K02T2PMLR-6224293-6225228
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 258422
Homologene: 74163
Gm5346
Name: predicted gene 5346
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 384813
Homologene: 78104
Pik3r5
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: Foap2, p101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 320207
Homologene: 8627
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 215772
Homologene: 100289
Smc1b
Name: structural maintenance of chromosomes 1B
Synonyms: SMC1beta, Smc1l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 140557
VEGA: 15
Homologene: 13786
Zcwpw1
Name: zinc finger, CW type with PWWP domain 1
Synonyms: LOC381678
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 381678
Homologene: 9944
Lbp
Name: lipopolysaccharide binding protein
Synonyms: Bpifd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16803
HGNC: HGNC:6517
Homologene: 3055
Rhbdd1
Name: rhomboid domain containing 1
Synonyms: 4930418P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 76867
Homologene: 12659
Stk25
Name: serine/threonine kinase 25 (yeast)
Synonyms: Ste20-like, SOK-1, 1500019J11Rik, Ysk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 59041
Homologene: 48428
Zscan29
Name: zinc finger SCAN domains 29
Synonyms: Zfp690
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99334
Homologene: 17586
Zbed6
Name: zinc finger, BED type containing 6
Synonyms: MGR, Gm8466, similar to Zinc finger BED domain containing protein 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 667118
Homologene: 130066
Naprt
Name: nicotinate phosphoribosyltransferase
Synonyms: 9130210N20Rik, Naprt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223646
VEGA: 15
Homologene: 82285
H2-Ab1
Name: histocompatibility 2, class II antigen A, beta 1
Synonyms: IAb, I-Abeta, Abeta, Ia2, Ia-2, Rmcs1, I-Ab, H2-Ab, A beta, H-2Ab
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14961
HGNC: HGNC:4944
Homologene: 1603
Kcnc3
Name: potassium voltage gated channel, Shaw-related subfamily, member 3
Synonyms: Kcr2-3, Kv3.3, KShIIID
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16504
HGNC: HGNC:6235
Homologene: 3650
Olfr193
Name: olfactory receptor 193
Synonyms: GA_x54KRFPKG5P-55338697-55337768, MOR113-7P, MOR113-7P, MOR183-7P, Olfr1540-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 257972
Homologene: 128162
Ccdc152
Name: coiled-coil domain containing 152
Synonyms: ENSMUSG00000071814
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 100039139
VEGA: 15
Homologene: 79247
Ndst1
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Synonyms: Hsst, b2b2230Clo, 1200015G06Rik, Ndst-1, glucosaminyl N-deacetylase/N-sulfotransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 15531
VEGA: 18
HGNC: HGNC:7680
Homologene: 20386
Brox
Name: BRO1 domain and CAAX motif containing
Synonyms: 0610010K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 71678
Homologene: 13499
Krt9
Name: keratin 9
Synonyms: K9, Krt1-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 107656
HGNC: HGNC:6447
Homologene: 138337
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 74,686,438 bp
  • A to G, chromosome 1 at 82,368,369 bp
  • T to C, chromosome 1 at 93,629,251 bp
  • C to T, chromosome 1 at 133,656,860 bp
  • A to G, chromosome 1 at 183,287,845 bp
  • A to G, chromosome 1 at 189,658,644 bp
  • T to A, chromosome 2 at 76,759,094 bp
  • T to C, chromosome 2 at 121,164,100 bp
  • G to A, chromosome 2 at 158,314,140 bp
  • T to C, chromosome 2 at 164,431,291 bp
  • A to G, chromosome 2 at 180,175,618 bp
  • C to T, chromosome 4 at 116,101,853 bp
  • T to C, chromosome 5 at 137,810,042 bp
  • T to C, chromosome 6 at 70,883,639 bp
  • A to G, chromosome 6 at 72,147,130 bp
  • G to A, chromosome 6 at 118,697,803 bp
  • A to G, chromosome 7 at 29,562,511 bp
  • G to T, chromosome 7 at 44,591,537 bp
  • T to A, chromosome 8 at 43,627,140 bp
  • C to A, chromosome 8 at 120,754,463 bp
  • A to T, chromosome 9 at 21,642,580 bp
  • T to G, chromosome 10 at 10,422,719 bp
  • A to G, chromosome 11 at 34,718,885 bp
  • C to A, chromosome 11 at 66,168,461 bp
  • T to C, chromosome 11 at 68,496,101 bp
  • C to A, chromosome 11 at 78,009,747 bp
  • C to A, chromosome 11 at 100,189,205 bp
  • A to T, chromosome 12 at 54,923,119 bp
  • A to G, chromosome 13 at 55,452,304 bp
  • A to G, chromosome 14 at 26,693,470 bp
  • T to A, chromosome 14 at 50,515,812 bp
  • A to G, chromosome 14 at 101,668,560 bp
  • T to C, chromosome 15 at 3,298,181 bp
  • T to C, chromosome 15 at 10,490,331 bp
  • A to G, chromosome 15 at 75,892,052 bp
  • A to G, chromosome 15 at 85,121,851 bp
  • C to T, chromosome 16 at 4,907,416 bp
  • A to T, chromosome 16 at 59,109,802 bp
  • A to C, chromosome 17 at 34,263,312 bp
  • GGA to GGAAGA, chromosome 18 at 5,772,859 bp
  • A to G, chromosome 18 at 48,047,784 bp
  • A to T, chromosome 18 at 60,690,047 bp
  • T to C, chromosome 18 at 84,951,092 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2875 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040463-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.