Strain Name:
C57BL/6J-MtgxR2877Btlr/Mmmh
Stock Number:
040465-MU
Citation ID:
RRID:MMRRC_040465-MU
Other Names:
R2877 (G1), C57BL/6J-MtgxR2877Btlr
Major Collection:

Gene Information

Foxa3
Name: forkhead box A3
Synonyms: Tcf-3g, Hnf3g, Hnf-3g, Tcf3g
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15377
HGNC: HGNC:5023
Homologene: 3308
Foxj2
Name: forkhead box J2
Synonyms: Fhx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 60611
Homologene: 10187
Rcbtb1
Name: regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
Synonyms: 5430409I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71330
Homologene: 10061
Zcchc8
Name: zinc finger, CCHC domain containing 8
Synonyms: 5730565F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70650
Homologene: 32349
Palb2
Name: partner and localizer of BRCA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233826
Homologene: 11652
Atg2b
Name: autophagy related 2B
Synonyms: C630028L02Rik, C030004M05Rik, 2410024A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76559
VEGA: 12
Homologene: 9974
Nedd1
Name: neural precursor cell expressed, developmentally down-regulated gene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17997
VEGA: 10
HGNC: HGNC:7723
Homologene: 7439
Naa16
Name: N(alpha)-acetyltransferase 16, NatA auxiliary subunit
Synonyms: 1300019C06Rik, Narg1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66897
Homologene: 134838
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 4632407J06Rik, 2810487N22Rik, B130055D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Gfm2
Name: G elongation factor, mitochondrial 2
Synonyms: MST027, EFG2, A930009M04Rik, 6530419G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 320806
Homologene: 6238
Anapc7
Name: anaphase promoting complex subunit 7
Synonyms: prediabetic NOD sera-reactive autoantigen, APC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56317
Homologene: 10512
Pwp1
Name: PWP1 homolog, endonuclein
Synonyms: 2610205J09Rik, 2310058A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103136
Homologene: 5129
Ambn
Name: ameloblastin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11698
HGNC: HGNC:452
Homologene: 7625
4930522L14Rik
Name: RIKEN cDNA 4930522L14 gene
Synonyms: Gm42152
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100041734
Fibcd1
Name: fibrinogen C domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98970
Homologene: 122246
Dync1li2
Name: dynein, cytoplasmic 1 light intermediate chain 2
Synonyms: LIC2, Dncli2, Dnclic2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234663
HGNC: HGNC:2966
Homologene: 4474
Eipr1
Name: EARP complex and GARP complex interacting protein 1
Synonyms: D12Ertd604e, Tssc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 380752
VEGA: 12
Homologene: 2481
Znhit6
Name: zinc finger, HIT type 6
Synonyms: 2410019A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229937
Homologene: 32378
Robo4
Name: roundabout guidance receptor 4
Synonyms: 1200012D01Rik, Magic roundabout
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74144
Homologene: 10397
Grin1
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1)
Synonyms: NMDAR1, NR1, Nmdar, M100174, GluRzeta1, Rgsc174
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14810
HGNC: HGNC:4584
Homologene: 7187
Muc19
Name: mucin 19
Synonyms: apomucin, sld
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239611
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328783
VEGA: 17
Homologene: 18633
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Tarbp1
Name: TAR RNA binding protein 1
Synonyms: Gm17296
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212728
Homologene: 38082
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
Casp1
Name: caspase 1
Synonyms: ICE, Caspase-1, interleukin 1 beta-converting enzyme, Il1bc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12362
VEGA: 9
HGNC: HGNC:1499
Homologene: 133272
Nuak1
Name: NUAK family, SNF1-like kinase, 1
Synonyms: B230104P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77976
Homologene: 8896
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Mi-2 alpha, Prp9-1, Prp7, 2600010P09Rik, Chd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Eif3f
Name: eukaryotic translation initiation factor 3, subunit F
Synonyms: 0610037M02Rik, Eif3s5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66085
HGNC: HGNC:3275
Homologene: 2783
Kcns1
Name: K+ voltage-gated channel, subfamily S, 1
Synonyms: Kv9.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16538
HGNC: HGNC:6300
Homologene: 20517
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Ulk4
Name: unc-51-like kinase 4
Synonyms: 4932415A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209012
Homologene: 41205
Nebl
Name: nebulette
Synonyms: Lnebl, 1200007O21Rik, A630080F05Rik, D830029A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74103
Homologene: 128431
Vmn2r56
Name: vomeronasal 2, receptor 56
Synonyms: EG629079
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 629079
Homologene: 104040
Myo1a
Name: myosin IA
Synonyms: BBM-I, brush border myosin 1, Myhl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432516
VEGA: 10
HGNC: HGNC:7595
Homologene: 21113
Rbak
Name: RB-associated KRAB zinc finger
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57782
Homologene: 23287
Axl
Name: AXL receptor tyrosine kinase
Synonyms: Tyro7, Ark, Ufo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26362
HGNC: HGNC:905
Homologene: 7583
Adssl1
Name: adenylosuccinate synthetase like 1
Synonyms: Adss
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11565
VEGA: 12
Homologene: 111992
Vmn1r215
Name: vomeronasal 1 receptor 215
Synonyms: V1ri2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171253
Homologene: 110880
Alg11
Name: asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 207958
Homologene: 68893
Olfr1036
Name: olfactory receptor 1036
Synonyms: GA_x6K02T2Q125-47549689-47550621, MOR262-13, MOR245-25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258245
Olfr1487
Name: olfactory receptor 1487
Synonyms: GA_x6K02T2RE5P-3951719-3952666, MOR202-18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258629
Homologene: 110492
Kiz
Name: kizuna centrosomal protein
Synonyms: LOC228730, Ncrna00153, Gm114, Plk1s1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228730
Homologene: 10219
Fbxw13
Name: F-box and WD-40 domain protein 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 211305
Homologene: 110776
Accsl
Name: 1-aminocyclopropane-1-carboxylate synthase (non-functional)-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381411
Homologene: 86007
Itpripl1
Name: inositol 1,4,5-triphosphate receptor interacting protein-like 1
Synonyms: 1700041B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 73338
Homologene: 77641
Tchh
Name: trichohyalin
Synonyms: AHF, Thh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99681
Homologene: 136273
Gm9934
Name: predicted gene 9934
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Cyp2a4
Name: cytochrome P450, family 2, subfamily a, polypeptide 4
Synonyms: Cyp15a1, D7Ucla4, testosterone 15alpha-hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13086
Homologene: 85917
Fbxw19
Name: F-box and WD-40 domain protein 19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235612
Homologene: 110776
Smpdl3a
Name: sphingomyelin phosphodiesterase, acid-like 3A
Synonyms: 0610010C24Rik, ASM3A, ASML3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 57319
Homologene: 4886
Vmn2r76
Name: vomeronasal 2, receptor 76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 675969
Homologene: 104330
Trpc4
Name: transient receptor potential cation channel, subfamily C, member 4
Synonyms: CCE1, Trp4, STRPC4, Trrp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22066
Homologene: 22955
Carmil2
Name: capping protein regulator and myosin 1 linker 2
Synonyms: D130029J02Rik, Rltpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234695
Homologene: 128439
Anxa10
Name: annexin A10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26359
HGNC: HGNC:534
Homologene: 21409
Creb3l4
Name: cAMP responsive element binding protein 3-like 4
Synonyms: 5330432F22Rik, ATCE1, 1700012K17Rik, mJAL, JAL, Tisp40beta, Tisp40alpha, Tisp40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 78284
Homologene: 12693
Speer4e
Name: spermatogenesis associated glutamate (E)-rich protein 4e
Synonyms: SPEER-4E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 624245
Homologene: 69402
Gpr25
Name: G protein-coupled receptor 25
Synonyms: LOC383563
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 383563
HGNC: HGNC:4480
Homologene: 3872
Naa80
Name: N(alpha)-acetyltransferase 80, NatH catalytic subunit
Synonyms: Nat6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56441
Homologene: 36325
Rassf6
Name: Ras association (RalGDS/AF-6) domain family member 6
Synonyms: 1600016B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 73246
Homologene: 37125
Fbxo48
Name: F-box protein 48
Synonyms: A630050E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319701
Homologene: 18541
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 90,775,599 bp
  • C to T, chromosome 1 at 136,260,815 bp
  • C to A, chromosome 2 at 17,434,929 bp
  • A to G, chromosome 2 at 25,297,629 bp
  • G to A, chromosome 2 at 31,838,666 bp
  • T to C, chromosome 2 at 76,737,065 bp
  • T to C, chromosome 2 at 86,075,331 bp
  • A to T, chromosome 2 at 93,859,410 bp
  • A to G, chromosome 2 at 127,141,614 bp
  • T to C, chromosome 2 at 146,889,556 bp
  • A to G, chromosome 2 at 164,164,762 bp
  • T to C, chromosome 3 at 54,291,340 bp
  • A to T, chromosome 3 at 90,242,308 bp
  • A to G, chromosome 3 at 93,444,228 bp
  • G to C, chromosome 3 at 145,576,654 bp
  • C to T, chromosome 5 at 14,937,116 bp
  • T to C, chromosome 5 at 88,460,700 bp
  • C to T, chromosome 5 at 90,606,805 bp
  • A to C, chromosome 5 at 109,738,945 bp
  • T to C, chromosome 5 at 122,428,156 bp
  • C to T, chromosome 5 at 123,700,703 bp
  • A to G, chromosome 5 at 143,174,105 bp
  • G to A, chromosome 6 at 122,842,832 bp
  • A to C, chromosome 7 at 12,711,027 bp
  • A to T, chromosome 7 at 19,014,880 bp
  • T to A, chromosome 7 at 25,766,524 bp
  • G to A, chromosome 7 at 26,312,187 bp
  • C to A, chromosome 7 at 86,225,993 bp
  • T to A, chromosome 7 at 93,080,071 bp
  • G to A, chromosome 7 at 108,934,812 bp
  • A to G, chromosome 7 at 122,114,429 bp
  • A to G, chromosome 8 at 22,065,358 bp
  • T to A, chromosome 8 at 62,060,339 bp
  • A to C, chromosome 8 at 104,429,415 bp
  • A to G, chromosome 8 at 105,695,423 bp
  • G to A, chromosome 8 at 126,427,832 bp
  • T to C, chromosome 9 at 5,303,110 bp
  • T to A, chromosome 9 at 27,044,487 bp
  • CGG to CG, chromosome 9 at 37,411,490 bp
  • A to T, chromosome 9 at 107,583,168 bp
  • A to G, chromosome 9 at 109,181,466 bp
  • A to T, chromosome 9 at 109,485,970 bp
  • T to C, chromosome 9 at 121,260,039 bp
  • C to A, chromosome 10 at 57,809,085 bp
  • T to C, chromosome 10 at 84,375,345 bp
  • T to C, chromosome 10 at 85,876,471 bp
  • T to A, chromosome 10 at 92,714,126 bp
  • C to T, chromosome 10 at 127,720,194 bp
  • C to T, chromosome 11 at 9,291,889 bp
  • A to G, chromosome 11 at 16,953,382 bp
  • A to T, chromosome 11 at 69,361,172 bp
  • C to T, chromosome 12 at 28,760,092 bp
  • A to G, chromosome 12 at 76,000,831 bp
  • A to T, chromosome 12 at 105,664,009 bp
  • A to C, chromosome 12 at 112,634,189 bp
  • A to G, chromosome 13 at 23,076,561 bp
  • A to G, chromosome 13 at 97,153,249 bp
  • A to G, chromosome 14 at 59,210,592 bp
  • A to G, chromosome 14 at 79,343,298 bp
  • T to A, chromosome 15 at 91,893,006 bp
  • G to A, chromosome 17 at 25,742,934 bp
  • A to T, chromosome 19 at 13,619,632 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2877 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040465-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.