Strain Name:
C57BL/6J-MtgxR2890Btlr/Mmmh
Stock Number:
040478-MU
Citation ID:
RRID:MMRRC_040478-MU
Other Names:
R2890 (G1), C57BL/6J-MtgxR2890Btlr
Major Collection:

Gene Information

Slc25a1tm1a(EUCOMM)Wtsi
Name: solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1; targeted mutation 1a, Wellcome Trust Sanger Institute
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
Adamts20
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
Synonyms: bt, ADAMTS-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223838
VEGA: 15
Homologene: 11808
Sbf2
Name: SET binding factor 2
Synonyms: SBF2, mMTMH1, B430219L04Rik, 4833411B01Rik, Mtmr13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 319934
VEGA: 7
HGNC: HGNC:2135
Homologene: 41810
Ylpm1
Name: YLP motif containing 1
Synonyms: A930013E17Rik, Zap3, ZAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 56531
VEGA: 12
Homologene: 87707
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: rjs, D7H15F37S1, jdf2, D7H15F32S1, D15F32S1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 15204
VEGA: 7
HGNC: HGNC:4868
Homologene: 3430
Zfp619
Name: zinc finger protein 619
Synonyms: 3000002G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 70227
VEGA: 7
Homologene: 133818
Dock4
Name: dedicator of cytokinesis 4
Synonyms: 6330411N01Rik, EST N28122
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238130
VEGA: 12
Homologene: 56680
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: dynein heavy chain, retrograde transport, Dnchc1, Loa, MAP1C, Swl, Dnec1, 9930018I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 13424
VEGA: 12
HGNC: HGNC:2961
Homologene: 1053
Fgd6
Name: FYVE, RhoGEF and PH domain containing 6
Synonyms: Etohd4, ZFYVE24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 13998
VEGA: 10
Homologene: 14209
Fzd7
Name: frizzled class receptor 7
Synonyms: Fz7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14369
VEGA: 1
HGNC: HGNC:4045
Homologene: 20751
Cep63
Name: centrosomal protein 63
Synonyms: D9Mgc48e, ET2, CD20R, D9Mgc41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 28135
VEGA: 9
Homologene: 11861
Grik4
Name: glutamate receptor, ionotropic, kainate 4
Synonyms: GluRgamma1, KA-1, 6330551K01Rik, KA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 110637
VEGA: 9
HGNC: HGNC:4582
Homologene: 81829
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: perlecan, Plc, per, Pcn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 15530
VEGA: 4
HGNC: HGNC:5273
Homologene: 68473
Baz1a
Name: bromodomain adjacent to zinc finger domain 1A
Synonyms: Acf1, Wcrf180, Gtl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217578
VEGA: 12
HGNC: HGNC:960
Homologene: 45654
Srek1ip1
Name: splicing regulatory glutamine/lysine-rich protein 1interacting protein 1
Synonyms: Srsf12ip1, 3110031B13Rik, Sfrs12ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 67288
VEGA: 13
Taf4b
Name: TATA-box binding protein associated factor 4b
Synonyms: Taf2c2, 2610524B04Rik, 105kDa, 4932409F03Rik, TAFII105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 72504
VEGA: 18
Homologene: 28266
Chrm5
Name: cholinergic receptor, muscarinic 5
Synonyms: M5R, muscarinic acetylcholine receptor 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 213788
VEGA: 2
HGNC: HGNC:1954
Homologene: 22697
Amdhd1
Name: amidohydrolase domain containing 1
Synonyms: 1300019J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 71761
VEGA: 10
Homologene: 14730
Ttn
Name: titin
Synonyms: D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, mdm, 1100001C23Rik, shru, connectin, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
VEGA: 2
Homologene: 130650
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mass1, Gpr98, VLGR1, Mgr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 110789
VEGA: 13
Homologene: 19815
Lcn10
Name: lipocalin 10
Synonyms: 9230112J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 332578
VEGA: 2
Homologene: 52253
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 268527
VEGA: 12
Homologene: 8780
Vmn2r66
Name: vomeronasal 2, receptor 66
Synonyms: F830104D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233437
Homologene: 115466
Lamp1
Name: lysosomal-associated membrane protein 1
Synonyms: Perk, Lamp-1, CD107a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 16783
VEGA: 8
HGNC: HGNC:6499
Homologene: 4061
Vmn2r13
Name: vomeronasal 2, receptor 13
Synonyms: Gm4867
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231589
Homologene: 129606
Pcdhb9
Name: protocadherin beta 9
Synonyms: PcdhbI, Pcdhb4C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93880
VEGA: 18
Homologene: 87124
Rbsn
Name: rabenosyn, RAB effector
Synonyms: Rabenosyn-5, 5330426D11Rik, Zfyve20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 78287
VEGA: 6
Homologene: 41477
Phex
Name: phosphate regulating endopeptidase homolog, X-linked
Synonyms: HPDR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 18675
VEGA: X
HGNC: HGNC:8918
Homologene: 37310
A1cf
Name: APOBEC1 complementation factor
Synonyms: ACF, 1810073H04Rik, apobec-1 complementation factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 69865
VEGA: 19
Homologene: 16363
Nostrin
Name: nitric oxide synthase trafficker
Synonyms: mDaIP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 329416
Homologene: 43142
Olfr1287
Name: olfactory receptor 1287
Synonyms: GA_x6K02T2Q125-72500603-72501520, MOR248-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 257935
VEGA: 2
Gusb
Name: glucuronidase, beta
Synonyms: adipose storage deficiency, Gus-u, g, Gus-s, Gus, Gus-r, Gut, Gur, asd, Gus-t
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 110006
VEGA: 5
HGNC: HGNC:4696
Homologene: 37271
Slc35a5
Name: solute carrier family 35, member A5
Synonyms: D730043G07Rik, 1010001J06Rik, D16Ertd450e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 74102
VEGA: 16
Homologene: 9930
Zfp51
Name: zinc finger protein 51
Synonyms: Zfp-51, zfec12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 22709
VEGA: 17
Homologene: 134003
Slc37a4
Name: solute carrier family 37 (glucose-6-phosphate transporter), member 4
Synonyms: G6PT, G6pt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 14385
VEGA: 9
HGNC: HGNC:4061
Homologene: 37482
4930480E11Rik
Name: RIKEN cDNA 4930480E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 74910
VEGA: X
Homologene: 136363
Slc25a1
Name: solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
Synonyms: 2610100G11Rik, Dgsj, Slc20a3, 1300019P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13358
VEGA: 16
Homologene: 4362
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 59,484,434 bp
  • T to C, chromosome 2 at 25,683,630 bp
  • A to G, chromosome 2 at 69,180,905 bp
  • T to C, chromosome 2 at 76,896,154 bp
  • A to T, chromosome 2 at 111,449,289 bp
  • T to C, chromosome 2 at 112,479,703 bp
  • T to C, chromosome 4 at 137,549,574 bp
  • T to C, chromosome 5 at 109,191,974 bp
  • T to C, chromosome 5 at 130,000,502 bp
  • C to T, chromosome 6 at 92,207,123 bp
  • C to A, chromosome 7 at 39,534,969 bp
  • A to G, chromosome 7 at 56,164,140 bp
  • C to T, chromosome 7 at 85,011,819 bp
  • A to G, chromosome 7 at 110,362,246 bp
  • T to A, chromosome 8 at 13,173,891 bp
  • T to C, chromosome 9 at 42,671,219 bp
  • T to C, chromosome 9 at 44,400,660 bp
  • T to C, chromosome 9 at 102,618,827 bp
  • T to C, chromosome 10 at 93,527,264 bp
  • C to A, chromosome 10 at 94,043,294 bp
  • A to G, chromosome 12 at 16,704,478 bp
  • A to T, chromosome 12 at 40,623,801 bp
  • T to C, chromosome 12 at 54,898,517 bp
  • G to T, chromosome 12 at 85,029,813 bp
  • T to C, chromosome 12 at 110,616,891 bp
  • A to G, chromosome 13 at 81,182,809 bp
  • A to T, chromosome 13 at 104,834,250 bp
  • C to T, chromosome 15 at 94,330,578 bp
  • A to T, chromosome 16 at 17,926,099 bp
  • A to G, chromosome 16 at 45,151,560 bp
  • C to G, chromosome 17 at 21,463,856 bp
  • T to C, chromosome 18 at 14,804,792 bp
  • G to A, chromosome 18 at 37,403,326 bp
  • A to G, chromosome 19 at 31,918,017 bp
  • A to T, chromosome X at 78,370,682 bp
  • T to C, chromosome X at 157,310,958 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2890 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040478-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.