Strain Name:
C57BL/6J-MtgxR2901Btlr/Mmmh
Stock Number:
040489-MU
Citation ID:
RRID:MMRRC_040489-MU
Other Names:
R2901 (G1), C57BL/6J-MtgxR2901Btlr
Major Collection:

Gene Information

Ssc4d
Name: scavenger receptor cysteine rich family, 4 domains
Synonyms: C330016E03Rik, Srcrb4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 109267
Homologene: 34137
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Nf-1, Mhdadsk9, Dsk9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Cep68
Name: centrosomal protein 68
Synonyms: 6030463E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216543
Homologene: 65235
Klf12
Name: Kruppel-like factor 12
Synonyms: D530033K05Rik, AP-2rep, 2700063E05Rik, B130052C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16597
VEGA: 14
HGNC: HGNC:6346
Homologene: 21417
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, Dnahc7a, LOC381341
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 627872
Homologene: 41287
Fabp3
Name: fatty acid binding protein 3, muscle and heart
Synonyms: Fabph1, Fabph-4, Fabph-1, Fabph4, Mdgi, H-FABP, Fabp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14077
HGNC: HGNC:3557
Homologene: 68379
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: Zfp650, 1110059H15Rik, 4833421P10Rik, A130030D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 68795
Homologene: 52092
Ptp4a1
Name: protein tyrosine phosphatase 4a1
Synonyms: Prl-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 19243
HGNC: HGNC:9634
Homologene: 2587
Lpin1
Name: lipin 1
Synonyms: Lipin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 14245
VEGA: 12
Homologene: 9266
C1qtnf1
Name: C1q and tumor necrosis factor related protein 1
Synonyms: 1600017K21Rik, CTRP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 56745
Homologene: 10548
Stmn2
Name: stathmin-like 2
Synonyms: Scgn10, SCG10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20257
Homologene: 5102
Vps51
Name: VPS51 GARP complex subunit
Synonyms: 1110014N23Rik, 3110057M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 68505
HGNC: HGNC:1172
Homologene: 34675
Klhl20
Name: kelch-like 20
Synonyms: D930050H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226541
Homologene: 8699
Cep192
Name: centrosomal protein 192
Synonyms: 4631422C13Rik, D430014P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 70799
VEGA: 18
Homologene: 73526
Prf1
Name: perforin 1 (pore forming protein)
Synonyms: perforin, Pfp, Pfn, Prf-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18646
VEGA: 10
HGNC: HGNC:9360
Homologene: 3698
4933406M09Rik
Name: RIKEN cDNA 4933406M09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240755
Homologene: 128441
Mrc1
Name: mannose receptor, C type 1
Synonyms: CD206, MR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Angpt4
Name: angiopoietin 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11602
HGNC: HGNC:487
Homologene: 36302
Olfr954
Name: olfactory receptor 954
Synonyms: MOR171-53, GA_x6K02T2PVTD-33158015-33158950, MOR171-42
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258328
VEGA: 9
Homologene: 71961
Olfr1490
Name: olfactory receptor 1490
Synonyms: MOR266-6P, GA_x6K02T2RE5P-3987000-3987950
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258098
Homologene: 79418
Nme8
Name: NME/NM23 family member 8
Synonyms: 1700056P15Rik, Sptrx-2, Txndc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 73412
Homologene: 9593
Zup1
Name: zinc finger containing ubiquitin peptidase 1
Synonyms: 2700019D07Rik, Zufsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 72580
VEGA: 10
Homologene: 12472
Simc1
Name: SUMO-interacting motifs containing 1
Synonyms: 4732471D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 319719
Homologene: 131217
Abhd13
Name: abhydrolase domain containing 13
Synonyms: 1110065L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 68904
Homologene: 6716
Krt23
Name: keratin 23
Synonyms: Krt1-23, CK23, K23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 94179
HGNC: HGNC:6438
Homologene: 9172
AC162446.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
Tspoap1
Name: TSPO associated protein 1
Synonyms: Bzrap1, peripheral
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 207777
Homologene: 37961
Clvs1
Name: clavesin 1
Synonyms: 4933402J24Rik, Rlbp1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74438
Homologene: 65267
Col25a1
Name: collagen, type XXV, alpha 1
Synonyms: 2700062B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 77018
Homologene: 57111
Snai2
Name: snail family zinc finger 2
Synonyms: Slug, Slugh, Snail2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 20583
VEGA: 16
Homologene: 31127
Gm9845
Name: predicted pseudogene 9845
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 100040853
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 30,943,304 bp
  • A to T, chromosome 1 at 53,427,872 bp
  • T to C, chromosome 1 at 134,390,924 bp
  • G to T, chromosome 1 at 161,109,552 bp
  • A to G, chromosome 2 at 14,328,543 bp
  • T to C, chromosome 2 at 70,016,192 bp
  • G to T, chromosome 2 at 151,911,339 bp
  • A to G, chromosome 3 at 8,541,921 bp
  • T to A, chromosome 3 at 39,358,593 bp
  • A to T, chromosome 3 at 130,546,391 bp
  • A to G, chromosome 4 at 9,281,972 bp
  • C to T, chromosome 4 at 130,312,387 bp
  • G to A, chromosome 5 at 135,964,663 bp
  • T to A, chromosome 8 at 9,988,231 bp
  • T to C, chromosome 8 at 70,720,626 bp
  • T to A, chromosome 9 at 39,461,938 bp
  • C to T, chromosome 10 at 33,927,612 bp
  • T to C, chromosome 10 at 33,928,063 bp
  • A to T, chromosome 10 at 61,300,319 bp
  • A to G, chromosome 11 at 20,240,187 bp
  • G to A, chromosome 11 at 79,409,381 bp
  • C to T, chromosome 11 at 87,777,975 bp
  • T to C, chromosome 11 at 99,483,971 bp
  • A to G, chromosome 11 at 118,448,104 bp
  • T to C, chromosome 12 at 16,553,998 bp
  • A to T, chromosome 13 at 19,675,664 bp
  • G to A, chromosome 13 at 54,541,518 bp
  • G to T, chromosome 14 at 99,900,146 bp
  • T to C, chromosome 16 at 14,705,983 bp
  • C to T, chromosome 18 at 67,869,441 bp
  • G to A, chromosome 19 at 6,076,438 bp
  • C to T, chromosome 19 at 13,654,945 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2901 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040489-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.