Strain Name:
C57BL/6J-MtgxR2913Btlr/Mmmh
Stock Number:
040500-MU
Citation ID:
RRID:MMRRC_040500-MU
Other Names:
R2913 (G1), C57BL/6J-MtgxR2913Btlr
Major Collection:

Strain Information

Hprt
Name: hypoxanthine guanine phosphoribosyl transferase
Synonyms: Hprt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 15452
HGNC: HGNC:5157
Homologene: 56590
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Med26
Name: mediator complex subunit 26
Synonyms: 5730493L18Rik, Crsp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70625
HGNC: HGNC:2376
Homologene: 68417
Yes1
Name: YES proto-oncogene 1, Src family tyrosine kinase
Synonyms: Yes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22612
Homologene: 55900
Acap2
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Synonyms: 9530039J15Rik, Centb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 78618
VEGA: 16
Homologene: 8182
Rc3h2
Name: ring finger and CCCH-type zinc finger domains 2
Synonyms: Rnf164, D930043C02Rik, 2900024N03Rik, 9430019J22Rik, Mnab
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 319817
Homologene: 28276
Ints1
Name: integrator complex subunit 1
Synonyms: 1110015K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68510
Homologene: 53111
Srrm2
Name: serine/arginine repetitive matrix 2
Synonyms: 5033413A03Rik, SRm300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75956
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71643
Homologene: 34708
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, D630048A14Rik, Ki67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Tcof1
Name: treacle ribosome biogenesis factor 1
Synonyms: treacle
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 21453
Homologene: 68049
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: 6720464I07Rik, Solo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223435
VEGA: 15
Homologene: 20847
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: 5230400C17Rik, Pip5k3, PipkIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18711
Homologene: 32115
Snx29
Name: sorting nexin 29
Synonyms: LOC381035, LOC385605, 4933437K13Rik, Gm11170, Rundc2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74478
Homologene: 32706
Arih2
Name: ariadne RBR E3 ubiquitin protein ligase 2
Synonyms: TRIAD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23807
HGNC: HGNC:690
Homologene: 48424
Adgrf3
Name: adhesion G protein-coupled receptor F3
Synonyms: LOC381628, PGR23, Gpr113
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381628
Homologene: 17826
Nktr
Name: natural killer tumor recognition sequence
Synonyms: D9Wsu172e, 5330401F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18087
HGNC: HGNC:7833
Homologene: 122148
Rbm45
Name: RNA binding motif protein 45
Synonyms: Drb1, G430095G15Rik, Drbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241490
Homologene: 15560
Gak
Name: cyclin G associated kinase
Synonyms: D130045N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231580
HGNC: HGNC:4113
Homologene: 3846
Pomt2
Name: protein-O-mannosyltransferase 2
Synonyms: A830009D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217734
VEGA: 12
Homologene: 5297
Ric3
Name: RIC3 acetylcholine receptor chaperone
Synonyms: E130307J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320360
Homologene: 49772
Adap1
Name: ArfGAP with dual PH domains 1
Synonyms: 4930431P11Rik, centaurin alpha 1, Centa1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231821
Homologene: 55997
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola2, Cola-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Aldh3b1
Name: aldehyde dehydrogenase 3 family, member B1
Synonyms: ALDH7, ALDH4, 1700001N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67689
VEGA: 19
HGNC: HGNC:410
Homologene: 73890
Mapk3
Name: mitogen-activated protein kinase 3
Synonyms: Erk-1, p44 MAP kinase, p44erk1, p44mapk, Prkm3, Erk1, Esrk1, Mtap2k
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26417
HGNC: HGNC:6877
Homologene: 55682
Itgam
Name: integrin alpha M
Synonyms: complement component receptor 3 alpha, CD11B (p170), Mac-1 alpha, Mac-1, complement receptor type 3, CR3, CD11b/CD18, Mac-1a, F730045J24Rik, Ly-40, Cd11b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16409
HGNC: HGNC:6149
Homologene: 526
Cdcp3
Name: CUB domain containing protein 3
Synonyms: 5430419D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71395
Homologene: 138430
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: b2b012Clo, Jbts17, Hug, 2410089E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 73692
Homologene: 11315
Cpne8
Name: copine VIII
Synonyms: 1200003E11Rik, 1500031E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66871
Homologene: 12049
9530053A07Rik
Name: RIKEN cDNA 9530053A07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319482
Homologene: 130055
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22371
Homologene: 466
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Wdr64
Name: WD repeat domain 64
Synonyms: 4930415O10Rik, 4930511H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75820
Homologene: 51634
Mapk4
Name: mitogen-activated protein kinase 4
Synonyms: Erk3-related, p63Mapk, A330097D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225724
HGNC: HGNC:6878
Homologene: 2058
4921528O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231470
Homologene: 23516
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: 6530405F15Rik, CMF608, Adlican2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242050
Homologene: 18712
Pam
Name: peptidylglycine alpha-amidating monooxygenase
Synonyms: PHM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18484
HGNC: HGNC:8596
Homologene: 37369
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: enteropeptidase, enterokinase, A130097D21Rik, Prss7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Crocc
Name: ciliary rootlet coiled-coil, rootletin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230872
Homologene: 16811
Slc9a9
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 9
Synonyms: 5730527A11Rik, Nhe9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 331004
Homologene: 69753
Txk
Name: TXK tyrosine kinase
Synonyms: Rlk, Btkl, PTK4, A130089B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22165
Homologene: 2497
Or5j3
Name: olfactory receptor family 5 subfamily J member 3
Synonyms: GA_x6K02T2Q125-47777498-47778436, MOR172-1, Olfr1052
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259012
Homologene: 79679
Mrgpra9
Name: MAS-related GPR, member A9
Synonyms: MrgA9, EG668725
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668725
Homologene: 79615
Cryl1
Name: crystallin, lambda 1
Synonyms: 1110025H08Rik, A230106J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 68631
VEGA: 14
Homologene: 9322
Or4c11
Name: olfactory receptor family 4 subfamily C member 11
Synonyms: GA_x6K02T2Q125-50339974-50340609, GA_x6K02T2Q125-50338497-50339264, MOR230-3, Olfr1207, Olfr1206
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258896
Homologene: 81567
4932411G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Fdxacb1
Name: ferredoxin-fold anticodon binding domain containing 1
Synonyms: D630004A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382137
Homologene: 19813
Etfa
Name: electron transferring flavoprotein, alpha polypeptide
Synonyms: 2010200I21Rik, D9Ertd394e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110842
HGNC: HGNC:3481
Homologene: 100
Spc25
Name: SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
Synonyms: 2610205L13Rik, 2600017H08Rik, Spbc25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66442
Homologene: 41387
Cyp11b1
Name: cytochrome P450, family 11, subfamily b, polypeptide 1
Synonyms: Cyp11b-1, Cyp11b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110115
Homologene: 106948
Tagap
Name: T cell activation Rho GTPase activating protein
Synonyms: tcs-1, Tcd-1, tcs1, TRD, Tcd1, Tcd1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72536
Homologene: 44943
Rrh
Name: retinal pigment epithelium derived rhodopsin homolog
Synonyms: Peropsin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20132
Homologene: 55977
Rspo2
Name: R-spondin 2
Synonyms: 2610028F08Rik, ftls
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239405
VEGA: 15
Homologene: 18235
Gpr157
Name: G protein-coupled receptor 157
Synonyms: F730108M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269604
Homologene: 18573
Hbb-bh1
Name: hemoglobin Z, beta-like embryonic chain
Synonyms: beta Hl globin, betaH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15132
Homologene: 110794
Sptssa
Name: serine palmitoyltransferase, small subunit A
Synonyms: 1110002B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104725
VEGA: 12
Homologene: 15889
Tmem181c-ps
Name: transmembrane protein 181C, pseudogene
Synonyms: Tmem181d-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100040525
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 65,253,517 bp
  • A to C, chromosome 1 at 97,923,129 bp
  • T to C, chromosome 1 at 163,044,003 bp
  • A to G, chromosome 1 at 175,764,082 bp
  • A to G, chromosome 2 at 31,460,210 bp
  • A to G, chromosome 2 at 37,378,959 bp
  • T to C, chromosome 2 at 69,199,987 bp
  • C to T, chromosome 2 at 76,375,454 bp
  • A to G, chromosome 2 at 86,298,389 bp
  • A to T, chromosome 2 at 88,865,114 bp
  • T to A, chromosome 3 at 59,331,736 bp
  • T to C, chromosome 3 at 127,598,707 bp
  • G to T, chromosome 3 at 129,815,609 bp
  • A to G, chromosome 4 at 113,524,092 bp
  • T to A, chromosome 4 at 123,475,911 bp
  • C to T, chromosome 4 at 141,020,350 bp
  • T to C, chromosome 4 at 144,392,734 bp
  • G to A, chromosome 4 at 150,098,765 bp
  • A to G, chromosome 5 at 30,196,994 bp
  • T to C, chromosome 5 at 32,640,582 bp
  • T to C, chromosome 5 at 72,724,451 bp
  • G to A, chromosome 5 at 96,733,915 bp
  • G to A, chromosome 5 at 108,617,065 bp
  • C to T, chromosome 5 at 139,274,821 bp
  • A to G, chromosome 5 at 139,757,913 bp
  • C to T, chromosome 6 at 4,519,923 bp
  • T to A, chromosome 6 at 125,685,846 bp
  • A to T, chromosome 7 at 28,164,307 bp
  • T to C, chromosome 7 at 47,235,080 bp
  • C to T, chromosome 7 at 103,843,047 bp
  • A to G, chromosome 7 at 109,054,453 bp
  • T to A, chromosome 7 at 126,760,806 bp
  • T to C, chromosome 7 at 128,112,406 bp
  • T to C, chromosome 7 at 131,182,024 bp
  • T to C, chromosome 7 at 135,700,686 bp
  • T to G, chromosome 8 at 72,496,112 bp
  • C to T, chromosome 9 at 50,768,399 bp
  • C to A, chromosome 9 at 55,482,329 bp
  • A to G, chromosome 9 at 95,137,993 bp
  • A to G, chromosome 9 at 108,644,076 bp
  • T to C, chromosome 9 at 121,749,604 bp
  • A to T, chromosome 12 at 54,656,482 bp
  • A to T, chromosome 12 at 87,128,969 bp
  • T to C, chromosome 13 at 59,726,955 bp
  • T to C, chromosome 14 at 57,275,918 bp
  • T to C, chromosome 15 at 8,270,685 bp
  • T to A, chromosome 15 at 27,854,912 bp
  • T to A, chromosome 15 at 43,078,114 bp
  • T to C, chromosome 15 at 74,836,421 bp
  • A to T, chromosome 15 at 90,615,099 bp
  • C to T, chromosome 16 at 11,447,453 bp
  • T to C, chromosome 16 at 31,116,069 bp
  • T to C, chromosome 16 at 78,962,190 bp
  • A to G, chromosome 17 at 6,621,209 bp
  • T to C, chromosome 17 at 7,927,016 bp
  • G to T, chromosome 17 at 23,815,684 bp
  • T to C, chromosome 18 at 60,816,084 bp
  • C to T, chromosome 18 at 73,935,165 bp
  • T to C, chromosome 19 at 3,921,275 bp
  • T to C, chromosome X at 53,020,139 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2913 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040500-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.