Strain Name:
C57BL/6J-MtgxR2915Btlr/Mmmh
Stock Number:
040502-MU
Citation ID:
RRID:MMRRC_040502-MU
Other Names:
R2915 (G1), C57BL/6J-MtgxR2915Btlr
Major Collection:

Gene Information

Tyrp1
Name: tyrosinase-related protein 1
Synonyms: Tyrp, isa, TRP-1, TRP1, Oca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22178
Homologene: 464
Poli
Name: polymerase (DNA directed), iota
Synonyms: Rad30b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 26447
HGNC: HGNC:9182
Homologene: 5209
Gdnf
Name: glial cell line derived neurotrophic factor
Synonyms: glial cell line-derived neurotrophic factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14573
VEGA: 15
HGNC: HGNC:4232
Homologene: 433
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, C030045D06Rik, Depdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109294
Homologene: 23523
Setx
Name: senataxin
Synonyms: A930037J23Rik, Als4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Wac
Name: WW domain containing adaptor with coiled-coil
Synonyms: Wwp4, 1110067P07Rik, A230035H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225131
Homologene: 41148
Spred2
Name: sprouty-related EVH1 domain containing 2
Synonyms: Spred-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 114716
Homologene: 24918
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: C130002K18Rik, 5430435M13Rik, 2610207I05Rik, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233789
Homologene: 56697
Rnf20
Name: ring finger protein 20
Synonyms: 4833430L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109331
Homologene: 5571
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: PEPP2, 2810431N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109135
Homologene: 10377
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195018
Homologene: 9027
Sgk1
Name: serum/glucocorticoid regulated kinase 1
Synonyms: Sgk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20393
Homologene: 48364
Ice2
Name: interactor of little elongation complex ELL subunit 2
Synonyms: B230343B06Rik, Narg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 93697
Homologene: 11618
Rad1
Name: RAD1 checkpoint DNA exonuclease
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19355
HGNC: HGNC:9806
Homologene: 37695
Dmkn
Name: dermokine
Synonyms: cI-36, sk30, sk89, Dmkn, dermokine, 1110014F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73712
Homologene: 136295
Vrk3
Name: vaccinia related kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101568
Homologene: 9509
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239102
Homologene: 52657
Pax1
Name: paired box 1
Synonyms: wt, hbs, Pax-1, hunchback, wavy tail
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18503
HGNC: HGNC:8615
Homologene: 4514
Nyap2
Name: neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
Synonyms: Jr6, 9430031J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241134
Homologene: 18239
Col5a2
Name: collagen, type V, alpha 2
Synonyms: 1110014L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12832
HGNC: HGNC:2210
Homologene: 20119
Ephb6
Name: Eph receptor B6
Synonyms: Mep, Cekl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13848
HGNC: HGNC:3396
Homologene: 20940
Elmo2
Name: engulfment and cell motility 2
Synonyms: 1190002F24Rik, CED-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 140579
Homologene: 44338
Ssu2
Name: ssu-2 homolog (C. elegans)
Synonyms: D630042P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243612
Homologene: 136556
Gabrb2
Name: gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
Synonyms: Gabrb-2, C030021G16Rik, C030002O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14401
HGNC: HGNC:4082
Homologene: 7327
C330019G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Prss1
Name: protease, serine 1 (trypsin 1)
Synonyms: PRSS1, Try-1, Try1, Trygn16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 114228
Homologene: 88408
Tbc1d9b
Name: TBC1 domain family, member 9B
Synonyms: 2700008N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76795
Homologene: 28106
Cracr2a
Name: calcium release activated channel regulator 2A
Synonyms: LOC381812, LOC243645, Efcab4b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381812
Homologene: 41883
Olfr27
Name: olfactory receptor 27
Synonyms: MTPCR56, MOR171-6, GA_x6K02T2PVTD-32841223-32842158
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258826
VEGA: 9
Homologene: 110610
Plin4
Name: perilipin 4
Synonyms: S3-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57435
Homologene: 69311
Pcdhb12
Name: protocadherin beta 12
Synonyms: Pcdhb5F, PcdhbL, Pcdh3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93883
Homologene: 87126
Otulin
Name: OTU deubiquitinase with linear linkage specificity
Synonyms: m7-1Sapc, gumby, Fam105b, m3Sapc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 432940
VEGA: 15
Homologene: 106591
Olfr1031
Name: olfactory receptor 1031
Synonyms: GA_x6K02T2Q125-47470765-47471775, MOR200-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257916
Homologene: 73973
Vmn1r90
Name: vomeronasal 1 receptor 90
Synonyms: B430211C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 627280
Homologene: 122945
Aif1
Name: allograft inflammatory factor 1
Synonyms: G1, Iba1, D17H6S50E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 11629
HGNC: HGNC:352
Homologene: 1226
Otop2
Name: otopetrin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237987
Homologene: 27803
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74691
Homologene: 14311
Mios
Name: meiosis regulator for oocyte development
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 252875
Homologene: 10371
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: GAP (1-12), 6530401L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228482
Homologene: 8862
Olfr1094
Name: olfactory receptor 1094
Synonyms: GA_x6K02T2Q125-48321457-48322449, MOR179-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258362
Homologene: 133609
Olfr1428
Name: olfactory receptor 1428
Synonyms: GA_x6K02T2RE5P-2468394-2467450, MOR239-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258673
Homologene: 17339
Olfr1306
Name: olfactory receptor 1306
Synonyms: GA_x6K02T2Q125-72954873-72953935, MOR245-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258023
Homologene: 128383
B3gnt6
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
Synonyms: Core3, Core-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 272411
Homologene: 16339
Dusp13
Name: dual specificity phosphatase 13
Synonyms: TMDP, LMW-DSP6, TS-DSP6, LOC382853
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 27389
Homologene: 121602
Grin2d
Name: glutamate receptor, ionotropic, NMDA2D (epsilon 4)
Synonyms: NMDAR2D, NR2D, GluRepsilon4, GluN2D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14814
HGNC: HGNC:4588
Homologene: 648
Gprin2
Name: G protein regulated inducer of neurite outgrowth 2
Synonyms: C130040D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 432839
VEGA: 14
Homologene: 40975
AC123686.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Six2
Name: sine oculis-related homeobox 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20472
Homologene: 56518
AC140409.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Gm20470
Name: predicted gene 20470
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 11,169,853 bp
  • C to G, chromosome 1 at 45,413,496 bp
  • C to T, chromosome 1 at 81,087,471 bp
  • A to G, chromosome 2 at 29,172,324 bp
  • T to A, chromosome 2 at 85,992,045 bp
  • T to C, chromosome 2 at 86,829,226 bp
  • G to T, chromosome 2 at 111,912,719 bp
  • A to G, chromosome 2 at 113,833,508 bp
  • A to G, chromosome 2 at 147,368,428 bp
  • A to G, chromosome 2 at 165,297,653 bp
  • A to G, chromosome 4 at 49,638,769 bp
  • A to G, chromosome 4 at 80,837,455 bp
  • A to T, chromosome 5 at 32,829,768 bp
  • T to C, chromosome 5 at 143,289,577 bp
  • C to T, chromosome 6 at 8,214,935 bp
  • A to T, chromosome 6 at 41,462,611 bp
  • T to C, chromosome 6 at 41,614,238 bp
  • A to T, chromosome 6 at 112,377,605 bp
  • A to G, chromosome 6 at 127,611,505 bp
  • A to G, chromosome 6 at 140,589,199 bp
  • T to C, chromosome 7 at 14,586,711 bp
  • A to G, chromosome 7 at 30,765,316 bp
  • C to T, chromosome 7 at 44,775,442 bp
  • T to C, chromosome 7 at 45,833,357 bp
  • T to C, chromosome 7 at 98,193,593 bp
  • T to A, chromosome 7 at 118,210,879 bp
  • G to T, chromosome 9 at 39,144,466 bp
  • A to G, chromosome 9 at 40,670,787 bp
  • A to G, chromosome 9 at 69,410,840 bp
  • A to G, chromosome 10 at 7,760,934 bp
  • C to T, chromosome 10 at 21,996,601 bp
  • T to C, chromosome 11 at 19,998,215 bp
  • T to A, chromosome 11 at 42,591,907 bp
  • T to A, chromosome 11 at 50,149,736 bp
  • G to A, chromosome 11 at 72,910,326 bp
  • G to A, chromosome 11 at 115,329,146 bp
  • G to A, chromosome 12 at 112,040,461 bp
  • T to A, chromosome 14 at 21,740,137 bp
  • C to T, chromosome 14 at 34,195,081 bp
  • G to T, chromosome 14 at 55,064,557 bp
  • T to A, chromosome 15 at 7,815,649 bp
  • T to C, chromosome 15 at 10,486,642 bp
  • A to G, chromosome 15 at 27,619,630 bp
  • G to A, chromosome 17 at 35,172,151 bp
  • T to A, chromosome 17 at 56,104,389 bp
  • A to G, chromosome 17 at 85,685,188 bp
  • A to C, chromosome 18 at 7,926,131 bp
  • A to T, chromosome 18 at 37,437,640 bp
  • A to G, chromosome 18 at 70,522,700 bp
  • G to A, chromosome 19 at 12,108,625 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2915 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040502-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.