Strain Name:
C57BL/6J-MtgxR2918Btlr/Mmmh
Stock Number:
040503-MU
Citation ID:
RRID:MMRRC_040503-MU
Other Names:
R2918 (G1), C57BL/6J-MtgxR2918Btlr
Major Collection:

Gene Information

Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRTe, SMRT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Mafa
Name: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
Synonyms: RIPE3b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 378435
VEGA: 15
Homologene: 65867
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: NMHC II-C, 2400004E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71960
Homologene: 23480
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: C530005A01Rik, 6030465E24Rik, spastic paraplegia 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214585
Homologene: 41614
Zbtb14
Name: zinc finger and BTB domain containing 14
Synonyms: ZF5, Zfp161, b2b1982Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22666
Homologene: 2560
Sptb
Name: spectrin beta, erythrocytic
Synonyms: Spnb-1, spectrin R, D330027P03Rik, LOC383567, brain erythroid spectrin (235E), Spnb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20741
Homologene: 295
Dnaja1
Name: DnaJ heat shock protein family (Hsp40) member A1
Synonyms: Hsj2, Nedd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15502
HGNC: HGNC:5229
Homologene: 55588
Acbd5
Name: acyl-Coenzyme A binding domain containing 5
Synonyms: 1300014E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74159
Homologene: 12541
Akap8
Name: A kinase (PRKA) anchor protein 8
Synonyms: AKAP95, 1200016A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56399
VEGA: 17
HGNC: HGNC:378
Homologene: 4278
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Itpr-3, Ip3r3, tf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Agtpbp1
Name: ATP/GTP binding protein 1
Synonyms: Nna1, 2900054O13Rik, 4930445M19Rik, 1700020N17Rik, 5730402G09Rik, 2310001G17Rik, Ccp1, atms
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67269
Homologene: 9067
Pik3ap1
Name: phosphoinositide-3-kinase adaptor protein 1
Synonyms: BCAP, 1810044J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83490
VEGA: 19
Homologene: 12848
Trpc1
Name: transient receptor potential cation channel, subfamily C, member 1
Synonyms: Trrp1, Trp1, Mtrp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22063
Homologene: 2478
Arrdc2
Name: arrestin domain containing 2
Synonyms: 4632416I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70807
Homologene: 79540
Smarcd1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Synonyms: Baf60a, D15Kz1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 83797
VEGA: 15
Homologene: 20670
Ifit2
Name: interferon-induced protein with tetratricopeptide repeats 2
Synonyms: Ifi54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 15958
HGNC: HGNC:5409
Homologene: 1187
Hcn3
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 3
Synonyms: Hac3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15168
Homologene: 22453
Stxbp5l
Name: syntaxin binding protein 5-like
Synonyms: t2md1, LLGL4, A830015P08Rik, insulin level locus 1, tomosyn-2, T2dm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207227
Homologene: 18173
Odad2
Name: outer dynein arm docking complex subunit 2
Synonyms: 4930463I21Rik, Armc4, b2b227.1Clo, b2b643Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 74934
VEGA: 18
Homologene: 9992
Olfr975
Name: olfactory receptor 975
Synonyms: GA_x6K02T2PVTD-33651220-33650288, MOR224-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258825
VEGA: 9
Homologene: 27275
Ift140
Name: intraflagellar transport 140
Synonyms: Wdtc2, Tce5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106633
Homologene: 40979
Mug2
Name: murinoglobulin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17837
Homologene: 136663
Acsf3
Name: acyl-CoA synthetase family member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 257633
Homologene: 14958
Nod2
Name: nucleotide-binding oligomerization domain containing 2
Synonyms: F830032C23Rik, Card15, Nlrc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 257632
HGNC: HGNC:5331
Homologene: 11156
Olfr24
Name: olfactory receptor 24
Synonyms: MTPCR51, MOR132-1, GA_x6K02T2PVTD-12498544-12497603
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18322
HGNC: HGNC:8220
Homologene: 64896
Pkdcc
Name: protein kinase domain containing, cytoplasmic
Synonyms: ESTM17, Vlk, MAd1, Adtk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106522
Homologene: 18932
Trim41
Name: tripartite motif-containing 41
Synonyms: RINCK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 211007
Homologene: 14140
Atg10
Name: autophagy related 10
Synonyms: 5330424L23Rik, 5430428K15Rik, APG10, Apg10p, Apg10l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66795
VEGA: 13
Homologene: 12036
Ergic2
Name: ERGIC and golgi 2
Synonyms: 4930572C01Rik, 1200009B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67456
Homologene: 6574
Pak3
Name: p21 (RAC1) activated kinase 3
Synonyms: PAK-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 18481
HGNC: HGNC:8592
Homologene: 55664
G6pd2
Name: glucose-6-phosphate dehydrogenase 2
Synonyms: Gpd2, Gpd-2, G6pdx-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14380
Rassf4
Name: Ras association (RalGDS/AF-6) domain family member 4
Synonyms: 3830411C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 213391
Homologene: 12926
Crb2
Name: crumbs family member 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241324
Homologene: 45474
Olfr223
Name: olfactory receptor 223
Synonyms: GA_x6K02T000SA-78-1037, MOR256-30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258421
Homologene: 73917
Scp2d1
Name: SCP2 sterol-binding domain containing 1
Synonyms: 1700010M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66328
Homologene: 11947
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 2 at 23,099,567 bp
  • G to T, chromosome 2 at 37,783,383 bp
  • A to G, chromosome 2 at 122,075,301 bp
  • T to A, chromosome 2 at 144,823,948 bp
  • A to G, chromosome 3 at 89,147,613 bp
  • C to T, chromosome 4 at 40,724,052 bp
  • A to G, chromosome 5 at 61,809,526 bp
  • T to A, chromosome 5 at 125,025,760 bp
  • G to A, chromosome 6 at 84,186,509 bp
  • A to G, chromosome 6 at 116,641,740 bp
  • A to G, chromosome 6 at 122,074,724 bp
  • A to C, chromosome 6 at 148,188,020 bp
  • T to C, chromosome 7 at 44,616,263 bp
  • C to T, chromosome 8 at 70,837,527 bp
  • T to C, chromosome 8 at 88,652,891 bp
  • A to G, chromosome 8 at 122,813,144 bp
  • T to A, chromosome 9 at 18,755,479 bp
  • A to G, chromosome 9 at 39,950,364 bp
  • C to T, chromosome 9 at 95,723,129 bp
  • TTCCTCCTCCTCCTCCTCCTCCTCCTCC to TTCCTCCTCCTCCTCCTCCTCCTCC, chromosome 11 at 48,816,257 bp
  • T to C, chromosome 11 at 59,589,439 bp
  • A to G, chromosome 12 at 76,598,758 bp
  • T to A, chromosome 13 at 59,497,015 bp
  • A to T, chromosome 13 at 91,040,908 bp
  • A to G, chromosome 15 at 75,747,298 bp
  • T to A, chromosome 15 at 99,712,269 bp
  • A to T, chromosome 16 at 37,200,642 bp
  • C to A, chromosome 17 at 25,035,831 bp
  • G to A, chromosome 17 at 27,096,072 bp
  • A to G, chromosome 17 at 32,305,648 bp
  • C to T, chromosome 17 at 69,388,219 bp
  • G to C, chromosome 17 at 83,215,949 bp
  • G to A, chromosome 18 at 7,222,625 bp
  • T to C, chromosome 19 at 34,573,059 bp
  • T to C, chromosome 19 at 41,302,531 bp
  • T to C, chromosome X at 143,764,976 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2918 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040503-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.