Strain Name:
C57BL/6J-MtgxR2924Btlr/Mmmh
Stock Number:
040509-MU
Citation ID:
RRID:MMRRC_040509-MU
Other Names:
R2924 (G1), C57BL/6J-MtgxR2924Btlr
Major Collection:

Gene Information

Oxr1
Name: oxidation resistance 1
Synonyms: C7, 2210416C20Rik, C7B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170719
VEGA: 15
Homologene: 24993
Gli2
Name: GLI-Kruppel family member GLI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14633
HGNC: HGNC:4318
Homologene: 12725
Hsp90aa1
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: hsp4, Hspca, Hsp90, Hsp89, Hsp86-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15519
HGNC: HGNC:5253
Homologene: 68464
Ddx50
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
Synonyms: 8430408E17Rik, 4933429B04Rik, RH-II/Gubeta, GU2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 94213
VEGA: 10
Homologene: 56986
Syt3
Name: synaptotagmin III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20981
Homologene: 9617
Dock6
Name: dedicator of cytokinesis 6
Synonyms: 2410095B20Rik, 4931431C02Rik, C330023D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319899
VEGA: 9
Homologene: 83291
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: C030045D06Rik, Depdc2, 6230420N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109294
Homologene: 23523
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77011
Homologene: 67120
Rnmt
Name: RNA (guanine-7-) methyltransferase
Synonyms: 2610002P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67897
Homologene: 2816
Nsf
Name: N-ethylmaleimide sensitive fusion protein
Synonyms: N-ethylmaleimide sensitive factor, SKD2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18195
HGNC: HGNC:8016
Homologene: 4502
Ncapg2
Name: non-SMC condensin II complex, subunit G2
Synonyms: Mtb, Luzp5, 5830426I05Rik, mCAP-G2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76044
VEGA: 12
Homologene: 9820
Mtbp
Name: Mdm2, transformed 3T3 cell double minute p53 binding protein
Synonyms: MDM2BP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105837
HGNC: HGNC:7417
Homologene: 11102
Dhx15
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 15
Synonyms: mDEAH9, DBP1, HRH2, Ddx15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13204
HGNC: HGNC:2738
Homologene: 1040
Rbbp5
Name: retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit
Synonyms: 4933411J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213464
HGNC: HGNC:9888
Homologene: 3709
Nup214
Name: nucleoporin 214
Synonyms: CAN, D2H9S46E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Mrgpra1
Name: MAS-related GPR, member A1
Synonyms: MrgA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233221
Homologene: 79615
Uba6
Name: ubiquitin-like modifier activating enzyme 6
Synonyms: Ube1l2, 5730469D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231380
Homologene: 10080
Bcl9
Name: B cell CLL/lymphoma 9
Synonyms: 2610202E01Rik, 8030475K17Rik, A330041G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77578
HGNC: HGNC:1008
Homologene: 3191
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: Hapip, LOC224126, 2210407G14Rik, E530005C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Zc3hav1
Name: zinc finger CCCH type, antiviral 1
Synonyms: 9130009D18Rik, ZAP, 9830115L13Rik, 1200014N16Rik, 2900058M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78781
Homologene: 10585
Slc24a2
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
Synonyms: 6330417K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76376
Homologene: 10669
Tmem132e
Name: transmembrane protein 132E
Synonyms: LOC270893
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 270893
Homologene: 41524
Cass4
Name: Cas scaffolding protein family member 4
Synonyms: F730031O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320664
Homologene: 75128
Unc13a
Name: unc-13 homolog A
Synonyms: 2410078G03Rik, Munc13-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382018
Homologene: 11279
Kansl1l
Name: KAT8 regulatory NSL complex subunit 1-like
Synonyms: 1110028C15Rik, C430010P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68691
Homologene: 27376
Olfr394
Name: olfactory receptor 394
Synonyms: MOR135-8, GA_x6K02T2P1NL-4043306-4042374
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 259009
Homologene: 133669
Ints6l
Name: integrator complex subunit 6 like
Synonyms: Ddx26b, 4930535D10Rik, 6330505F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 236790
Homologene: 52110
AC120787.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Zfp119a
Name: zinc finger protein 119a
Synonyms: Mzf13, Zfp119
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 104349
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: Kv4.3, potassium channel Kv4.3L, potassium channel Kv4.3M
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Man2b2
Name: mannosidase 2, alpha B2
Synonyms: 135 kDa alpha-D-mannosidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17160
Homologene: 7411
Il2rb
Name: interleukin 2 receptor, beta chain
Synonyms: CD122, IL-15 receptor beta chain, IL-2/15Rbeta, IL15Rbeta, Il-2Rbeta, IL-15Rbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16185
VEGA: 15
HGNC: HGNC:6009
Homologene: 47955
Dmrtc2
Name: doublesex and mab-3 related transcription factor like family C2
Synonyms: 4933432E21Rik, Dmrt7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71241
Homologene: 75260
Fuom
Name: fucose mutarotase
Synonyms: 1810014F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69064
Homologene: 19598
Upk3a
Name: uroplakin 3A
Synonyms: Upk3, 1110017C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22270
VEGA: 15
Homologene: 5066
Srd5a1
Name: steroid 5 alpha-reductase 1
Synonyms: 4930435F02Rik, Srd5a-1, 0610031P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 78925
Homologene: 37426
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 11,098,487 bp
  • A to G, chromosome 1 at 66,721,010 bp
  • C to T, chromosome 1 at 118,836,359 bp
  • G to C, chromosome 1 at 132,492,663 bp
  • A to G, chromosome 2 at 31,998,003 bp
  • A to G, chromosome 2 at 172,426,672 bp
  • A to G, chromosome 3 at 97,209,753 bp
  • C to T, chromosome 3 at 105,658,766 bp
  • A to G, chromosome 4 at 87,011,724 bp
  • A to G, chromosome 5 at 36,824,102 bp
  • A to G, chromosome 5 at 52,171,414 bp
  • A to T, chromosome 5 at 86,159,271 bp
  • T to C, chromosome 6 at 38,354,110 bp
  • G to A, chromosome 7 at 24,872,516 bp
  • T to A, chromosome 7 at 44,395,798 bp
  • G to A, chromosome 7 at 47,334,870 bp
  • A to T, chromosome 7 at 79,685,952 bp
  • T to C, chromosome 7 at 140,099,949 bp
  • A to G, chromosome 8 at 71,644,952 bp
  • A to T, chromosome 9 at 21,809,630 bp
  • A to T, chromosome 10 at 62,627,594 bp
  • A to G, chromosome 11 at 73,887,511 bp
  • T to C, chromosome 11 at 82,444,323 bp
  • C to T, chromosome 11 at 103,930,752 bp
  • T to A, chromosome 12 at 110,695,680 bp
  • C to A, chromosome 12 at 110,695,681 bp
  • C to A, chromosome 12 at 116,438,729 bp
  • A to G, chromosome 13 at 69,586,715 bp
  • T to C, chromosome 15 at 41,825,957 bp
  • G to A, chromosome 15 at 55,619,814 bp
  • A to G, chromosome 15 at 76,178,252 bp
  • T to C, chromosome 15 at 78,491,849 bp
  • A to G, chromosome 15 at 85,018,149 bp
  • A to T, chromosome 15 at 101,643,794 bp
  • C to T, chromosome 16 at 33,989,810 bp
  • C to A, chromosome 17 at 55,868,343 bp
  • C to A, chromosome 18 at 68,313,980 bp
  • A to G, chromosome X at 56,504,836 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2924 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040509-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.