Strain Name:
C57BL/6J-MtgxR2939Btlr/Mmmh
Stock Number:
040516-MU
Citation ID:
RRID:MMRRC_040516-MU
Other Names:
R2939 (G1), C57BL/6J-MtgxR2939Btlr
Major Collection:

Strain Information

Slc1a6
Name: solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Synonyms: EAAT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20513
VEGA: 10
Homologene: 21055
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Plcb4
Name: phospholipase C, beta 4
Synonyms: A930039J07Rik, C230058B11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Nphs1
Name: nephrosis 1, nephrin
Synonyms: nephrin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54631
HGNC: HGNC:7908
Homologene: 20974
Ssc4d
Name: scavenger receptor cysteine rich family, 4 domains
Synonyms: C330016E03Rik, Srcrb4d
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 109267
Homologene: 34137
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: D17Rp17, D17Rp17e, MAPKKK4, Mekk4, MTK1, Tas, RP17, T-associated sex reversal
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: A630020C16Rik, 4930502N04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74996
Homologene: 9929
Kdm3a
Name: lysine (K)-specific demethylase 3A
Synonyms: Jmjd1a, Jmjd1, Tsga, C230043E16Rik, 1700105C21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 104263
Homologene: 10196
Nherf1
Name: NHERF family PDZ scaffold protein 1
Synonyms: sodium-hydrogen exchanger regulatory factor, Slc9a3r1, NHE-RF, NHERF1, EBP-50
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26941
Homologene: 3137
Senp6
Name: SUMO/sentrin specific peptidase 6
Synonyms: 2810017C20Rik, E130319N12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215351
Homologene: 9196
Dock6
Name: dedicator of cytokinesis 6
Synonyms: C330023D02Rik, 2410095B20Rik, 4931431C02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319899
VEGA: 9
Homologene: 83291
Suco
Name: SUN domain containing ossification factor
Synonyms: osteopotentia, AI848100, Opt
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226551
HGNC: HGNC:1240
Homologene: 32212
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Myo9b
Name: myosin IXb
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Commd9
Name: COMM domain containing 9
Synonyms: 1810029F08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76501
Homologene: 8584
Eif5
Name: eukaryotic translation initiation factor 5
Synonyms: D12Ertd549e, 2810011H21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217869
VEGA: 12
HGNC: HGNC:3299
Homologene: 49610
Rph3a
Name: rabphilin 3A
Synonyms: 2900002P20Rik, Doc2 family
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19894
Homologene: 7921
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Nmnat2
Name: nicotinamide nucleotide adenylyltransferase 2
Synonyms: D030041I09Rik, PNAT1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226518
Homologene: 75037
Cldn14
Name: claudin 14
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56173
HGNC: HGNC:2035
Homologene: 8115
Carm1
Name: coactivator-associated arginine methyltransferase 1
Synonyms: m9Bei, Prmt4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 59035
Homologene: 10990
Trpv1
Name: transient receptor potential cation channel, subfamily V, member 1
Synonyms: OTRPC1, VR-1, capsaicin receptor, Vr1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 193034
Homologene: 12920
Gpatch8
Name: G patch domain containing 8
Synonyms: Fbm1, ENSMUSG00000075516, 5430405G24Rik, Gpatc8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237943
Homologene: 46117
Smpd3
Name: sphingomyelin phosphodiesterase 3, neutral
Synonyms: fro, neutral sphingomyelinase II, nSMase2, Nsm2, 4631433G07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 58994
Homologene: 10260
Fhdc1
Name: FH2 domain containing 1
Synonyms: 6330505N24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229474
Homologene: 18920
Col5a3
Name: collagen, type V, alpha 3
Synonyms: Pro-alpha3(V)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 53867
Homologene: 9253
Tecta
Name: tectorin alpha
Synonyms: Tctna, [a]-tectorin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21683
Homologene: 3955
Slc26a6
Name: solute carrier family 26, member 6
Synonyms: B930010B04Rik, CFEX, Pat1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 171429
Homologene: 99903
Spata31g1
Name: SPATA31 subfamily G member 1
Synonyms: 1700022I11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67317
Homologene: 52406
Or8g34
Name: olfactory receptor family 8 subfamily G member 34
Synonyms: MOR171-42, MOR171-53, Olfr954, GA_x6K02T2PVTD-33158015-33158950
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258328
VEGA: 9
HGNC: HGNC:8484
Homologene: 71961
Ttc39d
Name: tetratricopeptide repeat domain 39D
Synonyms: 4930560E09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67737
Homologene: 65053
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Cfap69
Name: cilia and flagella associated protein 69
Synonyms: A330021E22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207686
Homologene: 11718
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: Gm1557, 4930503E15Rik, LOC380658
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74978
Homologene: 46007
Lgi4
Name: leucine-rich repeat LGI family, member 4
Synonyms: clp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243914
Homologene: 16408
Rsph4a
Name: radial spoke head 4 homolog A (Chlamydomonas)
Synonyms: Rshl3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 212892
Homologene: 71779
Crybg2
Name: crystallin beta-gamma domain containing 2
Synonyms: Aim1l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230806
Homologene: 19232
Ksr1
Name: kinase suppressor of ras 1
Synonyms: B-KSR1, D11Bhm183e, D11Bhm184e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16706
HGNC: HGNC:6465
Homologene: 8410
Or8b12i
Name: olfactory receptor family 8 subfamily B member 12I
Synonyms: MOR141-1, GA_x6K02T2PVTD-13912679-13911744, Olfr870
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57251
Homologene: 138319
Azin2
Name: antizyme inhibitor 2
Synonyms: Odcp, Adc, 4933429I20Rik, AZIN2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242669
Homologene: 62172
Slc45a3
Name: solute carrier family 45, member 3
Synonyms: 2210413P12Rik, IPCA-6, Pcanap6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212980
HGNC: HGNC:8642
Homologene: 23813
Arhgef26
Name: Rho guanine nucleotide exchange factor 26
Synonyms: 8430436L14Rik, 4631416L12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 622434
Homologene: 9204
Vmn2r55
Name: vomeronasal 2, receptor 55
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042499
Homologene: 104040
Cfap410
Name: cilia and flagella associated protein 410
Synonyms: 1810043G02Rik, D10Jhu13e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67884
HGNC: HGNC:1260
Homologene: 3619
Actl11
Name: actin-like 11
Synonyms: 4921517D21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67722
Homologene: 69412
Adcy6
Name: adenylate cyclase 6
Synonyms: AC6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11512
VEGA: 15
HGNC: HGNC:237
Homologene: 22400
Pdzd7
Name: PDZ domain containing 7
Synonyms: EG435601, Pdzk7
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100503041
Homologene: 129509
Dixdc1
Name: DIX domain containing 1
Synonyms: Ccd1, 4930563F16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330938
Homologene: 82369
Garin4
Name: golgi associated RAB2 interactor family member 4
Synonyms: 4933417M04Rik, Fam71a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 619288
Homologene: 77474
Pcsk7
Name: proprotein convertase subtilisin/kexin type 7
Synonyms: SPC7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18554
VEGA: 9
HGNC: HGNC:8748
Homologene: 37955
Vmn2r22
Name: vomeronasal 2, receptor 22
Synonyms: EG546913
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 546913
Homologene: 84037
Zfp558
Name: zinc finger protein 558
Synonyms: Zfp558-ps, 1700007A21Rik, 4932704I17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72230
Homologene: 44903
Tmprss11b
Name: transmembrane protease, serine 11B
Synonyms: Tmprss11bnl, 9930019B18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319875
Homologene: 64599
Stard13
Name: StAR related lipid transfer domain containing 13
Synonyms: GT650, DLC2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243362
Homologene: 64844
Dagla
Name: diacylglycerol lipase, alpha
Synonyms: Nsddr
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 269060
HGNC: HGNC:1165
Homologene: 4468
Tmprss11e
Name: transmembrane protease, serine 11e
Synonyms: DESC1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243084
Homologene: 8543
Brsk1
Name: BR serine/threonine kinase 1
Synonyms: SAD-B, LOC381979
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381979
Homologene: 57169
Trim63
Name: tripartite motif-containing 63
Synonyms: MuRF1, Rnf28
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433766
Homologene: 41878
Heatr3
Name: HEAT repeat containing 3
Synonyms: C030036P15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234549
Homologene: 45429
AC159899.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Rnf25
Name: ring finger protein 25
Synonyms: 0610009H16Rik, AO7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 57751
Homologene: 11193
Pdrg1
Name: p53 and DNA damage regulated 1
Synonyms: 1110004D19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68559
Homologene: 12779
Zfp513
Name: zinc finger protein 513
Synonyms: D430028M17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 101023
Homologene: 16955
Smc1a
Name: structural maintenance of chromosomes 1A
Synonyms: Smc1alpha, Smc1l1, SB1.8, Smc1, SMCB, 5830426I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 24061
Homologene: 4597
Armcx6
Name: armadillo repeat containing, X-linked 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 278097
Homologene: 10373
Asl
Name: argininosuccinate lyase
Synonyms: 2510006M18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 109900
HGNC: HGNC:746
Homologene: 32
Haghl
Name: hydroxyacylglutathione hydrolase-like
Synonyms: 2810014I23Rik, C330022E15Rik, 1500017E18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68977
Homologene: 57062
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 74,595,888 bp
  • A to G, chromosome 1 at 131,977,899 bp
  • C to A, chromosome 1 at 153,074,728 bp
  • A to G, chromosome 1 at 161,848,651 bp
  • T to C, chromosome 1 at 191,163,906 bp
  • G to A, chromosome 2 at 101,886,331 bp
  • T to C, chromosome 2 at 135,939,203 bp
  • C to T, chromosome 2 at 153,012,435 bp
  • A to C, chromosome 2 at 180,198,954 bp
  • A to C, chromosome 3 at 62,380,910 bp
  • A to G, chromosome 3 at 84,457,270 bp
  • A to G, chromosome 4 at 42,972,946 bp
  • C to T, chromosome 4 at 128,934,604 bp
  • A to G, chromosome 4 at 134,082,434 bp
  • T to C, chromosome 4 at 134,322,997 bp
  • A to G, chromosome 4 at 143,966,677 bp
  • G to A, chromosome 5 at 5,644,432 bp
  • A to T, chromosome 5 at 31,201,569 bp
  • A to G, chromosome 5 at 86,663,375 bp
  • G to A, chromosome 5 at 86,721,407 bp
  • A to G, chromosome 5 at 120,980,149 bp
  • T to C, chromosome 5 at 130,013,404 bp
  • T to C, chromosome 5 at 135,965,724 bp
  • A to T, chromosome 5 at 151,047,583 bp
  • A to G, chromosome 6 at 71,614,005 bp
  • T to A, chromosome 6 at 123,637,635 bp
  • A to T, chromosome 7 at 4,708,140 bp
  • A to G, chromosome 7 at 12,651,905 bp
  • C to T, chromosome 7 at 30,463,228 bp
  • C to T, chromosome 7 at 31,067,828 bp
  • CG to CGACGGCGGTG, chromosome 7 at 97,579,908 bp
  • G to A, chromosome 7 at 112,082,536 bp
  • G to A, chromosome 8 at 71,334,337 bp
  • T to A, chromosome 8 at 88,161,865 bp
  • A to G, chromosome 8 at 106,257,407 bp
  • T to C, chromosome 9 at 18,456,628 bp
  • C to A, chromosome 9 at 20,170,765 bp
  • T to C, chromosome 9 at 20,795,658 bp
  • C to A, chromosome 9 at 21,579,396 bp
  • A to G, chromosome 9 at 21,839,200 bp
  • G to A, chromosome 9 at 39,461,930 bp
  • A to T, chromosome 9 at 42,377,994 bp
  • C to T, chromosome 9 at 45,916,024 bp
  • G to A, chromosome 9 at 50,710,959 bp
  • T to C, chromosome 9 at 53,494,711 bp
  • G to A, chromosome 9 at 80,143,842 bp
  • A to G, chromosome 9 at 99,232,474 bp
  • T to C, chromosome 9 at 107,931,210 bp
  • G to A, chromosome 9 at 108,857,037 bp
  • T to C, chromosome 10 at 33,908,056 bp
  • A to G, chromosome 10 at 77,981,673 bp
  • G to T, chromosome 10 at 78,814,614 bp
  • T to A, chromosome 10 at 103,144,889 bp
  • A to G, chromosome 11 at 73,254,849 bp
  • A to G, chromosome 11 at 79,045,181 bp
  • A to G, chromosome 11 at 102,508,184 bp
  • C to T, chromosome 11 at 115,180,444 bp
  • C to T, chromosome 12 at 102,991,425 bp
  • T to C, chromosome 12 at 111,540,279 bp
  • G to A, chromosome 15 at 98,598,498 bp
  • T to C, chromosome 16 at 93,919,304 bp
  • C to T, chromosome 17 at 12,261,270 bp
  • A to G, chromosome 17 at 25,785,086 bp
  • A to G, chromosome 17 at 80,217,553 bp
  • A to C, chromosome 19 at 10,256,364 bp
  • A to G, chromosome 19 at 45,045,423 bp
  • A to T, chromosome X at 134,749,876 bp
  • T to A, chromosome X at 152,033,699 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2939 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040516-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.