Strain Name:
C57BL/6J-MtgxR2940Btlr/Mmmh
Stock Number:
040517-MU
Citation ID:
RRID:MMRRC_040517-MU
Other Names:
R2940 (G1), C57BL/6J-MtgxR2940Btlr
Major Collection:

Gene Information

Cpe
Name: carboxypeptidase E
Synonyms: carboxypeptidase H, CPH, Cph-1, Cph1, NF-alpha1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12876
HGNC: HGNC:2303
Homologene: 48052
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, trabeculin alpha, Aclp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Clasrp
Name: CLK4-associating serine/arginine rich protein
Synonyms: SWAP2, Sfrs16, Srsf16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 53609
Homologene: 134306
Fgd4
Name: FYVE, RhoGEF and PH domain containing 4
Synonyms: ZFYVE6, 9330209B17Rik, Frabin-gamma, Frabin-beta, Frabin-alpha, Frabin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224014
Homologene: 26727
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: Tas, MAPKKK4, Mekk4, MTK1, D17Rp17e, RP17, D17Rp17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Senp6
Name: SUMO/sentrin specific peptidase 6
Synonyms: 2810017C20Rik, E130319N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 215351
Homologene: 9196
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Dock6
Name: dedicator of cytokinesis 6
Synonyms: 4931431C02Rik, C330023D02Rik, 2410095B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319899
VEGA: 9
Homologene: 83291
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: c-Cbl-associated protein, Sh3d5, CAP, Ponsin, 9530001P15Rik, 2310065E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: Tweek, FSA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229227
Homologene: 52105
Myo9b
Name: myosin IXb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Eif3a
Name: eukaryotic translation initiation factor 3, subunit A
Synonyms: Csma, Eif3, A830012B05Rik, Eif3s10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13669
VEGA: 19
HGNC: HGNC:3271
Homologene: 2779
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: P400, Itpr-1, Pcp1, opt, wblo, InsP3R type I, Ip3r, IP3R1, Pcp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Xpo7
Name: exportin 7
Synonyms: Ranbp16, 4930506C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 65246
VEGA: 14
Homologene: 22857
Dmap1
Name: DNA methyltransferase 1-associated protein 1
Synonyms: 1500016M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66233
Homologene: 41311
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: MUCLIN, CRP-[b], hensin, ebnerin, CRP-[a], Crpd, vomeroglandin, gp300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Lman1
Name: lectin, mannose-binding, 1
Synonyms: MR60, ERGIC53, MCFD1, 2610020P13Rik, F5F8D, gp58, P58
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70361
HGNC: HGNC:6631
Homologene: 4070
Fam180a
Name: family with sequence similarity 180, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 208164
Homologene: 18283
Fibcd1
Name: fibrinogen C domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98970
Homologene: 122246
Apc
Name: APC, WNT signaling pathway regulator
Synonyms: adenomatosis polyposis coli, Min, CC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 11789
HGNC: HGNC:583
Homologene: 30950
Hnrnph1
Name: heterogeneous nuclear ribonucleoprotein H1
Synonyms: Hnrph1, E430005G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 59013
HGNC: HGNC:5041
Homologene: 31318
Carm1
Name: coactivator-associated arginine methyltransferase 1
Synonyms: Prmt4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 59035
Homologene: 10990
Tubb6
Name: tubulin, beta 6 class V
Synonyms: 2310057H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67951
VEGA: 18
Homologene: 69414
Nmd3
Name: NMD3 ribosome export adaptor
Synonyms: C87860
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 97112
Homologene: 6127
Zswim4
Name: zinc finger SWIM-type containing 4
Synonyms: E130119J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212168
Homologene: 18183
Mideas
Name: mitotic deacetylase associated SANT domain protein
Synonyms: C130039O16Rik, 9430029N19Rik, Elmsan1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238317
Homologene: 19330
Pomgnt1
Name: protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase
Synonyms: 0610016I07Rik, 4930467B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68273
Homologene: 9806
Trpv1
Name: transient receptor potential cation channel, subfamily V, member 1
Synonyms: Vr1, OTRPC1, VR-1, capsaicin receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 193034
Homologene: 12920
Cngb1
Name: cyclic nucleotide gated channel beta 1
Synonyms: Cngb1, BC016201, Cngb1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 333329
HGNC: HGNC:2151
Homologene: 136420
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Irbp, Rbp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
Isl1
Name: ISL1 transcription factor, LIM/homeodomain
Synonyms: Islet 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16392
HGNC: HGNC:6132
Homologene: 1661
Tecta
Name: tectorin alpha
Synonyms: Tctna, [a]-tectorin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21683
Homologene: 3955
Lamc3
Name: laminin gamma 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23928
HGNC: HGNC:6494
Homologene: 21222
Grk2
Name: G protein-coupled receptor kinase 2
Synonyms: beta-adrenergic receptor kinase-1, beta-AR kinase-1, beta ARK, beta ARK1, Adrbk1, Adrbk-1, Bark-1, betaARK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 110355
HGNC: HGNC:289
Homologene: 1223
Khdrbs3
Name: KH domain containing, RNA binding, signal transduction associated 3
Synonyms: T-STAR, SLM-2, Etle, Salp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13992
VEGA: 15
Homologene: 4780
Slc26a6
Name: solute carrier family 26, member 6
Synonyms: CFEX, Pat1, B930010B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 171429
Homologene: 99903
Plek
Name: pleckstrin
Synonyms: 2010300B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56193
HGNC: HGNC:9070
Homologene: 2000
Olfr954
Name: olfactory receptor 954
Synonyms: MOR171-42, MOR171-53, GA_x6K02T2PVTD-33158015-33158950
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258328
VEGA: 9
Homologene: 71961
Ttc39d
Name: tetratricopeptide repeat domain 39D
Synonyms: 4930560E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67737
Homologene: 65053
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Crybg2
Name: crystallin beta-gamma domain containing 2
Synonyms: Aim1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230806
Homologene: 19232
Olfr870
Name: olfactory receptor 870
Synonyms: GA_x6K02T2PVTD-13912679-13911744, MOR141-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 57251
Homologene: 138319
Sh3rf2
Name: SH3 domain containing ring finger 2
Synonyms: 9130023G24Rik, RNF158
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 269016
Homologene: 17618
Cyp2d26
Name: cytochrome P450, family 2, subfamily d, polypeptide 26
Synonyms: 1300006E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76279
VEGA: 15
Homologene: 130660
Pramel28
Name: PRAME like 28
Synonyms: Gm13101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 626922
Dixdc1
Name: DIX domain containing 1
Synonyms: Ccd1, 4930563F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330938
Homologene: 82369
Rasgrf1
Name: RAS protein-specific guanine nucleotide-releasing factor 1
Synonyms: CDC25Mm, CDC25, Grfbeta, Grf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19417
HGNC: HGNC:9875
Homologene: 74972
Igfbp1
Name: insulin-like growth factor binding protein 1
Synonyms: IGFBP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16006
HGNC: HGNC:5469
Homologene: 498
Slc13a1
Name: solute carrier family 13 (sodium/sulfate symporters), member 1
Synonyms: NaSi-1, Nas1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 55961
Homologene: 31893
Pigc
Name: phosphatidylinositol glycan anchor biosynthesis, class C
Synonyms: 3110030E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67292
HGNC: HGNC:8960
Homologene: 7109
Mup21
Name: major urinary protein 21
Synonyms: Gm11208
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381531
Homologene: 74304
Sh3tc2
Name: SH3 domain and tetratricopeptide repeats 2
Synonyms: D430044G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225608
VEGA: 18
Homologene: 11596
AC159899.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Rnf25
Name: ring finger protein 25
Synonyms: 0610009H16Rik, AO7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 57751
Homologene: 11193
Smc1a
Name: structural maintenance of chromosomes 1A
Synonyms: Smc1, Smc1l1, Smc1alpha, SB1.8, SMCB, 5830426I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 24061
Homologene: 4597
Armcx6
Name: armadillo repeat containing, X-linked 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 278097
Homologene: 10373
Haghl
Name: hydroxyacylglutathione hydrolase-like
Synonyms: 2810014I23Rik, C330022E15Rik, 1500017E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68977
Homologene: 57062
Rps18-ps6
Name: ribosomal protein S18, pseudogene 6
Synonyms: Gm10260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100039740
VEGA: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 74,595,888 bp
  • T to C, chromosome 1 at 161,970,670 bp
  • T to C, chromosome 2 at 31,817,264 bp
  • A to G, chromosome 2 at 31,940,702 bp
  • A to G, chromosome 3 at 36,958,805 bp
  • C to G, chromosome 3 at 55,934,624 bp
  • A to G, chromosome 3 at 69,724,399 bp
  • T to C, chromosome 4 at 62,149,347 bp
  • T to C, chromosome 4 at 116,154,824 bp
  • G to A, chromosome 4 at 117,676,005 bp
  • A to T, chromosome 4 at 123,374,305 bp
  • A to G, chromosome 4 at 134,082,434 bp
  • A to G, chromosome 4 at 143,966,677 bp
  • T to A, chromosome 6 at 24,090,780 bp
  • A to T, chromosome 6 at 35,313,629 bp
  • T to C, chromosome 6 at 108,405,391 bp
  • C to A, chromosome 7 at 19,585,240 bp
  • G to A, chromosome 7 at 131,097,513 bp
  • A to G, chromosome 8 at 64,597,446 bp
  • G to A, chromosome 8 at 71,334,337 bp
  • A to T, chromosome 8 at 84,223,748 bp
  • T to C, chromosome 8 at 95,252,107 bp
  • T to C, chromosome 8 at 107,262,837 bp
  • C to A, chromosome 9 at 20,170,765 bp
  • C to A, chromosome 9 at 21,579,396 bp
  • A to G, chromosome 9 at 21,839,200 bp
  • G to A, chromosome 9 at 39,461,930 bp
  • A to T, chromosome 9 at 42,377,994 bp
  • G to A, chromosome 9 at 50,710,959 bp
  • G to A, chromosome 9 at 80,143,842 bp
  • C to T, chromosome 9 at 89,991,714 bp
  • A to G, chromosome 9 at 99,232,474 bp
  • G to A, chromosome 9 at 108,857,037 bp
  • A to G, chromosome 11 at 7,201,970 bp
  • C to T, chromosome 11 at 16,992,887 bp
  • C to T, chromosome 11 at 50,383,677 bp
  • A to G, chromosome 11 at 73,254,849 bp
  • C to T, chromosome 12 at 84,156,471 bp
  • A to G, chromosome 13 at 68,730,305 bp
  • T to C, chromosome 13 at 116,308,299 bp
  • C to T, chromosome 14 at 33,956,018 bp
  • A to T, chromosome 14 at 70,667,136 bp
  • G to T, chromosome 14 at 70,667,137 bp
  • T to A, chromosome 15 at 69,049,390 bp
  • T to C, chromosome 15 at 82,790,967 bp
  • A to T, chromosome 16 at 16,469,690 bp
  • C to T, chromosome 17 at 12,261,270 bp
  • A to G, chromosome 17 at 25,785,086 bp
  • A to G, chromosome 17 at 80,217,553 bp
  • G to A, chromosome 18 at 34,276,670 bp
  • G to A, chromosome 18 at 42,111,440 bp
  • A to G, chromosome 18 at 61,989,686 bp
  • G to T, chromosome 18 at 65,984,273 bp
  • A to G, chromosome 18 at 67,401,924 bp
  • G to A, chromosome 19 at 4,290,696 bp
  • T to C, chromosome 19 at 40,373,571 bp
  • T to C, chromosome 19 at 60,773,677 bp
  • A to T, chromosome X at 134,749,876 bp
  • T to A, chromosome X at 152,033,699 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2940 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040517-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.