Strain Name:
C57BL/6J-MtgxR2965Btlr/Mmmh
Stock Number:
040521-MU
Citation ID:
RRID:MMRRC_040521-MU
Other Names:
R2965 (G1), C57BL/6J-MtgxR2965Btlr
Major Collection:

Gene Information

Col2a1
Name: collagen, type II, alpha 1
Synonyms: Del1, Lpk, M100856, Col2, Rgsc856, Col2a, Col2a-1, M100413, Rgsc413
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12824
HGNC: HGNC:2200
Homologene: 55607
Add1
Name: adducin 1 (alpha)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 11518
HGNC: HGNC:243
Homologene: 22758
Anks1
Name: ankyrin repeat and SAM domain containing 1
Synonyms: Odin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224650
Homologene: 9068
Dbi
Name: diazepam binding inhibitor
Synonyms: diazepam-binding inhibitor, Acbp, endozepine, EP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13167
HGNC: HGNC:2690
Homologene: 39086
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Phr1, C130061D10Rik, Pam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105689
Homologene: 9005
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: Usp31, 2810449C13Rik, D330022K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 170707
Homologene: 12988
2610021A01Rik
Name: RIKEN cDNA 2610021A01 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 668572
Rsf1
Name: remodeling and spacing factor 1
Synonyms: XAP8, p325, 4832420A03Rik, C030033M12Rik, Hbxap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233532
Homologene: 41142
Rab21
Name: RAB21, member RAS oncogene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216344
VEGA: 10
Homologene: 8991
Fgd6
Name: FYVE, RhoGEF and PH domain containing 6
Synonyms: ZFYVE24, Etohd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 13998
Homologene: 14209
Ing1
Name: inhibitor of growth family, member 1
Synonyms: mING1h, 2610028J21Rik, p33Ing1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 26356
HGNC: HGNC:6062
Homologene: 40119
Ptprj
Name: protein tyrosine phosphatase, receptor type, J
Synonyms: Byp, CD148, DEP-1, RPTPJ, Scc-1, Scc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 19271
HGNC: HGNC:9673
Homologene: 2130
Chsy1
Name: chondroitin sulfate synthase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 269941
Homologene: 8950
Fstl3
Name: follistatin-like 3
Synonyms: Flrg, E030038F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 83554
HGNC: HGNC:3973
Homologene: 4280
Mnd1
Name: meiotic nuclear divisions 1
Synonyms: 2610034E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 76915
Homologene: 5890
Klhl2
Name: kelch-like 2, Mayven
Synonyms: 8530402H02Rik, ABP-KELCH, Mav, 6030411N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 77113
HGNC: HGNC:6353
Homologene: 21416
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218333
VEGA: 13
Homologene: 18902
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 171395
Homologene: 51376
Prss35
Name: protease, serine 35
Synonyms: 6030424L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244954
Homologene: 17734
H2-T22
Name: histocompatibility 2, T region locus 22
Synonyms: H-2T17, H2-T17, H-2T22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 15039
Homologene: 79525
Col4a3
Name: collagen, type IV, alpha 3
Synonyms: alpha3(IV), tumstatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12828
HGNC: HGNC:2204
Homologene: 68033
Col13a1
Name: collagen, type XIII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 12817
HGNC: HGNC:2190
Homologene: 22421
Nek10
Name: NIMA (never in mitosis gene a)- related kinase 10
Synonyms: LOC238944
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 674895
Homologene: 130947
Aff3
Name: AF4/FMR2 family, member 3
Synonyms: 3222402O04Rik, Laf4, LAF-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16764
HGNC: HGNC:6473
Homologene: 1718
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Cul9
Name: cullin 9
Synonyms: 1810035I07Rik, Parc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 78309
Homologene: 56696
Slc4a5
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 5
Synonyms: C330016K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232156
Homologene: 31125
Ltf
Name: lactotransferrin
Synonyms: lactoferrin, Lf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 17002
HGNC: HGNC:6720
Homologene: 1754
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 319695
Homologene: 85163
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: LOC380658, 4930503E15Rik, Gm1557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 74978
Homologene: 46007
Gria1
Name: glutamate receptor, ionotropic, AMPA1 (alpha 1)
Synonyms: 2900051M01Rik, GluR-A, Glur-1, Glr1, GluA1, GluRA, Glr-1, HIPA1, GluR1, Glur1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14799
HGNC: HGNC:4571
Homologene: 20226
Vmn1r228
Name: vomeronasal 1 receptor 228
Synonyms: V1re3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 171226
Homologene: 74320
Olfr1453
Name: olfactory receptor 1453
Synonyms: GA_x6K02T2RE5P-3357666-3356743, MOR202-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258695
Homologene: 120159
Gbp7
Name: guanylate binding protein 7
Synonyms: 9830147J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229900
Homologene: 138296
Cntln
Name: centlein, centrosomal protein
Synonyms: B430108F07Rik, D530005L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 338349
Homologene: 9805
Ppp4r4
Name: protein phosphatase 4, regulatory subunit 4
Synonyms: 8430415E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 74521
Homologene: 12571
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227058
Homologene: 41287
Fam187b
Name: family with sequence similarity 187, member B
Synonyms: 1700020B09Rik, Tmem162
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 76415
Homologene: 138431
Fbxw21
Name: F-box and WD-40 domain protein 21
Synonyms: E330009P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 320082
Homologene: 110776
Noa1
Name: nitric oxide associated 1
Synonyms: 2610024G14Rik, mAtNOS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 56412
Homologene: 10518
Atp8a1
Name: ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
Synonyms: Atp3a2, B230107D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 11980
Homologene: 48402
Asprv1
Name: aspartic peptidase, retroviral-like 1
Synonyms: 2300003P22Rik, SASPase, SASP, Taps, TPA-induced aspartic proteinase-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 67855
Homologene: 23582
Zfp229
Name: zinc finger protein 229
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 381067
Homologene: 136287
Ssrp1
Name: structure specific recognition protein 1
Synonyms: Hmgox, Hmgi-rs3, T160, Hmg1-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20833
Homologene: 110735
Cep250
Name: centrosomal protein 250
Synonyms: B230210E21Rik, Cep2, Inmp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Gpr45
Name: G protein-coupled receptor 45
Synonyms: 9230112G11Rik, PSP24alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 93690
HGNC: HGNC:4503
Homologene: 5228
Dyrk2
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Synonyms: 1810038L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 69181
VEGA: 10
HGNC: HGNC:3093
Homologene: 48437
Tcp11
Name: t-complex protein 11
Synonyms: D17Ken1, Tcp-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 21463
Homologene: 8433
Dpysl5
Name: dihydropyrimidinase-like 5
Synonyms: CRAM, CRMP-5, Crmp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 65254
Homologene: 41347
Tktl2
Name: transketolase-like 2
Synonyms: 4933401I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 74419
Homologene: 69456
Ddx43
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
Synonyms: OTTMUSG00000019690, ENSMUSG00000070291
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 100048658
Homologene: 56814
4930430A15Rik
Name: RIKEN cDNA 4930430A15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 67575
Homologene: 69410
Gm10542
Name: predicted gene 10542
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
Pth
Name: parathyroid hormone
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 19226
HGNC: HGNC:9606
Homologene: 266
Tcf15
Name: transcription factor 15
Synonyms: paraxis, bHLH-EC2, Meso1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 21407
Homologene: 37943
AC091683.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 38,209,710 bp
  • G to A, chromosome 1 at 43,032,508 bp
  • T to A, chromosome 1 at 46,207,572 bp
  • T to C, chromosome 1 at 72,675,820 bp
  • T to C, chromosome 1 at 82,648,600 bp
  • C to T, chromosome 1 at 120,120,116 bp
  • A to G, chromosome 2 at 85,041,586 bp
  • A to G, chromosome 2 at 90,458,128 bp
  • A to T, chromosome 2 at 111,204,019 bp
  • T to C, chromosome 2 at 152,143,951 bp
  • A to G, chromosome 2 at 155,994,878 bp
  • C to A, chromosome 3 at 84,134,109 bp
  • A to T, chromosome 3 at 142,545,858 bp
  • T to C, chromosome 4 at 84,974,027 bp
  • G to A, chromosome 4 at 137,613,762 bp
  • G to A, chromosome 5 at 30,791,597 bp
  • C to A, chromosome 5 at 34,630,714 bp
  • T to C, chromosome 5 at 67,647,706 bp
  • T to C, chromosome 5 at 77,306,344 bp
  • T to C, chromosome 6 at 40,768,220 bp
  • C to T, chromosome 6 at 83,296,669 bp
  • T to A, chromosome 6 at 86,628,366 bp
  • A to C, chromosome 7 at 30,977,729 bp
  • C to T, chromosome 7 at 41,626,405 bp
  • G to A, chromosome 7 at 66,172,164 bp
  • CG to CGACGGCGGGG, chromosome 7 at 97,579,908 bp
  • T to C, chromosome 7 at 113,385,929 bp
  • T to A, chromosome 8 at 11,561,641 bp
  • C to T, chromosome 8 at 64,752,760 bp
  • T to A, chromosome 8 at 66,512,063 bp
  • C to A, chromosome 9 at 78,406,379 bp
  • A to G, chromosome 9 at 86,755,582 bp
  • A to G, chromosome 9 at 109,145,510 bp
  • G to T, chromosome 9 at 111,028,472 bp
  • G to A, chromosome 10 at 61,961,331 bp
  • T to C, chromosome 10 at 79,781,223 bp
  • T to A, chromosome 10 at 94,044,194 bp
  • A to G, chromosome 10 at 103,214,900 bp
  • T to C, chromosome 10 at 115,294,909 bp
  • T to A, chromosome 10 at 118,860,337 bp
  • T to A, chromosome 11 at 8,874,236 bp
  • C to T, chromosome 11 at 57,185,801 bp
  • T to C, chromosome 12 at 103,612,821 bp
  • A to T, chromosome 13 at 49,945,197 bp
  • A to T, chromosome 13 at 70,602,578 bp
  • T to C, chromosome 14 at 14,836,202 bp
  • A to G, chromosome 14 at 103,297,358 bp
  • A to G, chromosome 15 at 97,976,095 bp
  • A to G, chromosome 17 at 20,776,347 bp
  • T to G, chromosome 17 at 21,746,029 bp
  • A to G, chromosome 17 at 28,053,905 bp
  • C to A, chromosome 17 at 28,069,265 bp
  • A to G, chromosome 17 at 36,040,645 bp
  • A to G, chromosome 17 at 46,502,228 bp
  • A to T, chromosome 18 at 44,204,695 bp
  • C to T, chromosome 19 at 13,028,048 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2965 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040521-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.