Strain Name:
C57BL/6J-MtgxR3051Btlr/Mmmh
Stock Number:
040560-MU
Citation ID:
RRID:MMRRC_040560-MU
Other Names:
R3051 (G1), C57BL/6J-MtgxR3051Btlr
Major Collection:

Gene Information

Pald1
Name: phosphatase domain containing, paladin 1
Synonyms: paladin, X99384
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 27355
VEGA: 10
Homologene: 8453
Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: b2b692Clo, b2b508.1Clo, Brg1, SNF2beta, SW1/SNF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20586
Homologene: 135927
Ubxn2a
Name: UBX domain protein 2A
Synonyms: Ubxd4, 6330407P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217379
Homologene: 17076
Top1
Name: topoisomerase (DNA) I
Synonyms: Top-1, D130064I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21969
Homologene: 2467
Cwf19l2
Name: CWF19-like 2, cell cycle control (S. pombe)
Synonyms: 3230401L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244672
Homologene: 12366
Axin1
Name: axin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12005
HGNC: HGNC:903
Homologene: 2614
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57752
Homologene: 5087
Rpa2
Name: replication protein A2
Synonyms: RPA34, Rf-A2, 30-kDa protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19891
Homologene: 37712
Xpo6
Name: exportin 6
Synonyms: Ranbp20, C230091E20Rik, 2610005L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74204
Homologene: 12544
Trp53bp2
Name: transformation related protein 53 binding protein 2
Synonyms: ASPP2, 53BP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 209456
Homologene: 3959
R3hcc1l
Name: R3H domain and coiled-coil containing 1 like
Synonyms: 1700036B12Rik, D19Ertd386e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 52013
Homologene: 8707
Tmem51
Name: transmembrane protein 51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214359
Homologene: 9966
Zfp345
Name: zinc finger protein 345
Synonyms: OTTMUSG00000015743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545471
Homologene: 134546
Ddr2
Name: discoidin domain receptor family, member 2
Synonyms: Ntrkr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18214
HGNC: HGNC:2731
Homologene: 68505
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: skrr, Ryr, calcium release channel isoform 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Akap6
Name: A kinase (PRKA) anchor protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Il13ra1
Name: interleukin 13 receptor, alpha 1
Synonyms: CD213a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 16164
HGNC: HGNC:5974
Homologene: 1198
Ptprd
Name: protein tyrosine phosphatase, receptor type, D
Synonyms: 1110002J03Rik, B230219D21Rik, 3000002J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: Shn-2, MIBP1, Gm20114, Schnurri-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: LTRPC1, 4732499L03Rik, Mlsn1, melastatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Acsl1
Name: acyl-CoA synthetase long-chain family member 1
Synonyms: Acas1, Facl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14081
HGNC: HGNC:3569
Homologene: 37561
B4galt3
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
Synonyms: R74981, ESTM26, 9530061M23Rik, beta4GalT-III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 57370
HGNC: HGNC:926
Homologene: 48241
Ltf
Name: lactotransferrin
Synonyms: Lf, lactoferrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17002
HGNC: HGNC:6720
Homologene: 1754
Slc6a7
Name: solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
Synonyms: Prot
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240332
VEGA: 18
Homologene: 8592
Olfr390
Name: olfactory receptor 390
Synonyms: GA_x6K02T2P1NL-3938806-3939741, MOR135-26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258344
Homologene: 115483
Ccdc178
Name: coiled coil domain containing 178
Synonyms: 4921528I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70950
VEGA: 18
Homologene: 12373
Ceacam20
Name: carcinoembryonic antigen-related cell adhesion molecule 20
Synonyms: 9130012D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71601
Homologene: 19010
Atp11a
Name: ATPase, class VI, type 11A
Synonyms: 4930558F19Rik, LOC100045280, 9130422H11Rik, Ih
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 50770
Homologene: 75050
Rbfox3
Name: RNA binding protein, fox-1 homolog (C. elegans) 3
Synonyms: D11Bwg0517e, Neuna60, NeuN, Hrnbp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52897
Homologene: 134629
Terf2
Name: telomeric repeat binding factor 2
Synonyms: TRF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21750
Homologene: 4133
4932429P05Rik
Name: RIKEN cDNA 4932429P05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 245509
Homologene: 87617
Qars
Name: glutaminyl-tRNA synthetase
Synonyms: 1200016L19Rik, 1110018N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 97541
HGNC: HGNC:9751
Homologene: 133975
Cyp2a5
Name: cytochrome P450, family 2, subfamily a, polypeptide 5
Synonyms: Coh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13087
Homologene: 85917
Tktl1
Name: transketolase-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 83553
Homologene: 8169
Ten1
Name: TEN1 telomerase capping complex subunit
Synonyms: 2310004N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69535
Homologene: 28494
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 169,988,455 bp
  • C to A, chromosome 1 at 171,274,043 bp
  • T to C, chromosome 1 at 182,453,782 bp
  • T to C, chromosome 2 at 150,474,852 bp
  • A to G, chromosome 2 at 160,704,982 bp
  • A to G, chromosome 4 at 76,100,630 bp
  • A to G, chromosome 4 at 132,775,126 bp
  • A to T, chromosome 4 at 142,032,024 bp
  • T to A, chromosome 7 at 19,976,185 bp
  • A to G, chromosome 7 at 26,842,985 bp
  • A to T, chromosome 7 at 29,053,090 bp
  • G to A, chromosome 7 at 64,269,101 bp
  • T to C, chromosome 7 at 126,104,721 bp
  • G to A, chromosome 7 at 130,625,496 bp
  • T to A, chromosome 8 at 12,859,494 bp
  • G to A, chromosome 8 at 46,521,337 bp
  • A to C, chromosome 8 at 107,079,384 bp
  • G to A, chromosome 9 at 3,410,006 bp
  • C to T, chromosome 9 at 21,699,921 bp
  • T to C, chromosome 9 at 108,509,428 bp
  • A to G, chromosome 9 at 111,024,522 bp
  • C to A, chromosome 10 at 14,128,969 bp
  • G to A, chromosome 10 at 61,346,763 bp
  • A to G, chromosome 11 at 73,787,234 bp
  • T to C, chromosome 11 at 116,205,730 bp
  • G to T, chromosome 11 at 118,502,888 bp
  • T to A, chromosome 12 at 4,891,322 bp
  • T to C, chromosome 12 at 52,887,033 bp
  • A to G, chromosome 17 at 26,190,125 bp
  • T to A, chromosome 18 at 22,135,131 bp
  • G to A, chromosome 18 at 61,009,517 bp
  • T to G, chromosome 19 at 42,562,625 bp
  • A to C, chromosome X at 36,155,534 bp
  • A to G, chromosome X at 74,177,404 bp
  • G to A, chromosome X at 89,754,103 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3051 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040560-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.