Strain Name:
C57BL/6J-MtgxR3080Btlr/Mmmh
Stock Number:
040570-MU
Citation ID:
RRID:MMRRC_040570-MU
Other Names:
R3080 (G1), C57BL/6J-MtgxR3080Btlr
Major Collection:

Strain Information

Npr3
Name: natriuretic peptide receptor 3
Synonyms: Nppc receptor, lgj, longjohn, NPR-C, B430320C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18162
VEGA: 15
HGNC: HGNC:7945
Homologene: 699
Dcx
Name: doublecortin
Synonyms: lissencephaly, X-linked (doublecortin), Dbct
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 13193
HGNC: HGNC:2714
Homologene: 7683
Slc1a2
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 2
Synonyms: GLT1, MGLT1, Eaat2, 1700091C19Rik, GLT-1, 2900019G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20511
Homologene: 3075
Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Mbtps1
Name: membrane-bound transcription factor peptidase, site 1
Synonyms: subtilisin/kexin isozyme-1, SKI-1, S1P, 0610038M03Rik, site-1 protease
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56453
Homologene: 2808
Plcb4
Name: phospholipase C, beta 4
Synonyms: A930039J07Rik, C230058B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Shroom3
Name: shroom family member 3
Synonyms: D5Ertd287e, Shrm, Shrm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27428
Homologene: 9263
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, Ndrp, 2810004D21Rik, 4632404O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83946
Homologene: 41209
Copa
Name: coatomer protein complex subunit alpha
Synonyms: xenin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12847
HGNC: HGNC:2230
Homologene: 3218
Zfp35
Name: zinc finger protein 35
Synonyms: Zfp-35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 22694
Homologene: 133081
Tbr1
Name: T-box brain transcription factor 1
Synonyms: T-box brain gene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21375
Homologene: 4807
Gemin2
Name: gem nuclear organelle associated protein 2
Synonyms: 1700012N19Rik, Sip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66603
Homologene: 37827
Clca4a
Name: chloride channel accessory 4A
Synonyms: 9130020L07Rik, Clca6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99663
HGNC: HGNC:2018
Homologene: 40808
Gak
Name: cyclin G associated kinase
Synonyms: D130045N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231580
HGNC: HGNC:4113
Homologene: 3846
Flt1
Name: FMS-like tyrosine kinase 1
Synonyms: vascular endothelial growth factor receptor-1, VEGFR-1, VEGFR1, Flt-1, sFlt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14254
HGNC: HGNC:3763
Homologene: 134179
Fbn2
Name: fibrillin 2
Synonyms: sy, Sne, Fib-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Tro
Name: trophinin
Synonyms: necdin and trophinin like, Tnn, trophinin-2, magphinin-gamma, magphinin-beta 2, magphinin-alpha, magphinin, Maged3l, Maged3, Trol
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 56191
Homologene: 75113
Ahnak2
Name: AHNAK nucleoprotein 2
Synonyms: LOC382643
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 100041194
Homologene: 131081
Or6d14
Name: olfactory receptor family 6 subfamily D member 14
Synonyms: GA_x54KRFPKN04-58190962-58191900, MOR119-1, Olfr214
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258754
Homologene: 133694
Vmn2r1
Name: vomeronasal 2, receptor 1
Synonyms: EG56544, V2r83
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56544
Homologene: 84832
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
Nebl
Name: nebulette
Synonyms: Lnebl, 1200007O21Rik, A630080F05Rik, D830029A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74103
Homologene: 128431
Pcdhb8
Name: protocadherin beta 8
Synonyms: Pcdhb5C, PcdhbH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93879
HGNC: HGNC:8690
Homologene: 89038
Ces1c
Name: carboxylesterase 1C
Synonyms: Es-N, Es-4, Es-1, Ee-1, Es1, Ces-N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13884
HGNC: HGNC:1863
Homologene: 117484
Vmn1r222
Name: vomeronasal 1 receptor 222
Synonyms: V1rh16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171274
Homologene: 110880
H3c2
Name: H3 clustered histone 2
Synonyms: H3-53, Hist1h3b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319150
Homologene: 134491
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665210
Homologene: 115024
Amer3
Name: APC membrane recruitment 3
Synonyms: Fam123c, 9430069J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 211383
Homologene: 51888
Ciao2b
Name: cytosolic iron-sulfur assembly component 2B
Synonyms: 1110019N10Rik, Fam96b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 68523
Homologene: 6115
Thnsl2
Name: threonine synthase-like 2 (bacterial)
Synonyms: TSH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232078
Homologene: 5489
Cyp3a25
Name: cytochrome P450, family 3, subfamily a, polypeptide 25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56388
Homologene: 135775
Pcdhb3
Name: protocadherin beta 3
Synonyms: PcdhbC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93874
HGNC: HGNC:8688
Homologene: 115665
Anks4b
Name: ankyrin repeat and sterile alpha motif domain containing 4B
Synonyms: Harp, 2010013E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72074
Homologene: 49898
Krt1
Name: keratin 1
Synonyms: Krt2-1, Krt-2.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16678
VEGA: 15
HGNC: HGNC:6412
Homologene: 38146
Shcbp1l
Name: Shc SH2-domain binding protein 1-like
Synonyms: 1700012A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71836
Homologene: 12800
Fastkd5
Name: FAST kinase domains 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 380601
Homologene: 36400
Tas2r136
Name: taste receptor, type 2, member 136
Synonyms: mt2r52, Tas2r36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353165
Homologene: 136304
Gm9790
Name: predicted gene 9790
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100042265
Map4k2
Name: mitogen-activated protein kinase kinase kinase kinase 2
Synonyms: BL44, Rab8ip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 26412
HGNC: HGNC:6864
Homologene: 3370
Sri
Name: sorcin
Synonyms: Sor, 2210417O06Rik, 2900070H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 109552
Homologene: 37736
Or14j4
Name: olfactory receptor family 14 subfamily J member 4
Synonyms: MOR218-11P, GA_x6K02T2PSCP-2070203-2069271, Olfr115
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 257908
Homologene: 115497
Gm11143
Name: predicted gene 11143
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Slc35a5
Name: solute carrier family 35, member A5
Synonyms: D16Ertd450e, 1010001J06Rik, D730043G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74102
Homologene: 9930
Fam76b
Name: family with sequence similarity 76, member B
Synonyms: 2810485I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72826
Homologene: 25107
Gm5150
Name: predicted gene 5150
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 381484
Homologene: 129516
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 34,588,422 bp
  • A to G, chromosome 1 at 153,436,037 bp
  • G to T, chromosome 1 at 172,113,149 bp
  • A to G, chromosome 2 at 17,376,651 bp
  • C to T, chromosome 2 at 61,807,291 bp
  • T to G, chromosome 2 at 102,748,556 bp
  • T to C, chromosome 2 at 130,615,453 bp
  • T to C, chromosome 2 at 136,012,960 bp
  • A to C, chromosome 3 at 15,990,921 bp
  • A to G, chromosome 3 at 64,089,784 bp
  • A to G, chromosome 3 at 85,915,861 bp
  • T to A, chromosome 3 at 144,963,790 bp
  • T to C, chromosome 5 at 8,063,415 bp
  • G to T, chromosome 5 at 92,943,086 bp
  • T to C, chromosome 5 at 108,613,602 bp
  • T to A, chromosome 5 at 145,998,531 bp
  • T to A, chromosome 5 at 147,683,807 bp
  • A to T, chromosome 6 at 58,856,646 bp
  • A to G, chromosome 6 at 69,617,470 bp
  • G to A, chromosome 6 at 71,129,280 bp
  • T to G, chromosome 6 at 116,557,217 bp
  • C to A, chromosome 6 at 132,778,009 bp
  • A to T, chromosome 7 at 120,181,923 bp
  • T to C, chromosome 7 at 128,185,787 bp
  • A to C, chromosome 8 at 93,120,347 bp
  • G to C, chromosome 8 at 104,641,627 bp
  • A to G, chromosome 8 at 119,531,205 bp
  • T to C, chromosome 8 at 119,538,863 bp
  • G to A, chromosome 9 at 13,833,162 bp
  • A to T, chromosome 9 at 82,930,300 bp
  • G to A, chromosome 12 at 59,025,091 bp
  • A to G, chromosome 12 at 111,295,818 bp
  • A to T, chromosome 12 at 112,788,007 bp
  • A to G, chromosome 13 at 23,232,461 bp
  • A to G, chromosome 13 at 23,752,498 bp
  • G to C, chromosome 15 at 11,905,149 bp
  • C to T, chromosome 15 at 101,846,187 bp
  • A to T, chromosome 16 at 45,144,395 bp
  • T to G, chromosome 17 at 18,135,711 bp
  • T to C, chromosome 17 at 37,610,278 bp
  • T to A, chromosome 18 at 24,003,310 bp
  • T to G, chromosome 18 at 37,301,482 bp
  • A to T, chromosome 18 at 37,356,166 bp
  • G to A, chromosome 18 at 58,149,050 bp
  • GTA to GTATA, chromosome 19 at 5,756,888 bp
  • G to A, chromosome 19 at 6,353,188 bp
  • T to A, chromosome X at 143,923,270 bp
  • G to A, chromosome X at 150,655,202 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3080 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040570-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.