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Strain Name:
C57BL/6J-MtgxR3113Btlr/Mmmh
Stock Number:
040586-MU
Citation ID:
RRID:MMRRC_040586-MU
Other Names:
R3113 (G1), C57BL/6J-MtgxR3113Btlr
Major Collection:

Strain Information

Pak1
Name: p21 (RAC1) activated kinase 1
Synonyms: PAK-1, Paka
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18479
HGNC: HGNC:8590
Homologene: 1936
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Csnk2a1
Name: casein kinase 2, alpha 1 polypeptide
Synonyms: Csnk2a1-rs4, CK2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12995
Homologene: 90874
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: 1110037D04Rik, Lrrc16, Carmil, Lrrc16a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68732
Homologene: 9757
Tab1
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
Synonyms: Tak1-binding protein 1, 2310012M03Rik, Map3k7ip1, b2b449Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66513
VEGA: 15
Homologene: 4461
Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms: 2410008J01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69719
HGNC: HGNC:1424
Homologene: 1412
Prmt3
Name: protein arginine N-methyltransferase 3
Synonyms: 2410018A17Rik, 2010005E20Rik, Hrmt1l3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71974
Homologene: 24255
Wrap53
Name: WD repeat containing, antisense to Trp53
Synonyms: Wdr79
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216853
Homologene: 9995
Wdr12
Name: WD repeat domain 12
Synonyms: Ytm1, Ytm1p, 4933402C23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 57750
Homologene: 10098
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70354
Homologene: 18923
Ddx18
Name: DEAD box helicase 18
Synonyms: 2310005B10Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66942
HGNC: HGNC:2741
Homologene: 6697
Gria3
Name: glutamate receptor, ionotropic, AMPA3 (alpha 3)
Synonyms: Glur-3, Glur3, GluR3, 2900064I19Rik, Gluralpha3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 53623
HGNC: HGNC:4573
Homologene: 37353
Smu1
Name: smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
Synonyms: 2600001O03Rik, SMU-1, 2610203K23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74255
Homologene: 10079
Ocrl
Name: OCRL, inositol polyphosphate-5-phosphatase
Synonyms: OCRL1, 9530014D17Rik, oculocerebrorenal syndrome of Lowe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 320634
HGNC: HGNC:8108
Homologene: 233
Flrt3
Name: fibronectin leucine rich transmembrane protein 3
Synonyms: 5530600M07Rik, C430047I10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71436
HGNC: HGNC:3762
Homologene: 8322
Pum3
Name: pumilio RNA-binding family member 3
Synonyms: 1110069H02Rik, D19Bwg1357e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 52874
VEGA: 19
Homologene: 5762
Nid2
Name: nidogen 2
Synonyms: entactin-2, entactin 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18074
VEGA: 14
Homologene: 40575
Dhx29
Name: DExH-box helicase 29
Synonyms: E130202M19Rik, DEAH (Asp-Glu-Ala-His) box polypeptide 29
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218629
VEGA: 13
Homologene: 10387
Zcchc2
Name: zinc finger, CCHC domain containing 2
Synonyms: 9930114B20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227449
Homologene: 9808
Galnt12
Name: polypeptide N-acetylgalactosaminyltransferase 12
Synonyms: A630062B03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230145
Homologene: 11637
Ank
Name: progressive ankylosis
Synonyms: D15Ertd221e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11732
Homologene: 10664
Sec31b
Name: SEC31 homolog B, COPII coat complex component
Synonyms: LOC240667, Sec31l2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240667
Homologene: 56708
Acta2
Name: actin alpha 2, smooth muscle, aorta
Synonyms: Actvs, a-SMA, 0610041G09Rik, SMalphaA, alphaSMA, SMAalpha
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11475
VEGA: 19
HGNC: HGNC:130
Homologene: 133938
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Alox15
Name: arachidonate 15-lipoxygenase
Synonyms: 12-LO, L-12LO, Alox12l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11687
HGNC: HGNC:433
Homologene: 44935
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, 2310008C07Rik, 2310003D02Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: E130120L08Rik, Liprin-alpha2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Nav1.2, A230052E19Rik, Scn2a1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110876
Homologene: 75001
Nlrp1a
Name: NLR family, pyrin domain containing 1A
Synonyms: Nalp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195046
Homologene: 133820
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5c, Nav1.5, mH1, SkM2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20271
Homologene: 22738
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: MyHC-IIa, MHC2A, Myhs-f, Myhs-f1, Myhsf1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Atg4b
Name: autophagy related 4B, cysteine peptidase
Synonyms: Apg4b, 2510009N07Rik, autophagin 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66615
Homologene: 100868
Atp2a1
Name: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Synonyms: SERCA1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11937
HGNC: HGNC:811
Homologene: 7635
Mroh1
Name: maestro heat-like repeat family member 1
Synonyms: D330001F17Rik, Heatr7a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223658
Homologene: 44882
Dnai2
Name: dynein axonemal intermediate chain 2
Synonyms: C030015H18Rik, Dnaic2, b2b3405Clo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432611
Homologene: 11311
Mmut
Name: methylmalonyl-Coenzyme A mutase
Synonyms: D230010K02Rik, Mut
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17850
VEGA: 17
HGNC: HGNC:7526
Homologene: 20097
Foxs1
Name: forkhead box S1
Synonyms: FREAC10, Fkh3, Fkhl18
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14239
HGNC: HGNC:3735
Homologene: 20871
Slc22a23
Name: solute carrier family 22, member 23
Synonyms: 3110004L20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73102
Homologene: 41457
9330159F19Rik
Name: RIKEN cDNA 9330159F19 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 212448
VEGA: 10
Homologene: 8804
Ehbp1l1
Name: EH domain binding protein 1-like 1
Synonyms: G430002G23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 114601
VEGA: 19
Homologene: 136059
Pilrb1
Name: paired immunoglobin-like type 2 receptor beta 1
Synonyms: Fdact, Pilrb
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 170741
Homologene: 114502
Usp31
Name: ubiquitin specific peptidase 31
Synonyms: 6330567E21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76179
Homologene: 44504
Lrrc27
Name: leucine rich repeat containing 27
Synonyms: 1700071K18Rik, 2310044E02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76612
Homologene: 19268
Ly6f
Name: lymphocyte antigen 6 family member F
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17071
Homologene: 113718
Fitm2
Name: fat storage-inducing transmembrane protein 2
Synonyms: Fit2, D930001I22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228859
Homologene: 35254
Gata6
Name: GATA binding protein 6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14465
VEGA: 18
HGNC: HGNC:4174
Homologene: 68449
Or6c2
Name: olfactory receptor family 6 subfamily C member 2
Synonyms: GA_x6K02T2PULF-11205096-11206034, MOR114-1, Olfr791
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258932
Homologene: 71950
Spef1l
Name: sperm flagellar 1 like
Synonyms: LOC381933, 6430531B16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381933
Homologene: 134514
Saxo2
Name: stabilizer of axonemal microtubules 2
Synonyms: 1700129I04Rik, Fam154b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330577
Homologene: 25135
Mboat2
Name: membrane bound O-acyltransferase domain containing 2
Synonyms: 2810049G06Rik, Oact2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67216
VEGA: 12
Homologene: 6971
Trub2
Name: TruB pseudouridine (psi) synthase family member 2
Synonyms: G430055L02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227682
Homologene: 41056
Popdc1
Name: popeye domain cAMP effector 1
Synonyms: popeye 1, Bves
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 23828
VEGA: 10
HGNC: HGNC:1152
Homologene: 48497
As3mt
Name: arsenite methyltransferase
Synonyms: Cyt19, 2310045H08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 57344
VEGA: 19
Homologene: 10754
Or2w1
Name: olfactory receptor family 2 subfamily W member 1
Synonyms: IA3, GA_x6K02T2N5E5-9379-8514, MOR256-31, GA_x6K02T2QHY8-12114828-12113875, MOR256-37P, MOR256-61, Olfr42, Olfr263-ps1, Olfr263
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18341
HGNC: HGNC:8281
Homologene: 12791
Gm17332
Name: predicted gene, 17332
Type: Gene
Species: Mouse
Chromosome: 11
Rhox6
Name: reproductive homeobox 6
Synonyms: Psx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 19202
Homologene: 137216
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 60,087,062 bp
  • C to T, chromosome 1 at 93,775,704 bp
  • T to C, chromosome 1 at 105,991,022 bp
  • A to G, chromosome 1 at 121,566,148 bp
  • A to T, chromosome 2 at 29,782,210 bp
  • A to C, chromosome 2 at 65,748,785 bp
  • A to G, chromosome 2 at 67,510,147 bp
  • A to T, chromosome 2 at 76,814,198 bp
  • A to T, chromosome 2 at 77,924,479 bp
  • A to T, chromosome 2 at 125,750,286 bp
  • T to C, chromosome 2 at 140,661,534 bp
  • T to A, chromosome 2 at 152,263,214 bp
  • A to G, chromosome 2 at 152,932,236 bp
  • T to C, chromosome 2 at 163,469,591 bp
  • A to G, chromosome 4 at 40,748,658 bp
  • A to G, chromosome 4 at 47,108,415 bp
  • A to C, chromosome 4 at 88,819,983 bp
  • C to A, chromosome 5 at 31,074,137 bp
  • C to T, chromosome 5 at 137,854,933 bp
  • C to A, chromosome 7 at 49,782,012 bp
  • A to C, chromosome 7 at 82,643,741 bp
  • C to A, chromosome 7 at 97,866,114 bp
  • A to G, chromosome 7 at 103,250,663 bp
  • A to G, chromosome 7 at 121,679,513 bp
  • A to T, chromosome 7 at 126,448,369 bp
  • A to G, chromosome 7 at 139,218,307 bp
  • G to T, chromosome 7 at 139,975,965 bp
  • A to G, chromosome 7 at 141,846,134 bp
  • A to G, chromosome 8 at 23,084,797 bp
  • T to A, chromosome 9 at 119,485,672 bp
  • T to A, chromosome 10 at 29,224,376 bp
  • T to C, chromosome 10 at 45,343,052 bp
  • T to A, chromosome 10 at 106,906,395 bp
  • A to G, chromosome 10 at 107,685,024 bp
  • A to T, chromosome 10 at 129,527,143 bp
  • T to C, chromosome 11 at 31,182,384 bp
  • A to G, chromosome 11 at 67,185,186 bp
  • A to G, chromosome 11 at 69,563,318 bp
  • A to T, chromosome 11 at 70,344,877 bp
  • A to T, chromosome 11 at 71,123,665 bp
  • T to A, chromosome 11 at 114,751,930 bp
  • A to G, chromosome 12 at 24,882,719 bp
  • A to G, chromosome 13 at 13,669,927 bp
  • T to A, chromosome 13 at 21,133,129 bp
  • A to G, chromosome 13 at 24,069,757 bp
  • C to T, chromosome 13 at 34,183,075 bp
  • T to C, chromosome 13 at 112,948,203 bp
  • G to A, chromosome 14 at 19,778,043 bp
  • T to A, chromosome 14 at 34,529,461 bp
  • T to A, chromosome 15 at 27,571,614 bp
  • A to G, chromosome 15 at 75,271,728 bp
  • T to A, chromosome 15 at 76,408,536 bp
  • C to T, chromosome 15 at 80,148,260 bp
  • G to A, chromosome 17 at 40,958,356 bp
  • T to C, chromosome 18 at 11,063,124 bp
  • A to T, chromosome 19 at 5,718,980 bp
  • A to G, chromosome 19 at 27,422,346 bp
  • T to C, chromosome 19 at 34,243,352 bp
  • C to A, chromosome 19 at 44,518,185 bp
  • T to C, chromosome 19 at 46,715,278 bp
  • T to A, chromosome X at 37,827,630 bp
  • T to G, chromosome X at 41,669,625 bp
  • A to G, chromosome X at 47,933,427 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3113 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040586-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.