Strain Name:
C57BL/6J-MtgxR3115Btlr/Mmmh
Stock Number:
040588-MU
Citation ID:
RRID:MMRRC_040588-MU
Other Names:
R3115 (G1), C57BL/6J-MtgxR3115Btlr
Major Collection:

Gene Information

Prph
Name: peripherin
Synonyms: Prph1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19132
VEGA: 15
HGNC: HGNC:9461
Homologene: 4559
Chrm4
Name: cholinergic receptor, muscarinic 4
Synonyms: muscarinic acetylcholine receptor 4, Chrm-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12672
HGNC: HGNC:1953
Homologene: 20192
Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: SSE, ESP1, separase, Cerp, PRCE, PRCE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151
Dcx
Name: doublecortin
Synonyms: lissencephaly, X-linked (doublecortin), Dbct
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 13193
HGNC: HGNC:2714
Homologene: 7683
Jarid2
Name: jumonji, AT rich interactive domain 2
Synonyms: Jmj, jumonji
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16468
HGNC: HGNC:6196
Homologene: 31279
Cacng7
Name: calcium channel, voltage-dependent, gamma subunit 7
Synonyms: TARP gamma 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 81904
Homologene: 12895
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: XRCC7, DNA-PK, DOXNPH, slip, dxnph, DNAPDcs, DNA-PKcs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Usp5
Name: ubiquitin specific peptidase 5 (isopeptidase T)
Synonyms: Ucht
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22225
Homologene: 55758
Mier3
Name: MIER family member 3
Synonyms: D130064H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218613
Homologene: 18196
Rnmt
Name: RNA (guanine-7-) methyltransferase
Synonyms: 2610002P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67897
Homologene: 2816
Knl1
Name: kinetochore scaffold 1
Synonyms: 2310043D08Rik, Casc5, 5730505K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76464
Homologene: 44890
Mynn
Name: myoneurin
Synonyms: SBBIZ1, 2810011C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80732
Homologene: 10253
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: opt, Pcp1, InsP3R type I, wblo, P400, Ip3r, Pcp-1, Itpr-1, IP3R1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: 2610040L17Rik, Odz2, 9330187F13Rik, Ten-m2, D3Bwg1534e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23964
Homologene: 22672
Smc6
Name: structural maintenance of chromosomes 6
Synonyms: 2810489L22Rik, Smc6l1, 3830418C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67241
VEGA: 12
Homologene: 41575
Micu3
Name: mitochondrial calcium uptake family, member 3
Synonyms: 2900075B16Rik, Efha2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78506
Homologene: 15058
Glul
Name: glutamate-ammonia ligase (glutamine synthetase)
Synonyms: Glns, GS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14645
HGNC: HGNC:4341
Homologene: 37567
Slc12a4
Name: solute carrier family 12, member 4
Synonyms: KCC1, K-Cl Co-transporter-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20498
Homologene: 21056
Zfp81
Name: zinc finger protein 81
Synonyms: D330034E10Rik, C330034P10Rik, KRAB13, Zfp78, Hszfp36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224694
Homologene: 138633
Zscan22
Name: zinc finger and SCAN domain containing 22
Synonyms: D530006B18Rik, Hkr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232878
HGNC: HGNC:4929
Homologene: 68122
Moxd1
Name: monooxygenase, DBH-like 1
Synonyms: 3230402N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 59012
Homologene: 22904
Grm2
Name: glutamate receptor, metabotropic 2
Synonyms: Gprc1b, 4930441L02Rik, mGluR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 108068
HGNC: HGNC:4594
Homologene: 20229
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: 9630011N22Rik, Dpde3, dunce
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Mgp
Name: matrix Gla protein
Synonyms: Mglap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17313
HGNC: HGNC:7060
Homologene: 693
Olfr651
Name: olfactory receptor 651
Synonyms: GA_x6K02T2PBJ9-7179540-7180481, MOR31-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258809
Homologene: 64922
Svs1
Name: seminal vesicle secretory protein 1
Synonyms: SVS I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243377
Homologene: 18250
Abcc12
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 12
Synonyms: MRP9, 4930467B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244562
Homologene: 57211
Nhsl1
Name: NHS-like 1
Synonyms: D10Bwg0940e, A630035H13Rik, 5730409E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215819
Homologene: 27834
Mprip
Name: myosin phosphatase Rho interacting protein
Synonyms: Rhoip3, Gm34094, p116 Rho interacting protein, RIP3, p116Rip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 26936
Homologene: 9034
Abcc9
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Synonyms: SUR2B, Sur2, SUR2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Mybph
Name: myosin binding protein H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53311
HGNC: HGNC:7552
Homologene: 3661
C130026I21Rik
Name: RIKEN cDNA C130026I21 gene
Synonyms: OTTMUSG00000029174
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 620078
Homologene: 131208
Wdr91
Name: WD repeat domain 91
Synonyms: 9530020G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101240
Homologene: 8562
Krt24
Name: keratin 24
Synonyms: 2310058N18Rik, 2310075C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75706
Homologene: 10379
Nr1d2
Name: nuclear receptor subfamily 1, group D, member 2
Synonyms: Rev-erb beta, RVR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 353187
HGNC: HGNC:7963
Homologene: 3763
Agbl2
Name: ATP/GTP binding protein-like 2
Synonyms: Ccp2, A430081C19Rik, Ccp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 271813
Homologene: 11715
Ifi205
Name: interferon activated gene 205
Synonyms: D3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226695
HGNC: HGNC:5395
Homologene: 115929
Gm597
Name: predicted gene 597
Synonyms: LOC210962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210962
Slc47a1
Name: solute carrier family 47, member 1
Synonyms: MATE1, 1300013J15Rik, mMATE1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67473
Homologene: 34364
Phactr2
Name: phosphatase and actin regulator 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215789
Homologene: 8816
Irs3
Name: insulin receptor substrate 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16369
HGNC: HGNC:6127
Homologene: 84788
Tll1
Name: tolloid-like
Synonyms: Tll-1, b2b2476Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21892
Homologene: 49202
Vmn2r71
Name: vomeronasal 2, receptor 71
Synonyms: EG233445
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233445
Homologene: 115466
Serpinb13
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13
Synonyms: PI13, HURPIN, headpin, HUR7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241196
HGNC: HGNC:8944
Homologene: 22718
Olfr448
Name: olfactory receptor 448
Synonyms: GA_x6K02T2P3E9-4663051-4662119, MOR261-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258270
HGNC: HGNC:8232
Homologene: 64846
Zfp511
Name: zinc finger protein 511
Synonyms: 2410004P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69752
Homologene: 42950
Olfr1512
Name: olfactory receptor 1512
Synonyms: GA_x6K02T2RJGY-622120-623061, MOR223-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258424
HGNC: HGNC:8171
Homologene: 27165
Prdx4
Name: peroxiredoxin 4
Synonyms: Prx4, Prx-iv, AOE372, Prx IV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 53381
Homologene: 4672
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 28,776,329 bp
  • C to G, chromosome 1 at 85,257,385 bp
  • A to T, chromosome 1 at 106,982,838 bp
  • A to G, chromosome 1 at 134,194,738 bp
  • T to C, chromosome 1 at 153,907,292 bp
  • T to A, chromosome 1 at 174,028,335 bp
  • T to C, chromosome 2 at 90,805,901 bp
  • A to G, chromosome 2 at 91,927,360 bp
  • C to A, chromosome 2 at 119,070,391 bp
  • C to T, chromosome 3 at 30,607,810 bp
  • A to G, chromosome 5 at 137,643,856 bp
  • A to G, chromosome 6 at 34,905,587 bp
  • T to C, chromosome 6 at 42,896,850 bp
  • A to G, chromosome 6 at 48,987,397 bp
  • A to G, chromosome 6 at 108,406,109 bp
  • T to C, chromosome 6 at 124,815,597 bp
  • A to C, chromosome 6 at 136,872,685 bp
  • T to C, chromosome 6 at 142,689,029 bp
  • T to C, chromosome 7 at 3,338,934 bp
  • T to C, chromosome 7 at 12,907,290 bp
  • A to C, chromosome 7 at 85,623,658 bp
  • C to A, chromosome 7 at 104,553,088 bp
  • T to A, chromosome 7 at 140,036,591 bp
  • A to G, chromosome 8 at 40,382,167 bp
  • A to G, chromosome 8 at 64,053,866 bp
  • A to G, chromosome 8 at 86,540,024 bp
  • T to C, chromosome 8 at 95,744,278 bp
  • A to T, chromosome 8 at 105,959,459 bp
  • A to G, chromosome 9 at 106,647,623 bp
  • C to A, chromosome 10 at 13,261,901 bp
  • A to T, chromosome 10 at 18,525,168 bp
  • G to T, chromosome 10 at 24,301,531 bp
  • A to G, chromosome 11 at 36,023,366 bp
  • T to A, chromosome 11 at 59,765,403 bp
  • A to G, chromosome 11 at 61,367,680 bp
  • T to A, chromosome 11 at 99,282,436 bp
  • T to C, chromosome 12 at 11,285,297 bp
  • T to C, chromosome 13 at 44,896,466 bp
  • T to A, chromosome 13 at 109,948,258 bp
  • T to A, chromosome 13 at 111,706,648 bp
  • A to T, chromosome 14 at 18,215,504 bp
  • T to C, chromosome 14 at 52,372,940 bp
  • T to A, chromosome 15 at 99,055,456 bp
  • T to A, chromosome 15 at 102,323,204 bp
  • C to T, chromosome 16 at 15,664,358 bp
  • C to T, chromosome 17 at 33,334,563 bp
  • A to G, chromosome 18 at 68,314,008 bp
  • A to G, chromosome X at 143,923,109 bp
  • C to T, chromosome X at 155,330,411 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3115 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040588-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.