Strain Name:
C57BL/6J-MtgxR3116Btlr/Mmmh
Stock Number:
040589-MU
Citation ID:
RRID:MMRRC_040589-MU
Other Names:
R3116 (G1), C57BL/6J-MtgxR3116Btlr
Major Collection:

Gene Information

Tln2
Name: talin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Slc12a5
Name: solute carrier family 12, member 5
Synonyms: KCC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 57138
Homologene: 10665
Pum1
Name: pumilio RNA-binding family member 1
Synonyms: Pumm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 80912
Homologene: 22830
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Mier3
Name: MIER family member 3
Synonyms: D130064H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218613
Homologene: 18196
Kif20b
Name: kinesin family member 20B
Synonyms: N-6 kinesin, C330014J10Rik, Kif20b, Mphosph1, 33cex, magoo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240641
VEGA: 19
HGNC: HGNC:7212
Homologene: 9418
Fdft1
Name: farnesyl diphosphate farnesyl transferase 1
Synonyms: squalene synthase, SQS, Ss
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14137
VEGA: 14
HGNC: HGNC:3629
Homologene: 3281
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208628
Homologene: 32227
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57752
Homologene: 5087
Rcl1
Name: RNA terminal phosphate cyclase-like 1
Synonyms: Rnac, 2310040A02Rik, RPCL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 59028
VEGA: 19
Homologene: 4217
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRTe, SMRT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Magoh
Name: mago homolog, exon junction complex core component
Synonyms: Mago-m, Mos2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17149
HGNC: HGNC:6815
Homologene: 1776
Nptx2
Name: neuronal pentraxin 2
Synonyms: np2, narp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 53324
HGNC: HGNC:7953
Homologene: 1892
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4921518A06Rik, 4933421G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Marchf6
Name: membrane associated ring-CH-type finger 6
Synonyms: F830029L24Rik, March6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223455
VEGA: 15
Homologene: 4301
Moxd1
Name: monooxygenase, DBH-like 1
Synonyms: 3230402N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 59012
Homologene: 22904
Rtn3
Name: reticulon 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20168
VEGA: 19
Homologene: 24934
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 1200017A24Rik, 5830472H07Rik, A130095G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Itgam
Name: integrin alpha M
Synonyms: complement component receptor 3 alpha, CD11B (p170), Mac-1 alpha, Mac-1, complement receptor type 3, CR3, CD11b/CD18, Mac-1a, F730045J24Rik, Ly-40, Cd11b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16409
HGNC: HGNC:6149
Homologene: 526
Ginm1
Name: glycoprotein integral membrane 1
Synonyms: BC013529
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215751
Homologene: 16347
Abcb4
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
Synonyms: mdr-2, Mdr2, Pgy-2, Pgy2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18670
HGNC: HGNC:45
Homologene: 136368
Olfr651
Name: olfactory receptor 651
Synonyms: GA_x6K02T2PBJ9-7179540-7180481, MOR31-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258809
Homologene: 64922
Aoc1l3
Name: amine oxidase copper containing 1-like 3
Synonyms: SVS I, Svs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243377
Homologene: 18250
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mass1, Mgr1, Gpr98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Zfp804a
Name: zinc finger protein 804A
Synonyms: C630007C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241514
Homologene: 18461
Grm3
Name: glutamate receptor, metabotropic 3
Synonyms: mGluR3, 0710001G23Rik, Gprc1c, mGlu3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108069
HGNC: HGNC:4595
Homologene: 651
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Npas3
Name: neuronal PAS domain protein 3
Synonyms: 4930423H22Rik, bHLHe12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 27386
VEGA: 12
Homologene: 8461
Nhsl1
Name: NHS-like 1
Synonyms: A630035H13Rik, D10Bwg0940e, 5730409E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215819
Homologene: 27834
Ccdc146
Name: coiled-coil domain containing 146
Synonyms: 4930528G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75172
Homologene: 67159
Pxdn
Name: peroxidasin
Synonyms: 2310075M15Rik, VPO1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69675
Homologene: 33907
Wdr91
Name: WD repeat domain 91
Synonyms: 9530020G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101240
Homologene: 8562
Tmed11
Name: transmembrane p24 trafficking protein 11
Synonyms: 1810008K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67366
Homologene: 48721
Rad21
Name: RAD21 cohesin complex component
Synonyms: SCC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19357
VEGA: 15
HGNC: HGNC:9811
Homologene: 38161
Oas1h
Name: 2'-5' oligoadenylate synthetase 1H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 246729
HGNC: HGNC:8086
Homologene: 77345
Meak7
Name: MTOR associated protein , eak-7 homolog
Synonyms: 4632415K11Rik, Tldc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74347
Homologene: 32494
Krt24
Name: keratin 24
Synonyms: 2310075C18Rik, 2310058N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75706
Homologene: 10379
Neil1
Name: nei endonuclease VIII-like 1 (E. coli)
Synonyms: 2810450N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72774
Homologene: 11616
Lcp1
Name: lymphocyte cytosolic protein 1
Synonyms: L-fimbrin, Pls2, D14Ertd310e, L-plastin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18826
HGNC: HGNC:6528
Homologene: 80174
Olfr701
Name: olfactory receptor 701
Synonyms: 4932441H21Rik, GA_x6K02T2PBJ9-9195805-9196755, MOR283-1, 4933433E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66786
Homologene: 12558
Olfr39
Name: olfactory receptor 39
Synonyms: MOR144-1, GA_x6K02T2PVTD-14025733-14026668
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258822
HGNC: HGNC:8380
Homologene: 81583
Ints5
Name: integrator complex subunit 5
Synonyms: 1110055N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 109077
Homologene: 35303
Phactr2
Name: phosphatase and actin regulator 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215789
Homologene: 8816
Slc7a11
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Synonyms: System xc, xc, xCT, sut, 9930009M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26570
Homologene: 22684
Ffar3
Name: free fatty acid receptor 3
Synonyms: LOC233080, Gpr41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233080
HGNC: HGNC:4499
Homologene: 82482
Desi2
Name: desumoylating isopeptidase 2
Synonyms: 5830417C01Rik, Fam152a, Pppde1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 78825
Homologene: 56741
Disp1
Name: dispatched RND transporter family member 1
Synonyms: DispA, 1190008H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68897
Homologene: 14133
Olfr448
Name: olfactory receptor 448
Synonyms: GA_x6K02T2P3E9-4663051-4662119, MOR261-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258270
HGNC: HGNC:8232
Homologene: 64846
Zfp511
Name: zinc finger protein 511
Synonyms: 2410004P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69752
Homologene: 42950
Tmem92
Name: transmembrane protein 92
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 544806
Homologene: 136274
Qpctl
Name: glutaminyl-peptide cyclotransferase-like
Synonyms: 1810019P04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67369
Homologene: 9765
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 178,244,442 bp
  • C to T, chromosome 1 at 183,088,922 bp
  • C to A, chromosome 2 at 82,259,417 bp
  • T to A, chromosome 2 at 164,996,181 bp
  • T to A, chromosome 3 at 50,384,139 bp
  • T to C, chromosome 4 at 107,887,212 bp
  • T to C, chromosome 4 at 130,772,660 bp
  • A to T, chromosome 5 at 8,896,610 bp
  • A to T, chromosome 5 at 9,570,752 bp
  • T to C, chromosome 5 at 21,316,955 bp
  • C to T, chromosome 5 at 108,779,839 bp
  • C to T, chromosome 5 at 120,861,616 bp
  • A to G, chromosome 5 at 123,802,058 bp
  • A to T, chromosome 5 at 125,024,166 bp
  • T to C, chromosome 5 at 144,548,341 bp
  • A to G, chromosome 6 at 34,905,587 bp
  • T to C, chromosome 6 at 42,896,850 bp
  • A to G, chromosome 6 at 48,987,397 bp
  • G to A, chromosome 7 at 19,143,317 bp
  • T to C, chromosome 7 at 30,855,806 bp
  • C to A, chromosome 7 at 104,553,088 bp
  • T to A, chromosome 7 at 106,818,364 bp
  • T to A, chromosome 7 at 128,116,029 bp
  • A to G, chromosome 7 at 130,759,249 bp
  • T to A, chromosome 7 at 140,036,591 bp
  • G to A, chromosome 8 at 119,768,317 bp
  • A to T, chromosome 9 at 20,286,227 bp
  • A to T, chromosome 9 at 57,146,663 bp
  • T to A, chromosome 9 at 67,355,139 bp
  • T to C, chromosome 10 at 7,777,767 bp
  • C to A, chromosome 10 at 13,261,901 bp
  • A to T, chromosome 10 at 18,525,168 bp
  • G to T, chromosome 10 at 24,301,531 bp
  • T to C, chromosome 11 at 94,782,428 bp
  • T to A, chromosome 11 at 99,282,436 bp
  • T to C, chromosome 12 at 30,002,307 bp
  • G to A, chromosome 12 at 54,067,725 bp
  • T to C, chromosome 13 at 81,270,737 bp
  • T to A, chromosome 13 at 111,706,648 bp
  • T to C, chromosome 14 at 63,177,698 bp
  • T to C, chromosome 14 at 75,212,316 bp
  • T to A, chromosome 15 at 8,343,592 bp
  • G to A, chromosome 15 at 31,486,119 bp
  • A to G, chromosome 15 at 47,657,599 bp
  • T to A, chromosome 15 at 51,965,001 bp
  • C to T, chromosome 16 at 15,664,358 bp
  • T to G, chromosome 19 at 7,431,990 bp
  • T to C, chromosome 19 at 8,894,772 bp
  • A to T, chromosome 19 at 25,188,494 bp
  • T to C, chromosome 19 at 29,134,387 bp
  • C to T, chromosome 19 at 34,970,080 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3116 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040589-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.