Strain Name:
C57BL/6J-MtgxR3121Btlr/Mmmh
Stock Number:
040594-MU
Citation ID:
RRID:MMRRC_040594-MU
Other Names:
R3121 (G1), C57BL/6J-MtgxR3121Btlr
Major Collection:

Gene Information

Pknox1
Name: Pbx/knotted 1 homeobox
Synonyms: D17Wsu76e, PREP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18771
HGNC: HGNC:9022
Homologene: 3363
Lamb1
Name: laminin B1
Synonyms: Lamb-1, D130003D08Rik, Lamb1-1, C81607, C80098
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 16777
HGNC: HGNC:6486
Homologene: 1722
Dst
Name: dystonin
Synonyms: A830042E19Rik, 2310001O04Rik, Macf2, bullous pemphigoid antigen 1, BPAG1-n, BPAG1, athetoid, Bpag, ah, bullous pemphigoid antigen 1, Bpag1, nmf339, nmf203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Khdc4
Name: KH domain containing 4, pre-mRNA splicing factor
Synonyms: 2810403A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 74200
Homologene: 41761
Spidr
Name: scaffolding protein involved in DNA repair
Synonyms: 2310008H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224008
VEGA: 16
Homologene: 51693
Cep83
Name: centrosomal protein 83
Synonyms: 5730513H21Rik, 4921537D05Rik, Ccdc41, 2600001G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 77048
VEGA: 10
Homologene: 9396
Rapgef2
Name: Rap guanine nucleotide exchange factor (GEF) 2
Synonyms: Pdzgef1, nRapGEP, RA-GEF-1, 5830453M24Rik, CNRasGEF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 76089
Homologene: 35477
Golga4
Name: golgi autoantigen, golgin subfamily a, 4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Bzw2
Name: basic leucine zipper and W2 domains 2
Synonyms: HSPC028, 1110001I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 66912
VEGA: 12
Homologene: 8530
Fbxl17
Name: F-box and leucine-rich repeat protein 17
Synonyms: C130023C01Rik, Fbx13, 6330576B01Rik, Fbxo13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 50758
Homologene: 79859
Relch
Name: RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms: 2310035C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227446
Homologene: 10834
Ago3
Name: argonaute RISC catalytic subunit 3
Synonyms: eIF2C3, C130014L07Rik, argonaute 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 214150
Homologene: 49799
Resf1
Name: retroelement silencing factor 1
Synonyms: 2810474O19Rik, GET
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 67246
Homologene: 19251
Wapl
Name: WAPL cohesin release factor
Synonyms: Wapal, A530089A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 218914
Homologene: 41002
Abcg5
Name: ATP binding cassette subfamily G member 5
Synonyms: Sterolin-1, trac, cmp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 27409
Homologene: 31909
Ctnnd1
Name: catenin (cadherin associated protein), delta 1
Synonyms: P120, Ctnnd, Catns, p120-catenin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12388
HGNC: HGNC:2515
Homologene: 1017
Cntrob
Name: centrobin, centrosomal BRCA2 interacting protein
Synonyms: 9830165K03Rik, Nip2, Lip8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216846
Homologene: 14205
L3mbtl3
Name: L3MBTL3 histone methyl-lysine binding protein
Synonyms: MBT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 237339
Homologene: 18226
Ramp3
Name: receptor (calcitonin) activity modifying protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 56089
HGNC: HGNC:9845
Homologene: 4276
Kif26a
Name: kinesin family member 26A
Synonyms: N-11 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 668303
Homologene: 18970
Dtl
Name: denticleless E3 ubiquitin protein ligase
Synonyms: 5730564G15Rik, 2810047L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 76843
Homologene: 32313
Adamtsl1
Name: ADAMTS-like 1
Synonyms: 6720426B09Rik, 5930437A14Rik, punctin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 77739
Homologene: 64642
Amph
Name: amphiphysin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218038
HGNC: HGNC:471
Homologene: 121585
Ccdc50
Name: coiled-coil domain containing 50
Synonyms: 5730448P06Rik, D16Bwg1543e, 2610529H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 67501
Homologene: 69406
Sec24b
Name: Sec24 related gene family, member B (S. cerevisiae)
Synonyms: SEC24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99683
Homologene: 55968
Pcdhb16
Name: protocadherin beta 16
Synonyms: Pcdhb8, PcdhbP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93887
HGNC: HGNC:8693
Homologene: 99843
H2-T23
Name: histocompatibility 2, T region locus 23
Synonyms: T18c, T23b, Qed-1, Qa1, Qa-1, 37b, H-2T23, T18c(37), T23d, 37c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 15040
HGNC: HGNC:4962
Homologene: 134018
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hy-3, hy3, 1700034M11Rik, hyrh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244653
Homologene: 52118
Fat2
Name: FAT atypical cadherin 2
Synonyms: Fath2, mKIAA0811, LOC245827, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Foxn4
Name: forkhead box N4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 116810
Homologene: 17526
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Proser3
Name: proline and serine rich 3
Synonyms: BC053749
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 333193
Homologene: 116064
Capn7
Name: calpain 7
Synonyms: PalBH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 12339
HGNC: HGNC:1484
Homologene: 7651
Farp1
Name: FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
Synonyms: Cdep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 223254
HGNC: HGNC:3591
Homologene: 38098
Ccdc146
Name: coiled-coil domain containing 146
Synonyms: 4930528G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 75172
Homologene: 67159
Cgn
Name: cingulin
Synonyms: 6330408J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 70737
Homologene: 41394
Slc2a2
Name: solute carrier family 2 (facilitated glucose transporter), member 2
Synonyms: liver-type glucose transporter, Glut2, Glut-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20526
Homologene: 68047
Cntln
Name: centlein, centrosomal protein
Synonyms: B430108F07Rik, D530005L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 338349
Homologene: 9805
Zbbx
Name: zinc finger, B-box domain containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 213234
Homologene: 11661
B3glct
Name: beta-3-glucosyltransferase
Synonyms: B3galtl, LOC381694
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 381694
Homologene: 14978
Zfp976
Name: zinc finger protein 976
Synonyms: 9830147E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 208111
Homologene: 134004
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240776
Homologene: 16121
Lmln
Name: leishmanolysin-like (metallopeptidase M8 family)
Synonyms: 5330415H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 239833
Homologene: 13198
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 24001
VEGA: 17
Homologene: 40796
Ankk1
Name: ankyrin repeat and kinase domain containing 1
Synonyms: 9930020N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244859
VEGA: 9
Homologene: 18258
BC080695
Name: cDNA sequence BC080695
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329986
Homologene: 83161
Fam98b
Name: family with sequence similarity 98, member B
Synonyms: 2610510H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 68215
Homologene: 72241
Olfr782
Name: olfactory receptor 782
Synonyms: MOR110-8, GA_x6K02T2PULF-11031172-11032116
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 257985
Homologene: 133581
Tktl2
Name: transketolase-like 2
Synonyms: 4933401I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 74419
Homologene: 69456
Map3k9
Name: mitogen-activated protein kinase kinase kinase 9
Synonyms: Mlk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 338372
VEGA: 12
HGNC: HGNC:6861
Homologene: 76377
Brdt
Name: bromodomain, testis-specific
Synonyms: Fsrg3, 7420412D09Rik, Brd6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 114642
HGNC: HGNC:1105
Homologene: 21064
Sowahb
Name: sosondowah ankyrin repeat domain family member B
Synonyms: Ankrd56, 5730467H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 78088
Homologene: 18429
Olfr1256
Name: olfactory receptor 1256
Synonyms: GA_x6K02T2Q125-51276848-51275928, MOR231-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258985
Homologene: 128157
Gm525
Name: predicted gene 525
Synonyms: LOC217071
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217071
Homologene: 129636
Wnt1
Name: wingless-type MMTV integration site family, member 1
Synonyms: Int-1, Wnt-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22408
Homologene: 3963
Klra4
Name: killer cell lectin-like receptor, subfamily A, member 4
Synonyms: Chok, ly49r129, Ly49d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16635
Homologene: 110821
Homez
Name: homeodomain leucine zipper-encoding gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239099
Homologene: 10828
Cidec
Name: cell death-inducing DFFA-like effector c
Synonyms: Fsp27, CIDE-3, CIDE-3alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14311
Homologene: 11128
1700080O16Rik
Name: RIKEN cDNA 1700080O16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 74279
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,289,648 bp
  • A to G, chromosome 1 at 105,725,799 bp
  • T to C, chromosome 1 at 140,428,884 bp
  • A to T, chromosome 1 at 191,553,063 bp
  • A to T, chromosome 2 at 84,613,874 bp
  • T to A, chromosome 2 at 89,835,514 bp
  • A to G, chromosome 2 at 117,267,927 bp
  • A to G, chromosome 3 at 28,721,749 bp
  • T to C, chromosome 3 at 75,081,846 bp
  • A to T, chromosome 3 at 79,066,881 bp
  • A to G, chromosome 3 at 88,689,292 bp
  • G to A, chromosome 3 at 94,778,482 bp
  • C to T, chromosome 3 at 130,002,304 bp
  • A to G, chromosome 4 at 85,005,052 bp
  • T to A, chromosome 4 at 86,337,009 bp
  • A to G, chromosome 4 at 126,417,372 bp
  • T to A, chromosome 4 at 143,571,013 bp
  • T to C, chromosome 5 at 21,294,593 bp
  • T to C, chromosome 5 at 93,043,402 bp
  • A to G, chromosome 5 at 107,377,145 bp
  • T to C, chromosome 5 at 114,258,715 bp
  • T to C, chromosome 5 at 149,696,483 bp
  • C to A, chromosome 6 at 113,428,125 bp
  • G to T, chromosome 6 at 130,063,178 bp
  • T to A, chromosome 6 at 149,329,243 bp
  • A to G, chromosome 7 at 30,540,371 bp
  • A to G, chromosome 7 at 42,613,514 bp
  • T to A, chromosome 8 at 66,512,156 bp
  • A to G, chromosome 8 at 110,506,506 bp
  • G to A, chromosome 9 at 49,426,967 bp
  • C to A, chromosome 9 at 118,557,380 bp
  • A to G, chromosome 10 at 26,344,221 bp
  • T to C, chromosome 10 at 94,786,838 bp
  • A to G, chromosome 10 at 129,350,683 bp
  • C to T, chromosome 11 at 6,674,754 bp
  • G to T, chromosome 11 at 55,311,796 bp
  • A to T, chromosome 11 at 69,322,700 bp
  • C to T, chromosome 11 at 89,088,548 bp
  • C to T, chromosome 11 at 118,041,086 bp
  • C to T, chromosome 12 at 31,287,529 bp
  • A to C, chromosome 12 at 36,120,789 bp
  • A to G, chromosome 12 at 81,743,924 bp
  • A to G, chromosome 12 at 112,179,361 bp
  • T to A, chromosome 13 at 19,113,146 bp
  • A to T, chromosome 14 at 31,359,210 bp
  • A to G, chromosome 14 at 34,729,215 bp
  • T to C, chromosome 14 at 54,857,321 bp
  • G to A, chromosome 14 at 121,222,726 bp
  • G to A, chromosome 15 at 98,791,970 bp
  • T to C, chromosome 16 at 16,140,860 bp
  • G to T, chromosome 16 at 27,409,389 bp
  • A to G, chromosome 16 at 33,066,301 bp
  • T to A, chromosome 17 at 3,439,702 bp
  • T to C, chromosome 17 at 31,604,743 bp
  • T to A, chromosome 17 at 36,030,963 bp
  • A to T, chromosome 17 at 63,471,424 bp
  • A to T, chromosome 17 at 84,658,663 bp
  • A to T, chromosome 18 at 37,478,218 bp
  • A to T, chromosome X at 51,969,091 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3121 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040594-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.