Strain Name:
C57BL/6J-MtgxR3405Btlr/Mmmh
Stock Number:
040623-MU
Citation ID:
RRID:MMRRC_040623-MU
Other Names:
R3405 (G1), C57BL/6J-MtgxR3405Btlr
Major Collection:

Gene Information

Lamb1
Name: laminin B1
Synonyms: Lamb-1, C81607, C80098, D130003D08Rik, Lamb1-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16777
HGNC: HGNC:6486
Homologene: 1722
Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk-2, Tsk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Plg
Name: plasminogen
Synonyms: Pg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18815
VEGA: 17
HGNC: HGNC:9071
Homologene: 55452
Mlst8
Name: MTOR associated protein, LST8 homolog (S. cerevisiae)
Synonyms: 0610033N12Rik, mLST8, Gbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56716
VEGA: 17
Homologene: 6833
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: MTK1, MAPKKK4, D17Rp17, RP17, D17Rp17e, Mekk4, Tas
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Zfp609
Name: zinc finger protein 609
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214812
Homologene: 72220
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77011
Homologene: 67120
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: 4930528H02Rik, Zfp294, Listerin, Rnf160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Exo1
Name: exonuclease 1
Synonyms: Msa, 5730442G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26909
HGNC: HGNC:3511
Homologene: 31352
Senp7
Name: SUMO1/sentrin specific peptidase 7
Synonyms: 6030449K19Rik, 2900036C23Rik, 2410152H17Rik, 2810413I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66315
Homologene: 10778
Ogdh
Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Synonyms: alpha-ketoglutarate dehydrogenase, 2210412K19Rik, 2210403E04Rik, d1401
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18293
HGNC: HGNC:8124
Homologene: 55662
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, D630048A14Rik, Ki67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Cdc27
Name: cell division cycle 27
Synonyms: APC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217232
HGNC: HGNC:1728
Homologene: 960
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 277939
Homologene: 19524
Uvssa
Name: UV stimulated scaffold protein A
Synonyms: D330017J19Rik, 4933407H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71101
Homologene: 13807
Commd9
Name: COMM domain containing 9
Synonyms: 1810029F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76501
Homologene: 8584
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Fancm
Name: Fanconi anemia, complementation group M
Synonyms: C730036B14Rik, D12Ertd364e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104806
VEGA: 12
Homologene: 35378
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230676
Homologene: 49413
Mfng
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms: manic fringe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17305
HGNC: HGNC:7038
Homologene: 1803
Pcdh17
Name: protocadherin 17
Synonyms: LOC219228, C030033F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219228
VEGA: 14
Homologene: 8700
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77505
Homologene: 131117
Dhodh
Name: dihydroorotate dehydrogenase
Synonyms: 2810417D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56749
HGNC: HGNC:2867
Homologene: 1043
Immp2l
Name: IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
Synonyms: IMP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 93757
Homologene: 6607
Cubn
Name: cubilin (intrinsic factor-cobalamin receptor)
Synonyms: D2Wsu88e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328783
VEGA: 17
Homologene: 18633
Mmp9
Name: matrix metallopeptidase 9
Synonyms: gelatinase B, Gel B, MMP-9, B/MMP9, Clg4b, Gelatinase B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17395
HGNC: HGNC:7176
Homologene: 3659
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329178
Homologene: 122243
Nlrp9c
Name: NLR family, pyrin domain containing 9C
Synonyms: Nalp9c, Nalp-zeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330490
Homologene: 116072
Stap2
Name: signal transducing adaptor family member 2
Synonyms: STAP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106766
VEGA: 17
Homologene: 9798
Eif2ak2
Name: eukaryotic translation initiation factor 2-alpha kinase 2
Synonyms: eIF-2 alpha, Pkr, dsRNA-activated kinase, IFN- type I-induced and dsRNA-activated kinase, IFN-induced and double-stranded RNA-activated kinase, Prkr, Tik, eIF-2 alpha, 2310047A08Rik, 4732414G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19106
HGNC: HGNC:9437
Homologene: 48134
Nrp1
Name: neuropilin 1
Synonyms: Neuropilin-1, NP-1, NPN-1, Npn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 4932416F07Rik, 1300010F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Hormad2
Name: HORMA domain containing 2
Synonyms: 4930529M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75828
Homologene: 45130
Myrfl
Name: myelin regulatory factor-like
Synonyms: LOC237558, Gm239
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237558
VEGA: 10
Homologene: 88588
Gsdma
Name: gasdermin A
Synonyms: H312E, Gsdm, Gsdm1, Gsdma1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57911
Homologene: 10962
Kbtbd10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Rbfox3
Name: RNA binding protein, fox-1 homolog (C. elegans) 3
Synonyms: NeuN, D11Bwg0517e, Neuna60, Hrnbp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52897
Homologene: 134629
Fmn1
Name: formin 1
Synonyms: Fmn, formin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14260
HGNC: HGNC:3768
Homologene: 121778
FP885536.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Ncf2
Name: neutrophil cytosolic factor 2
Synonyms: NADPH oxidase subunit (67kDa), p67phox, Ncf-2, NOXA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17970
HGNC: HGNC:7661
Homologene: 374
Bcorl1
Name: BCL6 co-repressor-like 1
Synonyms: 6720425J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 320376
Homologene: 41458
Pnlip
Name: pancreatic lipase
Synonyms: pancreatic triglyceride lipase, PTL, 1810007A24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69060
VEGA: 19
HGNC: HGNC:9155
Homologene: 30999
Mab21l3
Name: mab-21-like 3
Synonyms: BC037703
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242125
Homologene: 17564
Lrrc30
Name: leucine rich repeat containing 30
Synonyms: LOC240131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240131
VEGA: 17
Homologene: 33184
Ct55
Name: cancer/testis antigen 55
Synonyms: Ct55, 4930502E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 75013
Homologene: 137390
Kcne4
Name: potassium voltage-gated channel, Isk-related subfamily, gene 4
Synonyms: MiRP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 57814
HGNC: HGNC:6244
Homologene: 10959
Gm5612
Name: predicted gene 5612
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 434375
VEGA: 9
Dpt
Name: dermatopontin
Synonyms: early quiescence protein-1, EQ-1, 1810032B19Rik, 5033416F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56429
HGNC: HGNC:3011
Homologene: 1458
Myl12a
Name: myosin, light chain 12A, regulatory, non-sarcomeric
Synonyms: brain specific myosin regulatory light chain, NMDA receptor-interacting protein, 2900073G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67268
Homologene: 68515
Nalf2
Name: NALCN channel auxiliary factor 2
Synonyms: EG620592, Fam155b, Tmem28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 620592
Homologene: 83276
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 45,338,753 bp
  • A to G, chromosome 1 at 66,694,573 bp
  • C to T, chromosome 1 at 78,817,971 bp
  • A to G, chromosome 1 at 152,825,947 bp
  • A to C, chromosome 1 at 164,796,931 bp
  • A to G, chromosome 1 at 175,905,970 bp
  • C to T, chromosome 2 at 13,333,508 bp
  • A to G, chromosome 2 at 69,674,528 bp
  • G to A, chromosome 2 at 101,886,331 bp
  • A to G, chromosome 2 at 113,364,348 bp
  • A to G, chromosome 2 at 164,949,390 bp
  • C to A, chromosome 3 at 101,823,531 bp
  • A to G, chromosome 4 at 118,394,020 bp
  • G to T, chromosome 4 at 156,334,397 bp
  • G to T, chromosome 5 at 33,389,818 bp
  • C to A, chromosome 6 at 85,667,963 bp
  • T to A, chromosome 7 at 26,385,282 bp
  • G to C, chromosome 7 at 79,694,791 bp
  • T to C, chromosome 7 at 100,390,166 bp
  • C to T, chromosome 7 at 105,694,761 bp
  • T to A, chromosome 7 at 135,707,475 bp
  • G to A, chromosome 8 at 109,603,475 bp
  • T to A, chromosome 8 at 128,498,088 bp
  • A to T, chromosome 9 at 18,427,853 bp
  • A to T, chromosome 9 at 65,701,172 bp
  • A to G, chromosome 10 at 116,822,865 bp
  • T to G, chromosome 11 at 4,424,302 bp
  • T to C, chromosome 11 at 6,349,462 bp
  • T to C, chromosome 11 at 98,673,138 bp
  • T to C, chromosome 11 at 104,507,200 bp
  • T to A, chromosome 11 at 118,496,457 bp
  • C to T, chromosome 12 at 31,287,529 bp
  • T to A, chromosome 12 at 41,110,847 bp
  • T to C, chromosome 12 at 65,075,772 bp
  • T to A, chromosome 14 at 79,164,220 bp
  • T to A, chromosome 14 at 84,446,622 bp
  • A to C, chromosome 15 at 78,760,900 bp
  • T to A, chromosome 16 at 56,188,277 bp
  • A to T, chromosome 16 at 87,416,215 bp
  • A to T, chromosome 17 at 12,256,781 bp
  • G to T, chromosome 17 at 12,403,209 bp
  • A to T, chromosome 17 at 24,478,125 bp
  • A to G, chromosome 17 at 25,746,181 bp
  • A to T, chromosome 17 at 55,997,511 bp
  • A to G, chromosome 17 at 67,632,180 bp
  • A to T, chromosome 17 at 70,994,742 bp
  • A to G, chromosome 17 at 78,858,639 bp
  • A to T, chromosome 17 at 84,230,785 bp
  • A to G, chromosome 19 at 58,680,759 bp
  • T to A, chromosome X at 48,371,007 bp
  • A to C, chromosome X at 53,727,354 bp
  • A to G, chromosome X at 99,845,503 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3405 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040623-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.